Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.031 0.168 -9999.0 0.0 -0.516 16.0 16.0 IHH -0.011 0.134 -9999.0 0.0 -0.288 29.0 29.0 SHH Np/Cholesterol/GAS1 -0.001 0.091 -9999.0 0.0 -0.211 27.0 27.0 LRPAP1 0.026 0.03 -9999.0 0.0 -0.376 1.0 1.0 dorsoventral neural tube patterning 0.002 0.09 0.21 27.0 -9999.0 0.0 27.0 SMO/beta Arrestin2 -0.021 0.166 -9999.0 0.0 -0.363 29.0 29.0 SMO -0.037 0.165 -9999.0 0.0 -0.381 29.0 29.0 AKT1 -0.037 0.162 -9999.0 0.0 -0.413 21.0 21.0 ARRB2 0.024 0.012 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.03 0.047 -9999.0 0.0 -0.376 2.0 2.0 ADRBK1 0.028 0.031 -9999.0 0.0 -0.376 1.0 1.0 heart looping -0.037 0.162 -9999.0 0.0 -0.376 29.0 29.0 STIL -0.023 0.117 0.178 9.0 -0.282 21.0 30.0 DHH N/PTCH2 0.029 0.078 0.168 2.0 -0.267 11.0 13.0 DHH N/PTCH1 -0.004 0.119 -9999.0 0.0 -0.248 33.0 33.0 PIK3CA 0.028 0.03 -9999.0 0.0 -0.376 1.0 1.0 DHH 0.024 0.062 -9999.0 0.0 -0.376 4.0 4.0 PTHLH -0.062 0.24 -9999.0 0.0 -0.704 18.0 18.0 determination of left/right symmetry -0.037 0.162 -9999.0 0.0 -0.376 29.0 29.0 PIK3R1 0.027 0.03 -9999.0 0.0 -0.376 1.0 1.0 skeletal system development -0.061 0.237 -9999.0 0.0 -0.697 18.0 18.0 IHH N/Hhip -0.006 0.127 -9999.0 0.0 -0.297 27.0 27.0 DHH N/Hhip 0.016 0.095 -9999.0 0.0 -0.268 18.0 18.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.037 0.162 -9999.0 0.0 -0.376 29.0 29.0 pancreas development -0.0 0.108 -9999.0 0.0 -0.375 14.0 14.0 HHAT 0.022 0.052 -9999.0 0.0 -0.376 3.0 3.0 PI3K 0.039 0.034 -9999.0 0.0 -0.268 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.005 0.14 -9999.0 0.0 -0.376 22.0 22.0 somite specification -0.037 0.162 -9999.0 0.0 -0.376 29.0 29.0 SHH Np/Cholesterol/PTCH1 -0.017 0.118 0.185 2.0 -0.26 30.0 32.0 SHH Np/Cholesterol/PTCH2 0.01 0.065 -9999.0 0.0 -0.217 13.0 13.0 SHH Np/Cholesterol/Megalin 0.017 0.052 0.2 1.0 -0.206 8.0 9.0 SHH -0.023 0.049 -9999.0 0.0 -0.267 7.0 7.0 catabolic process -0.018 0.119 -9999.0 0.0 -0.284 29.0 29.0 SMO/Vitamin D3 -0.028 0.145 0.241 2.0 -0.327 30.0 32.0 SHH Np/Cholesterol/Hhip -0.001 0.082 -9999.0 0.0 -0.233 19.0 19.0 LRP2 0.032 0.025 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.031 0.139 -9999.0 0.0 -0.32 29.0 29.0 SHH Np/Cholesterol/BOC 0.018 0.05 -9999.0 0.0 -0.204 8.0 8.0 SHH Np/Cholesterol/CDO 0.015 0.05 -9999.0 0.0 -0.202 9.0 9.0 mesenchymal cell differentiation 0.001 0.082 0.231 19.0 -9999.0 0.0 19.0 mol:Vitamin D3 -0.011 0.126 0.204 11.0 -0.261 30.0 41.0 IHH N/PTCH2 0.005 0.112 0.178 1.0 -0.281 21.0 22.0 CDON 0.028 0.031 -9999.0 0.0 -0.376 1.0 1.0 IHH N/PTCH1 -0.007 0.125 -9999.0 0.0 -0.286 29.0 29.0 Megalin/LRPAP1 0.042 0.031 -9999.0 0.0 -0.27 1.0 1.0 PTCH2 0.017 0.08 -9999.0 0.0 -0.376 7.0 7.0 SHH Np/Cholesterol 0.005 0.044 -9999.0 0.0 -0.198 8.0 8.0 PTCH1 -0.018 0.12 -9999.0 0.0 -0.285 29.0 29.0 HHIP -0.0 0.108 -9999.0 0.0 -0.376 14.0 14.0