Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.008 0.102 0.349 22.0 -9999.0 0.0 22.0 KIRREL 0.021 0.041 -9999.0 0.0 -0.561 1.0 1.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.008 0.102 -9999.0 0.0 -0.35 22.0 22.0 PLCG1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.027 0.103 -9999.0 0.0 -0.436 6.0 6.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.007 0.06 -9999.0 0.0 -0.404 1.0 1.0 FYN -0.013 0.091 0.271 7.0 -0.395 6.0 13.0 mol:Ca2+ 0.027 0.099 -9999.0 0.0 -0.426 5.0 5.0 mol:DAG 0.028 0.1 -9999.0 0.0 -0.428 5.0 5.0 NPHS2 -0.015 0.087 -9999.0 0.0 -0.488 9.0 9.0 mol:IP3 0.028 0.1 -9999.0 0.0 -0.428 5.0 5.0 regulation of endocytosis 0.025 0.088 -9999.0 0.0 -0.371 6.0 6.0 Nephrin/NEPH1/podocin/Cholesterol 0.015 0.098 -9999.0 0.0 -0.299 21.0 21.0 establishment of cell polarity 0.008 0.102 -9999.0 0.0 -0.349 22.0 22.0 Nephrin/NEPH1/podocin/NCK1-2 0.036 0.097 -9999.0 0.0 -0.429 4.0 4.0 Nephrin/NEPH1/beta Arrestin2 0.027 0.089 -9999.0 0.0 -0.375 6.0 6.0 NPHS1 -0.027 0.126 -9999.0 0.0 -0.475 21.0 21.0 Nephrin/NEPH1/podocin 0.019 0.09 -9999.0 0.0 -0.397 6.0 6.0 TJP1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.024 0.011 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.029 0.101 -9999.0 0.0 -0.43 5.0 5.0 CD2AP 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.03 0.104 -9999.0 0.0 -0.439 6.0 6.0 GRB2 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.035 0.113 0.281 5.0 -0.305 29.0 34.0 cytoskeleton organization -0.005 0.072 -9999.0 0.0 -0.379 4.0 4.0 Nephrin/NEPH1 0.011 0.073 -9999.0 0.0 -0.242 22.0 22.0 Nephrin/NEPH1/ZO-1 0.026 0.088 -9999.0 0.0 -0.277 22.0 22.0