rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p	q
1	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(2), CD2(1), CD33(4), CD5(2), CSF2(2), IFNB1(1), IFNG(2), IL12B(1), IL3(1), ITGAX(6), TLR2(3), TLR4(1), TLR7(3), TLR9(2)	8029007	31	31	31	8	2	20	4	1	4	0	3.92e-07	0.000241
2	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	81	ANPEP(2), CD19(1), CD1B(1), CD1D(3), CD1E(2), CD2(1), CD22(3), CD33(4), CD37(1), CD38(1), CD3E(2), CD3G(1), CD44(3), CD5(2), CD55(1), CD59(1), CR2(3), CSF1R(1), CSF2(2), DNTT(1), EPO(1), FCER2(1), FLT3(4), HLA-DRA(1), IL1A(1), IL1B(1), IL1R1(2), IL3(1), IL4R(4), IL5RA(1), IL6(1), IL7(1), IL7R(1), ITGA1(2), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGAM(4), ITGB3(1), KIT(3), KITLG(1), MME(1), THPO(1), TPO(3)	34897969	79	70	78	28	18	36	9	2	14	0	0.000110	0.0339
3	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	123	BRAF(5), CD244(1), CSF2(2), FYN(1), ICAM1(1), ICAM2(1), IFNA10(4), IFNA21(1), IFNB1(1), IFNG(2), IFNGR2(3), ITGB2(4), KIR2DL1(2), KIR2DL3(1), KIR2DL4(1), KIR3DL1(3), KLRC3(2), KLRD1(1), KLRK1(1), KRAS(2), MAP2K1(1), MAPK1(1), MAPK3(1), NCR1(1), NFATC2(2), NFATC4(2), PAK1(1), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(6), PLCG2(2), PPP3CB(1), PPP3R2(1), PRKCA(1), PRKCG(2), PTK2B(2), PTPN11(4), RAF1(1), SH2D1A(1), SH2D1B(1), SHC4(1), SOS1(3), TNFSF10(2), ULBP1(1), VAV1(3), VAV2(2), VAV3(1), ZAP70(3)	47276775	102	78	95	34	30	30	19	9	14	0	0.000240	0.0494
4	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), CSF2(2), EPO(1), FLT3(4), IGF1(2), IL1A(1), IL3(1), IL6(1), KITLG(1)	3629573	14	14	14	1	1	6	5	0	2	0	0.000434	0.0532
5	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), CD86(2), HLA-DRA(1), IFNG(2), IFNGR2(3), IL12B(1), IL12RB1(2), IL12RB2(1), IL18R1(2), IL4R(4)	5517896	19	18	19	4	3	8	3	2	3	0	0.000515	0.0532
6	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CHUK(1), ELK1(2), FOS(1), IKBKB(1), IRAK1(2), LY96(2), MAP2K3(3), MAP3K1(2), MAP3K7(2), MAPK8(1), NFKB1(1), NFKBIA(1), PPARA(1), TLR10(2), TLR2(3), TLR3(1), TLR4(1), TLR6(5), TLR7(3), TLR9(2), TRAF6(1)	15827389	38	37	38	9	9	16	5	2	6	0	0.000518	0.0532
7	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(3), BDKRB1(1), C1QC(1), C1S(2), C2(2), C3(3), C4BPB(1), C5(1), C5AR1(3), C6(1), C8A(1), C8B(3), C9(2), CD46(2), CD55(1), CD59(1), CFB(1), CFH(2), CFI(1), CR2(3), F10(1), F13A1(3), F2(2), F5(4), F8(6), F9(4), FGA(4), FGB(2), FGG(3), KLKB1(1), KNG1(2), MASP2(1), MBL2(1), PLAT(1), PLG(2), SERPINA5(1), SERPINC1(1), SERPING1(2), VWF(5)	39287991	81	70	81	25	24	29	14	2	12	0	0.000661	0.0546
8	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(4)	312623	4	4	4	0	2	2	0	0	0	0	0.000709	0.0546
9	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	40	AKT1(1), BRAF(5), CREB1(1), CREBBP(4), CRKL(1), DAG1(2), EGR1(3), EGR2(1), EGR3(1), ELK1(2), MAP1B(2), MAPK1(1), MAPK3(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(2), NTRK1(1), PIK3C2G(6), PTPN11(4), RPS6KA3(1), SRC(2), TERF2IP(1)	20692311	46	42	42	14	12	14	6	4	10	0	0.000946	0.0648
10	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	19	ADCY1(3), AKT1(1), BCL2(2), CSF2RB(2), IGF1(2), IGF1R(2), IL3(1), KIT(3), KITLG(1), PRKAR1B(1), PRKAR2B(1), YWHAH(1)	7358109	20	20	20	4	4	7	5	1	3	0	0.00123	0.0684
11	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(1), F2(2), F5(4), F8(6), F9(4), FGA(4), FGB(2), FGG(3), LPA(2), PLAT(1), PLG(2), SERPINB2(1), VWF(5)	15208087	37	34	37	8	11	13	7	1	5	0	0.00133	0.0684
12	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F13A1(3), F2(2), FGA(4), FGB(2), FGG(3), PLAT(1), PLG(2), SERPINB2(1)	5783693	18	18	18	3	5	8	5	0	0	0	0.00136	0.0684
13	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	72	AKT1(1), CSF2(2), FCER1A(1), FYN(1), GAB2(1), IL3(1), INPP5D(3), KRAS(2), LYN(2), MAP2K1(1), MAP2K3(3), MAPK1(1), MAPK13(1), MAPK3(1), MAPK8(1), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLA2G2F(1), PLA2G3(1), PLA2G4A(2), PLA2G6(1), PLCG1(6), PLCG2(2), PRKCA(1), PRKCD(3), PRKCE(1), RAF1(1), SOS1(3), VAV1(3), VAV2(2), VAV3(1)	29587532	66	55	64	19	16	24	12	5	9	0	0.00148	0.0684
14	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	107	ACTN1(2), ACTN3(1), ARHGAP5(3), CDH5(1), CLDN14(1), CLDN15(1), CLDN17(1), CLDN18(1), CLDN19(1), CLDN9(1), CTNNA1(1), CTNNA2(2), CTNNA3(1), CYBB(1), EZR(3), F11R(1), GRLF1(1), ICAM1(1), ITGA4(3), ITGAM(4), ITGB1(1), ITGB2(4), MAPK13(1), MLLT4(4), MMP9(2), MSN(1), NCF1(1), NOX3(3), OCLN(1), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(6), PLCG2(2), PRKCA(1), PRKCG(2), PTK2B(2), PTPN11(4), PXN(1), RAPGEF3(1), RAPGEF4(1), ROCK1(1), ROCK2(1), SIPA1(2), TXK(1), VASP(1), VAV1(3), VAV2(2), VAV3(1), VCAM1(1)	52588430	98	83	97	39	21	39	15	9	14	0	0.00159	0.0684
15	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	230	ADCYAP1R1(1), ADRA2C(2), AGTR1(1), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BRS3(1), C5AR1(3), CALCRL(1), CCKAR(1), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), CNR2(1), CRHR2(2), CTSG(3), DRD2(1), DRD3(1), F2(2), F2RL3(1), GABBR2(2), GABRA2(1), GABRA3(1), GABRA4(2), GABRA5(3), GABRB3(4), GABRD(1), GABRE(2), GABRG1(1), GABRG2(3), GABRP(1), GALR1(1), GLP1R(1), GLP2R(2), GLRA1(1), GPR156(1), GPR50(1), GPR83(2), GRIA1(2), GRIA3(3), GRID1(1), GRID2(1), GRIK1(1), GRIK2(1), GRIK3(4), GRIN2A(8), GRIN2B(2), GRIN2C(1), GRIN2D(1), GRIN3A(1), GRIN3B(1), GRM1(4), GRM4(2), GRM5(2), GRM6(3), GRM7(2), GRM8(5), HRH2(2), HRH3(2), HTR1B(1), HTR1D(1), HTR1E(2), HTR2A(1), HTR2C(1), HTR4(1), HTR5A(3), HTR7(2), LEPR(1), LHCGR(2), MC2R(3), MC3R(3), MC4R(2), MC5R(2), MCHR1(1), MCHR2(1), NMBR(1), NMUR1(1), NMUR2(3), NPBWR1(1), NPY2R(1), NPY5R(3), NTSR1(3), OPRK1(1), OPRM1(2), P2RX2(1), P2RX5(1), P2RY2(1), P2RY4(1), PPYR1(1), PRLHR(1), PTAFR(1), PTGER4(1), PTGFR(1), PTH2R(1), RXFP1(2), RXFP2(1), SSTR4(2), TAAR1(1), TAAR5(1), TACR3(3), TRPV1(2)	93125688	176	127	176	79	50	80	19	16	11	0	0.00167	0.0684
16	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(4), ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), AMD1(1), AOC2(2), CKB(1), CKMT1A(3), CKMT1B(2), CPS1(4), DAO(4), GAMT(1), GATM(2), MAOB(2), NOS1(5), NOS3(4), OTC(2), RARS(1)	18918444	43	39	42	9	11	21	7	4	0	0	0.00204	0.0784
17	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ASS1(1), CKB(1), CKMT1A(3), CKMT1B(2), CPS1(4), DAO(4), EPRS(2), GAMT(1), GATM(2), GLUD2(1), NOS1(5), NOS3(4), OTC(2), PARS2(1), RARS(1)	15394114	34	33	33	9	11	13	6	4	0	0	0.00330	0.119
18	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	60	AKT1(1), BCL10(1), CARD11(5), CD19(1), CD22(3), CHUK(1), CR2(3), FOS(1), GSK3B(1), IFITM1(2), IKBKB(1), INPP5D(3), KRAS(2), LILRB3(1), LYN(2), MALT1(2), NFATC2(2), NFATC4(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG2(2), PPP3CB(1), PPP3R2(1), VAV1(3), VAV2(2), VAV3(1)	30550804	65	54	64	22	19	25	8	4	9	0	0.00356	0.122
19	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	27	CCL3(1), CCR1(1), CCR3(1), CD28(1), CSF2(2), IFNG(2), IFNGR2(3), IL12B(1), IL12RB1(2), IL12RB2(1), IL18R1(2), IL4R(4)	8171462	21	20	21	5	3	7	4	2	5	0	0.00523	0.170
20	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	7	GABRA2(1), GABRA3(1), GABRA4(2), GABRA5(3), GPX1(1), PRKCE(1)	2594780	9	9	9	4	0	5	2	2	0	0	0.00827	0.252
21	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	65	AGTR1(1), ATP8A1(1), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BRS3(1), CCKAR(1), CCR1(1), CCR3(1), CX3CR1(1), GALR1(1), GALT(1), LHCGR(2), MC2R(3), MC3R(3), MC4R(2), MC5R(2), NMBR(1), NPY2R(1), NPY5R(3), NTSR1(3), OPRK1(1), OPRM1(2), PPYR1(1), SSTR4(2), TACR3(3)	21986223	42	42	42	16	18	15	4	2	3	0	0.00860	0.252
22	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2(2), F5(4), FGA(4), FGB(2), FGG(3), SERPINC1(1)	7052009	17	17	17	5	4	8	3	0	2	0	0.00955	0.260
23	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(1), IFNB1(1), IKBKB(1), IL1A(1), IL1B(1), IL1R1(2), IL1RAP(1), IL1RN(2), IL6(1), IRAK1(2), IRAK3(3), MAP2K3(3), MAP3K1(2), MAP3K7(2), MAPK8(1), NFKB1(1), NFKBIA(1), TRAF6(1)	12838756	27	27	27	6	8	10	2	1	6	0	0.0100	0.260
24	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(6), PRKCA(1), PTK2B(2)	2922983	10	9	10	3	3	3	1	1	2	0	0.0104	0.260
25	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVRL1(1), AKT1(1), AURKB(1), BMPR2(1), BUB1(1), CDKL1(2), CDKL2(2), CSNK2B(2), DGKB(1), DGKD(4), DGKE(2), DGKG(2), DGKQ(1), DGKZ(1), INPP1(1), INPP4B(1), INPP5A(1), INPPL1(3), NEK1(1), NEK3(2), OCRL(2), PAK4(3), PIK3C2A(1), PIK3C2B(3), PIK3C2G(6), PIK3CB(4), PIK3CG(5), PIM2(2), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(1), PLCG1(6), PLCG2(2), PLK3(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(1), PRKD1(1), RAF1(1), RPS6KA2(2), RPS6KA3(1), TGFBR1(1)	48209435	88	71	86	23	16	29	17	11	15	0	0.0107	0.260
26	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	5	AKT1(1), PLCB1(1), PLCG1(6), PRKCA(1), VAV1(3)	3923657	12	11	12	3	1	5	1	2	3	0	0.0111	0.260
27	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(1), COL4A2(1), COL4A4(5), COL4A5(2), COL4A6(2), F10(1), F2(2), F5(4), F8(6), F9(4), FGA(4), FGB(2), FGG(3), KLKB1(1), SERPINC1(1), SERPING1(2)	19392242	41	37	41	10	13	15	8	0	5	0	0.0119	0.260
28	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	18	ELK1(2), FOS(1), IGF1(2), IGF1R(2), IRS1(2), MAP2K1(1), MAPK3(1), MAPK8(1), PTPN11(4), RAF1(1), SOS1(3), SRF(1)	9066593	21	19	21	4	5	4	7	1	4	0	0.0136	0.260
29	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA2C(2), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), DRD2(1), DRD3(1), HRH2(2), HTR1B(1), HTR1D(1), HTR1E(2), HTR2A(1), HTR2C(1), HTR4(1), HTR5A(3), HTR7(2)	10640936	25	24	25	5	6	15	2	2	0	0	0.0141	0.260
30	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	97	AKT1(1), CCL3(1), CD86(2), CHUK(1), FOS(1), IFNA10(4), IFNA21(1), IFNB1(1), IKBKB(1), IL12B(1), IL1B(1), IL6(1), IRAK1(2), IRF5(1), LBP(3), LY96(2), MAP2K1(1), MAP2K3(3), MAP3K7(2), MAPK1(1), MAPK13(1), MAPK3(1), MAPK8(1), NFKB1(1), NFKB2(1), NFKBIA(1), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), RIPK1(1), STAT1(1), TLR1(2), TLR2(3), TLR3(1), TLR4(1), TLR5(1), TLR6(5), TLR7(3), TLR8(1), TLR9(2), TRAF6(1)	37242543	75	61	73	22	17	32	10	4	12	0	0.0142	0.260
31	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	67	AKT1(1), CASP9(1), KDR(6), KRAS(2), MAP2K1(1), MAPK1(1), MAPK13(1), MAPK3(1), NFATC2(2), NFATC4(2), NOS3(4), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLA2G2F(1), PLA2G3(1), PLA2G4A(2), PLA2G6(1), PLCG1(6), PLCG2(2), PPP3CB(1), PPP3R2(1), PRKCA(1), PRKCG(2), PXN(1), RAF1(1), SRC(2), VEGFA(2)	29608070	62	50	61	17	13	26	8	6	9	0	0.0146	0.260
32	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(2), CD3G(1)	494731	3	3	3	0	0	1	1	0	1	0	0.0146	0.260
33	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD28(1), CD3E(2), CD3G(1), ICAM1(1), ITGB2(4), PTPRC(2)	4641027	12	12	12	4	3	5	1	0	3	0	0.0147	0.260
34	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	GPR109B(2), GPR161(1), GPR34(2), GPR45(2), GPR65(1), GPR68(1), GPR75(1), GPR81(1)	4252744	11	11	11	3	4	3	2	1	1	0	0.0148	0.260
35	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), LDLR(1), NR0B2(1), NR1H3(1), NR1H4(2), RXRA(2)	2351195	8	8	8	1	3	4	0	0	1	0	0.0158	0.260
36	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	INPP1(1), INPP4B(1), INPP5A(1), INPPL1(3), OCRL(2), PIK3C2A(1), PIK3C2B(3), PIK3C2G(6), PIK3CB(4), PIK3CG(5), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(1), PLCG1(6), PLCG2(2)	18590778	41	33	40	15	7	12	7	5	10	0	0.0159	0.260
37	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(1), ITGA4(3), ITGAM(4), ITGB1(1), ITGB2(4), SELE(1), SELP(1)	7503073	18	17	18	10	5	8	1	1	3	0	0.0159	0.260
38	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	15	CD28(1), CD3E(2), CD3G(1), CD86(2), HLA-DRA(1), PTPN11(4)	3910560	11	11	11	3	1	6	2	1	1	0	0.0161	0.260
39	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(1), CD3E(2), CD3G(1), CD58(1), IL3(1), IL6(1), KITLG(1)	2720165	8	8	8	1	1	3	2	0	2	0	0.0173	0.273
40	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(1), CSF2(2), HLA-DRA(1), IL3(1)	1320343	5	5	5	0	1	2	1	0	1	0	0.0195	0.298
41	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	29	ACPT(2), ALPP(2), CYP19A1(2), CYP1A2(2), CYP2A13(1), CYP2B6(3), CYP2C19(1), CYP2D6(4), CYP2E1(1), CYP2F1(1), CYP3A4(1), CYP4B1(2), CYP4F8(2), PON1(2)	11847904	26	24	25	8	7	11	5	0	3	0	0.0206	0.298
42	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	27	AKT1(1), CHRM1(1), FLT1(5), FLT4(1), KDR(6), NOS3(4), PDE2A(1), PDE3A(1), PRKAR1B(1), PRKAR2B(1), PRKG2(4)	13462312	26	26	26	6	3	13	1	5	4	0	0.0209	0.298
43	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD28(1), CD3E(2), CD3G(1), ICAM1(1), ITGB2(4), PTPRC(2)	4882248	12	12	12	4	3	5	1	0	3	0	0.0211	0.298
44	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	66	ADH1A(2), ADH1B(2), ADH1C(1), AKR1C1(1), AKR1C4(2), ALDH3A1(2), CYP1A2(2), CYP1B1(1), CYP2B6(3), CYP2C19(1), CYP2E1(1), CYP2F1(1), CYP2S1(1), CYP3A4(1), GSTA1(1), GSTA4(2), GSTK1(1), UGT1A10(1), UGT1A5(1), UGT1A6(1), UGT1A9(1), UGT2A1(3), UGT2B10(4), UGT2B11(1), UGT2B15(1), UGT2B4(2), UGT2B7(1)	22434757	41	40	41	17	16	14	8	0	3	0	0.0231	0.298
45	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(1), ITGAM(4), ITGB2(4), SELE(1)	5097909	13	12	13	7	4	5	0	1	3	0	0.0232	0.298
46	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	90	AKT1(1), BCL10(1), CARD11(5), CBL(1), CBLB(1), CD28(1), CD3E(2), CD3G(1), CHUK(1), CSF2(2), FOS(1), FYN(1), IFNG(2), IKBKB(1), KRAS(2), MALT1(2), NFATC2(2), NFATC4(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), PAK1(1), PAK3(1), PAK4(3), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(6), PPP3CB(1), PPP3R2(1), PRKCQ(1), PTPRC(2), SOS1(3), TEC(1), VAV1(3), VAV2(2), VAV3(1), ZAP70(3)	42346108	79	64	78	22	17	29	17	4	12	0	0.0233	0.298
47	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	21	MAP2K1(1), MAPK1(1), MAPK3(1), NFKB1(1), PIK3C2G(6), PLCG1(6), PRKCA(1), PTK2B(2), PXN(1), RAF1(1)	10472944	21	20	21	3	3	6	4	4	4	0	0.0237	0.298
48	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	CRKL(1), MAP2K1(1), MAP2K3(3), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), PAK1(1), PLCG1(6), PRKCA(1), PTK2B(2), RAF1(1), SOS1(3), SRC(2)	12364217	26	24	26	5	6	7	5	3	5	0	0.0238	0.298
49	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	16	ELK1(2), FOS(1), MAP2K1(1), MAPK3(1), MAPK8(1), PLCG1(6), RAF1(1), SOS1(3)	6659731	16	15	16	1	4	4	5	1	2	0	0.0239	0.298
50	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	AKT1(1), BRAF(5), EIF4B(1), FIGF(2), IGF1(2), MAPK1(1), MAPK3(1), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), RICTOR(2), RPS6KA2(2), RPS6KA3(1), RPS6KA6(2), TSC2(2), ULK2(1), VEGFA(2), VEGFB(1)	21325577	42	37	38	11	11	16	6	4	5	0	0.0242	0.298
51	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	244	AMHR2(1), BMP2(1), BMPR2(1), CCL13(1), CCL14(1), CCL2(1), CCL24(2), CCL3(1), CCR1(1), CCR3(1), CD70(1), CSF1R(1), CSF2(2), CSF2RB(2), CX3CL1(1), CX3CR1(1), CXCL1(1), CXCL6(1), EDA(1), EGF(3), EPO(1), FLT1(5), FLT3(4), FLT4(1), HGF(1), IFNA10(4), IFNA21(1), IFNB1(1), IFNG(2), IFNGR2(3), IL12B(1), IL12RB1(2), IL12RB2(1), IL15RA(1), IL17RA(1), IL17RB(1), IL18R1(2), IL18RAP(5), IL1A(1), IL1B(1), IL1R1(2), IL1RAP(1), IL20(1), IL21R(2), IL22(2), IL26(1), IL28B(1), IL28RA(1), IL3(1), IL4R(4), IL5RA(1), IL6(1), IL7(1), IL7R(1), INHBE(1), KDR(6), KIT(3), KITLG(1), LEPR(1), MET(1), MPL(2), OSM(1), OSMR(1), PDGFRB(2), PPBP(1), RELT(1), TGFBR1(1), TGFBR2(2), TNFRSF11A(2), TNFRSF19(1), TNFRSF1A(1), TNFRSF4(2), TNFRSF8(1), TNFRSF9(1), TNFSF10(2), TNFSF11(1), TNFSF14(1), TNFSF8(1), TNFSF9(3), TPO(3), VEGFA(2), VEGFB(1), XCL1(1)	73129927	131	100	127	55	31	57	18	8	17	0	0.0248	0.299
52	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(1), ITGA4(3), ITGB1(1), ITGB2(4), SELE(1)	5828922	13	13	13	7	4	4	1	1	3	0	0.0287	0.337
53	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(4), AOC2(2), CES1(2)	2603156	8	8	8	0	1	6	1	0	0	0	0.0294	0.337
54	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	36	ABP1(4), AGXT(1), ALAS1(1), AMT(2), AOC2(2), CBS(1), CTH(1), DAO(4), DLD(1), GAMT(1), GATM(2), GLDC(1), MAOB(2), PISD(1), PLCB2(3), PLCG1(6), PLCG2(2), TARS(1)	18066774	36	32	36	8	8	15	5	4	4	0	0.0301	0.337
55	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT3(2), FUT5(3), FUT6(1)	2183771	6	6	6	3	3	1	1	1	0	0	0.0303	0.337
56	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR2(3), JAK1(2), JAK2(1), STAT1(1)	3554721	9	9	9	0	0	2	2	2	3	0	0.0306	0.337
