Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.031 0.161 -9999.0 0.0 -0.508 21.0 21.0 IHH -0.011 0.134 -9999.0 0.0 -0.294 39.0 39.0 SHH Np/Cholesterol/GAS1 -0.006 0.094 -9999.0 0.0 -0.213 41.0 41.0 LRPAP1 0.027 0.026 -9999.0 0.0 -0.381 1.0 1.0 dorsoventral neural tube patterning 0.007 0.093 0.212 41.0 -9999.0 0.0 41.0 SMO/beta Arrestin2 -0.022 0.159 -9999.0 0.0 -0.359 37.0 37.0 SMO -0.036 0.159 -9999.0 0.0 -0.358 43.0 43.0 AKT1 -0.034 0.158 -9999.0 0.0 -0.422 26.0 26.0 ARRB2 0.024 0.012 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.029 0.049 -9999.0 0.0 -0.381 3.0 3.0 ADRBK1 0.029 0.028 -9999.0 0.0 -0.381 1.0 1.0 heart looping -0.036 0.157 -9999.0 0.0 -0.353 43.0 43.0 STIL -0.022 0.116 0.191 12.0 -0.285 28.0 40.0 DHH N/PTCH2 0.025 0.084 0.173 2.0 -0.271 18.0 20.0 DHH N/PTCH1 -0.006 0.121 -9999.0 0.0 -0.253 46.0 46.0 PIK3CA 0.026 0.036 -9999.0 0.0 -0.381 2.0 2.0 DHH 0.018 0.079 -9999.0 0.0 -0.381 9.0 9.0 PTHLH -0.06 0.231 -9999.0 0.0 -0.743 21.0 21.0 determination of left/right symmetry -0.036 0.157 -9999.0 0.0 -0.353 43.0 43.0 PIK3R1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.06 0.229 -9999.0 0.0 -0.735 21.0 21.0 IHH N/Hhip -0.012 0.134 -9999.0 0.0 -0.301 41.0 41.0 DHH N/Hhip 0.008 0.11 -9999.0 0.0 -0.287 30.0 30.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.036 0.157 -9999.0 0.0 -0.353 43.0 43.0 pancreas development -0.006 0.118 -9999.0 0.0 -0.38 23.0 23.0 HHAT 0.024 0.044 -9999.0 0.0 -0.381 3.0 3.0 PI3K 0.04 0.029 -9999.0 0.0 -0.271 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.011 0.146 -9999.0 0.0 -0.381 33.0 33.0 somite specification -0.036 0.157 -9999.0 0.0 -0.353 43.0 43.0 SHH Np/Cholesterol/PTCH1 -0.017 0.114 0.181 1.0 -0.26 41.0 42.0 SHH Np/Cholesterol/PTCH2 0.009 0.068 -9999.0 0.0 -0.226 18.0 18.0 SHH Np/Cholesterol/Megalin 0.016 0.052 0.201 1.0 -0.208 11.0 12.0 SHH -0.024 0.048 -9999.0 0.0 -0.271 9.0 9.0 catabolic process -0.017 0.116 -9999.0 0.0 -0.282 39.0 39.0 SMO/Vitamin D3 -0.031 0.142 0.202 3.0 -0.332 40.0 43.0 SHH Np/Cholesterol/Hhip -0.004 0.088 -9999.0 0.0 -0.238 29.0 29.0 LRP2 0.031 0.024 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.034 0.136 -9999.0 0.0 -0.321 40.0 40.0 SHH Np/Cholesterol/BOC 0.017 0.052 -9999.0 0.0 -0.207 12.0 12.0 SHH Np/Cholesterol/CDO 0.014 0.05 -9999.0 0.0 -0.205 12.0 12.0 mesenchymal cell differentiation 0.005 0.087 0.237 29.0 -9999.0 0.0 29.0 mol:Vitamin D3 -0.013 0.123 0.211 12.0 -0.264 40.0 52.0 IHH N/PTCH2 0.005 0.111 0.184 1.0 -0.285 28.0 29.0 CDON 0.027 0.037 -9999.0 0.0 -0.381 2.0 2.0 IHH N/PTCH1 -0.007 0.121 -9999.0 0.0 -0.284 39.0 39.0 Megalin/LRPAP1 0.042 0.028 -9999.0 0.0 -0.275 1.0 1.0 PTCH2 0.018 0.078 -9999.0 0.0 -0.381 9.0 9.0 SHH Np/Cholesterol 0.005 0.044 -9999.0 0.0 -0.2 11.0 11.0 PTCH1 -0.017 0.116 -9999.0 0.0 -0.283 39.0 39.0 HHIP -0.006 0.119 -9999.0 0.0 -0.381 23.0 23.0