Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling mediated by p38-alpha and p38-beta	25.0	1109.0	44.0	-0.082	0.03	1000.0	-1000.0	-0.018	-1000.0
TCGA08_p53	22.0	154.0	7.0	-0.055	0.025	1000.0	-1000.0	-0.014	-1000.0
IL23-mediated signaling events	20.0	1239.0	60.0	-0.3	0.03	1000.0	-1000.0	-0.093	-1000.0
IL4-mediated signaling events	18.0	1719.0	91.0	-0.465	0.376	1000.0	-1000.0	-0.113	-1000.0
FOXA2 and FOXA3 transcription factor networks	18.0	855.0	46.0	-0.238	0.03	1000.0	-1000.0	-0.075	-1000.0
Endothelins	17.0	1701.0	96.0	-0.095	0.043	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by the Hedgehog family	16.0	860.0	52.0	-0.062	0.042	1000.0	-1000.0	-0.025	-1000.0
Fc-epsilon receptor I signaling in mast cells	14.0	1426.0	97.0	-0.165	0.056	1000.0	-1000.0	-0.048	-1000.0
BCR signaling pathway	14.0	1420.0	99.0	-0.125	0.04	1000.0	-1000.0	-0.037	-1000.0
IL12-mediated signaling events	13.0	1163.0	87.0	-0.176	0.035	1000.0	-1000.0	-0.054	-1000.0
Osteopontin-mediated events	13.0	520.0	38.0	-0.074	0.032	1000.0	-1000.0	-0.042	-1000.0
Noncanonical Wnt signaling pathway	13.0	345.0	26.0	-0.05	0.03	1000.0	-1000.0	-0.037	-1000.0
Glypican 1 network	13.0	670.0	48.0	-0.061	0.051	1000.0	-1000.0	-0.03	-1000.0
IL1-mediated signaling events	13.0	833.0	62.0	-0.042	0.089	1000.0	-1000.0	-0.037	-1000.0
TCR signaling in naïve CD8+ T cells	13.0	1217.0	93.0	-0.058	0.043	1000.0	-1000.0	-0.037	-1000.0
EPHB forward signaling	13.0	1181.0	85.0	-0.051	0.095	1000.0	-1000.0	-0.051	-1000.0
Wnt signaling	13.0	95.0	7.0	-0.043	0.03	1000.0	-1000.0	-0.014	-1000.0
Thromboxane A2 receptor signaling	12.0	1272.0	105.0	-0.085	0.036	1000.0	-1000.0	-0.037	-1000.0
amb2 Integrin signaling	12.0	1038.0	82.0	-0.053	0.047	1000.0	-1000.0	-0.03	-1000.0
TCGA08_retinoblastoma	12.0	103.0	8.0	-0.002	0.03	1000.0	-1000.0	-0.005	-1000.0
EGFR-dependent Endothelin signaling events	12.0	267.0	21.0	-0.046	0.046	1000.0	-1000.0	-0.04	-1000.0
HIF-1-alpha transcription factor network	11.0	876.0	76.0	-0.116	0.031	1000.0	-1000.0	-0.064	-1000.0
a4b1 and a4b7 Integrin signaling	11.0	55.0	5.0	-0.005	0.02	1000.0	-1000.0	0.02	-1000.0
Ephrin B reverse signaling	11.0	550.0	48.0	-0.055	0.046	1000.0	-1000.0	-0.032	-1000.0
Angiopoietin receptor Tie2-mediated signaling	11.0	1014.0	88.0	-0.07	0.04	1000.0	-1000.0	-0.064	-1000.0
PDGFR-beta signaling pathway	11.0	1157.0	97.0	-0.059	0.088	1000.0	-1000.0	-0.048	-1000.0
Ephrin A  reverse signaling	10.0	70.0	7.0	-0.034	0.027	1000.0	-1000.0	-0.017	-1000.0
Reelin signaling pathway	10.0	577.0	56.0	-0.049	0.074	1000.0	-1000.0	-0.03	-1000.0
Retinoic acid receptors-mediated signaling	10.0	636.0	58.0	-0.058	0.048	1000.0	-1000.0	-0.036	-1000.0
Syndecan-4-mediated signaling events	10.0	698.0	67.0	-0.027	0.047	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	10.0	783.0	78.0	-0.139	0.037	1000.0	-1000.0	-0.051	-1000.0
Syndecan-2-mediated signaling events	9.0	663.0	69.0	-0.016	0.04	1000.0	-1000.0	-0.039	-1000.0
BMP receptor signaling	9.0	756.0	81.0	-0.045	0.047	1000.0	-1000.0	-0.026	-1000.0