57	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	160	ADRA2C(2), AGTR1(1), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BRS3(1), CCBP2(1), CCKAR(1), CCR1(1), CCR3(1), CHML(1), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), CNR2(1), CX3CR1(1), DRD2(1), DRD3(1), F2RL3(1), GALR1(1), GALT(1), GPR17(1), GPR27(1), GPR4(1), GPR50(1), GPR83(2), GPR85(2), HRH2(2), HRH3(2), HTR1B(1), HTR1D(1), HTR1E(2), HTR2A(1), HTR2C(1), HTR4(1), HTR5A(3), HTR7(2), LHCGR(2), MC3R(3), MC4R(2), MC5R(2), NMBR(1), NMUR1(1), NMUR2(3), NPY2R(1), NPY5R(3), NTSR1(3), OPRK1(1), OPRM1(2), OR1F1(1), OR1Q1(1), OR2H1(2), OR7C1(1), P2RY2(1), PPYR1(1), PTAFR(1), PTGER4(1), PTGFR(1), RGR(1), SSTR4(2)	51577921	88	78	87	44	28	43	7	5	5	0	0.0316	0.341
58	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), CD3E(2), CD3G(1), ICAM1(1), ITGB2(4)	3748418	9	9	9	2	2	3	1	0	3	0	0.0330	0.350
59	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(2), CYR61(1), IFNG(2), IFRD1(1), IL1A(1), IL1R1(2), WDR1(2)	4741790	11	11	11	5	1	3	1	1	5	0	0.0339	0.353
60	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	CKB(1), CKMT1A(3), CKMT1B(2), CPS1(4), GAMT(1), GATM(2), OTC(2)	7395785	15	15	14	4	4	4	3	4	0	0	0.0344	0.353
61	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(2), CD3G(1), FYN(1), HLA-DRA(1), PTPRC(2), ZAP70(3)	3946713	10	10	10	4	3	4	2	0	1	0	0.0357	0.358
62	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), CYP11A1(1), CYP11B1(1), CYP11B2(2), CYP21A2(2), HSD11B1(1)	3837211	9	9	9	3	4	2	0	1	2	0	0.0372	0.358
63	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), CYP11A1(1), CYP11B1(1), CYP11B2(2), CYP21A2(2), HSD11B1(1)	3837211	9	9	9	3	4	2	0	1	2	0	0.0372	0.358
64	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	BCL2(2), CHUK(1), DAXX(2), EGF(3), ETS1(1), FOS(1), IKBKB(1), MAP2K1(1), MAP2K3(3), MAP3K1(2), MAP3K5(1), MAPK1(1), MAPK13(1), MAPK3(1), MAPK8(1), NFKB1(1), NFKBIA(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(1), RAF1(1), RIPK1(1), TNFRSF1A(1)	20197054	35	34	34	9	9	11	5	3	7	0	0.0383	0.358
65	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	15	AKT1(1), CREB1(1), MAPK1(1), MAPK3(1), MAPK7(1), MEF2A(2), MEF2D(1), NTRK1(1), PLCG1(6)	6611974	15	14	15	4	2	6	2	2	3	0	0.0385	0.358
66	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(1), TGDS(1), UGDH(1), UXS1(1)	1710073	5	5	5	0	0	1	2	0	2	0	0.0391	0.358
67	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	EGF(3), ELK1(2), FOS(1), JAK1(2), MAP2K1(1), MAP3K1(2), MAPK3(1), MAPK8(1), PLCG1(6), PRKCA(1), RAF1(1), SOS1(3), SRF(1), STAT1(1), STAT3(1)	13456839	27	25	27	7	7	9	5	2	4	0	0.0396	0.358
68	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	19	CD3E(2), CD3G(1), ETV5(1), IFNG(2), IL12B(1), IL12RB1(2), IL12RB2(1), IL18R1(2), JAK2(1), MAPK8(1), STAT4(2), TYK2(1)	7809070	17	17	17	3	3	7	4	0	3	0	0.0401	0.358
69	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	14	CD2(1), CD3E(2), CD3G(1), IFNG(2), IL12B(1), IL12RB1(2), IL12RB2(1), JAK2(1), STAT4(2), TYK2(1)	6105492	14	14	14	2	1	7	3	0	3	0	0.0408	0.358
70	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	40	CD3E(2), CD3G(1), ELK1(2), FOS(1), FYN(1), MAP2K1(1), MAP3K1(2), MAPK3(1), MAPK8(1), NFATC2(2), NFATC4(2), NFKB1(1), NFKBIA(1), PLCG1(6), PPP3CB(1), PRKCA(1), RAF1(1), SOS1(3), VAV1(3), ZAP70(3)	19055455	36	32	36	10	9	11	8	3	5	0	0.0409	0.358
71	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	5	CD28(1), CD3E(2), CD3G(1)	1094328	4	4	4	0	0	2	1	0	1	0	0.0412	0.358
72	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	31	ABP1(4), ADH1A(2), ADH1B(2), ADH1C(1), ALDH3A1(2), AOC2(2), AOX1(4), DDC(1), MAOB(2), TAT(2), TPO(3), TYR(1)	13320935	26	26	24	6	7	14	5	0	0	0	0.0444	0.376
73	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	13	AKT1(1), IGF1R(2), IRS1(2), MAP2K1(1), MAPK1(1), MAPK3(1), RAF1(1), SOS1(3), YWHAH(1)	6524169	13	13	13	2	2	2	4	1	4	0	0.0445	0.376
74	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(1), GRIN2A(8), GRIN2B(2), GRIN2C(1), GRIN2D(1), NOS1(5), PPP3CB(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1)	10895283	22	21	22	9	11	8	2	1	0	0	0.0500	0.417
75	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	ELK1(2), FOS(1), IL6(1), JAK1(2), JAK2(1), JAK3(2), MAP2K1(1), MAPK3(1), PTPN11(4), RAF1(1), SOS1(3), SRF(1), STAT3(1)	10418574	21	20	21	2	3	10	5	1	2	0	0.0510	0.419
76	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	19	ELK1(2), FOS(1), INSR(2), IRS1(2), MAP2K1(1), MAPK3(1), MAPK8(1), PTPN11(4), RAF1(1), SOS1(3), SRF(1)	9385676	19	18	19	6	4	6	5	1	3	0	0.0525	0.425
77	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1(1), ELK1(2), MAP2K1(1), MAP2K3(3), MAP3K1(2), MAPK1(1), MAPK3(1), NCF1(1), NFATC2(2), NFATC4(2), NFKB1(1), NFKBIA(1), PAK1(1), PIK3C2G(6), PLCB1(1), PPP3CB(1), RAF1(1)	16695470	28	28	28	11	5	9	4	3	7	0	0.0531	0.425
78	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(3), CD3E(2), CD3G(1), CREBBP(4), CSK(1), HLA-DRA(1), PRKAR1B(1), PRKAR2B(1), PTPRC(2), ZAP70(3)	9801015	19	19	19	6	7	6	2	1	3	0	0.0558	0.430
79	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(3), CD3E(2), CD3G(1), CREBBP(4), CSK(1), HLA-DRA(1), PRKAR1B(1), PRKAR2B(1), PTPRC(2), ZAP70(3)	9801015	19	19	19	6	7	6	2	1	3	0	0.0558	0.430
80	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	12	CASR(3), GRM1(4), GRM4(2), GRM5(2), GRM7(2), GRM8(5)	8259379	18	17	18	16	8	6	2	1	1	0	0.0563	0.430
81	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(2), AASS(3), KARS(2)	3018145	7	7	5	3	2	1	1	0	3	0	0.0566	0.430
82	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	ELK1(2), EPO(1), FOS(1), JAK2(1), MAP2K1(1), MAPK3(1), MAPK8(1), PLCG1(6), RAF1(1), SOS1(3), STAT5B(1)	9325827	19	18	19	1	4	6	5	1	3	0	0.0572	0.430
83	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BRAF(5), CREB1(1), MAPK1(1), RAF1(1), SRC(2), TERF2IP(1)	4945446	11	10	7	1	6	0	2	1	2	0	0.0582	0.432
84	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	10	AKT1(1), NTRK1(1), PLCG1(6), PRKCA(1), SOS1(3)	5114208	12	11	12	3	1	5	3	1	2	0	0.0589	0.432
85	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT3(2), FUT3(2), FUT4(1), FUT5(3), FUT6(1), FUT7(1), GCNT2(1), ST3GAL6(1), ST8SIA1(1)	6945818	13	13	13	4	3	4	1	3	2	0	0.0613	0.444
86	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASS(3), KARS(2)	2047473	5	5	4	2	1	1	1	0	2	0	0.0631	0.452
87	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	49	AKT1(1), CAMK1(1), CAMK4(1), CREBBP(4), ELSPBP1(2), F2(2), GATA4(1), GSK3B(1), IGF1(2), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8(1), MYH2(8), NFATC2(2), NFATC4(2), NPPA(1), PPP3CB(1), PRKAR1B(1), PRKAR2B(1), RAF1(1)	20114719	36	32	36	9	6	11	10	2	7	0	0.0658	0.465
88	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	22	ELK1(2), FOS(1), JAK1(2), MAP2K1(1), MAP3K1(2), MAPK3(1), MAPK8(1), PLCG1(6), PRKCA(1), RAF1(1), SOS1(3), SRF(1), STAT1(1), STAT3(1)	12377790	24	22	24	4	6	7	5	2	4	0	0.0666	0.465
89	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	81	ABL1(1), ABL2(1), AKT1(1), BRAF(5), CAMK2A(1), CBL(1), CBLB(1), CDKN1A(1), CRKL(1), EGF(3), ELK1(2), ERBB2(1), ERBB4(1), GSK3B(1), KRAS(2), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8(1), MYC(1), PAK1(1), PAK3(1), PAK4(3), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(6), PLCG2(2), PRKCA(1), PRKCG(2), RAF1(1), SHC4(1), SOS1(3), SRC(2), STAT5B(1)	41779710	68	60	63	20	23	21	12	4	8	0	0.0672	0.465
90	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), CYP2E1(1), NR1I3(2), PTGS1(1)	2294427	6	6	6	2	1	2	1	0	2	0	0.0679	0.465
91	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(1), ADH1A(2), ADH1B(2), ADH1C(1), AKR1C4(2), ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), CEL(3), CYP27A1(1), SRD5A1(1), SRD5A2(1)	10112870	19	19	19	6	7	8	3	0	1	0	0.0704	0.468
92	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	CHAT(2), PCYT1A(2), PDHA1(1), PDHA2(2)	3027399	7	7	7	2	3	2	0	1	1	0	0.0704	0.468
93	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(4), ALDH3A1(2), AOC2(2), DDC(1), EPX(2), MAOB(2), MPO(1), TAT(2), TPO(3)	9515278	19	19	18	2	5	11	3	0	0	0	0.0724	0.468
94	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), HDAC9(2), MEF2A(2), MEF2D(1), MYOD1(1), YWHAH(1)	3482875	8	8	8	3	2	3	2	0	1	0	0.0729	0.468
95	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1), IFNG(2), IL12B(1)	1296081	4	4	4	1	0	2	1	0	1	0	0.0741	0.468
96	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	EIF2S2(1), EIF2S3(1), FLT1(5), FLT4(1), KDR(6), NOS3(4), PLCG1(6), PRKCA(1), PXN(1)	13064588	26	23	26	7	2	12	3	4	5	0	0.0748	0.468
97	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	23	RPE(1), UGDH(1), UGT1A10(1), UGT1A5(1), UGT1A6(1), UGT1A9(1), UGT2A1(3), UGT2B10(4), UGT2B11(1), UGT2B15(1), UGT2B4(2), UGT2B7(1), XYLB(1)	9836171	19	19	19	11	7	5	4	1	2	0	0.0755	0.468
98	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(1), ESR2(2), PDE1A(2), PLCB1(1), PLCB2(3), TRH(1)	4809744	10	10	10	4	5	2	0	1	2	0	0.0758	0.468
99	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	20	FOS(1), JAK2(1), MAP2K1(1), MAPK3(1), MPL(2), PLCG1(6), PRKCA(1), RAF1(1), SOS1(3), STAT1(1), STAT3(1), STAT5B(1), THPO(1)	11315088	21	20	21	2	4	7	5	1	4	0	0.0763	0.468
100	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA2(1), ACTN3(1), DES(2), DMD(9), FAM48A(1), MYBPC3(1), MYH3(2), MYH6(1), MYH7(3), MYH8(7), MYL3(1), MYOM1(2), NEB(5), TMOD1(1), TNNC2(1), TNNT1(1), TNNT2(1), TPM3(1), TTN(70)	59498363	111	82	110	23	26	44	18	8	15	0	0.0764	0.468
101	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(3), C5(1), C6(1), ICAM1(1), IL1A(1), IL6(1), ITGA4(3), ITGB1(1), ITGB2(4), SELP(1), SELPLG(2), VCAM1(1)	10775962	20	19	20	8	4	7	3	1	5	0	0.0768	0.468
102	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(1), BMP5(2), BMP6(1), BTRC(1), CSNK1G1(1), CSNK1G3(1), DHH(1), GLI1(4), GLI2(3), GSK3B(1), IHH(1), LRP2(13), PRKX(1), PTCH1(1), PTCH2(1), RAB23(1), SHH(2), SMO(1), SUFU(1), WNT1(1), WNT10A(2), WNT2B(1), WNT3(1), WNT5B(1), WNT9B(1)	26092930	45	42	45	7	10	17	8	2	8	0	0.0800	0.476
103	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	44	ABP1(4), AGXT(1), ALAS1(1), AMT(2), AOC2(2), CBS(1), CTH(1), DAO(4), DLD(1), GAMT(1), GATM(2), GLDC(1), MAOB(2), PHGDH(1), PIPOX(1), PISD(1), PSAT1(1), SARS2(1), TARS(1), TARS2(1)	18397073	30	30	30	5	7	12	6	2	3	0	0.0805	0.476
104	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	B2M(1), ITGB1(1), KLRC3(2), KLRD1(1), MAP2K1(1), MAPK3(1), PAK1(1), PTK2B(2), VAV1(3)	6448362	13	13	13	4	4	2	1	1	5	0	0.0807	0.476
105	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	77	AIFM1(1), AKT1(1), ATM(4), BCL2(2), BIRC3(1), CAPN1(2), CASP9(1), CHUK(1), CSF2RB(2), IKBKB(1), IL1A(1), IL1B(1), IL1R1(2), IL1RAP(1), IL3(1), IRAK1(2), IRAK3(3), NFKB1(1), NFKB2(1), NFKBIA(1), NTRK1(1), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), PPP3CB(1), PPP3R2(1), PRKAR1B(1), PRKAR2B(1), RIPK1(1), TNFRSF1A(1), TNFSF10(2)	33892408	55	51	55	16	11	24	7	4	9	0	0.0811	0.476
106	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	35	ELK1(2), FCER1A(1), FOS(1), LYN(2), MAP2K1(1), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), NFATC2(2), NFATC4(2), PLA2G4A(2), PLCG1(6), PPP3CB(1), RAF1(1), SOS1(3), VAV1(3)	16964832	32	28	32	9	7	9	8	4	4	0	0.0820	0.476
107	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	32	CRKL(1), DOCK1(1), ELK1(2), FOS(1), HGF(1), ITGA1(2), ITGB1(1), MAP2K1(1), MAP4K1(2), MAPK1(1), MAPK3(1), MAPK8(1), MET(1), PAK1(1), PTK2B(2), PTPN11(4), PXN(1), RAF1(1), SOS1(3), SRC(2), STAT3(1)	17291107	31	29	31	5	7	11	7	3	3	0	0.0827	0.476
108	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	7	ACE(2), AGTR1(1), KNG1(2), NOS3(4)	3943899	9	9	9	2	2	5	0	0	2	0	0.0844	0.481
109	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3E(2), CD3G(1), IFNG(2), TGFBR1(1), TGFBR2(2), TGFBR3(1)	4618304	10	10	10	1	1	4	3	0	2	0	0.0855	0.483
110	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	52	ABP1(4), ACMSD(1), ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), AOC2(2), AOX1(4), CYP19A1(2), CYP1A2(2), CYP2A13(1), CYP2B6(3), CYP2C19(1), CYP2D6(4), CYP2E1(1), CYP2F1(1), CYP3A4(1), CYP4B1(2), CYP4F8(2), DDC(1), ECHS1(1), EHHADH(1), KYNU(1), MAOB(2), TPH1(2), WARS(1)	23144414	45	37	43	10	9	25	8	0	3	0	0.0874	0.485
111	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	APOBEC1(3), APOBEC2(1), APOBEC3F(2), APOBEC3G(1)	3167649	7	7	7	2	3	2	1	1	0	0	0.0874	0.485
112	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	43	CBL(1), CD28(1), CSK(1), DAG1(2), EPHB2(1), FBXW7(1), MAPK1(1), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), PAK1(1), PAK3(1), PAK4(3), PLCG1(6), PTPRC(2), RAF1(1), RASGRP2(1), RASGRP4(1), SOS1(3), VAV1(3), ZAP70(3)	24105165	40	37	40	8	6	15	9	3	7	0	0.0901	0.496
113	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(4), PSAT1(1)	2095452	5	5	4	0	1	4	0	0	0	0	0.0910	0.496
114	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(1), TGDS(1), UGDH(1), UXS1(1)	2164996	5	5	5	0	0	1	2	0	2	0	0.0923	0.499
115	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	70	DGKB(1), DGKD(4), DGKE(2), DGKG(2), DGKI(2), DGKQ(1), DGKZ(1), INPP1(1), INPP4B(1), INPP5A(1), INPP5B(1), INPP5D(3), INPP5E(1), INPPL1(3), ITPR1(4), ITPR2(2), ITPR3(3), OCRL(2), PI4KB(2), PIK3C2A(1), PIK3C2B(3), PIK3C2G(6), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP4K2C(3), PIP5K1B(2), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(1), PLCE1(2), PLCG1(6), PLCG2(2), PLCZ1(1), PRKCA(1), PRKCG(2), SYNJ2(2)	52366293	90	69	89	24	25	31	12	7	15	0	0.0945	0.502
116	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	39	ALAS1(1), COX10(1), CP(3), EPRS(2), FECH(1), FTMT(2), HMBS(1), HMOX1(1), MMAB(1), UGT1A10(1), UGT1A5(1), UGT1A6(1), UGT1A9(1), UGT2A1(3), UGT2B10(4), UGT2B11(1), UGT2B15(1), UGT2B4(2), UGT2B7(1)	16350877	29	28	29	12	10	9	7	2	1	0	0.0945	0.502
117	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(3), ADRBK2(2), CAMK2A(1), CLCA1(2), CLCA4(1), CNGA4(1), CNGB1(2), GUCA1C(1), PDC(1), PDE1C(4), PRKG2(4), PRKX(1)	13206146	23	23	23	2	4	10	4	2	3	0	0.104	0.547
118	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	20	AKT1(1), BCL2(2), CRKL(1), FOS(1), JAK2(1), MAP2K1(1), MAP3K1(2), MAPK3(1), MAPK8(1), MYC(1), RAF1(1), SOS1(3), STAT1(1), STAT5B(1)	10452283	18	18	18	3	3	4	4	1	6	0	0.106	0.551
119	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	16	CCL2(1), FOS(1), MAPK8(1), PLCG1(6), PRKCA(1), PTK2B(2)	5668328	12	11	12	3	4	3	2	1	2	0	0.106	0.551
120	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	45	ACCN1(2), ADCY6(2), ADCY8(2), CACNA1A(1), GRM4(2), ITPR3(3), KCNB1(2), PDE1A(2), PLCB2(3), PRKX(1), SCNN1A(1), SCNN1B(2), SCNN1G(4), TAS1R1(3), TAS1R2(2), TAS2R1(1), TAS2R10(1), TAS2R16(1), TAS2R39(1), TAS2R4(1), TAS2R5(1), TAS2R60(1), TRPM5(1)	23709506	40	39	39	17	8	20	5	1	6	0	0.109	0.557
121	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), PTK2B(2), SOS1(3), SRC(2)	3819577	8	8	8	1	2	1	3	0	2	0	0.110	0.557
122	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG2(2), ADCY3(3), ADCY9(3), AK1(1), ATP6V0A4(3), ATP6V0D1(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1G1(1), PLCG1(6), PLCG2(2), PRKCA(1), TRIM23(1)	16036713	28	26	28	10	6	12	3	2	5	0	0.111	0.557
123	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGTR1(1), ELK1(2), MAP2K1(1), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), MEF2A(2), MEF2D(1), PAK1(1), PRKCA(1), PTK2B(2), RAF1(1), SOS1(3), SRC(2)	13455157	22	22	22	4	10	2	5	2	3	0	0.111	0.557
124	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	EGR1(3), MAP2K1(1), MAPK1(1), MAPK3(1), RAF1(1)	3569181	7	7	7	0	2	1	1	1	2	0	0.114	0.568
125	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	IFNG(2), IFNGR2(3), IKBKB(1), JAK2(1), NFKB1(1), NFKBIA(1), TNFRSF1A(1), USH1C(1), WT1(1)	6865497	12	12	12	1	1	4	3	2	2	0	0.117	0.577
126	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(1), HS3ST3A1(2), XYLT1(1), XYLT2(2)	2892500	6	6	6	1	2	1	1	2	0	0	0.120	0.583
127	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(1), HS3ST3A1(2), XYLT1(1), XYLT2(2)	2892500	6	6	6	1	2	1	1	2	0	0	0.120	0.583
128	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	AGPAT1(1), CHAT(2), DGKB(1), DGKD(4), DGKE(2), DGKG(2), DGKQ(1), DGKZ(1), GNPAT(1), GPD2(1), LCAT(2), LGALS13(1), PAFAH2(1), PCYT1A(2), PISD(1), PLA2G3(1), PLA2G4A(2), PLA2G6(1), PLCB2(3), PLCG1(6), PLCG2(2)	21750113	38	34	38	11	9	15	4	5	5	0	0.122	0.587
129	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	13	AKT1(1), CREB1(1), MAP2K1(1), MAP2K3(3), MAP3K1(2), MAPK1(1), MAPK3(1), NFKB1(1)	6040819	11	11	11	3	2	4	0	2	3	0	0.123	0.587
130	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(3), ADCY8(2), BRAF(5), CACNA1C(5), CAMK2A(1), CAMK4(1), CREBBP(4), GRIA1(2), GRIN2A(8), GRIN2B(2), GRIN2C(1), GRIN2D(1), GRM1(4), GRM5(2), ITPR1(4), ITPR2(2), ITPR3(3), KRAS(2), MAP2K1(1), MAPK1(1), MAPK3(1), PLCB1(1), PLCB2(3), PLCB4(1), PPP3CB(1), PPP3R2(1), PRKCA(1), PRKCG(2), PRKX(1), RAF1(1), RAPGEF3(1), RPS6KA2(2), RPS6KA3(1), RPS6KA6(2)	43570236	73	62	68	26	32	23	8	3	7	0	0.124	0.587
