Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.176 0.149 -9999.0 0.0 -0.523 3.0 3.0 IHH -0.04 0.06 -9999.0 0.0 -0.444 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.001 0.084 -9999.0 0.0 -0.259 28.0 28.0 LRPAP1 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.001 0.083 0.257 28.0 -9999.0 0.0 28.0 SMO/beta Arrestin2 -0.088 0.116 -9999.0 0.0 -0.442 10.0 10.0 SMO -0.092 0.117 -9999.0 0.0 -0.464 10.0 10.0 AKT1 -0.042 0.104 -9999.0 0.0 -0.5 8.0 8.0 ARRB2 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.025 0.163 -9999.0 0.0 -0.553 26.0 26.0 ADRBK1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.09 0.117 -9999.0 0.0 -0.458 10.0 10.0 STIL -0.093 0.102 -9999.0 0.0 -0.381 5.0 5.0 DHH N/PTCH2 0.021 0.091 -9999.0 0.0 -0.386 14.0 14.0 DHH N/PTCH1 -0.096 0.102 -9999.0 0.0 -0.432 3.0 3.0 PIK3CA 0.02 0.013 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.014 0.078 -9999.0 0.0 -0.524 6.0 6.0 PTHLH -0.252 0.194 -9999.0 0.0 -0.583 10.0 10.0 determination of left/right symmetry -0.09 0.117 -9999.0 0.0 -0.458 10.0 10.0 PIK3R1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.25 0.193 -9999.0 0.0 -0.578 10.0 10.0 IHH N/Hhip -0.039 0.103 -9999.0 0.0 -0.385 21.0 21.0 DHH N/Hhip 0.005 0.111 -9999.0 0.0 -0.35 26.0 26.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.09 0.117 -9999.0 0.0 -0.458 10.0 10.0 pancreas development -0.013 0.124 -9999.0 0.0 -0.472 20.0 20.0 HHAT 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.029 0.02 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.021 0.062 -9999.0 0.0 -0.509 4.0 4.0 somite specification -0.09 0.117 -9999.0 0.0 -0.458 10.0 10.0 SHH Np/Cholesterol/PTCH1 -0.099 0.101 -9999.0 0.0 -0.365 17.0 17.0 SHH Np/Cholesterol/PTCH2 -0.004 0.096 -9999.0 0.0 -0.283 30.0 30.0 SHH Np/Cholesterol/Megalin -0.009 0.1 -9999.0 0.0 -0.282 33.0 33.0 SHH -0.022 0.093 -9999.0 0.0 -0.334 24.0 24.0 catabolic process -0.108 0.1 -9999.0 0.0 -0.352 2.0 2.0 SMO/Vitamin D3 -0.092 0.112 -9999.0 0.0 -0.442 5.0 5.0 SHH Np/Cholesterol/Hhip -0.015 0.112 -9999.0 0.0 -0.3 37.0 37.0 LRP2 -0.002 0.104 -9999.0 0.0 -0.465 14.0 14.0 receptor-mediated endocytosis -0.094 0.113 -9999.0 0.0 -0.464 4.0 4.0 SHH Np/Cholesterol/BOC -0.025 0.115 -9999.0 0.0 -0.293 45.0 45.0 SHH Np/Cholesterol/CDO -0.002 0.085 -9999.0 0.0 -0.263 28.0 28.0 mesenchymal cell differentiation 0.015 0.112 0.299 37.0 -9999.0 0.0 37.0 mol:Vitamin D3 -0.096 0.11 0.374 1.0 -0.365 17.0 18.0 IHH N/PTCH2 -0.023 0.082 -9999.0 0.0 -0.427 9.0 9.0 CDON 0.019 0.067 -9999.0 0.0 -0.553 4.0 4.0 IHH N/PTCH1 -0.107 0.104 -9999.0 0.0 -0.354 2.0 2.0 Megalin/LRPAP1 0.021 0.078 -9999.0 0.0 -0.326 14.0 14.0 PTCH2 0.013 0.091 -9999.0 0.0 -0.533 8.0 8.0 SHH Np/Cholesterol -0.005 0.074 -9999.0 0.0 -0.255 24.0 24.0 PTCH1 -0.109 0.1 -9999.0 0.0 -0.353 2.0 2.0 HHIP -0.013 0.124 -9999.0 0.0 -0.472 20.0 20.0