Glucocorticoid receptor regulatory network	9.0	1135.0	114.0	-0.173	0.084	1000.0	-1000.0	-0.04	-1000.0
Signaling events regulated by Ret tyrosine kinase	9.0	779.0	82.0	-0.041	0.045	1000.0	-1000.0	-0.041	-1000.0
LPA receptor mediated events	9.0	1012.0	102.0	-0.058	0.036	1000.0	-1000.0	-0.044	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	9.0	649.0	68.0	-0.15	0.053	1000.0	-1000.0	-0.055	-1000.0
VEGFR1 specific signals	9.0	539.0	56.0	-0.007	0.076	1000.0	-1000.0	-0.033	-1000.0
Syndecan-1-mediated signaling events	8.0	300.0	34.0	-0.033	0.036	1000.0	-1000.0	-0.028	-1000.0
JNK signaling in the CD4+ TCR pathway	8.0	149.0	17.0	-0.056	0.05	1000.0	-1000.0	-0.025	-1000.0
p75(NTR)-mediated signaling	8.0	1072.0	125.0	-0.064	0.067	1000.0	-1000.0	-0.061	-1000.0
Arf6 downstream pathway	8.0	344.0	43.0	-0.039	0.04	1000.0	-1000.0	-0.029	-1000.0
EPO signaling pathway	8.0	449.0	55.0	-0.031	0.058	1000.0	-1000.0	-0.033	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	8.0	319.0	37.0	-0.032	0.05	1000.0	-1000.0	-0.026	-1000.0
Integrins in angiogenesis	8.0	700.0	84.0	-0.077	0.057	1000.0	-1000.0	-0.036	-1000.0
Canonical Wnt signaling pathway	8.0	437.0	51.0	-0.13	0.088	1000.0	-1000.0	-0.027	-1000.0
IGF1 pathway	8.0	484.0	57.0	-0.042	0.057	1000.0	-1000.0	-0.038	-1000.0
Plasma membrane estrogen receptor signaling	8.0	701.0	86.0	-0.042	0.071	1000.0	-1000.0	-0.047	-1000.0
FOXM1 transcription factor network	8.0	428.0	51.0	-0.135	0.056	1000.0	-1000.0	-0.11	-1000.0
ErbB2/ErbB3 signaling events	7.0	492.0	65.0	-0.058	0.043	1000.0	-1000.0	-0.058	-1000.0
Caspase cascade in apoptosis	7.0	540.0	74.0	-0.043	0.054	1000.0	-1000.0	-0.029	-1000.0
Arf6 signaling events	7.0	441.0	62.0	-0.053	0.073	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by PTP1B	7.0	594.0	76.0	-0.047	0.053	1000.0	-1000.0	-0.025	-1000.0
Presenilin action in Notch and Wnt signaling	7.0	474.0	61.0	-0.045	0.064	1000.0	-1000.0	-0.029	-1000.0
Ceramide signaling pathway	7.0	581.0	76.0	-0.041	0.071	1000.0	-1000.0	-0.026	-1000.0
FAS signaling pathway (CD95)	7.0	353.0	47.0	-0.086	0.047	1000.0	-1000.0	-0.033	-1000.0
Effects of Botulinum toxin	7.0	193.0	26.0	-0.053	0.051	1000.0	-1000.0	-0.012	-1000.0
Glypican 2 network	7.0	30.0	4.0	0.016	0.027	1000.0	-1000.0	0.019	-1000.0
Nongenotropic Androgen signaling	7.0	400.0	52.0	-0.022	0.053	1000.0	-1000.0	-0.027	-1000.0
IL6-mediated signaling events	7.0	563.0	75.0	-0.037	0.062	1000.0	-1000.0	-0.044	-1000.0
Class I PI3K signaling events	7.0	562.0	73.0	-0.056	0.039	1000.0	-1000.0	-0.027	-1000.0
Class IB PI3K non-lipid kinase events	7.0	21.0	3.0	-0.014	0.014	1000.0	-1000.0	-0.02	-1000.0
Ras signaling in the CD4+ TCR pathway	7.0	132.0	17.0	-0.02	0.038	1000.0	-1000.0	-0.021	-1000.0
Cellular roles of Anthrax toxin	6.0	264.0	39.0	-0.039	0.031	1000.0	-1000.0	-0.016	-1000.0
PLK1 signaling events	6.0	576.0	85.0	-0.014	0.062	1000.0	-1000.0	-0.031	-1000.0
IFN-gamma pathway	6.0	458.0	68.0	-0.07	0.048	1000.0	-1000.0	-0.047	-1000.0