131	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CSF2(2), EPO(1), IL3(1), IL6(1), IL7(1)	2676018	6	6	6	2	1	3	1	0	1	0	0.127	0.594
132	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(3), CREB1(1), ELK1(2), FOS(1), MAP2K1(1), MAPK3(1), NFATC2(2), NFATC4(2), PLCG1(6), PPP3CB(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), RAF1(1), RPS6KA3(1)	14936666	25	24	25	3	7	7	5	2	4	0	0.128	0.594
133	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CSF2(2), HLA-DRA(1), IFNB1(1), IFNG(2), IL12B(1), IL1A(1), IL3(1), IL6(1), IL7(1)	5663359	11	11	11	5	2	5	2	0	2	0	0.128	0.594
134	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	52	AKR1C4(2), ARSD(1), ARSE(3), CARM1(3), CYP11B1(1), CYP11B2(2), CYP19A1(2), HSD11B1(1), HSD17B3(1), LCMT1(1), LCMT2(1), SRD5A1(1), SRD5A2(1), SULT2B1(1), UGT1A10(1), UGT1A5(1), UGT1A6(1), UGT1A9(1), UGT2A1(3), UGT2B10(4), UGT2B11(1), UGT2B15(1), UGT2B4(2), UGT2B7(1)	19848364	37	32	36	16	14	11	8	1	3	0	0.135	0.621
135	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	144	AKT1(1), CBL(1), CBLB(1), CCND2(1), CCND3(1), CREBBP(4), CSF2(2), CSF2RB(2), EPO(1), IFNA10(4), IFNA21(1), IFNB1(1), IFNG(2), IFNGR2(3), IL12B(1), IL12RB1(2), IL12RB2(1), IL15RA(1), IL20(1), IL21R(2), IL22(2), IL26(1), IL28B(1), IL28RA(1), IL3(1), IL4R(4), IL5RA(1), IL6(1), IL7(1), IL7R(1), IRF9(1), JAK1(2), JAK2(1), JAK3(2), LEPR(1), MPL(2), MYC(1), OSM(1), OSMR(1), PIAS1(1), PIAS3(1), PIAS4(2), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIM1(1), PTPN11(4), SOCS4(1), SOS1(3), STAM2(1), STAT1(1), STAT2(1), STAT3(1), STAT4(2), STAT5B(1), STAT6(1), TPO(3), TYK2(1)	59745234	100	78	98	36	15	46	18	7	14	0	0.137	0.623
136	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(1), BCL2(2), GSK3B(1), IL4R(4), IRS1(2), JAK1(2), JAK3(2), MAP4K1(2), MAPK1(1), MAPK3(1), RAF1(1), SOS1(3), STAT6(1)	14212254	23	23	23	8	2	9	5	1	6	0	0.138	0.624
137	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(1), BRAF(5), DAG1(2), DRD2(1), EPHB2(1), ITPR1(4), ITPR2(2), ITPR3(3), KCNJ5(2), MAPK1(1), PIK3CB(4), PITX2(2), PLCB1(1), PLCB2(3), PLCB4(1), RAF1(1), SOS1(3), SRC(2), STAT3(1), TERF2IP(1)	24344853	41	35	37	7	15	11	7	4	4	0	0.143	0.642
138	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(1), ANKRD6(1), APC(1), AXIN1(3), DACT1(1), DKK1(1), DKK2(2), DVL1(1), FSTL1(1), GSK3B(1), LRP1(8), MVP(3), NKD1(1), PTPRA(3), WIF1(1)	17248503	29	27	29	3	4	12	8	0	5	0	0.146	0.651
139	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(1), IL4R(4), IRS1(2), JAK1(2), JAK3(2), STAT6(1)	6458330	12	12	12	4	1	6	1	0	4	0	0.147	0.651
140	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(2), CYP11A1(1), CYP11B2(2), HSD11B1(1)	2988112	6	6	6	2	4	1	0	0	1	0	0.150	0.654
141	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(2), ARSD(1), ARSE(3), CYP11B1(1), CYP11B2(2), HSD11B1(1), HSD17B3(1), SRD5A1(1), SRD5A2(1), UGT1A10(1), UGT1A5(1), UGT1A6(1), UGT1A9(1), UGT2B15(1), UGT2B4(2)	11290052	20	19	20	11	9	5	3	1	2	0	0.150	0.654
142	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	30	AKT1(1), DAG1(2), GCA(1), ITGA9(1), ITPR1(4), ITPR2(2), ITPR3(3), MAP2K1(1), MAPK1(1), MAPK3(1), NR1I3(2), PAK1(1), PDE3A(1), PIK3C2G(6), RIPK3(1), RPS4X(1), VASP(1)	19665955	30	29	30	9	8	9	3	4	6	0	0.153	0.663
143	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	97	ADCY1(3), ADCY2(2), ADCY3(3), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(3), CAMK2A(1), CREB1(1), CREB3L1(1), CREB3L3(2), CREB3L4(1), CREBBP(4), DVL1(1), DVL2(1), DVL3(1), FZD1(1), FZD10(3), FZD9(2), GNAO1(1), GSK3B(1), KIT(3), KITLG(1), KRAS(2), MAP2K1(1), MAPK1(1), MAPK3(1), PLCB1(1), PLCB2(3), PLCB4(1), PRKCA(1), PRKCG(2), PRKX(1), RAF1(1), TCF7L2(2), TYR(1), TYRP1(2), WNT1(1), WNT10A(2), WNT2B(1), WNT3(1), WNT5B(1), WNT9B(1)	45676254	68	60	66	20	19	22	13	3	11	0	0.158	0.676
144	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1), PGLYRP2(1)	797225	2	2	2	0	1	1	0	0	0	0	0.158	0.676
145	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(4), ADC(2), ALDH3A1(2), AMD1(1), AOC2(2), ASS1(1), CPS1(4), GATM(2), MAOB(2), OTC(2)	12828348	22	21	22	6	1	12	6	2	1	0	0.160	0.676
146	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1S(2), C2(2), C3(3), C5(1), C6(1), C8A(1), C8B(3), C9(2)	9123223	15	15	15	6	5	3	2	1	4	0	0.160	0.676
147	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	27	ELK1(2), IGF1R(2), ITGB1(1), MAP2K1(1), MAPK1(1), MAPK3(1), MYC(1), PTPRR(3), RAF1(1), RPS6KA5(1), SOS1(3), SRC(2), STAT3(1)	12278977	20	20	20	3	6	6	4	1	3	0	0.166	0.697
148	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	10	GABRA2(1), GABRA3(1), GABRA4(2), GABRA5(3), SRC(2)	4323960	9	8	9	5	1	5	1	2	0	0	0.172	0.716
149	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ELK1(2), FOS(1), LYN(2), MAP2K1(1), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8IP3(2), PAPPA(2), RPS6KA3(1), SOS1(3), VAV1(3), VAV2(2), VAV3(1)	13848746	24	22	24	7	6	8	4	4	2	0	0.178	0.735
150	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(1), IARS(3), IL4R(4), INPP5D(3), JAK1(2), JAK2(1), JAK3(2), NR0B2(1), SOS1(3), SRC(2), STAT6(1), TYK2(1)	15087822	24	24	24	6	6	11	4	1	2	0	0.179	0.736
151	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	ELK1(2), FOS(1), LYN(2), MAP2K1(1), MAP3K1(2), MAPK3(1), MAPK8(1), NFATC2(2), NFATC4(2), PLCG1(6), PPP3CB(1), PRKCA(1), RAF1(1), SOS1(3), VAV1(3)	16543052	29	25	29	9	8	7	7	3	4	0	0.180	0.736
152	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(1), EGF(3), FOS(1), MYC(1), NFKB1(1), PLCG1(6), PRKCA(1)	7755400	14	13	14	5	2	6	3	1	2	0	0.182	0.737
153	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	88	ADCY1(3), ADCY2(2), ADCY3(3), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(3), DRD2(1), EGF(3), GJD2(2), GRM1(4), GRM5(2), GUCY1B3(1), GUCY2F(1), HTR2A(1), HTR2C(1), ITPR1(4), ITPR2(2), ITPR3(3), KRAS(2), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK7(1), NPR1(1), PDGFD(1), PDGFRB(2), PLCB1(1), PLCB2(3), PLCB4(1), PRKCA(1), PRKCG(2), PRKG2(4), PRKX(1), RAF1(1), SOS1(3), SRC(2), TJP1(2), TUBA1A(1), TUBA3C(3), TUBA3D(1), TUBA4A(1), TUBB4(3), TUBB4Q(3)	54163383	84	72	82	33	25	33	11	4	11	0	0.183	0.737
154	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), CBS(1), CTH(1), MUT(1)	2115066	4	4	4	1	1	1	1	1	0	0	0.184	0.737
155	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(2), ADH1C(1)	2442402	5	5	5	1	2	2	1	0	0	0	0.187	0.743
156	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BCL2(2), MAP2K1(1), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), NFKB1(1), NSMAF(2), RAF1(1), RIPK1(1), TNFRSF1A(1)	8949940	14	14	14	4	3	4	1	2	4	0	0.189	0.743
157	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	16	ACE(2), ACE2(2), AGTR1(1), ANPEP(2), CMA1(1), CTSG(3), ENPEP(2), LNPEP(1), MME(1)	8795293	15	15	15	3	3	7	1	0	4	0	0.190	0.743
158	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	16	CBL(1), EGF(3), MAP2K1(1), MAPK1(1), MAPK3(1), PTPRB(2), RAF1(1), SOS1(3), SRC(2)	9427019	15	15	15	7	3	3	5	2	2	0	0.191	0.743
159	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(1), IKBKB(1), IL1A(1), IL1R1(2), IRAK1(2), MAP3K1(2), MAP3K7(2), NFKB1(1), NFKBIA(1), RIPK1(1), TLR4(1), TNFRSF1A(1), TRAF6(1)	10617620	17	17	17	4	4	7	2	1	3	0	0.193	0.743
160	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	93	ADCY1(3), ADCY2(2), ADCY3(3), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(3), CACNA1C(5), CACNA1D(4), CACNA1F(1), CACNA1S(4), CAMK2A(1), ELK1(2), ITPR1(4), ITPR2(2), ITPR3(3), KRAS(2), MAP2K1(1), MAP2K3(3), MAP3K1(2), MAP3K4(3), MAPK1(1), MAPK13(1), MAPK3(1), MAPK7(1), MAPK8(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(2), PLA2G6(1), PLCB1(1), PLCB2(3), PLCB4(1), PLD1(1), PRKCA(1), PRKCD(3), PRKX(1), PTK2B(2), RAF1(1), SOS1(3), SRC(2)	53575404	82	71	80	23	26	30	12	4	10	0	0.194	0.743
161	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	BRAF(5), CACNA1A(1), GNAO1(1), GRIA1(2), GRIA3(3), GRID2(1), GRM1(4), GRM5(2), GUCY1B3(1), GUCY2F(1), IGF1(2), IGF1R(2), ITPR1(4), ITPR2(2), ITPR3(3), KRAS(2), LYN(2), MAP2K1(1), MAPK1(1), MAPK3(1), NOS1(5), NOS3(4), NPR1(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(2), PLA2G6(1), PLCB1(1), PLCB2(3), PLCB4(1), PPP2R1B(2), PRKCA(1), PRKCG(2), PRKG2(4), RAF1(1), RYR1(3)	48108928	74	63	69	30	30	20	11	5	8	0	0.194	0.743
162	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	19	AKT1(1), CASP9(1), CHUK(1), ELK1(2), MAP2K1(1), MAPK3(1), NFKB1(1), RAF1(1), RALBP1(1), RALGDS(1)	6663873	11	11	11	0	3	4	2	0	2	0	0.198	0.751
163	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	14	ABCA1(1), CETP(2), LCAT(2), LDLR(1), LRP1(8), SOAT1(3)	10855118	17	16	17	5	4	3	4	1	5	0	0.200	0.755
164	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(1), IFNG(2), IL12B(1), IL16(1), IL1A(1), IL3(1), IL6(1)	4271934	8	8	8	4	1	4	2	0	1	0	0.205	0.770
165	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(1), HLA-DRA(1), IL1B(1), IL5RA(1), IL6(1)	2327308	5	5	5	1	2	2	0	0	1	0	0.206	0.770
166	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	CDKN1A(1), CDKN2A(2), MDM2(2), PRB1(1)	3109345	6	6	6	0	1	2	0	0	3	0	0.210	0.775
167	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(4), ATR(3), CHEK1(2), CHEK2(1), YWHAH(1)	6596845	11	11	11	3	0	4	4	1	2	0	0.214	0.775
168	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(1), ATM(4), BRCA1(3), CDKN1A(1), CHEK1(2), CHEK2(1), MAPK8(1), MDM2(2), MRE11A(1), NFKB1(1), NFKBIA(1), RAD50(1), RBBP8(1)	12573760	20	20	20	6	2	10	3	1	4	0	0.214	0.775
169	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	44	AKT1(1), BCL2(2), CD19(1), CD22(3), CR2(3), CSK(1), DAG1(2), FLOT1(1), GSK3B(1), INPP5D(3), ITPR1(4), ITPR2(2), ITPR3(3), LYN(2), MAP4K1(2), MAPK1(1), MAPK3(1), NFATC2(2), NR0B2(1), PLCG2(2), PPP3CB(1), PTPRC(2), RAF1(1), SOS1(3), VAV1(3)	30479385	48	43	48	17	16	13	7	2	10	0	0.216	0.775
170	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	11	CREBBP(4), DAXX(2), PAX3(3), SP100(2), TNFRSF1A(1)	7175492	12	12	12	4	2	5	1	1	3	0	0.216	0.775
171	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	23	INSR(2), IRS1(2), JAK2(1), MAP2K1(1), MAPK1(1), MAPK3(1), PLCG1(6), PRKCA(1), RAF1(1), SOS1(3), SRF(1), STAT5B(1)	12659046	21	19	21	5	2	8	4	2	5	0	0.218	0.775
172	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	164	ADCY1(3), ADCY2(2), ADCY3(3), ADCY7(1), ADCY8(2), ADCY9(3), AGTR1(1), ATP2A1(1), ATP2A3(1), ATP2B2(3), ATP2B3(2), AVPR1A(1), AVPR1B(1), BDKRB1(1), BST1(1), CACNA1A(1), CACNA1C(5), CACNA1D(4), CACNA1E(5), CACNA1F(1), CACNA1G(1), CACNA1H(2), CACNA1I(3), CACNA1S(4), CAMK2A(1), CAMK4(1), CCKAR(1), CD38(1), CHRM1(1), CHRM2(3), CHRM3(1), ERBB2(1), ERBB4(1), GRIN2A(8), GRIN2C(1), GRIN2D(1), GRM1(4), GRM5(2), HRH2(2), HTR2A(1), HTR2C(1), HTR4(1), HTR5A(3), HTR7(2), ITPR1(4), ITPR2(2), ITPR3(3), LHCGR(2), MYLK(2), NOS1(5), NOS3(4), NTSR1(3), P2RX2(1), P2RX5(1), PDE1A(2), PDE1C(4), PDGFRB(2), PHKA1(1), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(1), PLCE1(2), PLCG1(6), PLCG2(2), PLCZ1(1), PPP3CB(1), PPP3R2(1), PRKCA(1), PRKCG(2), PRKX(1), PTAFR(1), PTGFR(1), PTK2B(2), RYR1(3), RYR3(10), TACR3(3), TNNC2(1), TRPC1(1), VDAC1(1)	111310760	171	125	170	68	55	72	17	5	22	0	0.218	0.775
173	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1S(2), C2(2), C3(3), C5(1), C6(1), C8A(1), C9(2)	7696465	12	12	12	6	4	2	2	1	3	0	0.218	0.775
174	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDK7(1), CDKN1A(1), CHEK1(2), NEK1(1), WEE1(1)	3107501	6	6	6	0	2	2	1	0	1	0	0.222	0.780
175	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHB1(1), FYN(1), ITGA1(2), ITGB1(1), L1CAM(4), LYN(2), SELP(1)	6822621	12	12	12	4	2	6	4	0	0	0	0.222	0.780
176	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), IL1B(1), MST1(1), MST1R(2)	2802594	5	5	5	3	3	0	0	0	2	0	0.225	0.783
177	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	FOS(1), MAP2K1(1), MAPK1(1), MAPK3(1), MYC(1), NFKB1(1), NFKBIA(1), PLCB1(1), PRKCA(1), RAF1(1)	6704191	10	10	10	2	2	2	2	1	3	0	0.226	0.783
178	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	31	GTF2A1L(1), GTF2H1(2), TAF1(3), TAF1L(8), TAF2(3), TAF4(2), TAF6(1), TAF7(1), TAF7L(2), TBPL2(1)	15528835	24	23	24	9	8	3	6	3	4	0	0.227	0.783
179	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(4), ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), AOC2(2), CNDP1(1), DDC(1), HAL(2), HARS(1), HDC(1), MAOB(2)	10596263	19	18	19	3	2	14	3	0	0	0	0.228	0.783
180	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), IFNB1(1), MAPK8(1), NFKB1(1), TNFRSF11A(2), TNFSF11(1), TRAF6(1)	4821422	8	8	8	4	3	3	1	0	1	0	0.231	0.790
181	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADS(3), ECHS1(1)	2334095	4	5	5	1	1	2	1	0	0	0	0.232	0.790
182	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(2), FOS(1), IL3(1), JAK2(1), MAP2K1(1), MAPK3(1), RAF1(1), SOS1(3), STAT5B(1)	7290038	12	12	12	0	1	5	4	0	2	0	0.235	0.793
183	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CSK(1), PRKCA(1), PTPRA(3), SRC(2)	3993959	7	7	7	0	4	2	1	0	0	0	0.235	0.793
184	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	AKT1(1), CABIN1(3), CAMK1(1), IGF1(2), IGF1R(2), INSR(2), MAPK7(1), MEF2A(2), MEF2D(1), MYOD1(1), NFATC2(2), PPP3CB(1), YWHAH(1)	13399152	20	20	20	7	4	7	6	0	3	0	0.238	0.796
185	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	130	COL11A1(1), COL11A2(5), COL17A1(2), COL1A1(1), COL2A1(1), COL3A1(4), COL4A1(1), COL4A2(1), COL4A4(5), COL4A6(2), COL5A1(1), COL5A2(1), COL5A3(1), COL6A6(5), DES(2), DSC1(2), DSC2(4), DSC3(4), DSG1(2), DSG2(1), DSG4(4), FN1(2), GJA10(1), GJA9(1), GJB3(2), GJC1(1), GJC3(1), GJD2(2), INA(1), ITGB4(2), KRT1(1), KRT12(1), KRT13(2), KRT14(1), KRT15(2), KRT16(2), KRT2(1), KRT20(1), KRT23(2), KRT24(1), KRT25(3), KRT28(1), KRT31(1), KRT32(1), KRT33B(1), KRT34(1), KRT35(1), KRT36(1), KRT37(4), KRT4(1), KRT6B(1), KRT74(1), KRT75(1), KRT76(1), KRT79(2), KRT8(1), KRT81(1), KRT84(2), KRT86(1), KRT9(2), LAMA1(3), LAMA2(6), LAMA3(4), LAMA4(1), LAMA5(5), LAMB1(2), LAMB3(3), LAMB4(3), LAMC1(1), LAMC3(3), NES(1), THBS3(1), THBS4(1), TNC(1), TNN(2), TNXB(2), VWF(5)	99021986	149	115	148	65	42	66	14	9	18	0	0.242	0.807
186	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	14	BCL2(2), CREBBP(4), FYN(1), IL7(1), IL7R(1), JAK1(2), JAK3(2), PTK2B(2), STAT5B(1)	10547775	16	16	16	9	3	4	2	0	7	0	0.247	0.814
187	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), PPARG(1), RETN(1), RXRA(2)	2505472	5	5	5	0	1	2	0	0	2	0	0.247	0.814
188	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	16	AKT1(1), EIF2S2(1), EIF2S3(1), GSK3B(1), IGF1(2), IGF1R(2), INPPL1(3)	6556075	11	10	11	2	1	2	4	0	4	0	0.254	0.825
189	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL4R(4), JAK1(2), JAK2(1), TYK2(1)	4517951	8	8	8	4	0	5	1	0	2	0	0.255	0.825
190	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL4R(4), JAK1(2), JAK2(1), TYK2(1)	4517951	8	8	8	4	0	5	1	0	2	0	0.255	0.825
191	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CHUK(1), EGR2(1), EGR3(1), MAP3K1(2), MYC(1), NFATC2(2), NFKB1(1), NFKBIA(1), PLCG1(6), PPP3CB(1), PRKAR1B(1), PRKAR2B(1)	11875443	19	17	19	4	2	7	3	3	4	0	0.257	0.829
192	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	CHUK(1), IFNG(2), IKBKB(1), MAP3K1(2), MAP3K5(1), MAPK8(1), NFKB1(1), NFKBIA(1), TNFRSF9(1), TNFSF9(3)	8475412	14	13	13	5	5	4	2	1	2	0	0.259	0.832
193	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(2), F2RL3(1), ITGA1(2), ITGB1(1), MAP2K1(1), MAPK1(1), MAPK3(1), PLA2G4A(2), PLCB1(1), PRKCA(1), PTGS1(1), RAF1(1), SRC(2), TBXAS1(1)	10574431	18	16	18	1	4	7	4	1	2	0	0.263	0.840
194	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1S(2), C2(2), C3(3), C5(1), C6(1), C8A(1), C9(2), MASP2(1), MBL2(1)	9336561	14	14	14	7	4	4	2	1	3	0	0.264	0.840
195	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(4), ACACB(5), MCAT(1), OXSM(1)	6773157	11	11	11	2	4	4	1	1	1	0	0.266	0.841
196	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	198	ABI2(1), ACTN1(2), ACTN3(1), APC(1), APC2(2), ARHGEF12(1), ARHGEF6(2), ARHGEF7(1), ARPC2(1), BDKRB1(1), BRAF(5), CFL2(1), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), CRKL(1), CSK(1), DIAPH2(2), DIAPH3(1), DOCK1(1), EGF(3), EZR(3), F2(2), FGD1(1), FGD3(2), FGF14(2), FGF18(1), FGF7(1), FGFR1(1), FGFR3(4), FGFR4(1), FN1(2), GRLF1(1), GSN(1), IQGAP2(1), IQGAP3(3), ITGA1(2), ITGA10(2), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(1), ITGAD(1), ITGAE(1), ITGAM(4), ITGAV(1), ITGAX(6), ITGB1(1), ITGB2(4), ITGB3(1), ITGB4(2), ITGB6(2), ITGB7(1), ITGB8(1), KRAS(2), LIMK2(2), MAP2K1(1), MAPK1(1), MAPK3(1), MSN(1), MYH14(2), MYH9(3), MYLK(2), NCKAP1L(1), PAK1(1), PAK3(1), PAK4(3), PDGFRB(2), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP4K2C(3), PIP5K1B(2), PPP1R12B(1), PXN(1), RAF1(1), ROCK1(1), ROCK2(1), SOS1(3), SSH1(2), SSH2(1), TIAM2(4), VAV1(3), VAV2(2), VAV3(1), WAS(1)	116362947	168	124	160	60	41	68	27	9	23	0	0.272	0.856
