Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.042 0.21 -9999.0 0.0 -0.559 31.0 31.0 IHH -0.043 0.163 -9999.0 0.0 -0.512 27.0 27.0 SHH Np/Cholesterol/GAS1 -0.068 0.132 -9999.0 0.0 -0.251 86.0 86.0 LRPAP1 0.01 0.03 -9999.0 0.0 -0.476 1.0 1.0 dorsoventral neural tube patterning 0.067 0.131 0.25 86.0 -9999.0 0.0 86.0 SMO/beta Arrestin2 -0.036 0.184 -9999.0 0.0 -0.545 19.0 19.0 SMO -0.044 0.193 -9999.0 0.0 -0.58 19.0 19.0 AKT1 -0.007 0.118 -9999.0 0.0 -0.486 7.0 7.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.017 0.113 -9999.0 0.0 -0.447 17.0 17.0 ADRBK1 0.003 0.063 -9999.0 0.0 -0.448 5.0 5.0 heart looping -0.043 0.19 -9999.0 0.0 -0.568 19.0 19.0 STIL -0.018 0.143 -9999.0 0.0 -0.461 16.0 16.0 DHH N/PTCH2 -0.031 0.123 -9999.0 0.0 -0.335 36.0 36.0 DHH N/PTCH1 -0.038 0.148 -9999.0 0.0 -0.465 13.0 13.0 PIK3CA 0.008 0.042 -9999.0 0.0 -0.476 2.0 2.0 DHH -0.024 0.124 -9999.0 0.0 -0.457 20.0 20.0 PTHLH -0.069 0.278 -9999.0 0.0 -0.848 25.0 25.0 determination of left/right symmetry -0.043 0.19 -9999.0 0.0 -0.568 19.0 19.0 PIK3R1 0.01 0.03 -9999.0 0.0 -0.476 1.0 1.0 skeletal system development -0.068 0.275 -9999.0 0.0 -0.837 25.0 25.0 IHH N/Hhip -0.057 0.163 -9999.0 0.0 -0.372 52.0 52.0 DHH N/Hhip -0.048 0.142 -9999.0 0.0 -0.343 48.0 48.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.043 0.19 -9999.0 0.0 -0.568 19.0 19.0 pancreas development -0.045 0.155 -9999.0 0.0 -0.47 31.0 31.0 HHAT 0.007 0.052 -9999.0 0.0 -0.476 3.0 3.0 PI3K 0.014 0.037 -9999.0 0.0 -0.334 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.123 0.213 -9999.0 0.0 -0.457 76.0 76.0 somite specification -0.043 0.19 -9999.0 0.0 -0.568 19.0 19.0 SHH Np/Cholesterol/PTCH1 -0.022 0.15 -9999.0 0.0 -0.49 16.0 16.0 SHH Np/Cholesterol/PTCH2 -0.012 0.097 -9999.0 0.0 -0.275 29.0 29.0 SHH Np/Cholesterol/Megalin -0.016 0.086 -9999.0 0.0 -0.243 32.0 32.0 SHH -0.001 0.081 -9999.0 0.0 -0.33 15.0 15.0 catabolic process -0.027 0.15 -9999.0 0.0 -0.378 27.0 27.0 SMO/Vitamin D3 -0.034 0.177 -9999.0 0.0 -0.538 20.0 20.0 SHH Np/Cholesterol/Hhip -0.025 0.114 -9999.0 0.0 -0.282 40.0 40.0 LRP2 -0.026 0.112 -9999.0 0.0 -0.441 18.0 18.0 receptor-mediated endocytosis -0.036 0.173 -9999.0 0.0 -0.539 18.0 18.0 SHH Np/Cholesterol/BOC -0.01 0.089 -9999.0 0.0 -0.253 30.0 30.0 SHH Np/Cholesterol/CDO 0.001 0.073 -9999.0 0.0 -0.257 19.0 19.0 mesenchymal cell differentiation 0.025 0.113 0.28 40.0 -9999.0 0.0 40.0 mol:Vitamin D3 -0.02 0.152 -9999.0 0.0 -0.492 16.0 16.0 IHH N/PTCH2 -0.038 0.143 -9999.0 0.0 -0.358 40.0 40.0 CDON 0.003 0.065 -9999.0 0.0 -0.462 5.0 5.0 IHH N/PTCH1 -0.026 0.152 -9999.0 0.0 -0.381 27.0 27.0 Megalin/LRPAP1 -0.011 0.083 -9999.0 0.0 -0.307 19.0 19.0 PTCH2 -0.02 0.119 -9999.0 0.0 -0.461 18.0 18.0 SHH Np/Cholesterol -0.002 0.061 -9999.0 0.0 -0.251 15.0 15.0 PTCH1 -0.027 0.15 -9999.0 0.0 -0.38 27.0 27.0 HHIP -0.045 0.155 -9999.0 0.0 -0.471 31.0 31.0