Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.254 0.208 -9999.0 0.0 -0.908 2.0 2.0 IHH -0.049 0.062 -9999.0 0.0 -0.759 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.044 0.139 -9999.0 0.0 -0.478 28.0 28.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.044 0.138 0.475 28.0 -9999.0 0.0 28.0 SMO/beta Arrestin2 -0.126 0.133 -9999.0 0.0 -0.534 8.0 8.0 SMO -0.14 0.141 -9999.0 0.0 -0.568 8.0 8.0 AKT1 -0.051 0.071 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.047 0.19 -9999.0 0.0 -0.641 28.0 28.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.138 0.139 -9999.0 0.0 -0.559 8.0 8.0 STIL -0.121 0.154 -9999.0 0.0 -0.581 18.0 18.0 DHH N/PTCH2 -0.025 0.111 -9999.0 0.0 -0.509 15.0 15.0 DHH N/PTCH1 -0.129 0.128 -9999.0 0.0 -0.589 5.0 5.0 PIK3CA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.004 0.106 -9999.0 0.0 -0.687 7.0 7.0 PTHLH -0.43 0.319 -9999.0 0.0 -1.165 1.0 1.0 determination of left/right symmetry -0.138 0.139 -9999.0 0.0 -0.559 8.0 8.0 PIK3R1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.427 0.316 -9999.0 0.0 -0.637 77.0 77.0 IHH N/Hhip -0.057 0.173 -9999.0 0.0 -0.67 22.0 22.0 DHH N/Hhip -0.054 0.17 -9999.0 0.0 -0.584 28.0 28.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.138 0.139 -9999.0 0.0 -0.559 8.0 8.0 pancreas development -0.045 0.205 -9999.0 0.0 -0.794 21.0 21.0 HHAT 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.004 0.084 -9999.0 0.0 -0.722 4.0 4.0 somite specification -0.138 0.139 -9999.0 0.0 -0.559 8.0 8.0 SHH Np/Cholesterol/PTCH1 -0.134 0.159 -9999.0 0.0 -0.618 17.0 17.0 SHH Np/Cholesterol/PTCH2 -0.049 0.153 -9999.0 0.0 -0.526 24.0 24.0 SHH Np/Cholesterol/Megalin -0.061 0.178 -9999.0 0.0 -0.543 34.0 34.0 SHH -0.03 0.172 -9999.0 0.0 -0.615 24.0 24.0 catabolic process -0.146 0.128 -9999.0 0.0 -9999.0 0.0 0.0 SMO/Vitamin D3 -0.139 0.162 -9999.0 0.0 -0.598 17.0 17.0 SHH Np/Cholesterol/Hhip -0.071 0.199 -9999.0 0.0 -0.57 38.0 38.0 LRP2 -0.026 0.171 -9999.0 0.0 -0.803 14.0 14.0 receptor-mediated endocytosis -0.156 0.147 -9999.0 0.0 -0.582 20.0 20.0 SHH Np/Cholesterol/BOC -0.072 0.164 -9999.0 0.0 -0.429 51.0 51.0 SHH Np/Cholesterol/CDO -0.043 0.137 -9999.0 0.0 -0.47 28.0 28.0 mesenchymal cell differentiation 0.071 0.197 0.564 38.0 -9999.0 0.0 38.0 mol:Vitamin D3 -0.133 0.159 -9999.0 0.0 -0.616 17.0 17.0 IHH N/PTCH2 -0.023 0.098 -9999.0 0.0 -0.569 9.0 9.0 CDON 0.005 0.075 -9999.0 0.0 -0.641 4.0 4.0 IHH N/PTCH1 -0.147 0.128 -9999.0 0.0 -9999.0 0.0 0.0 Megalin/LRPAP1 -0.028 0.129 -9999.0 0.0 -0.613 14.0 14.0 PTCH2 -0.005 0.112 -9999.0 0.0 -0.681 8.0 8.0 SHH Np/Cholesterol -0.039 0.134 -9999.0 0.0 -0.496 24.0 24.0 PTCH1 -0.146 0.128 -9999.0 0.0 -9999.0 0.0 0.0 HHIP -0.045 0.205 -9999.0 0.0 -0.795 21.0 21.0