197	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	76	ABL1(1), ACTN1(2), AKT1(1), ARHGEF6(2), ARHGEF7(1), BRAF(5), CDKN2A(2), CSE1L(1), DOCK1(1), EPHB2(1), FYN(1), GRB7(2), GRLF1(1), ITGA1(2), ITGA10(2), ITGA11(1), ITGA2(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(1), MAPK1(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(2), MYLK(2), PAK1(1), PAK3(1), PAK4(3), PIK3CB(4), PLCG1(6), PLCG2(2), RAF1(1), ROCK1(1), ROCK2(1), SOS1(3), SRC(2), TERF2IP(1), TLN2(2), VASP(1), WAS(1), ZYX(2)	51677514	77	63	73	20	17	22	15	8	15	0	0.279	0.862
198	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(1), CCNE2(1), CDKN2A(2), E2F4(1), PRB1(1)	3714191	6	6	6	0	1	1	1	1	2	0	0.280	0.862
199	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	EPX(2), MPO(1), MTHFR(2), TPO(3)	5036457	8	8	8	1	3	3	0	1	1	0	0.281	0.862
200	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX5(1), CBR1(2), CYP4F2(1), CYP4F3(2), EPX(2), GGT1(1), MPO(1), PLA2G3(1), PLA2G4A(2), PLA2G6(1), PTGIS(1), PTGS1(1), TBXAS1(1), TPO(3)	12059434	20	19	20	3	7	10	2	0	1	0	0.283	0.862
201	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	11	AKT1(1), CHRNG(1), MUSK(1), PTK2B(2), SRC(2), TERT(1), YWHAH(1)	5482973	9	9	9	1	3	3	2	0	1	0	0.283	0.862
202	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	24	AKT1(1), APC(1), AXIN1(3), DVL1(1), FZD1(1), GSK3B(1), IRAK1(2), LBP(3), LY96(2), NFKB1(1), TLR4(1), WNT1(1)	11360005	18	17	18	5	3	7	5	1	2	0	0.285	0.862
203	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	12	ABL1(1), CDKN2A(2), MDM2(2), MYC(1), POLR1A(2), POLR1B(1)	5927298	9	9	9	0	1	2	1	1	4	0	0.286	0.862
204	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	32	AKT1(1), BCL2(2), CBL(1), CRKL(1), FOS(1), IRS1(2), JAK1(2), JAK3(2), MAPK1(1), MAPK3(1), MYC(1), RAF1(1), SOS1(3), STAT5B(1)	14053905	20	20	20	4	1	6	5	1	7	0	0.287	0.862
205	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), TAT(2), TYR(1)	2029685	4	4	3	0	2	1	1	0	0	0	0.289	0.862
206	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ESR1(1), ESR2(2), HNF4A(3), NR1H2(2), NR1H3(1), NR1I2(1), NR1I3(2), NR2C2(1), NR2F2(1), NR4A1(2), NR5A2(1), PGR(4), PPARA(1), PPARG(1), RORC(2), RXRA(2)	18263674	27	26	27	8	7	10	4	1	5	0	0.290	0.862
207	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	129	ACTN1(2), ACTN3(1), AKT1(1), AMOTL1(1), CGN(1), CLDN14(1), CLDN15(1), CLDN17(1), CLDN18(1), CLDN19(1), CLDN9(1), CSDA(1), CSNK2B(2), CTNNA1(1), CTNNA2(2), CTNNA3(1), CTTN(2), EPB41(1), EPB41L2(2), EPB41L3(3), F11R(1), HCLS1(2), INADL(1), KRAS(2), LLGL1(2), MAGI1(2), MAGI2(2), MLLT4(4), MPDZ(1), MYH1(5), MYH11(5), MYH13(6), MYH14(2), MYH15(3), MYH2(8), MYH3(2), MYH4(4), MYH6(1), MYH7(3), MYH7B(2), MYH8(7), MYH9(3), OCLN(1), PARD6B(1), PPM1J(2), PPP2R1B(2), PPP2R3A(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(1), SPTAN1(2), SRC(2), SYMPK(2), TJAP1(1), TJP1(2), TJP3(4), ZAK(2)	83504294	125	97	123	29	32	48	22	5	18	0	0.290	0.862
208	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	12	AKT1(1), BCL2(2), IGF1R(2), MYC(1), POLR2A(2), PRKCA(1), TEP1(3), TERT(1), TNKS(1)	9943915	14	14	14	4	4	3	1	1	5	0	0.293	0.866
209	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	ELK1(2), FOS(1), JAK1(2), JAK3(2), MAP2K1(1), MAPK3(1), MAPK8(1), RAF1(1), SOS1(3), STAT5B(1)	10205977	15	15	15	7	4	4	4	0	3	0	0.299	0.876
210	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	20	CCNA1(1), CCND2(1), CCND3(1), CDK7(1), CDKN1A(1), CDKN2A(2), CDKN2B(1), RBL1(1)	5938841	9	9	9	1	4	1	1	0	3	0	0.299	0.876
211	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(2), ACADS(3), ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), ALDH5A1(1), ECHS1(1), EHHADH(1), PDHA1(1), PDHA2(2)	11166277	16	17	17	5	4	8	2	0	2	0	0.303	0.886
212	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR2(3), HLA-DRA(1), ICAM1(1), ITGB2(4), PTPRC(2)	6562480	11	10	11	4	4	5	0	0	2	0	0.306	0.890
213	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	A1BG(1), AKT1(1), CDKN2A(2), GSK3B(1), IARS(3), INPP5D(3), RPS6KA2(2), RPS6KA3(1), SFN(1), SOS1(3), TEC(1), YWHAE(1), YWHAH(1)	14271876	21	20	21	5	5	8	4	1	3	0	0.311	0.895
214	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(2), MPO(1), TPO(3), TYR(1)	4181447	7	7	7	1	3	3	1	0	0	0	0.314	0.895
215	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), FOS(1), MAPK3(1), OPRK1(1), POLR2A(2), PRKAR1B(1), PRKAR2B(1)	5405096	8	8	8	2	1	2	1	1	3	0	0.316	0.895
216	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(2), JAK2(1), JAK3(2), MAPK1(1), MAPK3(1), STAT3(1), TYK2(1)	5134220	9	8	9	1	1	6	0	1	1	0	0.317	0.895
217	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(2), ASNS(2), CPS1(4), CTH(1), GLS(1), GLUL(1), HAL(2)	8104493	13	12	13	1	3	6	1	1	2	0	0.317	0.895
218	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(3), C5(1), C6(1), C8A(1), C9(2)	5491892	8	8	8	5	2	0	2	1	3	0	0.318	0.895
219	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(3), CASP1(1), GAPDH(1), INSR(2), MAGI1(2), MAGI2(2), RERE(4), WWP2(1)	10309672	16	15	16	3	4	6	2	1	3	0	0.318	0.895
220	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(4), CD38(1), ENPP1(1), NADSYN1(1), NNT(1), NT5E(2)	6319162	10	10	9	3	2	5	3	0	0	0	0.329	0.918
221	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	27	BRAF(5), ERBB2(1), ERBB4(1), ETS1(1), KRAS(2), MAP2K1(1), MAPK1(1), MAPK3(1), NOTCH2(2), NOTCH3(1), NOTCH4(2), PIWIL1(2), PIWIL2(1), PIWIL3(2), RAF1(1), SOS1(3), SPIRE1(1), SPIRE2(1)	21475254	29	28	24	6	12	7	6	1	3	0	0.329	0.918
222	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	ALOX15B(1), ALOX5(1), CBR1(2), CYP2B6(3), CYP2C19(1), CYP2E1(1), CYP2U1(1), CYP4A11(2), CYP4F2(1), CYP4F3(2), GGT1(1), GPX1(1), GPX4(1), GPX5(2), PLA2G2F(1), PLA2G3(1), PLA2G4A(2), PLA2G6(1), PTGIS(1), PTGS1(1), TBXAS1(1)	16890082	28	24	28	11	6	15	5	0	2	0	0.336	0.930
223	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(2)	1681503	3	3	3	1	1	2	0	0	0	0	0.338	0.930
224	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(2), CD44(3), IL1B(1), TNFRSF1A(1), TNFRSF8(1), TNFSF8(1)	5867714	9	9	9	1	1	3	0	1	4	0	0.338	0.930
225	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(1), MAP2K1(1), MAPK1(1), MAPK3(1), PIK3C2G(6), PLCB1(1), PPP1R12B(1), PRKCA(1), RAF1(1), ROCK2(1)	10997841	15	15	15	3	3	4	3	2	3	0	0.340	0.930
226	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS1(1), CPO(1), FECH(1), GATA1(1), HMBS(1)	3485438	5	5	5	1	0	3	0	2	0	0	0.341	0.930
227	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(2), MPO(1), TPO(3)	3645859	6	6	6	1	3	3	0	0	0	0	0.344	0.933
228	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(1), CDKN1A(1), ELK1(2), MAP2K1(1), NTRK1(1), SOS1(3)	6082268	9	9	9	4	3	2	2	0	2	0	0.346	0.933
229	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	29	ANPEP(2), G6PD(1), GGT1(1), GPX1(1), GPX4(1), GPX5(2), GSTA1(1), GSTA4(2)	7456527	11	11	11	1	3	4	3	0	1	0	0.347	0.933
230	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	BCL2(2), CABIN1(3), CAMK4(1), CD3E(2), CD3G(1), CDKN1A(1), CREBBP(4), CSF2(2), CSNK2B(2), EGR2(1), EGR3(1), FCER1A(1), FOS(1), GATA4(1), GRLF1(1), GSK3B(1), IFNB1(1), IFNG(2), IL1B(1), IL3(1), IL6(1), KPNA5(1), MAPK8(1), MEF2A(2), MEF2D(1), MYF5(1), NFATC2(2), NFATC4(2), NFKB2(1), NFKBIE(2), NUP214(2), PAK1(1), PPP3CB(1), PTPRC(2), SFN(1), VAV1(3), VAV2(2), VAV3(1)	38711362	57	51	57	19	11	18	12	1	15	0	0.352	0.941
231	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	31	AKT1(1), CD19(1), CDKN2A(2), FLOT1(1), ITPR1(4), ITPR2(2), ITPR3(3), LYN(2), NR0B2(1), PITX2(2), PLCG2(2), PREX1(5), PTPRC(2), RPS6KA2(2), RPS6KA3(1), TEC(1), VAV1(3)	22774055	35	33	35	14	12	12	2	2	7	0	0.353	0.941
232	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(4), BST1(1), CD38(1), ENPP1(1), NADSYN1(1), NNT(1), NT5C1B(2), NT5E(2), NUDT12(1)	9349270	14	14	13	7	2	7	5	0	0	0	0.356	0.942
233	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), ECHS1(1), EHHADH(1)	2094895	3	3	3	0	1	1	0	0	1	0	0.357	0.942
234	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CLOCK(4), CRY1(1), PER1(1)	3693114	6	6	5	1	1	2	0	0	3	0	0.359	0.942
235	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO2(1), ENO3(1), PAH(2), TAT(2)	3582283	6	6	5	1	2	3	1	0	0	0	0.359	0.942
236	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(2), ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1G1(1), CHUK(1), CSK(1), CXCL1(1), F11R(1), IKBKB(1), LYN(2), MAPK13(1), MAPK8(1), MET(1), NFKB1(1), NFKB2(1), NFKBIA(1), NOD1(2), PAK1(1), PLCG1(6), PLCG2(2), PTPN11(4), PTPRZ1(1), SRC(2), TJP1(2)	29302667	45	39	45	14	8	18	8	3	8	0	0.365	0.945
237	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	BCL10(1), BCL2(2), CASP8AP2(1), CASP9(1), CES1(2)	4830646	7	7	7	0	2	2	0	0	3	0	0.366	0.945
238	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	128	CADM3(1), CD2(1), CD22(3), CD276(1), CD28(1), CD58(1), CD6(2), CD86(2), CDH4(1), CDH5(1), CLDN14(1), CLDN15(1), CLDN17(1), CLDN18(1), CLDN19(1), CLDN9(1), CNTN1(1), CNTN2(2), CNTNAP1(1), F11R(1), HLA-DMB(1), HLA-DRA(1), HLA-F(1), ICAM1(1), ICAM2(1), ICOSLG(2), ITGA4(3), ITGA8(1), ITGA9(1), ITGAM(4), ITGAV(1), ITGB1(1), ITGB2(4), ITGB7(1), ITGB8(1), L1CAM(4), MAG(3), MPZL1(2), NCAM1(2), NEGR1(1), NLGN1(1), NLGN3(1), NRCAM(1), NRXN1(4), NRXN3(1), OCLN(1), PTPRC(2), PTPRF(4), PTPRM(1), PVR(1), PVRL1(2), PVRL2(1), SDC1(1), SDC2(1), SDC4(1), SELE(1), SELP(1), SELPLG(2), SIGLEC1(1), VCAM1(1), VCAN(2)	63571232	92	78	92	44	20	42	11	7	12	0	0.366	0.945
239	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1)	875338	1	1	1	0	1	0	0	0	0	0	0.369	0.945
240	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	ATM(4), BCL2(2), CDKN1A(1), MDM2(2), TIMP3(1)	6768332	10	10	10	1	1	1	3	0	5	0	0.369	0.945
241	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(2), ASNS(2), CPS1(4), CTH(1), GLS(1), GLUD2(1), GLUL(1), HAL(2)	9080446	14	13	14	2	3	7	1	1	2	0	0.371	0.945
242	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(1), CREB1(1), ELK1(2), IL1R1(2), MAP2K3(3), MAP3K4(3), MAP3K5(1), MAP3K7(2), MAPK1(1), MAPK13(1), NFKB1(1), NR2C2(1), SRF(1), TRAF6(1)	14505443	21	20	21	3	5	7	3	2	4	0	0.374	0.945
243	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	44	ADH1A(2), ADH1B(2), ADH1C(1), AGPAT1(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), CEL(3), DGKB(1), DGKD(4), DGKE(2), DGKG(2), DGKQ(1), DGKZ(1), LCT(1), LIPG(1), PNLIP(1)	20637665	29	29	29	7	9	15	2	1	2	0	0.375	0.945
244	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	35	ANPEP(2), G6PD(1), GGT1(1), GPX1(1), GPX4(1), GPX5(2), GSTA1(1), GSTA4(2), GSTK1(1), OPLAH(1)	9087561	13	13	13	1	5	4	3	0	1	0	0.375	0.945
245	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	BRAF(5), CHUK(1), CREB1(1), DAXX(2), ELK1(2), FOS(1), IKBKB(1), MAP2K1(1), MAP2K3(3), MAP3K1(2), MAP3K12(1), MAP3K13(1), MAP3K4(3), MAP3K5(1), MAP3K7(2), MAP3K9(1), MAP4K1(2), MAP4K2(1), MAP4K3(2), MAP4K4(2), MAPK1(1), MAPK13(1), MAPK3(1), MAPK7(1), MAPK8(1), MAX(2), MEF2A(2), MEF2D(1), MYC(1), NFKB1(1), NFKBIA(1), PAK1(1), RAF1(1), RIPK1(1), RPS6KA2(2), RPS6KA3(1), RPS6KA5(1), STAT1(1), TGFBR1(1)	41666357	57	52	53	12	19	18	7	4	9	0	0.376	0.945
246	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(3), CREB1(1), CREBBP(4), NCOA3(1), PRKAR1B(1), PRKAR2B(1), RXRA(2)	8768662	13	13	12	5	5	3	0	1	4	0	0.377	0.945
247	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	24	ADCY1(3), AKT1(1), CAMK2A(1), CREB1(1), MAPK1(1), MAPK3(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), RPS6KA5(1), SOS1(3)	10800918	15	15	15	1	4	5	3	2	1	0	0.380	0.948
248	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), HLA-DRA(1)	1044718	2	2	2	0	0	2	0	0	0	0	0.387	0.962
249	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(2)	1395548	2	2	2	0	0	1	1	0	0	0	0.394	0.971
250	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	TAT(2)	1135454	2	2	1	0	2	0	0	0	0	0	0.396	0.971
251	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(1), CREBBP(4), IKBKB(1), IL1B(1), MAP2K3(3), MAP3K7(2), NFKB1(1), NFKBIA(1), TGFBR1(1), TGFBR2(2), TLR2(3)	12862646	20	18	20	5	3	8	3	0	6	0	0.396	0.971
252	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG2(2), AKT1(1), CFL2(1), FLNC(3), GDI1(1), MYH2(8), MYLK(2), PAK1(1), PAK3(1), PAK4(3), ROCK1(1), ROCK2(1), RPS4X(1), VASP(1)	20634189	27	26	27	8	6	10	4	3	4	0	0.400	0.971
253	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	DLG4(1), EPHB2(1), F2(2), F2RL3(1), MAPK1(1), MAPK7(1), MAPK8(1), PLD1(1), RAF1(1), RASAL1(1), SRC(2), TEC(1), VAV1(3)	11931253	17	16	17	5	4	4	5	2	2	0	0.400	0.971
254	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	IARS(3), PDHA1(1), PDHA2(2)	4346650	6	6	6	2	2	3	0	1	0	0	0.401	0.971
255	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(2), JAK2(1), JAK3(2), PIAS1(1), PIAS3(1), SOAT1(3)	6058462	10	9	10	2	1	6	1	0	2	0	0.402	0.971
256	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(4), CCND2(1), EGR1(3), ESR2(2), LHCGR(2), MSH5(2), NCOR1(1), NRIP1(1), PGR(4), ZP2(1)	15205801	21	21	21	1	5	9	3	1	3	0	0.406	0.973
257	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(1), CAPN1(2), CAPN11(2), CAPN6(1), CAPNS1(1), CAV3(1), CSK(1), DOCK1(1), FYN(1), ITGA10(2), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(1), ITGAD(1), ITGAE(1), ITGAM(4), ITGAV(1), ITGAX(6), ITGB1(1), ITGB2(4), ITGB3(1), ITGB4(2), ITGB6(2), ITGB7(1), ITGB8(1), MAP2K1(1), MAP2K3(3), MAPK7(1), PAK1(1), PAK3(1), PAK4(3), PIK3R2(3), PXN(1), ROCK1(1), ROCK2(1), SDCCAG8(1), SORBS1(1), SOS1(3), SRC(2), TNS1(3), VASP(1), VAV2(2), VAV3(1), ZYX(2)	58279953	82	71	82	25	18	39	12	4	9	0	0.406	0.973
258	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	CREB1(1), DAXX(2), ELK1(2), MAP3K1(2), MAP3K5(1), MAP3K7(2), MAP3K9(1), MAX(2), MEF2A(2), MEF2D(1), MYC(1), PLA2G4A(2), RIPK1(1), RPS6KA5(1), STAT1(1), TGFBR1(1)	15962681	23	21	23	3	7	5	5	2	4	0	0.410	0.973
259	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	8	CCNA1(1), CUL1(2), SKP2(1)	2965398	4	4	4	0	2	1	0	0	1	0	0.410	0.973
260	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(1), CANX(1), CIITA(3), CREB1(1), CTSS(1), HLA-DMB(1), HLA-DRA(1), HLA-F(1), IFNA10(4), IFNA21(1), KIR2DL1(2), KIR2DL3(1), KIR2DL4(1), KIR3DL1(3), KLRC3(2), KLRD1(1), NFYB(1), PDIA3(1), TAP2(3)	20142880	30	26	28	14	11	9	5	2	3	0	0.414	0.973
261	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	MAP2K3(3), NFATC2(2), PRKAR1B(1), PRKAR2B(1)	5071437	7	7	7	3	0	3	1	1	2	0	0.416	0.973
262	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	9	EGF(3), MAP2K1(1), MAP3K1(2), NCOR2(1), RXRA(2)	6304698	9	9	9	5	2	3	0	1	3	0	0.417	0.973
263	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1)	700226	1	1	1	0	0	0	1	0	0	0	0.420	0.973
264	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSA(1), PAH(2), TAT(2), YARS2(1)	3781985	6	6	5	1	2	3	1	0	0	0	0.420	0.973
265	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(1), CTTN(2), EZR(3), FYN(1), HCLS1(2), ITGB1(1), LY96(2), NCL(1), OCLN(1), PRKCA(1), ROCK1(1), ROCK2(1), TLR4(1), TLR5(1), TUBA1A(1), TUBA3C(3), TUBA3D(1), TUBA4A(1), TUBB4(3), TUBB4Q(3), WAS(1)	22781844	32	31	32	14	6	15	7	2	2	0	0.421	0.973
266	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(1), CTTN(2), EZR(3), FYN(1), HCLS1(2), ITGB1(1), LY96(2), NCL(1), OCLN(1), PRKCA(1), ROCK1(1), ROCK2(1), TLR4(1), TLR5(1), TUBA1A(1), TUBA3C(3), TUBA3D(1), TUBA4A(1), TUBB4(3), TUBB4Q(3), WAS(1)	22781844	32	31	32	14	6	15	7	2	2	0	0.421	0.973
267	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(1), JAK1(2), JAK2(1), JAK3(2), PIAS3(1), SRC(2), STAT3(1)	6697196	10	10	10	2	1	7	1	0	1	0	0.423	0.973
268	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	CREB1(1), FOS(1), MAPK1(1), MAPK8(1), PRKCA(1)	3774772	5	5	5	3	2	0	1	1	1	0	0.424	0.973
269	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	MAX(2), MYC(1), WT1(1)	2683688	4	4	4	2	2	0	0	0	2	0	0.426	0.973
270	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(1), CTH(1), GGT1(1), MARS(2), MAT1A(2), SCLY(1)	5350897	8	7	8	2	4	2	0	1	1	0	0.428	0.973
271	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	61	ATM(4), CCNA1(1), CCND2(1), CCND3(1), CCNE2(1), CDK7(1), CDKN1A(1), CDKN2A(2), CDKN2B(1), CREB3L1(1), CREB3L3(2), CREB3L4(1), E2F4(1), E2F6(1), MCM2(1), MCM3(2), MCM4(2), MCM5(2), MCM6(3), MCM7(2), MDM2(2), MYC(1), NACA(1), POLA2(1), POLE(1), PRIM1(1), RBL1(1), TNXB(2), WEE1(1)	31839469	42	40	42	5	6	10	10	5	11	0	0.431	0.973
272	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	11	CUL1(2), SKP2(1), UBE2M(1)	2963093	4	4	4	0	1	1	0	0	2	0	0.431	0.973
