E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.029 0.044 -9999.0 0.0 -0.408 2.0 2.0 KLHL20 -0.02 0.057 -9999.0 0.0 -0.216 17.0 17.0 CYFIP2 -0.001 0.078 -9999.0 0.0 -0.476 7.0 7.0 Rac1/GDP 0.038 0.05 -9999.0 0.0 -0.413 1.0 1.0 ENAH 0.022 0.061 -9999.0 0.0 -0.406 3.0 3.0 AP1M1 0.009 0.041 -9999.0 0.0 -0.459 2.0 2.0 RAP1B 0.009 0.042 -9999.0 0.0 -0.476 2.0 2.0 RAP1A 0.01 0.03 -9999.0 0.0 -0.476 1.0 1.0 CTNNB1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.008 0.046 -9999.0 0.0 -0.377 3.0 3.0 ABI1/Sra1/Nap1 -0.016 0.043 -9999.0 0.0 -0.195 6.0 6.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.015 0.065 -9999.0 0.0 -0.243 10.0 10.0 RAPGEF1 0.037 0.045 -9999.0 0.0 -0.358 3.0 3.0 CTNND1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.025 0.043 -9999.0 0.0 -0.424 2.0 2.0 CRK 0.034 0.042 -9999.0 0.0 -0.38 2.0 2.0 E-cadherin/gamma catenin/alpha catenin 0.018 0.05 -9999.0 0.0 -0.322 5.0 5.0 alphaE/beta7 Integrin -0.001 0.078 -9999.0 0.0 -0.32 15.0 15.0 IQGAP1 0.008 0.042 -9999.0 0.0 -0.476 2.0 2.0 NCKAP1 0.008 0.042 -9999.0 0.0 -0.476 2.0 2.0 Rap1/GTP/I-afadin 0.021 0.036 -9999.0 0.0 -0.373 2.0 2.0 DLG1 0.027 0.048 -9999.0 0.0 -0.408 2.0 2.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.005 0.03 -9999.0 0.0 -0.238 3.0 3.0 MLLT4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.003 0.07 -9999.0 0.0 -0.234 21.0 21.0 PI3K -0.007 0.039 -9999.0 0.0 -0.313 3.0 3.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.012 0.053 -9999.0 0.0 -0.398 4.0 4.0 TIAM1 -0.023 0.124 -9999.0 0.0 -0.455 20.0 20.0 E-cadherin(dimer)/Ca2+ 0.026 0.027 -9999.0 0.0 -0.228 3.0 3.0 AKT1 -0.004 0.027 -9999.0 0.0 -0.255 2.0 2.0 PIK3R1 0.01 0.03 -9999.0 0.0 -0.476 1.0 1.0 CDH1 0.009 0.042 -9999.0 0.0 -0.476 2.0 2.0 RhoA/GDP 0.037 0.052 -9999.0 0.0 -0.413 1.0 1.0 actin cytoskeleton organization 0.017 0.053 -9999.0 0.0 -0.157 17.0 17.0 CDC42/GDP 0.034 0.061 -9999.0 0.0 -0.351 3.0 3.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.016 0.04 -9999.0 0.0 -0.281 4.0 4.0 ITGB7 -0.013 0.106 -9999.0 0.0 -0.461 14.0 14.0 RAC1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.029 0.029 -9999.0 0.0 -0.243 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.019 0.027 -9999.0 0.0 -0.233 3.0 3.0 mol:GDP 0.034 0.056 -9999.0 0.0 -0.497 1.0 1.0 CDC42/GTP/IQGAP1 0.009 0.058 -9999.0 0.0 -0.386 5.0 5.0 JUP 0.007 0.051 -9999.0 0.0 -0.465 3.0 3.0 p120 catenin/RhoA/GDP 0.037 0.051 -9999.0 0.0 -0.418 1.0 1.0 RAC1/GTP/IQGAP1 0.014 0.026 -9999.0 0.0 -0.281 2.0 2.0 PIP5K1C/AP1M1 0.015 0.044 -9999.0 0.0 -0.463 2.0 2.0 RHOA 0.01 0.03 -9999.0 0.0 -0.476 1.0 1.0 CDC42 0.003 0.067 -9999.0 0.0 -0.476 5.0 5.0 CTNNA1 0.01 0.03 -9999.0 0.0 -0.476 1.0 1.0 positive regulation of S phase of mitotic cell cycle 0.015 0.038 -9999.0 0.0 -0.255 1.0 1.0 NME1 0.01 0.028 -9999.0 0.0 -0.441 1.0 1.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.029 0.044 -9999.0 0.0 -0.408 2.0 2.0 regulation of cell-cell adhesion -0.007 0.04 -9999.0 0.0 -0.325 3.0 3.0 WASF2 -0.008 0.022 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.005 0.037 -9999.0 0.0 -0.358 2.0 2.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.017 0.071 -9999.0 0.0 -0.461 1.0 1.0 CCND1 0.017 0.046 -9999.0 0.0 -0.324 1.0 1.0 VAV2 -0.006 0.175 -9999.0 0.0 -0.624 19.0 19.0 RAP1/GDP 0.033 0.048 -9999.0 0.0 -0.391 2.0 2.0 adherens junction assembly 0.029 0.043 -9999.0 0.0 -0.395 2.0 2.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.01 0.03 -9999.0 0.0 -0.476 1.0 1.0 PIP5K1C 0.01 0.03 -9999.0 0.0 -0.476 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.021 0.068 -9999.0 0.0 -0.438 1.0 1.0 E-cadherin/beta catenin -0.003 0.043 -9999.0 0.0 -0.378 3.0 3.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.029 0.044 -9999.0 0.0 -0.407 2.0 2.0 PIK3CA 0.008 0.042 -9999.0 0.0 -0.476 2.0 2.0 Rac1/GTP -0.032 0.093 -9999.0 0.0 -0.347 19.0 19.0 E-cadherin/beta catenin/alpha catenin 0.022 0.032 -9999.0 0.0 -0.275 3.0 3.0 ITGAE 0.01 0.028 -9999.0 0.0 -0.441 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.025 0.043 -9999.0 0.0 -0.433 2.0 2.0