Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.013 0.049 -9999.0 0.0 -0.19 10.0 10.0 epithelial cell differentiation 0.058 0.035 -9999.0 0.0 -0.194 3.0 3.0 CYFIP2 0.02 0.059 -9999.0 0.0 -0.376 4.0 4.0 ENAH -0.036 0.064 -9999.0 0.0 -0.318 5.0 5.0 EGFR 0.023 0.043 -9999.0 0.0 -0.376 2.0 2.0 EPHA2 0.028 0.033 -9999.0 0.0 -0.376 1.0 1.0 MYO6 -0.022 0.027 0.173 1.0 -9999.0 0.0 1.0 CTNNB1 0.03 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.048 0.059 -9999.0 0.0 -0.259 6.0 6.0 AQP5 -0.005 0.088 -9999.0 0.0 -0.455 6.0 6.0 CTNND1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.022 0.029 0.171 1.0 -9999.0 0.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.026 0.052 -9999.0 0.0 -0.349 1.0 1.0 EGF -0.009 0.15 -9999.0 0.0 -0.376 25.0 25.0 NCKAP1 0.026 0.042 -9999.0 0.0 -0.376 2.0 2.0 AQP3 0.002 0.063 -9999.0 0.0 -0.361 4.0 4.0 cortical microtubule organization 0.058 0.035 -9999.0 0.0 -0.194 3.0 3.0 GO:0000145 -0.022 0.027 0.156 1.0 -0.181 1.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.064 0.037 -9999.0 0.0 -0.196 3.0 3.0 MLLT4 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.037 0.044 -9999.0 0.0 -0.271 5.0 5.0 ARF6 0.025 0.031 -9999.0 0.0 -0.376 1.0 1.0 Ephrin A1/EPHA2/NCK1/GIT1 0.061 0.056 -9999.0 0.0 -0.254 4.0 4.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.009 0.03 0.165 1.0 -0.218 1.0 2.0 PVRL2 0.027 0.03 -9999.0 0.0 -0.376 1.0 1.0 ZYX -0.022 0.03 0.173 1.0 -9999.0 0.0 1.0 ARF6/GTP 0.063 0.063 -9999.0 0.0 -0.278 4.0 4.0 CDH1 0.026 0.042 -9999.0 0.0 -0.376 2.0 2.0 EGFR/EGFR/EGF/EGF 0.017 0.095 -9999.0 0.0 -0.196 28.0 28.0 RhoA/GDP 0.058 0.04 -9999.0 0.0 -0.189 4.0 4.0 actin cytoskeleton organization -0.024 0.031 0.158 1.0 -9999.0 0.0 1.0 IGF-1R heterotetramer 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.026 0.03 -9999.0 0.0 -0.376 1.0 1.0 IGF1R 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.009 0.125 -9999.0 0.0 -0.376 19.0 19.0 DIAPH1 0.025 0.154 -9999.0 0.0 -0.6 9.0 9.0 Wnt receptor signaling pathway -0.058 0.035 0.194 3.0 -9999.0 0.0 3.0 RHOA 0.027 0.03 -9999.0 0.0 -0.376 1.0 1.0 RhoA/GTP -0.038 0.043 -9999.0 0.0 -0.256 6.0 6.0 CTNNA1 0.027 0.03 -9999.0 0.0 -0.376 1.0 1.0 VCL -0.024 0.031 0.159 1.0 -9999.0 0.0 1.0 EFNA1 0.028 0.031 -9999.0 0.0 -0.376 1.0 1.0 LPP -0.025 0.029 0.161 1.0 -9999.0 0.0 1.0 Ephrin A1/EPHA2 0.046 0.047 -9999.0 0.0 -0.228 4.0 4.0 SEC6/SEC8 -0.031 0.025 -9999.0 0.0 -0.186 4.0 4.0 MGAT3 -0.026 0.053 -9999.0 0.0 -0.355 1.0 1.0 HGF/MET 0.045 0.05 -9999.0 0.0 -0.192 7.0 7.0 HGF 0.023 0.052 -9999.0 0.0 -0.376 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.013 0.049 -9999.0 0.0 -0.191 10.0 10.0 actin cable formation -0.022 0.086 0.233 3.0 -0.318 7.0 10.0 KIAA1543 -0.022 0.032 0.157 1.0 -0.339 1.0 2.0 KIFC3 -0.023 0.037 0.173 1.0 -0.194 5.0 6.0 NCK1 0.025 0.042 -9999.0 0.0 -0.376 2.0 2.0 EXOC3 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.021 0.027 0.173 1.0 -0.19 3.0 4.0 NCK1/GIT1 0.037 0.04 -9999.0 0.0 -0.266 3.0 3.0 mol:GDP 0.058 0.035 -9999.0 0.0 -0.194 3.0 3.0 EXOC4 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.021 0.027 0.173 1.0 -9999.0 0.0 1.0 PIP5K1C -0.023 0.03 0.173 1.0 -9999.0 0.0 1.0 LIMA1 0.019 0.066 -9999.0 0.0 -0.376 5.0 5.0 ABI1 0.028 0.03 -9999.0 0.0 -0.376 1.0 1.0 ROCK1 -0.03 0.066 0.282 1.0 -0.34 3.0 4.0 adherens junction assembly -0.016 0.077 -9999.0 0.0 -0.433 4.0 4.0 IGF-1R heterotetramer/IGF1 0.026 0.082 -9999.0 0.0 -0.193 21.0 21.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.042 0.024 -9999.0 0.0 -0.266 1.0 1.0 MET 0.027 0.03 -9999.0 0.0 -0.376 1.0 1.0 PLEKHA7 -0.023 0.034 0.173 1.0 -0.355 1.0 2.0 mol:GTP 0.059 0.055 -9999.0 0.0 -0.252 4.0 4.0 establishment of epithelial cell apical/basal polarity -0.019 0.065 0.312 2.0 -9999.0 0.0 2.0 cortical actin cytoskeleton stabilization 0.013 0.049 -9999.0 0.0 -0.19 10.0 10.0 regulation of cell-cell adhesion -0.024 0.031 0.158 1.0 -9999.0 0.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.013 0.049 -9999.0 0.0 -0.191 10.0 10.0