273	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(4), ESR1(1), MAPK1(1), MAPK3(1), SRC(2)	6408309	9	9	9	5	4	1	1	1	2	0	0.432	0.973
274	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT7(1), CHST1(1), CHST2(2), CHST4(1), CHST6(2), FUT8(1)	5384302	8	8	8	1	2	4	1	0	1	0	0.433	0.973
275	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	57	ABP1(4), ACMSD(1), ALDH3A1(2), AOC2(2), AOX1(4), CARM1(3), CYP1A2(2), CYP1B1(1), DDC(1), ECHS1(1), EHHADH(1), HSD17B4(1), KYNU(1), LCMT1(1), LCMT2(1), MAOB(2), NFX1(1), OGDH(3), TPH1(2), WARS(1)	25973660	35	35	31	8	8	16	4	0	7	0	0.436	0.973
276	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	30	MAPK1(1), MAPK13(1), MAPK3(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), TRAF6(1)	12758072	17	17	17	4	3	8	0	2	4	0	0.437	0.973
277	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	12	AKT1(1), CASP9(1), CHUK(1), NFKB1(1), NFKBIA(1), YWHAH(1)	4497505	6	6	6	0	0	4	1	0	1	0	0.445	0.973
278	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(2), ALDH3A1(2)	3464219	5	5	5	2	1	4	0	0	0	0	0.445	0.973
279	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(2), ALDH3A1(2)	3464219	5	5	5	2	1	4	0	0	0	0	0.445	0.973
280	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABP1(4), ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), AOC2(2), CNDP1(1), DPYD(2), ECHS1(1), EHHADH(1), MLYCD(1)	12583512	17	17	17	5	4	9	2	1	1	0	0.446	0.973
281	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	18	ADCY1(3), AKT1(1), ITGAV(1), ITGB3(1), MAPK1(1), MAPK3(1), PLCB1(1), PRKCA(1), SRC(2)	9135969	12	12	12	2	6	2	2	1	1	0	0.448	0.973
282	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL22(2), JAK1(2), JAK2(1), JAK3(2), STAT1(1), STAT3(1), STAT5B(1), TYK2(1)	8004687	11	11	11	4	1	6	1	0	3	0	0.450	0.973
283	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(1), ATP6V1A(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1G1(1)	6548929	9	9	9	4	1	5	2	0	1	0	0.451	0.973
284	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(1), ATP6V1A(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1G1(1)	6548929	9	9	9	4	1	5	2	0	1	0	0.451	0.973
285	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(1), ATP6V1A(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1G1(1)	6548929	9	9	9	4	1	5	2	0	1	0	0.451	0.973
286	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(5), ACSL1(1), ACSL3(1), ACSL4(1), AKT1(1), CAMKK1(1), CHUK(1), CPT1A(1), CPT1C(1), CPT2(1), G6PC(1), IKBKB(1), IRS1(2), IRS4(2), JAK1(2), JAK2(1), JAK3(2), LEPR(1), MAPK8(1), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), PCK1(2), PPARA(1), PRKAG3(1), PRKCQ(1), PTPN11(4), RXRA(2), SLC2A1(2), STAT3(1), TNFRSF1A(1), TYK2(1)	35985449	48	46	48	14	8	24	4	4	8	0	0.452	0.973
287	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	17	ADCY1(3), F2(2), F2RL3(1), MAP3K7(2), PLCB1(1), PPP1R12B(1), PRKCA(1), PTK2B(2), ROCK1(1)	9586464	14	13	14	2	4	4	3	0	3	0	0.458	0.983
288	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	GLI2(3), GSK3B(1), PRKAR1B(1), PRKAR2B(1), SHH(2), SMO(1), SUFU(1)	7078064	10	9	10	2	2	4	1	1	2	0	0.462	0.985
289	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(2)	1671061	2	2	2	0	0	0	0	0	2	0	0.464	0.985
290	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(1), AXIN1(3), BMP2(1), BMP5(2), BMPR2(1), CHRD(1), DVL1(1), FZD1(1), GATA4(1), GSK3B(1), MAP3K7(2), NPPA(1), RFC1(1), TGFBR1(1), TGFBR2(2), TGFBR3(1), WNT1(1)	15530159	22	20	22	4	4	6	6	2	4	0	0.467	0.985
291	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(1), CHST13(1), DSE(2), UST(1), XYLT1(1), XYLT2(2)	6116235	8	8	8	1	4	2	0	1	1	0	0.469	0.985
292	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(3), PLCE1(2), PRKAR1B(1), PRKAR2B(1), RAP2B(1)	6214183	8	8	8	0	2	3	1	1	1	0	0.470	0.985
293	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), ECHS1(1), EHHADH(1), HSD17B4(1), SIRT2(1), SIRT5(1), VNN2(1)	5021695	7	7	7	0	1	3	1	0	2	0	0.473	0.985
294	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	NDUFA12(1), NDUFA13(1)	1770413	2	2	2	1	0	2	0	0	0	0	0.476	0.985
295	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	19	AKT1(1), CDKN1A(1), MAPK1(1), MAPK3(1), NFKB1(1), NFKBIA(1), PAK1(1), RAF1(1)	6376034	8	8	8	0	2	3	1	1	1	0	0.477	0.985
296	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), ECHS1(1), EHHADH(1)	5266679	7	7	7	2	2	4	0	0	1	0	0.478	0.985
297	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(1), ADH1A(2), ADH1B(2), ADH1C(1), AKR1C4(2), ALDH3A1(2), CEL(3), CYP27A1(1), SOAT1(3), SRD5A1(1), SRD5A2(1)	13835603	19	18	19	6	7	6	4	0	2	0	0.479	0.985
298	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	APH1A(1), CREBBP(4), CTBP2(1), DLL1(1), DTX1(1), DTX2(1), DTX3L(1), DTX4(1), DVL1(1), DVL2(1), DVL3(1), HDAC2(3), HES1(1), JAG1(1), JAG2(4), LFNG(1), MAML1(2), MAML3(1), MFNG(1), NCOR2(1), NCSTN(1), NOTCH2(2), NOTCH3(1), NOTCH4(2), RBPJL(3)	29747800	38	36	38	15	6	10	9	4	9	0	0.479	0.985
299	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	CCR3(1), CELSR1(3), CELSR2(2), CELSR3(2), CHRM2(3), CHRM3(1), EMR2(1), EMR3(2), GPR116(4), GPR132(1), GPR133(3), GPR143(2), GPR17(1), GPR61(1), GRM1(4), LGR6(1), LPHN3(2), NTSR1(3), OR8G2(1), PTGFR(1), SMO(1), TAAR5(1)	28437488	41	37	41	28	14	17	6	1	3	0	0.479	0.985
300	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	129	ACACA(4), ACACB(5), AKT1(1), BRAF(5), CBL(1), CBLB(1), CRKL(1), ELK1(2), EXOC7(2), FBP1(1), FLOT1(1), FOXO1(1), G6PC(1), GSK3B(1), IKBKB(1), INPP5D(3), INSR(2), IRS1(2), IRS4(2), KRAS(2), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8(1), PCK1(2), PDE3A(1), PFKL(1), PFKP(1), PHKA1(1), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), PPP1R3A(3), PRKAG3(1), PRKAR1B(1), PRKAR2B(1), PRKX(1), PTPRF(4), PYGB(1), PYGL(1), PYGM(1), RAF1(1), RHOQ(1), SH2B2(1), SHC4(1), SOCS4(1), SORBS1(1), SOS1(3), SREBF1(1), TSC2(2)	67613158	91	75	86	33	30	30	14	7	10	0	0.481	0.985
301	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(1), AXIN1(3), BTRC(1), CREBBP(4), DVL1(1), FZD1(1), GSK3B(1), MAP3K7(2), MYC(1), WIF1(1), WNT1(1)	12459981	17	16	17	8	3	3	4	1	6	0	0.482	0.985
302	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	FUCA1(1), HEXA(1), LCT(1), MAN2B1(4), MAN2B2(2), NEU2(2)	8859893	11	11	11	2	6	1	0	2	2	0	0.483	0.985
303	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	CPS1(4), GLS(1)	3244649	5	4	5	2	1	2	1	1	0	0	0.486	0.988
304	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PLCD1(1), PRKCA(1), TGM2(1)	2180493	3	3	3	2	2	1	0	0	0	0	0.495	1.000
305	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CDKN1A(1), NFATC2(2), NFATC4(2), PLCG1(6), PPP3CB(1), PRKCA(1)	9030959	13	12	13	3	3	5	2	1	2	0	0.499	1.000
306	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(3), CFTR(2), PRKAR1B(1), PRKAR2B(1)	5485227	7	7	7	0	2	2	2	1	0	0	0.501	1.000
307	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNB1(1), JAK1(2), STAT1(1), STAT2(1), TYK2(1)	4672441	6	6	6	1	1	2	0	1	2	0	0.502	1.000
308	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	11	AKT1(1), IGF1(2), IGF1R(2)	4112083	5	5	5	1	1	1	2	0	1	0	0.506	1.000
309	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	136	ACTA2(1), ADCY1(3), ADCY2(2), ADCY3(3), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(3), ATP2A3(1), CACNB3(2), CALCA(1), CAMK2A(1), CNN2(1), CORIN(2), DGKZ(1), FOS(1), GNB4(1), GNG2(1), GNG5(1), IL1B(1), IL6(1), ITPR1(4), ITPR2(2), ITPR3(3), MIB1(4), NFKB1(1), NOS1(5), NOS3(4), PLCD1(1), PLCG1(6), PLCG2(2), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCQ(1), PRKD1(1), RAMP3(1), RGS1(1), RGS14(1), RGS3(2), RGS4(1), RGS6(1), RGS9(2), RYR1(3), RYR3(10), SFN(1), TNXB(2), YWHAH(1)	70349080	99	82	98	32	25	41	14	4	15	0	0.508	1.000
310	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(4), CHEK1(2), WEE1(1), YWHAH(1)	5967043	8	8	8	0	0	2	4	0	2	0	0.510	1.000
311	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	CP(3), EPRS(2), FECH(1), HMBS(1), HMOX1(1), UGT1A10(1), UGT1A5(1), UGT1A6(1), UGT1A9(1), UGT2B15(1), UGT2B4(2)	11255326	15	15	15	7	6	4	2	2	1	0	0.517	1.000
312	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(1), ATP6V1A(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1G1(1)	6947927	9	9	9	4	1	5	2	0	1	0	0.521	1.000
313	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(1), IL6(1), LDLR(1)	2308315	3	3	3	1	1	2	0	0	0	0	0.522	1.000
314	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABP1(4), ALDH3A1(2), AOC2(2), CNDP1(1), DPYD(2), ECHS1(1), EHHADH(1), HIBCH(1), MLYCD(1)	11705168	15	15	15	2	4	7	2	1	1	0	0.522	1.000
315	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	IARS(3), PDHA1(1), PDHA2(2), VARS(2), VARS2(2)	8057520	10	10	10	2	2	4	2	1	1	0	0.526	1.000
316	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SRP19(1), SRP54(1), SRPR(2)	3246608	4	4	4	0	0	1	2	0	1	0	0.528	1.000
317	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	18	ADCYAP1R1(1), CALCRL(1), CD97(1), CRHR2(2), EMR1(1), EMR2(1), GLP1R(1), GLP2R(2), GPR64(1), LPHN1(1), LPHN3(2)	10665444	14	14	14	10	1	7	4	0	2	0	0.529	1.000
318	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	AKT1(1), ATM(4), CDKN1A(1), MAPK8(1), MDM2(2), NQO1(1)	7527351	10	10	10	2	2	2	2	0	4	0	0.530	1.000
319	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	INPP1(1), INPP4B(1), INPP5A(1), INPP5B(1), INPP5E(1), INPPL1(3), OCRL(2), PI4KB(2), PIK3CB(4), PIK3CG(5), PIP4K2C(3), PIP5K1B(2), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(1), PLCE1(2), PLCG1(6), PLCG2(2), PLCZ1(1), SYNJ2(2)	30853830	45	36	45	16	10	14	8	5	8	0	0.533	1.000
320	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	ATM(4), ATR(3), CASP9(1), CCNB3(2), CCND2(1), CCND3(1), CCNE2(1), CCNG1(2), CDKN1A(1), CDKN2A(2), CHEK1(2), CHEK2(1), GADD45B(1), GTSE1(1), IGF1(2), MDM2(2), RPRM(1), RRM2(1), SERPINB5(1), SESN3(1), SFN(1), TSC2(2)	27392242	34	34	34	15	3	11	9	3	8	0	0.533	1.000
321	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(1), ATM(4), ATR(3), CCNA1(1), CDKN1A(1), CDKN2A(2), CDKN2B(1), GSK3B(1), SKP2(1)	11859498	15	15	15	1	3	4	4	0	4	0	0.533	1.000
322	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	CAMK2A(1), F2(2), FYN(1), JAK2(1), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8(1), MYLK(2), PLCG1(6), PRKCA(1), PTK2B(2), RAF1(1), SOS1(3), STAT1(1), STAT3(1)	18075630	26	22	26	4	4	8	6	3	5	0	0.534	1.000
323	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(1), NFKBIA(1), PLCB1(1), PRKCA(1)	3576946	4	4	4	1	1	2	0	0	1	0	0.534	1.000
324	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	23	CAPN1(2), CAPNS1(1), EGF(3), ITGA1(2), ITGB1(1), MAPK1(1), MAPK3(1), MYLK(2), PRKAR1B(1), PRKAR2B(1), PXN(1)	12929929	16	16	16	4	2	8	0	5	1	0	0.534	1.000
325	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADS(3), ACADVL(1), ACSL1(1), ACSL3(1), ACSL4(1), CPT1A(1), CPT2(1), EHHADH(1)	7278128	10	10	11	2	1	4	2	1	2	0	0.537	1.000
326	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP9(2), RECK(1), TIMP3(1)	3246505	4	4	4	2	1	1	2	0	0	0	0.538	1.000
327	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	20	ACP6(2), ACPT(2), ALPP(2), CYP3A4(1), PON1(2)	6720707	9	9	9	3	3	5	0	0	1	0	0.540	1.000
328	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	31	AKT1(1), APC(1), BRAF(5), CCL13(1), DAG1(2), ITPR1(4), ITPR2(2), ITPR3(3), KCNJ5(2), MAPK1(1), PITX2(2), RAF1(1), SRC(2)	20500987	27	25	23	6	11	7	4	3	2	0	0.542	1.000
329	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	HMOX1(1), IL1A(1), IL6(1), JAK1(2), STAT1(1), STAT3(1)	5287209	7	7	7	2	0	5	0	0	2	0	0.547	1.000
330	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACADS(3), ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), ALDH6A1(1), AOX1(4), BCKDHB(1), ECHS1(1), EHHADH(1), MCCC1(1), MUT(1), PCCA(1), PCCB(1)	15591919	21	21	21	7	5	10	5	0	1	0	0.547	1.000
331	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDPS(2), MVD(1), MVK(1), NQO1(1)	4820236	6	6	6	0	0	3	1	1	1	0	0.548	1.000
332	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	4	DCN(1)	1264406	1	1	1	1	0	0	0	0	1	0	0.557	1.000
333	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CHUK(1), IKBKB(1), MAP2K3(3), MAP3K1(2), MAP4K2(1), MAPK8(1), NFKB1(1), NFKBIA(1), RIPK1(1), TNFRSF1A(1)	10545229	13	13	13	7	3	6	0	1	3	0	0.559	1.000
334	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(2)	1862679	2	2	2	0	0	1	1	0	0	0	0.559	1.000
335	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), DARS(1), EPRS(2), HARS(1), IARS(3), KARS(2), MARS(2), QARS(2), RARS(1), TARS(1), WARS(1)	13885906	17	17	17	2	1	7	6	1	2	0	0.561	1.000
336	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(1), CAPN1(2), CAPNS1(1), GSK3B(1)	4038731	5	5	5	0	1	2	1	1	0	0	0.562	1.000
337	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	5	ABCB11(1), ABCB4(3), ABCC1(1), ABCC3(1)	5098956	6	6	6	4	2	1	1	0	2	0	0.565	1.000
338	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	126	ABL1(1), ABLIM3(1), ARHGEF12(1), CFL2(1), DCC(3), DPYSL5(1), EFNA3(1), EFNA5(1), EFNB1(1), EFNB2(1), EFNB3(1), EPHA1(4), EPHA3(2), EPHA5(3), EPHA6(3), EPHA7(3), EPHA8(2), EPHB1(1), EPHB2(1), EPHB4(2), EPHB6(2), FYN(1), GSK3B(1), ITGB1(1), KRAS(2), L1CAM(4), LIMK2(2), LRRC4C(2), MAPK1(1), MAPK3(1), MET(1), NFATC2(2), NFATC4(2), NRP1(1), NTN1(2), NTN4(3), NTNG1(1), PAK1(1), PAK3(1), PAK4(3), PLXNA1(1), PLXNA2(1), PLXNB1(1), PLXNB3(1), PLXNC1(1), PPP3CB(1), PPP3R2(1), RGS3(2), ROBO1(3), ROBO2(1), ROCK1(1), ROCK2(1), SEMA3E(5), SEMA3F(1), SEMA4A(1), SEMA4F(2), SEMA5B(1), SEMA6B(1), SEMA6D(1), SEMA7A(1), SLIT2(1), SLIT3(6), SRGAP1(2), SRGAP3(1), UNC5A(1), UNC5C(2), UNC5D(1)	84573453	110	91	108	37	30	34	25	6	15	0	0.565	1.000
339	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA3(1), CYP11A1(1), HPGD(1), HSD11B1(1), PLA2G4A(2), PTGER4(1), PTGFR(1), PTGIS(1), PTGS1(1), TBXAS1(1)	8953293	11	11	11	4	2	5	1	0	3	0	0.581	1.000
340	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	46	AKT1(1), BRD4(1), CBL(1), CDKN2A(2), FLOT1(1), GSK3B(1), INPPL1(3), IRS1(2), IRS4(2), LNPEP(1), MAPK1(1), MAPK3(1), PPYR1(1), RAF1(1), RPS6KA2(2), RPS6KA3(1), SFN(1), SORBS1(1), SOS1(3), YWHAE(1), YWHAH(1)	23610685	29	28	29	8	1	9	9	1	9	0	0.583	1.000
341	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	55	ABP1(4), ADH1A(2), ADH1B(2), ADH1C(1), ALDH3A1(2), AOC2(2), AOX1(4), CARM1(3), DDC(1), LCMT1(1), LCMT2(1), MAOB(2), TAT(2), TPO(3), TYR(1), TYRP1(2)	25333463	33	33	29	7	10	15	5	0	3	0	0.586	1.000
342	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT6(1), ENPP2(4), PAFAH2(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(2), PLA2G6(1), PLD1(1)	10079499	13	13	13	3	0	9	3	1	0	0	0.586	1.000
343	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ACACA(4), ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), ALDH6A1(1), ECHS1(1), EHHADH(1), MLYCD(1), MUT(1), PCCA(1), PCCB(1), SUCLA2(1), SUCLG1(2)	14306801	19	18	19	6	7	7	2	1	2	0	0.591	1.000
344	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CUL1(2), FBXW7(1)	2855656	3	3	3	0	1	0	0	0	2	0	0.595	1.000
345	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(5), DGKI(2), FAU(2), RPL10(1), RPL11(2), RPL15(1), RPL22(1), RPL7(1), RPLP0(1), RPS12(1), RPS21(1), RPS4X(1), RPS5(1), RPS6KA2(2), RPS6KA3(1), RPS6KA6(2), SLC36A2(1), TBC1D10C(1), TSPAN9(1), UBA52(1)	22512366	29	27	29	6	4	8	5	4	8	0	0.595	1.000
346	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD2(1), GRM1(4), PLCB1(1), PRKAR1B(1), PRKAR2B(1)	6763814	8	8	8	5	2	3	0	1	2	0	0.597	1.000
347	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	80	ABL1(1), ATM(4), BUB1(1), CCNA1(1), CCNB3(2), CCND2(1), CCND3(1), CCNE2(1), CDAN1(1), CDKN1A(1), CDKN2A(2), CHEK1(2), CHEK2(1), DTX4(1), E2F4(1), E2F6(1), ESPL1(2), GSK3B(1), HDAC2(3), HDAC4(1), HDAC6(1), MAD1L1(1), MCM2(1), MCM3(2), MCM4(2), MCM5(2), MCM6(3), MCM7(2), MDM2(2), MPEG1(1), MPL(2), PRKDC(4), PTPRA(3), RBL1(1), SKP2(1), TBC1D8(2), WEE1(1)	46948406	60	56	60	15	10	21	12	5	12	0	0.598	1.000
348	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(2), ADH1C(1), ALDH3A1(2)	5782852	7	7	7	2	2	4	1	0	0	0	0.599	1.000
349	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	RPE(1), UGDH(1), UGT1A10(1), UGT1A5(1), UGT1A6(1), UGT1A9(1), UGT2B15(1), UGT2B4(2)	7004695	9	9	9	8	5	2	0	0	2	0	0.600	1.000
350	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	ATM(4), CHEK1(2), WEE1(1), YWHAH(1)	6505232	8	8	8	0	0	2	4	0	2	0	0.606	1.000
351	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	37	AKT1(1), CD19(1), CSK(1), DAG1(2), EPHB2(1), LYN(2), MAP2K1(1), MAPK1(1), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), PLCG2(2), RAF1(1), SOS1(3), VAV1(3)	21037651	26	25	26	11	4	11	5	2	4	0	0.610	1.000
352	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	16	ABCC1(1), ABCG2(2), BCHE(2), CES1(2), CYP3A4(1), UGT1A10(1), UGT1A5(1), UGT1A6(1), UGT1A9(1)	9436432	12	12	12	8	3	5	2	0	2	0	0.613	1.000