Class I PI3K signaling events mediated by Akt	6.0	469.0	68.0	-0.038	0.059	1000.0	-1000.0	-0.025	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	6.0	352.0	52.0	-0.015	0.075	1000.0	-1000.0	-0.033	-1000.0
S1P1 pathway	6.0	231.0	36.0	-0.045	0.043	1000.0	-1000.0	-0.034	-1000.0
Signaling mediated by p38-gamma and p38-delta	6.0	92.0	15.0	-0.025	0.028	1000.0	-1000.0	-0.028	-1000.0
Paxillin-dependent events mediated by a4b1	6.0	239.0	36.0	-0.04	0.043	1000.0	-1000.0	-0.038	-1000.0
Syndecan-3-mediated signaling events	6.0	218.0	35.0	-0.017	0.064	1000.0	-1000.0	-0.022	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	6.0	278.0	45.0	-0.029	0.076	1000.0	-1000.0	-0.044	-1000.0
Regulation of p38-alpha and p38-beta	6.0	352.0	54.0	-0.072	0.054	1000.0	-1000.0	-0.039	-1000.0
Calcium signaling in the CD4+ TCR pathway	6.0	214.0	31.0	-0.049	0.03	1000.0	-1000.0	-0.041	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	6.0	173.0	27.0	-0.036	0.041	1000.0	-1000.0	-0.03	-1000.0
Arf6 trafficking events	6.0	437.0	71.0	-0.041	0.048	1000.0	-1000.0	-0.035	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	6.0	745.0	120.0	-0.054	0.077	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by PRL	6.0	216.0	34.0	-0.015	0.076	1000.0	-1000.0	-0.029	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	5.0	184.0	34.0	-0.035	0.074	1000.0	-1000.0	-0.025	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	5.0	306.0	54.0	-0.03	0.043	1000.0	-1000.0	-0.036	-1000.0
Insulin-mediated glucose transport	5.0	170.0	32.0	-0.15	0.042	1000.0	-1000.0	-0.026	-1000.0
PDGFR-alpha signaling pathway	5.0	233.0	44.0	-0.033	0.067	1000.0	-1000.0	-0.036	-1000.0
Visual signal transduction: Rods	5.0	299.0	52.0	-0.042	0.059	1000.0	-1000.0	-0.025	-1000.0
S1P4 pathway	5.0	147.0	25.0	-0.02	0.038	1000.0	-1000.0	-0.019	-1000.0
Regulation of Androgen receptor activity	5.0	386.0	70.0	-0.06	0.054	1000.0	-1000.0	-0.039	-1000.0
Aurora B signaling	5.0	368.0	67.0	-0.146	0.06	1000.0	-1000.0	-0.039	-1000.0
ErbB4 signaling events	4.0	284.0	69.0	-0.043	0.047	1000.0	-1000.0	-0.039	-1000.0
mTOR signaling pathway	4.0	258.0	53.0	-0.082	0.035	1000.0	-1000.0	-0.026	-1000.0
Nectin adhesion pathway	4.0	263.0	63.0	-0.013	0.074	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by HDAC Class III	4.0	183.0	40.0	-0.047	0.05	1000.0	-1000.0	-0.037	-1000.0
ceramide signaling pathway	4.0	241.0	49.0	-0.006	0.043	1000.0	-1000.0	-0.03	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	4.0	357.0	83.0	-0.055	0.059	1000.0	-1000.0	-0.021	-1000.0
IL2 signaling events mediated by PI3K	4.0	264.0	58.0	-0.027	0.048	1000.0	-1000.0	-0.036	-1000.0
IL27-mediated signaling events	4.0	249.0	51.0	-0.061	0.048	1000.0	-1000.0	-0.034	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	302.0	74.0	-0.058	0.064	1000.0	-1000.0	-0.054	-1000.0
E-cadherin signaling in the nascent adherens junction	4.0	325.0	76.0	-0.016	0.076	1000.0	-1000.0	-0.049	-1000.0
IL2 signaling events mediated by STAT5	4.0	95.0	22.0	-0.025	0.03	1000.0	-1000.0	-0.039	-1000.0
