E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.008 0.064 -9999.0 0.0 -0.361 6.0 6.0 KLHL20 0.033 0.094 0.203 18.0 -0.224 16.0 34.0 CYFIP2 0.019 0.062 -9999.0 0.0 -0.381 6.0 6.0 Rac1/GDP 0.051 0.101 0.269 6.0 -0.287 3.0 9.0 ENAH 0.003 0.071 -9999.0 0.0 -0.357 7.0 7.0 AP1M1 0.028 0.026 -9999.0 0.0 -0.381 1.0 1.0 RAP1B 0.026 0.036 -9999.0 0.0 -0.381 2.0 2.0 RAP1A 0.027 0.026 -9999.0 0.0 -0.381 1.0 1.0 CTNNB1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.04 0.066 -9999.0 0.0 -0.281 2.0 2.0 ABI1/Sra1/Nap1 -0.015 0.045 -9999.0 0.0 -0.163 17.0 17.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.054 0.057 -9999.0 0.0 -0.202 8.0 8.0 RAPGEF1 0.048 0.095 0.27 7.0 -0.334 4.0 11.0 CTNND1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.022 0.062 -9999.0 0.0 -0.381 5.0 5.0 CRK 0.047 0.089 -9999.0 0.0 -0.367 3.0 3.0 E-cadherin/gamma catenin/alpha catenin 0.052 0.046 -9999.0 0.0 -0.28 4.0 4.0 alphaE/beta7 Integrin 0.028 0.056 -9999.0 0.0 -0.26 8.0 8.0 IQGAP1 0.025 0.037 -9999.0 0.0 -0.381 2.0 2.0 NCKAP1 0.027 0.036 -9999.0 0.0 -0.381 2.0 2.0 Rap1/GTP/I-afadin 0.05 0.036 -9999.0 0.0 -0.299 2.0 2.0 DLG1 0.007 0.063 -9999.0 0.0 -0.374 5.0 5.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.016 0.027 -9999.0 0.0 -0.229 2.0 2.0 MLLT4 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.043 0.049 -9999.0 0.0 -0.206 7.0 7.0 PI3K -0.018 0.036 -9999.0 0.0 -0.299 2.0 2.0 ARF6 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.038 0.044 -9999.0 0.0 -0.343 3.0 3.0 TIAM1 0.021 0.071 -9999.0 0.0 -0.381 7.0 7.0 E-cadherin(dimer)/Ca2+ 0.064 0.034 -9999.0 0.0 -0.2 3.0 3.0 AKT1 0.012 0.054 0.154 3.0 -0.222 2.0 5.0 PIK3R1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.026 0.036 -9999.0 0.0 -0.381 2.0 2.0 RhoA/GDP 0.065 0.105 0.295 7.0 -0.288 3.0 10.0 actin cytoskeleton organization 0.032 0.078 0.179 23.0 -0.164 16.0 39.0 CDC42/GDP 0.061 0.108 0.295 8.0 -0.288 4.0 12.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.013 0.037 -9999.0 0.0 -0.235 5.0 5.0 ITGB7 0.019 0.073 -9999.0 0.0 -0.381 8.0 8.0 RAC1 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.069 0.036 -9999.0 0.0 -0.213 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.048 0.029 -9999.0 0.0 -0.195 3.0 3.0 mol:GDP 0.055 0.115 0.302 9.0 -0.329 3.0 12.0 CDC42/GTP/IQGAP1 0.03 0.048 -9999.0 0.0 -0.323 4.0 4.0 JUP 0.026 0.037 -9999.0 0.0 -0.381 2.0 2.0 p120 catenin/RhoA/GDP 0.075 0.107 0.297 7.0 -0.294 3.0 10.0 RAC1/GTP/IQGAP1 0.032 0.027 -9999.0 0.0 -0.226 2.0 2.0 PIP5K1C/AP1M1 0.042 0.034 -9999.0 0.0 -0.487 1.0 1.0 RHOA 0.028 0.026 -9999.0 0.0 -0.381 1.0 1.0 CDC42 0.022 0.051 -9999.0 0.0 -0.381 4.0 4.0 CTNNA1 0.028 0.026 -9999.0 0.0 -0.381 1.0 1.0 positive regulation of S phase of mitotic cell cycle 0.028 0.059 0.141 26.0 -0.114 14.0 40.0 NME1 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.008 0.061 -9999.0 0.0 -0.374 5.0 5.0 regulation of cell-cell adhesion 0.004 0.036 -9999.0 0.0 -0.222 3.0 3.0 WASF2 0.012 0.039 0.091 17.0 -0.109 2.0 19.0 Rap1/GTP 0.07 0.085 0.28 3.0 -0.305 2.0 5.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.06 0.067 -9999.0 0.0 -0.216 9.0 9.0 CCND1 0.032 0.069 0.166 24.0 -0.139 14.0 38.0 VAV2 0.038 0.213 0.406 1.0 -0.643 18.0 19.0 RAP1/GDP 0.073 0.1 0.3 6.0 -0.334 2.0 8.0 adherens junction assembly 0.008 0.06 -9999.0 0.0 -0.364 5.0 5.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.028 0.026 -9999.0 0.0 -0.381 1.0 1.0 PIP5K1C 0.028 0.026 -9999.0 0.0 -0.381 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.043 0.058 -9999.0 0.0 -0.209 9.0 9.0 E-cadherin/beta catenin 0.009 0.034 -9999.0 0.0 -0.282 3.0 3.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.002 0.053 -9999.0 0.0 -0.361 4.0 4.0 PIK3CA 0.026 0.036 -9999.0 0.0 -0.381 2.0 2.0 Rac1/GTP -0.021 0.099 -9999.0 0.0 -0.368 16.0 16.0 E-cadherin/beta catenin/alpha catenin 0.054 0.034 -9999.0 0.0 -0.231 3.0 3.0 ITGAE 0.024 0.013 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.022 0.063 -9999.0 0.0 -0.388 5.0 5.0