353	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BRAF(5), CREB1(1), MAP2K1(1), MAPK1(1), MAPK3(1), NFKB1(1), RPS6KA2(2), RPS6KA3(1), SOS1(3)	12858357	16	15	12	4	6	5	2	1	2	0	0.616	1.000
354	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	242	ACVR1C(1), AKT1(1), BRAF(5), CACNA1A(1), CACNA1C(5), CACNA1D(4), CACNA1E(5), CACNA1F(1), CACNA1G(1), CACNA1H(2), CACNA1I(3), CACNA1S(4), CACNA2D1(4), CACNA2D2(2), CACNA2D3(2), CACNB3(2), CACNG3(1), CHUK(1), CRKL(1), DAXX(2), DUSP5(1), DUSP8(1), EGF(3), ELK1(2), ELK4(1), FGF14(2), FGF18(1), FGF7(1), FGFR1(1), FGFR3(4), FGFR4(1), FLNB(1), FLNC(3), FOS(1), GADD45B(1), IKBKB(1), IL1A(1), IL1B(1), IL1R1(2), KRAS(2), MAP2K1(1), MAP2K3(3), MAP3K1(2), MAP3K12(1), MAP3K13(1), MAP3K4(3), MAP3K5(1), MAP3K7(2), MAP4K1(2), MAP4K2(1), MAP4K3(2), MAP4K4(2), MAPK1(1), MAPK13(1), MAPK3(1), MAPK7(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(2), MAX(2), MYC(1), NFATC2(2), NFATC4(2), NFKB1(1), NFKB2(1), NR4A1(2), NTF3(1), NTRK1(1), PAK1(1), PDGFRB(2), PLA2G2F(1), PLA2G3(1), PLA2G4A(2), PLA2G6(1), PPM1B(1), PPP3CB(1), PPP3R2(1), PRKCA(1), PRKCG(2), PRKX(1), PTPRR(3), RAF1(1), RASGRF1(2), RASGRP2(1), RASGRP4(1), RPS6KA2(2), RPS6KA3(1), RPS6KA5(1), RPS6KA6(2), SOS1(3), SRF(1), TAOK1(1), TAOK2(1), TAOK3(2), TGFBR1(1), TGFBR2(2), TNFRSF1A(1), TRAF6(1), ZAK(2)	119654185	167	121	160	60	45	68	20	9	25	0	0.619	1.000
355	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	43	ABCA1(1), ABCA10(3), ABCA12(1), ABCA13(3), ABCA3(1), ABCA4(4), ABCA5(3), ABCA6(2), ABCA7(2), ABCA9(2), ABCB11(1), ABCB4(3), ABCB5(4), ABCB6(1), ABCB9(2), ABCC1(1), ABCC11(1), ABCC3(1), ABCC4(4), ABCC5(2), ABCC6(1), ABCC9(8), ABCD1(1), ABCD2(4), ABCD3(1), ABCG1(1), ABCG2(2), ABCG4(1), ABCG8(1), CFTR(2), TAP2(3)	50296436	67	57	67	27	12	26	17	6	6	0	0.621	1.000
356	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CLOCK(4), CRY1(1), PER1(1), PER2(1), PER3(2)	7381198	9	9	8	3	2	4	0	0	3	0	0.623	1.000
357	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	HK2(2), HK3(1), PGM1(1), TGDS(1)	4414679	5	5	5	0	2	2	1	0	0	0	0.625	1.000
358	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNG(2), JAK1(2), JAK2(1), STAT1(1)	4981759	6	6	6	1	0	2	1	0	3	0	0.626	1.000
359	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(1), AXIN1(3), CREBBP(4), DVL1(1), FZD1(1), GSK3B(1), PITX2(2), TRRAP(4), WNT1(1)	14069169	18	17	18	10	4	4	4	1	5	0	0.626	1.000
360	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(3)	2836232	3	3	3	0	2	0	1	0	0	0	0.627	1.000
361	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), GPD2(1), UQCRC1(1)	2856490	3	3	3	3	1	1	1	0	0	0	0.628	1.000
362	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	CHAT(2), DDC(1), HDC(1), PAH(2), TPH1(2)	6222077	8	8	8	5	1	6	0	1	0	0	0.629	1.000
363	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), CYP2A13(1), XDH(1)	3453068	4	4	4	4	0	3	0	0	1	0	0.633	1.000
364	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	105	ABL1(1), ANAPC1(2), ANAPC4(1), ATM(4), ATR(3), BUB1(1), CCNA1(1), CCNB3(2), CCND2(1), CCND3(1), CCNE2(1), CDC23(2), CDK7(1), CDKN1A(1), CDKN2A(2), CDKN2B(1), CHEK1(2), CHEK2(1), CREBBP(4), CUL1(2), DBF4(1), ESPL1(2), FZR1(1), GADD45B(1), GSK3B(1), HDAC2(3), MAD1L1(1), MCM2(1), MCM3(2), MCM4(2), MCM5(2), MCM6(3), MCM7(2), MDM2(2), PRKDC(4), RBL1(1), SFN(1), SKP2(1), SMC1A(3), SMC1B(1), WEE1(1), YWHAE(1), YWHAH(1)	57179681	72	65	72	20	10	23	15	6	18	0	0.633	1.000
365	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(1), EIF2S2(1), NFKB1(1), NFKBIA(1)	3951151	4	4	4	0	0	2	1	0	1	0	0.634	1.000
366	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACA(4), ACACB(5), ALDH3A1(2), ALDH6A1(1), ECHS1(1), EHHADH(1), HIBCH(1), LDHAL6B(1), MLYCD(1), MUT(1), PCCA(1), PCCB(1), SUCLA2(1), SUCLG1(2)	17173704	23	21	23	4	10	7	2	2	2	0	0.634	1.000
367	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(4), ALDH3A1(2), AOC2(2), DDC(1), EPX(2), MAOB(2), MPO(1), TAT(2), TPO(3)	14811012	19	19	18	2	5	11	3	0	0	0	0.637	1.000
368	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	APC(1), AXIN1(3), CCND2(1), CCND3(1), DVL1(1), DVL2(1), DVL3(1), FZD1(1), FZD10(3), FZD9(2), GSK3B(1), LDLR(1), MYC(1), PPP2R5E(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(1), PRKD1(1), WNT1(1), WNT10A(2), WNT2B(1), WNT3(1), WNT5B(1)	25336482	34	30	33	8	8	10	8	1	7	0	0.641	1.000
369	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(1), GSK3B(1), LYN(2), PFKL(1), PFKP(1), PLCG1(6), PRKCE(1), VAV2(2)	10854584	15	14	15	3	2	7	4	1	1	0	0.643	1.000
370	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	DLD(1), ENO2(1), ENO3(1), FBP1(1), G6PC(1), GAPDH(1), GAPDHS(1), HK2(2), HK3(1), LDHAL6B(1), PC(1), PCK1(2), PDHA1(1), PDHA2(2), PFKL(1), PFKP(1), PGK1(1), PGK2(1), TNFAIP1(1)	18038642	22	22	22	9	6	9	5	1	1	0	0.646	1.000
371	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	6	DAB1(1), FYN(1), LRP8(1)	2999641	3	3	3	2	0	2	1	0	0	0	0.647	1.000
372	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLUD2(1)	1835508	2	2	2	2	0	2	0	0	0	0	0.647	1.000
373	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), HLA-DRA(1)	1737727	2	2	2	2	0	2	0	0	0	0	0.650	1.000
374	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(2), MRPL13(1), RPL10L(1), RPL11(2), RPL22L1(1), RPL36A(1), RPL7(1), RPS12(1), RPS21(1), RPS5(1)	9819049	12	11	12	5	0	2	2	1	7	0	0.651	1.000
375	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNB1(1), JAK1(2), STAT1(1), STAT2(1), TYK2(1)	5425466	6	6	6	2	1	2	0	1	2	0	0.654	1.000
376	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(3), CARM1(3), CREBBP(4), ESR1(1), GRIP1(4), HDAC2(3), HDAC4(1), HDAC6(1), NCOR2(1), NRIP1(1), POLR2A(2), TBP(2)	20145177	26	25	25	8	9	9	1	1	6	0	0.658	1.000
377	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	EPX(2), MPO(1), TPO(3)	5114310	6	6	6	1	3	3	0	0	0	0	0.661	1.000
378	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	BCL2(2), CASP9(1), DAXX(2), IL1A(1)	4916710	6	5	6	1	1	2	0	1	2	0	0.663	1.000
379	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(1), FECH(1), HMBS(1)	3303571	3	3	3	0	0	1	0	2	0	0	0.664	1.000
380	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(2), ADH1B(2), ADH1C(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), DLD(1), ENO2(1), ENO3(1), FBP1(1), G6PC(1), GAPDH(1), HK2(2), HK3(1), PDHA1(1), PDHA2(2), PFKP(1), PGK1(1), PGM1(1)	20869210	26	25	26	10	8	13	4	1	0	0	0.664	1.000
381	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(2), ADH1B(2), ADH1C(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), DLD(1), ENO2(1), ENO3(1), FBP1(1), G6PC(1), GAPDH(1), HK2(2), HK3(1), PDHA1(1), PDHA2(2), PFKP(1), PGK1(1), PGM1(1)	20869210	26	25	26	10	8	13	4	1	0	0	0.664	1.000
382	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AMD1(1), CBS(1), CTH(1), DNMT1(1), MARS(2), MAT1A(2), TAT(2)	8997083	10	10	9	3	4	3	0	1	2	0	0.665	1.000
383	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	HDC(1), TPH1(2)	2594436	3	3	3	4	0	3	0	0	0	0	0.668	1.000
384	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), AARS2(1), DARS(1), EPRS(2), FARSA(1), HARS(1), IARS(3), KARS(2), MARS(2), PARS2(1), QARS(2), RARS(1), SARS2(1), TARS(1), TARS2(1), VARS(2), VARS2(2), WARS(1), YARS2(1)	23535454	27	27	27	4	3	9	9	1	5	0	0.672	1.000
385	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	AGPAT1(1), AGPAT6(1), CHAT(2), CRLS1(1), DGKB(1), DGKD(4), DGKE(2), DGKG(2), DGKI(2), DGKQ(1), DGKZ(1), GNPAT(1), GPD2(1), LCAT(2), PCYT1A(2), PISD(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(2), PLA2G6(1), PLD1(1), PTDSS1(3)	28558842	34	34	34	7	9	13	7	2	3	0	0.673	1.000
386	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	OGDH(3), SUCLA2(1)	4061458	4	4	2	3	0	1	0	0	3	0	0.676	1.000
387	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	PLA2G2F(1), PLA2G3(1), PLA2G4A(2), PLA2G6(1)	4410361	5	5	5	1	0	3	2	0	0	0	0.677	1.000
388	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(3), CAPNS1(1), HDAC2(3), MEF2D(1), NFATC2(2), PPP3CB(1), PRKCA(1)	10486855	12	12	12	4	4	3	2	1	2	0	0.678	1.000
389	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	10	CBL(1), CSF1R(1), EGF(3), MET(1), PRKCA(1), SRC(2)	6299925	9	7	9	3	3	2	3	0	1	0	0.680	1.000
390	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(1), HTR2C(1), PLCB1(1)	3097302	3	3	3	1	1	1	0	0	1	0	0.681	1.000
391	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(4), NCOA1(1), NCOA2(2), PPARG(1), RXRA(2)	7987657	10	10	10	5	1	4	1	0	4	0	0.682	1.000
392	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	26	ACO1(1), CLYBL(3), DLD(1), OGDH(3), PC(1), PCK1(2), SUCLA2(1), SUCLG1(2)	12505438	14	14	12	5	3	3	4	1	3	0	0.684	1.000
393	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ACAA1(1), ACADS(3), ALDH3A1(2), ALDH6A1(1), AOX1(4), BCKDHB(1), DBT(1), DLD(1), ECHS1(1), EHHADH(1), HIBCH(1), HSD17B4(1), MCCC1(1), MUT(1), OXCT2(1), PCCA(1), PCCB(1)	18711401	23	23	23	4	8	8	5	0	2	0	0.687	1.000
394	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	B3GALNT1(1), B3GNT3(2), B4GALNT1(1), B4GALT6(1), FUT3(2), FUT4(1), FUT5(3), FUT6(1), FUT7(1), GCNT2(1), PIGF(1), PIGN(1), PIGO(2), PIGU(1), PIGZ(1), ST3GAL6(1), ST6GALNAC4(1), ST8SIA1(1)	21090210	23	23	23	11	4	9	3	3	4	0	0.691	1.000
395	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(1), EIF2AK4(1), EIF2S2(1), EIF2S3(1), GSK3B(1)	5018662	5	5	5	1	1	0	3	0	1	0	0.691	1.000
396	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ADCY1(3), ADCY2(2), ADCY3(3), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(3), ATP1A4(1), ATP2A3(1), ATP2B2(3), ATP2B3(2), CACNA1A(1), CACNA1C(5), CACNA1D(4), CACNA1E(5), CACNA1S(4), CACNB3(2), CAMK1(1), CAMK2A(1), CAMK4(1), CASQ2(1), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), GJB3(2), GNAO1(1), GNB4(1), GNG2(1), GNG5(1), ITPR1(4), ITPR2(2), ITPR3(3), KCNB1(2), KCNJ5(2), MIB1(4), NME7(2), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(1), PRKD1(1), RGS1(1), RGS14(1), RGS3(2), RGS4(1), RGS6(1), RGS9(2), RYR1(3), RYR3(10), SFN(1), YWHAH(1)	77086666	114	86	112	33	32	47	19	2	14	0	0.693	1.000
397	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(4), ALDH3A1(2), AMDHD1(1), AOC2(2), CARM1(3), CNDP1(1), DDC(1), HAL(2), HARS(1), HDC(1), LCMT1(1), LCMT2(1), MAOB(2), UROC1(1)	17141810	23	22	22	4	4	14	4	0	1	0	0.697	1.000
398	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(1), COL4A2(1), COL4A4(5), COL4A5(2), COL4A6(2), SLC23A2(1), SLC2A1(2), SLC2A3(2)	10956610	16	13	16	5	6	5	3	0	2	0	0.700	1.000
399	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR2(1), DNMT1(1), PTAFR(1), PTGER4(1), PTGFR(1)	4875591	5	5	5	6	1	2	0	0	2	0	0.704	1.000
400	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(1)	1406013	1	1	1	0	1	0	0	0	0	0	0.707	1.000
401	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	15	AKT1(1), NFKB1(1), NOS3(4), NPPA(1)	6143104	7	7	7	1	0	6	1	0	0	0	0.709	1.000
402	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACPT(2), ENPP1(1), TYR(1)	4168656	4	4	4	0	2	0	2	0	0	0	0.710	1.000
403	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1A(2), ADH1B(2), ADH1C(1), AGPAT1(1), AGPAT6(1), AKR1A1(1), ALDH3A1(2), CEL(3), DGKB(1), DGKD(4), DGKE(2), DGKG(2), DGKI(2), DGKQ(1), DGKZ(1), GK2(1), LCT(1), LIPG(1), PNLIP(1)	25212158	30	30	30	6	9	15	2	1	3	0	0.710	1.000
404	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	DAG1(2)	2624105	2	2	2	0	0	1	1	0	0	0	0.710	1.000
405	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(4), ATR(3), BRCA1(3), CDKN1A(1), CHEK1(2), CHEK2(1), MDM2(2), PRKDC(4), WEE1(1), YWHAH(1)	18116856	22	22	22	8	1	10	5	1	5	0	0.712	1.000
406	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN1(2), ACTN3(1), CAPN1(2), CAPNS1(1), ITGA1(2), ITGB1(1), ITGB3(1), PXN(1), SPTAN1(2), SRC(2)	12353114	15	14	15	1	3	7	2	2	1	0	0.712	1.000
407	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(1), MAPK1(1), MAPK3(1), PTK2B(2), SOS1(3)	7493428	8	8	8	3	2	2	2	1	1	0	0.712	1.000
408	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	SUCLA2(1)	918711	1	1	1	0	0	1	0	0	0	0	0.713	1.000
409	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	13	AKT1(1), ITGB1(1), MAPK1(1), MAPK3(1), SOS1(3)	6401037	7	7	7	0	1	3	2	1	0	0	0.715	1.000
410	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(1), CAMK2A(1), CAMK4(1), CAMKK1(1), CREB1(1)	5027368	5	5	5	4	0	2	1	0	2	0	0.719	1.000
411	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(3), MAPK1(1), MAPK3(1), PRKAR1B(1), PRKAR2B(1), SRC(2)	8709763	9	9	9	1	4	1	2	2	0	0	0.719	1.000
412	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	20	ARHGAP5(3), FYN(1), GSN(1), ITGA1(2), ITGB1(1), MAP2K1(1), MAPK1(1), MAPK3(1), MYLK(2), PXN(1), RAF1(1), ROCK1(1), SRC(2)	14630761	18	16	17	4	2	7	3	3	3	0	0.724	1.000
413	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	65	ACAA1(1), ACOX2(1), ACSL1(1), ACSL3(1), ACSL4(1), CPT1A(1), CPT1C(1), CPT2(1), CYP27A1(1), CYP4A11(2), CYP8B1(2), EHHADH(1), FABP6(1), GK2(1), MMP1(1), NR1H3(1), OLR1(1), PCK1(2), PLTP(1), PPARA(1), PPARG(1), RXRA(2), SLC27A1(1), SLC27A2(5), SLC27A6(4), SORBS1(1)	28043610	37	34	37	12	8	18	7	1	3	0	0.729	1.000
414	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	AKT1(1), DAG1(2), ITPR1(4), ITPR2(2), ITPR3(3), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), PIK3CB(4), PITX2(2), PLD1(1)	19446730	26	22	26	5	6	11	4	2	3	0	0.729	1.000
415	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC3(1), MAP3K7(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), NR2C2(1), RALBP1(1), RIPK1(1), TNFRSF1A(1)	11770465	14	13	14	3	0	8	4	0	2	0	0.729	1.000
416	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(2), AADAC(1), ACADS(3), ACSM1(1), ALDH3A1(2), ALDH5A1(1), ECHS1(1), EHHADH(1), HSD17B4(1), OXCT2(1), PDHA1(1), PDHA2(2), PLA1A(1), PPME1(1)	17670570	19	20	20	6	4	8	3	1	3	0	0.729	1.000
417	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(1), CREB1(1), DAG1(2), EPHB2(1), FOS(1), MAPK1(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(2)	12287538	13	13	13	3	2	3	3	2	3	0	0.730	1.000
418	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(1)	1653145	1	1	1	2	0	1	0	0	0	0	0.732	1.000
419	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(3), LCMT1(1), LCMT2(1), PCYT1A(2)	6106044	7	7	6	2	3	2	0	0	2	0	0.733	1.000
420	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	HK2(2), HK3(1), PGM1(1), TGDS(1)	5030266	5	5	5	0	2	2	1	0	0	0	0.734	1.000
421	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CARM1(3), CBS(1), CTH(1), GGT1(1), LCMT1(1), LCMT2(1), MARS(2), MAT1A(2), SCLY(1)	10769216	13	12	12	3	7	3	0	1	2	0	0.735	1.000
422	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(1), AXIN1(3), BTRC(1), DLL1(1), DVL1(1), FZD1(1), GSK3B(1), WNT1(1)	8898061	10	9	10	4	1	2	3	1	3	0	0.739	1.000
423	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP6(2), ACPT(2), ENPP1(1), MTMR1(1), TYR(1)	6473556	7	7	7	2	2	3	2	0	0	0	0.739	1.000
424	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	14	NDUFA10(1), NDUFA4(1), NDUFS2(1)	2906509	3	3	3	1	0	1	1	0	1	0	0.740	1.000
425	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	FUCA1(1), HEXA(1), HGSNAT(1), HPSE(2), HPSE2(2), LCT(1), MAN2B1(4), MAN2B2(2), NEU2(2)	14983233	16	16	16	4	7	4	1	2	2	0	0.741	1.000
426	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ECHS1(1), HSD17B4(1), MECR(1)	3691784	3	3	3	0	1	0	1	0	1	0	0.743	1.000
427	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN1(2), ACTN3(1), CAPN1(2), CAPNS1(1), CRKL(1), CSK(1), FYN(1), ITGA1(2), ITGB1(1), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8(1), PPP1R12B(1), PXN(1), RAF1(1), ROCK1(1), SOS1(3), SRC(2), ZYX(2)	20389003	27	22	27	3	4	11	6	4	2	0	0.746	1.000
428	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(1)	1830718	1	1	1	0	1	0	0	0	0	0	0.746	1.000
429	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	BCL2(2), BIRC3(1), CASP9(1), MAP3K1(2), MCL1(1), MDM2(2), MYC(1), NFKB1(1), NFKBIA(1), PARP1(2), RIPK1(1), TNFRSF1A(1), TNFSF10(2)	15939922	18	18	18	6	3	7	2	1	5	0	0.749	1.000
430	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	BNIP1(1), STX6(1), STX7(1), TSNARE1(1), USE1(1), VAMP3(1), VAMP5(1)	7025832	7	7	7	2	2	1	1	1	2	0	0.751	1.000
431	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	142	APC(1), APC2(2), AXIN1(3), BTRC(1), CAMK2A(1), CCND2(1), CCND3(1), CHD8(8), CREBBP(4), CSNK2B(2), CTBP2(1), CUL1(2), DAAM2(1), DKK1(1), DKK2(2), DVL1(1), DVL2(1), DVL3(1), FZD1(1), FZD10(3), FZD9(2), GSK3B(1), LRP6(2), MAP3K7(2), MAPK8(1), MMP7(1), MYC(1), NFATC2(2), NFATC4(2), NKD1(1), PLCB1(1), PLCB2(3), PLCB4(1), PORCN(3), PPP2R1B(2), PPP3CB(1), PPP3R2(1), PRKCA(1), PRKCG(2), PRKX(1), ROCK1(1), ROCK2(1), RUVBL1(2), SOX17(1), TCF7L2(2), VANGL1(1), WIF1(1), WNT1(1), WNT10A(2), WNT2B(1), WNT3(1), WNT5B(1), WNT9B(1)	69283541	85	72	85	22	23	19	16	5	22	0	0.753	1.000