Regulation of Telomerase	4.0	447.0	102.0	-0.063	0.05	1000.0	-1000.0	-0.04	-1000.0
S1P3 pathway	4.0	174.0	42.0	-0.027	0.046	1000.0	-1000.0	-0.025	-1000.0
Arf1 pathway	4.0	221.0	54.0	-0.005	0.068	1000.0	-1000.0	-0.016	-1000.0
LPA4-mediated signaling events	3.0	41.0	12.0	-0.03	0.005	1000.0	-1000.0	-0.02	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	469.0	136.0	-0.069	0.061	1000.0	-1000.0	-0.036	-1000.0
Coregulation of Androgen receptor activity	3.0	301.0	76.0	-0.036	0.051	1000.0	-1000.0	-0.023	-1000.0
BARD1 signaling events	3.0	172.0	57.0	-0.034	0.077	1000.0	-1000.0	-0.043	-1000.0
Sphingosine 1-phosphate (S1P) pathway	3.0	105.0	28.0	-0.022	0.045	1000.0	-1000.0	-0.025	-1000.0
Visual signal transduction: Cones	3.0	127.0	38.0	-0.019	0.053	1000.0	-1000.0	-0.021	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	3.0	331.0	85.0	-0.083	0.068	1000.0	-1000.0	-0.034	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	227.0	65.0	-0.023	0.049	1000.0	-1000.0	-0.03	-1000.0
S1P5 pathway	3.0	62.0	17.0	-0.007	0.032	1000.0	-1000.0	-0.01	-1000.0
HIF-2-alpha transcription factor network	3.0	150.0	43.0	-0.084	0.086	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by HDAC Class I	3.0	402.0	104.0	-0.056	0.071	1000.0	-1000.0	-0.037	-1000.0
FoxO family signaling	3.0	224.0	64.0	-0.068	0.049	1000.0	-1000.0	-0.044	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	410.0	125.0	-0.035	0.089	1000.0	-1000.0	-0.046	-1000.0
TCGA08_rtk_signaling	3.0	96.0	26.0	-0.032	0.068	1000.0	-1000.0	-0.008	-1000.0
Insulin Pathway	3.0	227.0	74.0	-0.038	0.087	1000.0	-1000.0	-0.05	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	3.0	128.0	33.0	-0.012	0.069	1000.0	-1000.0	-0.026	-1000.0
Canonical NF-kappaB pathway	2.0	101.0	39.0	-0.013	0.064	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by HDAC Class II	2.0	216.0	75.0	-0.03	0.075	1000.0	-1000.0	-0.027	-1000.0
PLK2 and PLK4 events	2.0	7.0	3.0	-0.02	0.027	1000.0	-1000.0	-0.026	-1000.0
E-cadherin signaling in keratinocytes	2.0	103.0	43.0	-0.035	0.083	1000.0	-1000.0	-0.029	-1000.0
p38 MAPK signaling pathway	2.0	89.0	44.0	-0.016	0.061	1000.0	-1000.0	-0.016	-1000.0
Circadian rhythm pathway	1.0	23.0	22.0	-0.005	0.063	1000.0	-1000.0	-0.023	-1000.0
Aurora A signaling	1.0	85.0	60.0	-0.015	0.074	1000.0	-1000.0	-0.024	-1000.0
Aurora C signaling	1.0	11.0	7.0	-0.0	0.04	1000.0	-1000.0	-0.011	-1000.0
TRAIL signaling pathway	1.0	60.0	48.0	-0.017	0.066	1000.0	-1000.0	-0.026	-1000.0
Atypical NF-kappaB pathway	1.0	58.0	31.0	-0.012	0.049	1000.0	-1000.0	-0.024	-1000.0
Rapid glucocorticoid signaling	1.0	26.0	20.0	-0.01	0.029	1000.0	-1000.0	-0.013	-1000.0
E-cadherin signaling events	1.0	9.0	5.0	0.026	0.053	1000.0	-1000.0	0.017	-1000.0
Alternative NF-kappaB pathway	1.0	20.0	13.0	-0.0	0.073	1000.0	-1000.0	-0.0	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	19.0	23.0	0.007	0.041	1000.0	-1000.0	-0.018	-1000.0
Total	928	57264	7203	-7.09950608232	7.17909389027	131000	-131000	-4.32656390891	-131000