432	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(2), ACTN3(1), CSK(1), CTNNA1(1), CTNNA2(2), PXN(1), SRC(2)	8896833	10	9	10	2	2	2	4	1	1	0	0.754	1.000
433	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(1), CAMK2A(1), CAMK4(1), MEF2A(2), MEF2D(1), PPARA(1), PPP3CB(1), YWHAH(1)	8787673	9	9	9	3	3	2	3	0	1	0	0.755	1.000
434	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ECHS1(1), EHHADH(1)	3609859	3	3	3	0	2	0	0	0	1	0	0.757	1.000
435	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	83	AGRN(2), CD44(3), COL11A1(1), COL11A2(5), COL1A1(1), COL2A1(1), COL3A1(4), COL4A1(1), COL4A2(1), COL4A4(5), COL4A6(2), COL5A1(1), COL5A2(1), COL5A3(1), COL6A6(5), DAG1(2), FN1(2), FNDC1(1), FNDC4(1), HSPG2(5), ITGA1(2), ITGA10(2), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(1), ITGAV(1), ITGB1(1), ITGB3(1), ITGB4(2), ITGB6(2), ITGB7(1), ITGB8(1), LAMA1(3), LAMA2(6), LAMA3(4), LAMA4(1), LAMA5(5), LAMB1(2), LAMB3(3), LAMB4(3), LAMC1(1), LAMC3(3), SDC1(1), SDC2(1), SDC4(1), SV2B(1), SV2C(2), THBS3(1), THBS4(1), TNC(1), TNN(2), TNXB(2), VWF(5)	90889596	119	95	120	47	28	52	18	6	15	0	0.760	1.000
436	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	GCNT2(1), ST8SIA1(1)	2681439	2	2	2	2	0	1	0	0	1	0	0.768	1.000
437	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1)	1675708	1	1	1	1	0	0	1	0	0	0	0.770	1.000
438	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST6GALNAC4(1), ST8SIA1(1)	2424967	2	2	2	1	0	1	0	0	1	0	0.772	1.000
439	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(1), CREBBP(4), IKBKB(1), NFKB1(1), NFKBIA(1), RIPK1(1), TNFRSF1A(1), TRAF6(1)	9740577	11	10	11	4	2	5	0	0	4	0	0.774	1.000
440	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXTL1(1), HS3ST1(1), HS3ST3A1(2), NDST3(1), NDST4(5)	9054855	10	9	10	2	2	3	4	1	0	0	0.779	1.000
441	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	11	ACE2(2), AGTR1(1), CMA1(1), COL4A1(1), COL4A2(1), COL4A4(5), COL4A5(2), COL4A6(2)	10751025	15	12	15	6	7	5	3	0	0	0	0.782	1.000
442	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA3(1), PSMA5(1), PSMB8(1)	3765853	3	3	3	0	0	2	0	1	0	0	0.782	1.000
443	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	8	ALPP(2)	2458837	2	2	2	1	0	1	0	0	1	0	0.784	1.000
444	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	61	AKT1(1), CDKN2A(2), CREB1(1), ERBB4(1), GSK3B(1), IGF1(2), INPPL1(3), IRS1(2), IRS4(2), MET(1), MYC(1), PAK1(1), PAK3(1), PAK4(3), PREX1(5), RPS6KA2(2), RPS6KA3(1), SFN(1), SOS1(3), TSC2(2), YWHAE(1), YWHAH(1)	31947625	38	34	38	13	3	11	11	0	13	0	0.788	1.000
445	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	58	ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(1), ATP6V1A(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1G1(1), ATP7B(1), COX10(1), COX7C(1), NDUFA10(1), NDUFA4(1), NDUFS2(1), PPA2(1), UQCRC1(1)	15099459	17	17	17	5	3	8	4	0	2	0	0.790	1.000
446	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	CBS(1), CTH(1), DNMT1(1), MARS(2), MAT1A(2)	7572774	7	7	7	3	2	2	0	1	2	0	0.790	1.000
447	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(1), ARSE(3), B4GALT6(1), ENPP7(3), GAL3ST1(1), LCT(1), NEU2(2), SGMS2(1), SGPP2(2), UGT8(1)	15464050	16	16	16	8	4	6	4	1	1	0	0.791	1.000
448	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	DLD(1), OGDH(3), PC(1), PDHA1(1), PDHA2(2), PDK4(1), PDP2(1), SUCLA2(1), SUCLG1(2)	12299117	13	13	11	5	7	2	1	0	3	0	0.792	1.000
449	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(4), ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), DLD(1), HAGH(1), ME2(1), PC(1), PCK1(2), PDHA1(1), PDHA2(2)	15964138	18	17	18	6	6	8	3	0	1	0	0.793	1.000
450	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(4), ACACB(5), ACOT12(1), ALDH3A1(2), DLD(1), HAGH(1), LDHAL6B(1), ME2(1), PC(1), PCK1(2), PDHA1(1), PDHA2(2)	20213396	22	22	22	7	8	8	4	1	1	0	0.795	1.000
451	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	4	EGF(3)	3309105	3	3	3	3	1	2	0	0	0	0	0.795	1.000
452	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	PRKAR1B(1), PRKAR2B(1), PRKCA(1)	3991372	3	3	3	0	1	1	0	1	0	0	0.796	1.000
453	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(1), CREBBP(4), MAP2K1(1), MAP3K7(2), MAPK3(1), TGFBR1(1), TGFBR2(2)	11120508	12	12	12	6	2	3	3	0	4	0	0.798	1.000
454	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(1), APC(1), CAV3(1), DAG1(2), DLG4(1), EPHB2(1), ITPR1(4), ITPR2(2), ITPR3(3), KCNJ5(2), MAPK1(1), PITX2(2), RYR1(3)	20087401	24	22	24	10	6	9	5	2	2	0	0.801	1.000
455	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	FUT3(2)	3127275	2	2	2	3	2	0	0	0	0	0	0.802	1.000
456	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(5), MAP2(1), PRKAR2B(1), PRKCE(1)	7888460	8	7	8	0	1	0	2	2	3	0	0.805	1.000
457	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	CDKN1A(1), EPO(1), JAK2(1), NFKB1(1), NFKBIA(1)	5463708	5	5	5	0	1	4	0	0	0	0	0.806	1.000
458	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(2), NCL(1)	3838650	3	3	3	2	0	1	1	0	1	0	0.806	1.000
459	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH3A1(2), UGDH(1)	3702096	3	3	3	1	0	2	0	0	1	0	0.810	1.000
460	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(1), IKBKB(1), MAP3K1(2), NFKB1(1), NFKBIA(1), TRAF6(1)	7896627	7	7	7	2	2	2	0	1	2	0	0.812	1.000
461	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(1), POLR2A(2), POLR2B(1), POLRMT(1)	5866088	5	5	5	2	0	2	1	0	2	0	0.814	1.000
462	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	5	NFYB(1)	2111057	1	1	1	1	0	0	1	0	0	0	0.814	1.000
463	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(3), MYLK(2), PLCB1(1), PPP1R12B(1), PRKCA(1), ROCK1(1)	8958488	9	9	8	4	1	5	0	1	2	0	0.816	1.000
464	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BIRC3(1), RIPK1(1), TNFRSF1A(1)	3681763	3	3	3	1	0	2	1	0	0	0	0.822	1.000
465	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	NCOA1(1), NCOA2(2), NCOA3(1), NCOR2(1), POLR2A(2), RXRA(2), TBP(2)	10808010	11	11	11	3	1	4	1	0	5	0	0.822	1.000
466	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(2), DHCR7(1), FDPS(2), MVD(1), MVK(1), NQO1(1)	8386484	8	8	8	1	2	3	1	1	1	0	0.826	1.000
467	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(1), FDPS(2), MVD(1), MVK(1)	5738835	5	5	5	0	0	3	1	1	0	0	0.826	1.000
468	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(4)	4564721	4	4	4	3	1	1	0	0	2	0	0.832	1.000
469	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	19	MAP3K1(2), MYLK(2), PAK1(1), PLD1(1), PPP1R12B(1), RALBP1(1), TRIO(1), VAV1(3)	12576719	12	12	12	6	1	2	3	3	3	0	0.832	1.000
470	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACADS(3), ACADVL(1), ACSL1(1), ACSL3(1), ACSL4(1), ADH1A(2), ADH1B(2), ADH1C(1), ALDH3A1(2), CPT1A(1), CPT1C(1), CPT2(1), CYP4A11(2), ECHS1(1), EHHADH(1), HSD17B4(1)	21183820	23	23	24	7	5	11	3	1	3	0	0.834	1.000
471	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(1), DLD(1), DUSP8(1), IL1R1(2), MAP3K1(2), MAP3K12(1), MAP3K13(1), MAP3K4(3), MAP3K5(1), MAP3K7(2), MAP3K9(1), MAPK7(1), MAPK8(1), NR2C2(1), PAPPA(2), TRAF6(1), ZAK(2)	21494760	24	23	24	7	6	9	3	3	3	0	0.835	1.000
472	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	30	ALOX5(1), CYP1A2(2), CYP2C19(1), CYP2E1(1), CYP3A4(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(2), PLA2G6(1)	9896968	11	10	11	3	1	6	3	0	1	0	0.837	1.000
473	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	FOS(1), FYN(1)	3191336	2	2	2	4	0	0	2	0	0	0	0.838	1.000
474	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(1), BCL2(2), DLG4(1), LPA(2), MAP3K1(2), MAP3K5(1), MAPK8(1), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), PIK3CB(4), PLD1(1), ROCK1(1), ROCK2(1), SRF(1)	21240204	25	22	25	7	4	10	5	2	4	0	0.842	1.000
475	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15B(1), ALOX5(1), GGT1(1), PLA2G6(1), PTGIS(1), PTGS1(1), TBXAS1(1)	6496871	7	6	7	2	2	3	1	0	1	0	0.842	1.000
476	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	51	BCL2(2), BIRC3(1), CASP9(1), CHUK(1), DAXX(2), GSN(1), MAP3K1(2), MAP3K5(1), MAPK8(1), MDM2(2), NFKB1(1), NFKBIA(1), NUMA1(4), PRKCD(3), PRKDC(4), RIPK1(1), SPTAN1(2), TNFRSF1A(1)	29561943	31	31	30	7	5	12	3	2	9	0	0.843	1.000
477	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(4), CPT1A(1), LEPR(1)	6282362	6	6	6	2	3	1	0	0	2	0	0.845	1.000
478	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	BCL2(2), BIRC3(1), CASP1(1), CASP9(1), CHUK(1), IKBKB(1), IRF1(1), IRF2(1), IRF4(2), IRF5(1), IRF6(2), MAP3K1(2), MDM2(2), MYC(1), NFKB1(1), NFKBIA(1), NFKBIE(2), PLEKHG5(1), RIPK1(1), TNFRSF1A(1), TNFSF10(2)	24469895	28	26	28	9	5	14	3	1	5	0	0.847	1.000
479	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	29	GALNT11(1), GALNT13(1), GALNT14(3), GALNT2(1), GALNT5(2), GALNT7(1), GALNT8(1), GALNTL4(1), GCNT1(1), GCNT3(1), GCNT4(1)	13461424	14	14	14	6	2	6	2	0	4	0	0.847	1.000
480	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(2), PRKAR2B(1)	4383485	3	3	3	2	0	1	0	2	0	0	0.848	1.000
481	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ECHS1(1), EHHADH(1)	3378177	2	2	2	0	1	0	0	0	1	0	0.856	1.000
482	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(1), ATM(4), BCL2(2), CASP9(1), PRKCA(1), PXN(1), STAT1(1)	11575098	11	11	11	1	1	2	2	1	5	0	0.856	1.000
483	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(1), RANGAP1(2)	3591517	3	3	3	0	1	1	0	0	1	0	0.859	1.000
484	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	11	ARPC2(1), PAK1(1)	3198906	2	2	2	0	0	0	0	0	2	0	0.860	1.000
485	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(2), IFNA10(4), IFNA21(1), IFNG(2), ULK2(1)	9033130	10	8	8	1	0	3	4	0	3	0	0.862	1.000
486	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GGT1(1)	2438357	1	1	1	0	1	0	0	0	0	0	0.865	1.000
487	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	GLS(1)	2279345	1	1	1	1	0	1	0	0	0	0	0.865	1.000
488	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	57	CAD(1), CASP8AP2(1), DAXX(2), DEDD(1), DEDD2(1), EPHB2(1), FAF1(1), IL1A(1), MAP3K1(2), MAP3K5(1), MAPK1(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(2), MET(1), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), NR0B2(1), PTPN13(1), RALBP1(1), RIPK1(1), ROCK1(1), TPX2(2)	30285124	34	30	34	8	10	12	4	4	4	0	0.867	1.000
489	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), ABP1(4), AOC2(2), CES1(2), PLA1A(1), PPME1(1)	10997423	11	11	11	1	1	8	1	1	0	0	0.869	1.000
490	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), NFKB1(1), XDH(1)	4343866	3	3	3	0	0	2	1	0	0	0	0.869	1.000
491	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	19	ACO1(1), DLD(1), PC(1), PCK1(2), SUCLA2(1), SUCLG1(2)	8524040	8	8	8	1	3	3	2	0	0	0	0.869	1.000
492	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	41	AKT1(1), ARHGAP4(2), CFL2(1), GDI1(1), INPPL1(3), ITPR1(4), ITPR2(2), ITPR3(3), MYLK(2), PAK1(1), PAK3(1), PAK4(3), PIK3CG(5), PITX2(2), RACGAP1(1), ROCK1(1), ROCK2(1), RPS4X(1)	28581287	35	29	35	10	10	13	2	3	7	0	0.870	1.000
493	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(4), ATR(3), BRCA1(3), BRCA2(3), CHEK1(2), CHEK2(1), FANCD2(2), MRE11A(1), RAD50(1)	18776862	20	20	20	4	2	9	6	1	2	0	0.871	1.000
494	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	LCT(1), PGM1(1), PYGL(1), PYGM(1), TREH(1)	5801878	5	5	5	2	1	3	1	0	0	0	0.874	1.000
495	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	GGT1(1)	2495650	1	1	1	0	1	0	0	0	0	0	0.874	1.000
496	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	ARHGAP5(3), CASP1(1), CASP9(1)	5579595	5	5	4	5	0	5	0	0	0	0	0.875	1.000
497	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(3)	4123399	3	3	3	0	2	0	1	0	0	0	0.876	1.000
498	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	183	ACTN1(2), ACTN3(1), AKT1(1), ARHGAP5(3), BCL2(2), BIRC3(1), BRAF(5), CAV3(1), CCND2(1), CCND3(1), COL11A1(1), COL11A2(5), COL1A1(1), COL2A1(1), COL3A1(4), COL4A1(1), COL4A2(1), COL4A4(5), COL4A6(2), COL5A1(1), COL5A2(1), COL5A3(1), COL6A6(5), CRKL(1), DOCK1(1), EGF(3), ELK1(2), ERBB2(1), FIGF(2), FLNB(1), FLNC(3), FLT1(5), FN1(2), FYN(1), GRLF1(1), GSK3B(1), HGF(1), IGF1(2), IGF1R(2), ITGA1(2), ITGA10(2), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(1), ITGAV(1), ITGB1(1), ITGB3(1), ITGB4(2), ITGB6(2), ITGB7(1), ITGB8(1), KDR(6), LAMA1(3), LAMA2(6), LAMA3(4), LAMA4(1), LAMA5(5), LAMB1(2), LAMB3(3), LAMB4(3), LAMC1(1), LAMC3(3), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8(1), MET(1), MYLK(2), PAK1(1), PAK3(1), PAK4(3), PDGFD(1), PDGFRB(2), PIK3CB(4), PIK3CG(5), PIK3R2(3), PIK3R3(1), PIK3R5(3), PRKCA(1), PRKCG(2), PXN(1), RAF1(1), ROCK1(1), ROCK2(1), SHC4(1), SOS1(3), SRC(2), THBS3(1), THBS4(1), TLN2(2), TNC(1), TNN(2), TNXB(2), VASP(1), VAV1(3), VAV2(2), VAV3(1), VEGFA(2), VEGFB(1), VWF(5), ZYX(2)	149541324	208	131	202	75	49	81	34	15	29	0	0.876	1.000
499	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(3), PRKAR1B(1), PRKAR2B(1)	6482689	5	5	5	0	2	1	1	1	0	0	0.882	1.000
500	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	63	ADH1A(2), ADH1B(2), ADH1C(1), AKR1A1(1), ALDH3A1(2), DLD(1), ENO2(1), ENO3(1), FBP1(1), G6PC(1), GAPDH(1), GAPDHS(1), HK2(2), HK3(1), LDHAL6B(1), PDHA1(1), PDHA2(2), PFKL(1), PFKP(1), PGK1(1), PGK2(1), PGM1(1)	24693634	27	26	27	11	8	13	4	1	1	0	0.884	1.000
501	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR2(1)	2718651	1	1	1	2	0	0	0	1	0	0	0.887	1.000
502	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	P2RY2(1)	2569191	1	1	1	2	1	0	0	0	0	0	0.887	1.000
503	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACTN1(2), ACTN3(1), ACVR1C(1), CREBBP(4), CSNK2B(2), CTNNA1(1), CTNNA2(2), CTNNA3(1), ERBB2(1), FGFR1(1), FYN(1), IGF1R(2), INSR(2), LMO7(2), MAP3K7(2), MAPK1(1), MAPK3(1), MET(1), MLLT4(4), PTPRB(2), PTPRF(4), PTPRJ(1), PTPRM(1), PVRL1(2), PVRL2(1), PVRL4(2), SNAI2(2), SORBS1(1), SRC(2), TCF7L2(2), TGFBR1(1), TGFBR2(2), TJP1(2), WAS(1), WASF3(1)	50530225	59	52	59	19	10	17	14	2	16	0	0.887	1.000
504	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	HSD17B3(1), HSD17B4(1)	3512366	2	2	2	1	0	1	0	0	1	0	0.888	1.000
505	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	112	ATP4A(2), ATP5A1(1), ATP5B(1), ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1G1(1), COX10(1), COX7C(1), CYC1(1), NDUFA10(1), NDUFA12(1), NDUFA13(1), NDUFA4(1), NDUFB1(1), NDUFS2(1), PPA2(1), UQCRC1(1), UQCRQ(1)	24103551	26	25	26	9	5	13	4	1	3	0	0.888	1.000
506	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	DAXX(2), FAF1(1), MAP3K1(2), MAP3K7(2), MAPK8(1), PAK1(1), PRKDC(4), PTPN13(1), SPTAN1(2)	17386857	16	16	16	4	4	4	1	2	5	0	0.893	1.000
507	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP4(2), ARHGAP5(3), ARHGAP6(2), ARHGEF5(2), ARPC2(1), GSN(1), MYLK(2), OPHN1(2), PIP5K1B(2), PPP1R12B(1), ROCK1(1), SRC(2)	19878432	21	20	20	7	3	9	5	1	3	0	0.895	1.000
508	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	GFPT1(1), GNPDA1(1), HEXA(1), HK2(2), HK3(1)	7314515	6	6	6	0	3	1	1	0	1	0	0.898	1.000
509	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	DIAPH2(2), MCM2(1), MCM3(2), MCM4(2), MCM5(2), MCM6(3), MCM7(2), NACA(1), POLA2(1), POLE(1), PRIM1(1), RFC1(1), RFC4(1), RPA4(1), UBA52(1)	22029075	22	22	22	4	2	8	4	4	4	0	0.899	1.000
510	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	13	GALNT2(1), GALNT7(1), GALNT8(1), GCNT1(1)	5692565	4	4	4	4	1	0	1	0	2	0	0.901	1.000
511	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(1), HEXA(1), LCT(1), SLC33A1(1), ST6GALNAC4(1), ST8SIA1(1)	7137043	6	6	6	7	2	3	0	0	1	0	0.902	1.000
512	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ESR1(1), MTA1(1), MTA3(1)	4699944	3	3	3	3	2	0	0	0	1	0	0.905	1.000
513	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(2), AASS(3), ALDH1A1(1), ALDH1A2(2), ALDH3A1(2), DOT1L(1), ECHS1(1), EHHADH(1), EHMT2(2)	16023513	15	15	13	7	4	7	0	0	4	0	0.908	1.000
514	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST13(1), SULT2B1(1), SUOX(1)	4021001	3	3	3	0	0	2	1	0	0	0	0.909	1.000
515	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CDK7(1), SHH(2)	3786821	3	2	3	0	2	1	0	0	0	0	0.911	1.000
516	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), HAO1(2), HYI(1)	5530124	4	4	4	2	1	1	1	1	0	0	0.912	1.000
517	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	BCL2(2), BCL2A1(1), BOK(1), CASP1(1), CASP9(1), DAXX(2), MCL1(1), NFKB1(1), NFKBIA(1), NTRK1(1), PTPN13(1), RIPK1(1), SFRS2IP(2), TNFRSF1A(1), TRAF6(1)	19143112	18	17	17	8	2	7	0	1	8	0	0.915	1.000
518	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	FBP1(1), HK2(2), HK3(1), PFKFB1(2), PFKFB4(1), PFKP(1), PMM1(1)	10368529	9	9	9	5	2	5	0	1	1	0	0.915	1.000
519	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CTH(1)	2938769	1	1	1	0	1	0	0	0	0	0	0.917	1.000
520	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	PC(1), PDHA1(1)	3983137	2	2	2	1	0	1	1	0	0	0	0.918	1.000
521	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ALDH5A1(1), CAD(1), CPS1(4), EPRS(2), GFPT1(1), GLS(1), GLUL(1), NADSYN1(1), QARS(2)	14251932	14	13	14	2	4	4	5	1	0	0	0.918	1.000
522	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	6	EGF(3)	4409665	3	3	3	3	1	2	0	0	0	0	0.922	1.000
523	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1C(1), ACVRL1(1), AMHR2(1), BMP2(1), BMP5(2), BMP6(1), BMPR2(1), CDKN2B(1), CHRD(1), CREBBP(4), CUL1(2), DCN(1), E2F4(1), FST(1), GDF6(1), ID1(1), IFNG(2), INHBE(1), LEFTY2(2), MAPK1(1), MAPK3(1), MYC(1), PITX2(2), PPP2R1B(2), RBL1(1), ROCK1(1), ROCK2(1), SMAD7(1), SMURF1(1), TGFBR1(1), TGFBR2(2), THBS3(1), THBS4(1), ZFYVE9(1)	43016841	44	43	44	12	7	13	7	7	10	0	0.922	1.000
524	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	19	AKT1(1), EIF4A1(1), EIF4G1(1), EIF4G3(1), IRS1(2), MAPK1(1), MAPK3(1), PRKCA(1)	10199792	9	8	9	2	3	1	2	1	2	0	0.924	1.000
525	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(1), PRKCA(1)	3876603	2	2	2	0	1	1	0	0	0	0	0.925	1.000
526	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	MADD(1), MAP3K1(2), MAP3K7(2), MAPK8(1), PAK1(1), PRKDC(4), RIPK1(1), SPTAN1(2), TNFRSF1A(1)	16359141	15	15	15	5	3	6	1	1	4	0	0.926	1.000
527	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	CARM1(3), LCMT1(1), LCMT2(1)	6219972	5	5	4	3	3	1	0	0	1	0	0.928	1.000
528	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), DAG1(2), ITPR1(4), ITPR2(2), ITPR3(3), PDE6A(1), PDE6B(1), SLC6A13(1)	15594423	15	16	16	2	6	6	1	0	2	0	0.928	1.000
529	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ADC(2), ALDH5A1(1), CAD(1), CPS1(4), EPRS(2), GFPT1(1), GLS(1), GLUD2(1), GLUL(1), NADSYN1(1), QARS(2)	16998280	17	16	17	5	4	6	5	1	1	0	0.929	1.000
530	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), HAO1(2), HYI(1)	5793778	4	4	4	2	1	1	1	1	0	0	0.929	1.000
531	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	HEXA(1), HGSNAT(1), HPSE(2), HPSE2(2), LCT(1)	8889791	7	7	7	3	3	3	1	0	0	0	0.930	1.000
532	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	45	CREBBP(4), EHHADH(1), HSD17B4(1), MAPK1(1), MAPK3(1), MYC(1), NCOA1(1), NCOR1(1), NCOR2(1), NFKBIA(1), NR0B2(1), NR1H3(1), NRIP1(1), PPARA(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), RXRA(2), STAT5B(1)	24443033	23	23	23	10	6	7	0	2	8	0	0.932	1.000
533	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(1), MAPK8(1), NFKB1(1), TRAF6(1)	6319389	4	4	4	1	1	1	0	0	2	0	0.932	1.000
534	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	CREB1(1), EPO(1), NOS3(4)	7272071	6	6	6	5	0	5	0	0	1	0	0.932	1.000
535	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CDK7(1), GTF2H1(2), POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), POLR3B(1), TAF6(1), TAF7(1), TBP(2)	15281636	14	13	14	5	3	5	2	1	3	0	0.932	1.000
536	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	BCL2(2), BIRC3(1), CASP9(1)	5911694	4	4	4	2	0	1	1	0	2	0	0.933	1.000
537	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(1), HEXA(1), ST8SIA1(1)	4630736	3	3	3	5	2	1	0	0	0	0	0.934	1.000
538	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(1), E2F4(1), ETS1(1), FOS(1), HDAC2(3), NCOR2(1), RBL1(1), SIN3A(1)	11303779	10	10	10	2	1	2	3	1	3	0	0.935	1.000
539	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), AARS2(1), AGXT(1), ASNS(2), ASS1(1), CAD(1), CRAT(1), DARS(1), DLD(1), PC(1), PDHA1(1), PDHA2(2)	16351681	14	14	14	6	4	4	1	1	4	0	0.936	1.000
540	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	G6PC(1), GAA(1), GALE(1), GALK1(1), GALT(1), HK2(2), HK3(1), LCT(1), MGAM(1), PFKP(1), PGM1(1)	14127094	12	12	12	7	6	4	0	1	1	0	0.937	1.000
541	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	PON1(2)	3645123	2	2	2	3	1	1	0	0	0	0	0.937	1.000
542	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	FBP1(1), G6PD(1), PFKP(1), PGM1(1), PRPS1L1(2), RPE(1)	8840705	7	7	7	5	2	3	2	0	0	0	0.941	1.000
543	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSD(1), ARSE(3), GAL3ST1(1), LCT(1), NEU2(2)	10513889	8	8	8	6	3	1	2	1	1	0	0.941	1.000
544	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	FUCA1(1), HEXA(1), LCT(1), NEU2(2)	7198546	5	5	5	1	3	1	0	0	1	0	0.943	1.000
545	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(1), IKBKB(1), MAP3K1(2), NFKB1(1), NFKBIA(1), RIPK1(1)	9744649	7	7	7	4	2	3	0	1	1	0	0.944	1.000
546	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(1), SREBF1(1), SREBF2(1)	5171459	3	3	3	1	2	1	0	0	0	0	0.944	1.000
547	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	FBP1(1), G6PD(1), PFKL(1), PFKP(1), PGM1(1), PRPS1L1(2), RPE(1), TKTL1(1)	10516203	9	9	9	6	3	4	2	0	0	0	0.948	1.000
548	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	SUOX(1)	2630256	1	1	1	0	0	0	1	0	0	0	0.949	1.000
549	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(2), ANAPC4(1), BTRC(1), CDC23(2), CUL1(2), CUL2(1), FBXW7(1), FZR1(1), SKP2(1), SMURF1(1), WWP2(1)	16708759	14	14	14	4	2	3	2	3	4	0	0.950	1.000
550	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	8	ACO1(1), SUCLA2(1)	3479091	2	2	2	0	0	2	0	0	0	0	0.951	1.000
551	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), AGXT(1), ASNS(2), CAD(1), CRAT(1), DARS(1), PC(1)	11242522	8	8	8	3	1	2	1	1	3	0	0.953	1.000
552	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	CLOCK(4), CRY1(1), GFRA1(1), HERPUD1(1), KLF9(1), PER1(1), PER2(1), PIGF(1), SF3A3(1), ZFR(2)	15822553	14	13	13	2	3	4	2	0	5	0	0.954	1.000
553	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	BCL2(2), BIRC3(1), CASP9(1), CHUK(1), NFKB1(1), NFKBIA(1), RIPK1(1), SPTAN1(2), TNFSF10(2)	14559545	12	12	12	2	2	5	2	0	3	0	0.957	1.000
554	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), POLR3B(1)	10155087	7	7	7	1	1	3	1	1	1	0	0.959	1.000
555	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	OXCT2(1)	3144223	1	1	1	1	1	0	0	0	0	0	0.962	1.000
556	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	PFKL(1), PGK1(1)	3744744	2	2	2	3	0	1	1	0	0	0	0.963	1.000
557	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ARPC2(1)	3519011	1	1	1	0	0	0	0	0	1	0	0.964	1.000
558	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA3(1), PSMA5(1), PSMC3(1)	5599282	3	3	3	0	0	1	0	1	1	0	0.964	1.000
559	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	91	ADCY1(3), ADCY2(2), ADCY3(3), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(3), AKAP5(1), AKAP6(3), AKAP8(1), AKAP9(5), GNAO1(1), GNG5(1), GNGT2(1), ITPR1(4), KRAS(2), PDE1A(2), PDE1C(4), PDE4A(1), PDE8A(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(1), PRKD1(1), PRKD3(2)	49787108	56	46	54	9	15	18	9	4	10	0	0.965	1.000
560	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	FUT8(1)	3417266	1	1	1	0	0	0	0	0	1	0	0.967	1.000
561	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	TAX1BP3(1), UBE2M(1)	4519048	2	2	2	0	0	1	0	0	1	0	0.967	1.000
562	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(2), FUT8(1), MGAT2(1), MGAT5(1), ST6GAL1(1)	8538402	6	6	6	0	1	2	1	0	2	0	0.970	1.000
563	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(2), EPS15(1), PICALM(1), PPP3CB(1), SYNJ2(2)	9479391	7	7	7	3	4	1	1	0	1	0	0.970	1.000
564	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(1)	2763819	1	1	1	2	0	1	0	0	0	0	0.972	1.000
565	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	18	AKT1(1), EIF4A1(1), EIF4B(1), EIF4G1(1), EIF4G3(1), TSC2(2)	9944634	7	7	7	2	2	2	2	0	1	0	0.972	1.000
566	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	HEXA(1), ST8SIA1(1)	4360620	2	2	2	5	1	1	0	0	0	0	0.973	1.000
567	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	DPYD(2), ENPP1(1)	6013633	3	3	3	1	1	0	2	0	0	0	0.973	1.000
568	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLE(1), POLQ(3)	7257528	4	4	4	3	0	0	3	0	1	0	0.973	1.000
569	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	16	CTH(1), LDHAL6B(1)	5156554	2	2	2	1	2	0	0	0	0	0	0.974	1.000
570	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AMY2B(2), ENPP1(1), G6PC(1), GAA(1), HK2(2), HK3(1), MGAM(1), PGM1(1), PYGB(1), PYGL(1), PYGM(1), SI(1), UGDH(1), UGT1A10(1), UGT1A5(1), UGT1A6(1), UGT1A9(1), UGT2B15(1), UGT2B4(2), UXS1(1)	24202080	23	21	23	15	10	6	3	1	3	0	0.979	1.000
571	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	AMT(2), MTHFR(2)	7772610	4	4	4	2	0	1	0	1	2	0	0.979	1.000
572	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(1)	3910906	1	1	1	1	0	0	0	0	1	0	0.979	1.000
573	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	54	CAD(1), CDA(1), CTPS(1), DCK(1), DPYD(2), NT5E(2), NUDT2(1), POLE(1), POLQ(3), POLR1B(1), POLR2A(2), POLR2B(1), POLRMT(1), RRM2(1), TXNRD1(1), UCK1(1), UPP1(1)	24819937	22	20	22	11	3	6	8	1	4	0	0.980	1.000
574	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	G6PC(1), GAA(1), GALE(1), GALK1(1), GALT(1), HK2(2), HK3(1), LCT(1), MGAM(1), PFKL(1), PFKP(1), PGM1(1)	16735817	13	13	13	7	6	5	0	1	1	0	0.982	1.000
575	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ARPC2(1), NTRK1(1), WASF3(1)	6631473	3	3	3	4	0	0	0	0	3	0	0.982	1.000
576	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	CARM1(3), DOT1L(1), EHMT2(2), EZH2(2), HCFC1(1), JMJD4(1), JMJD6(1), KDM6A(1), MEN1(2), MLL(2), MLL2(4), MLL3(8), MLL4(5), MLL5(1), NSD1(1), PRDM9(7), RBBP5(1), SETD1A(3), SETD2(5), SETDB1(1), SMYD3(1), SUV420H1(1), SUZ12(1), WHSC1(1)	51869131	56	47	55	17	14	19	11	4	8	0	0.985	1.000
577	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	AMT(2), MTHFR(2)	8213716	4	4	4	2	0	1	0	1	2	0	0.986	1.000
578	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASS(3), ALDH3A1(2), DOT1L(1), ECHS1(1), EHHADH(1), EHMT2(2), HSD17B4(1), NSD1(1), OGDH(3), PIPOX(1), SETD1A(3), SETDB1(1)	25200424	20	20	17	11	3	8	2	0	7	0	0.987	1.000
579	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	FBP1(1), ME2(1), PGK1(1), RPE(1)	7555983	4	4	4	7	1	1	2	0	0	0	0.988	1.000
580	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	FBP1(1), PGK1(1), PGK2(1), RPE(1), TKTL1(1)	8472464	5	5	5	9	2	2	1	0	0	0	0.990	1.000
581	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA3(1), PSMA5(1), PSMC3(1)	6907793	3	3	3	0	0	1	0	1	1	0	0.990	1.000
582	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	BIRC3(1), CASP9(1), SREBF1(1), SREBF2(1)	7911849	4	4	4	1	2	1	1	0	0	0	0.991	1.000
583	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), GFPT1(1), GNPDA1(1), HEXA(1), HK2(2), HK3(1), MTMR1(1)	12377105	8	8	8	4	3	3	1	0	1	0	0.991	1.000
584	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	AICDA(1), CAD(1), CDA(1), CTPS(1), DCK(1), DPYD(2), NME7(2), NT5C1B(2), NT5E(2), NUDT2(1), PNPT1(1), POLA1(1), POLA2(1), POLE(1), POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), POLR3B(1), PRIM1(1), PRIM2(1), RRM2(1), TXNRD1(1), TXNRD2(1), UCK1(1), UPP1(1), UPP2(1)	35181438	33	29	33	13	9	10	8	3	3	0	0.992	1.000
585	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	HEXA(1), LCT(1)	6230061	2	2	2	3	2	0	0	0	0	0	0.992	1.000
586	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	ALG1(1), ALG10B(1), ALG3(2), B3GNT7(1), CHST1(1), CHST13(1), CHST2(2), CHST4(1), CHST6(2), EXTL1(1), FUT8(1), GALNT11(1), GALNT13(1), GALNT14(3), GALNT2(1), GALNT5(2), GALNT7(1), GALNT8(1), GALNTL4(1), GCNT1(1), GCNT3(1), GCNT4(1), HS3ST1(1), HS3ST3A1(2), MGAT2(1), MGAT5(1), MGAT5B(1), NDST3(1), NDST4(5), ST6GAL1(1), UST(1), XYLT1(1), XYLT2(2)	47350665	45	43	45	14	11	18	8	2	6	0	0.993	1.000
587	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	PIGF(1), PIGN(1), PIGO(2), PIGU(1), PIGZ(1)	10429646	6	6	6	1	0	4	1	0	1	0	0.993	1.000
588	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	DPYD(2), ENPP1(1)	7479435	3	3	3	1	1	0	2	0	0	0	0.993	1.000
589	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CD2BP2(2), COL2A1(1), CPSF1(2), CSTF1(1), DHX38(1), DICER1(4), NONO(1), NUDT21(1), NXF1(1), PABPN1(1), PAPOLA(2), PHF5A(1), POLR2A(2), PRPF4(1), PRPF4B(1), PRPF8(1), PTBP1(1), SF3A1(2), SF3A2(1), SF3A3(1), SF3B1(2), SF3B2(2), SFRS16(1), SFRS2(1), SFRS5(1), SFRS8(2), SNRPB(1), SRPK1(1), SRPK2(1), SRRM1(1)	45588206	41	38	41	13	5	13	7	3	13	0	0.994	1.000
590	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGEF2(3)	6984155	3	3	3	4	1	2	0	0	0	0	0.995	1.000
591	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	10	ACO1(1), SUCLA2(1)	5376107	2	2	2	0	0	2	0	0	0	0	0.995	1.000
592	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(1), POLA2(1), POLE(1), POLI(2), POLQ(3), PRIM1(1), PRIM2(1), REV1(2)	17870575	12	12	12	4	2	2	5	1	2	0	0.995	1.000
593	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF2(1), EIF2AK2(1), EIF2AK3(1), EIF2S2(1), EIF2S3(1), EIF4A1(1), EIF4G1(1), EIF4G3(1), EIF5B(1), GSPT2(1), PABPC3(3)	19033205	13	13	13	5	4	2	4	0	3	0	0.996	1.000
594	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	141	ADCY1(3), ADCY2(2), ADCY3(3), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(3), AK1(1), AK5(1), AK7(2), ALLC(3), AMPD1(2), AMPD2(1), AMPD3(1), DCK(1), ENPP1(1), GDA(1), GMPR2(1), GUCY1B3(1), GUCY2F(1), IMPDH1(1), NME7(2), NPR1(1), NT5C1B(2), NT5E(2), NUDT2(1), PDE10A(1), PDE11A(1), PDE1A(2), PDE1C(4), PDE2A(1), PDE4A(1), PDE8A(1), PFAS(1), PNPT1(1), POLA1(1), POLA2(1), POLE(1), POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), POLR3B(1), PRIM1(1), PRIM2(1), PRPS1L1(2), RRM2(1), XDH(1)	70238886	71	60	71	25	15	29	14	4	9	0	0.996	1.000
595	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	FBP1(1), HK2(2), HK3(1), MTMR1(1), PFKFB1(2), PFKFB4(1), PFKL(1), PFKP(1), PMM1(1)	16092721	11	11	11	9	2	7	0	1	1	0	0.996	1.000
596	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ACOT11(1), ALDH3A1(2), CYP2C19(1), ECHS1(1), EHHADH(1), YOD1(1)	13145214	7	7	7	3	3	3	0	0	1	0	0.997	1.000
597	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	78	AMY2B(2), ASCC3(2), DDX41(2), DDX56(1), DHX58(1), ENPP1(1), G6PC(1), GAA(1), HK2(2), HK3(1), MGAM(1), PGM1(1), PYGB(1), PYGL(1), PYGM(1), RAD54B(2), RAD54L(1), RUVBL2(2), SETX(1), SI(1), SMARCA2(3), SMARCA5(1), TREH(1), UGDH(1), UGT1A10(1), UGT1A5(1), UGT1A6(1), UGT1A9(1), UGT2A1(3), UGT2B10(4), UGT2B11(1), UGT2B15(1), UGT2B4(2), UGT2B7(1), UXS1(1)	51865018	49	44	49	21	18	14	11	2	4	0	0.997	1.000
598	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ADH1A(2), ADH1B(2), ADH1C(1)	10571449	5	5	5	3	2	2	1	0	0	0	0.997	1.000
599	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	BIRC3(1), CASP1(1), CASP9(1)	8373601	3	3	3	2	0	2	1	0	0	0	0.999	1.000
600	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(1)	6133522	1	1	1	1	1	0	0	0	0	0	0.999	1.000
601	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	109	ADCY1(3), ADCY2(2), ADCY3(3), ADCY6(2), ADCY7(1), ADCY8(2), AK1(1), AK5(1), ALLC(3), AMPD1(2), AMPD2(1), AMPD3(1), ATP5A1(1), ATP5B(1), DCK(1), ENPP1(1), GDA(1), GUCY1B3(1), GUCY2F(1), IMPDH1(1), NPR1(1), NT5E(2), NUDT2(1), PDE1A(2), PDE4A(1), PDE6B(1), PDE8A(1), PFAS(1), POLE(1), POLQ(3), POLR1B(1), POLR2A(2), POLR2B(1), POLRMT(1), PRPS1L1(2), RRM2(1)	54908023	52	44	52	21	9	22	12	0	9	0	0.999	1.000
602	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	IMPDH1(1)	5466162	1	1	1	2	0	1	0	0	0	0	0.999	1.000
603	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	ACOT11(1), ECHS1(1), EHHADH(1), YOD1(1)	10976719	4	4	4	2	2	1	0	0	1	0	0.999	1.000
604	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	40	ALPP(2), ASCC3(2), DDX41(2), DDX56(1), DHX58(1), RAD54B(2), RAD54L(1), RUVBL2(2), SETX(1), SMARCA2(3), SMARCA5(1)	26890754	18	17	18	5	6	6	3	1	2	0	1.000	1.000
605	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10B(1), ALG3(2), FUT8(1), MGAT2(1), MGAT5(1), MGAT5B(1), ST6GAL1(1)	18394661	9	9	9	4	2	4	1	0	2	0	1.000	1.000
606	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10		4181979	0	0	0	1	0	0	0	0	0	0	1.000	1.000
607	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7		2089940	0	0	0	2	0	0	0	0	0	0	1.000	1.000
608	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		219401	0	0	0	0	0	0	0	0	0	0	1.000	1.000
609	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11		6904772	0	0	0	2	0	0	0	0	0	0	1.000	1.000
610	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	2		565329	0	0	0	0	0	0	0	0	0	0	1.000	1.000
611	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4		1351174	0	0	0	0	0	0	0	0	0	0	1.000	1.000
612	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		659071	0	0	0	1	0	0	0	0	0	0	1.000	1.000
613	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10		2768111	0	0	0	0	0	0	0	0	0	0	1.000	1.000
614	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3		732168	0	0	0	0	0	0	0	0	0	0	1.000	1.000
615	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9		1860397	0	0	0	0	0	0	0	0	0	0	1.000	1.000
616	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4		1462857	0	0	0	0	0	0	0	0	0	0	1.000	1.000
