rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(3), CYP2C9(5)	922599	8	8	8	0	0	3	4	1	0	0	0.0867	0.0521	1.000
2	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(2)	231812	2	2	2	0	0	0	0	0	2	0	0.660	0.120	1.000
3	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(12), GNAS(6), GNB1(2), PRKACA(4), PRKAR1A(2)	2991458	26	23	26	2	10	3	9	4	0	0	0.0192	0.155	1.000
4	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(2), B3GNT1(1), FUT1(1), FUT2(2), FUT9(10), GCNT2(4), ST8SIA1(2)	2797416	22	21	22	4	2	7	10	2	1	0	0.124	0.182	1.000
5	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(4), CYP2E1(5), PTGS1(6), PTGS2(2)	2433197	17	15	17	2	2	1	9	0	5	0	0.159	0.261	1.000
6	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(3)	829283	5	5	5	1	1	2	0	1	1	0	0.394	0.323	1.000
7	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(3), ACADS(2), ECHS1(2), HADHA(3)	2467452	12	12	12	1	2	2	4	3	1	0	0.127	0.339	1.000
8	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CCNE1(3), CDC34(1), CUL1(6), RB1(9), TFDP1(3)	2976526	22	21	22	4	3	4	2	2	11	0	0.155	0.343	1.000
9	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	16	CSNK2A1(6), ELK1(1), FOS(1), MAP2K1(4), MAPK8(4), NGFR(1), PIK3R1(6), PLCG1(5), RAF1(2), SHC1(1), SOS1(8)	7493191	39	35	39	3	6	4	17	3	9	0	0.00916	0.389	1.000
10	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(2), LDLR(3), NR0B2(1), NR1H4(5), RXRA(4)	2480469	15	15	15	1	2	2	6	1	4	0	0.104	0.397	1.000
11	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(2), FMOD(4), KERA(4)	1651973	10	8	10	2	0	4	5	0	1	0	0.317	0.454	1.000
12	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IFNG(1), IL12A(1), IL12B(4)	1362330	8	8	8	2	1	2	0	4	1	0	0.515	0.462	1.000
13	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS1(3), PAPSS2(3), SULT1E1(3), SULT2A1(2), SUOX(1)	2786733	13	11	13	0	1	4	4	3	1	0	0.0325	0.494	1.000
14	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(1), GRIA2(10)	1693069	11	11	11	2	1	2	8	0	0	0	0.287	0.499	1.000
15	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	11	APAF1(9), ARHGAP5(6), CASP1(2), CASP10(2), CASP3(1), GZMB(1), PRF1(3)	5346347	24	23	24	3	4	4	3	9	4	0	0.0741	0.541	1.000
16	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(1), TGDS(2), UGDH(3), UXS1(1)	1758796	7	7	7	0	0	1	3	3	0	0	0.188	0.556	1.000
17	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(2), NR3C1(5), RXRA(4)	2635335	11	11	11	0	2	1	4	2	2	0	0.0436	0.561	1.000
18	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(4), PSMA2(1), PSMA6(1), PSMB10(3), PSMB2(1), PSMB4(2), PSMB5(2), PSMB6(1), PSMB7(1), PSMB8(1)	3977611	17	16	17	0	0	4	6	4	3	0	0.0122	0.580	1.000
19	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(1), CHST11(3), CHST12(2), CHST13(3), PAPSS1(3), PAPSS2(3), SULT1E1(3), SULT2A1(2), SUOX(1)	4218503	21	19	21	2	3	4	6	6	2	0	0.0500	0.581	1.000
20	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD28(2), CD3D(1), CD80(5), CD86(1), CTLA4(1), HLA-DRA(1), ICOS(1), ITK(1), LCK(5), PIK3R1(6), PTPN11(1)	4824124	25	21	25	3	1	7	5	5	7	0	0.0609	0.652	1.000
21	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(4), PSMA2(1), PSMA6(1), PSMB2(1), PSMB4(2), PSMB5(2), PSMB6(1), PSMB7(1), PSMC3(1), PSMD14(2), RPN1(1), RPN2(2), UBE3A(4)	5879770	23	22	23	1	0	5	8	7	3	0	0.0157	0.685	1.000
22	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A2(6), BCMO1(2)	1777605	8	8	8	2	2	1	2	1	2	0	0.458	0.686	1.000
23	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(3), EPHX2(4), RDH11(1), RDH12(3)	2186793	11	10	11	2	2	2	5	2	0	0	0.279	0.687	1.000
24	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(1), TGDS(2), UGDH(3), UGP2(1), UXS1(1)	2237857	8	8	8	0	0	1	4	3	0	0	0.158	0.689	1.000
25	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(1), FOS(1), FYN(3), MAPK14(1), THBS1(7)	3373854	13	12	13	1	0	4	4	4	1	0	0.0798	0.691	1.000
26	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(4), FYN(3), LRP8(1), RELN(37), VLDLR(1)	6372797	46	39	44	7	5	5	13	15	8	0	0.0993	0.691	1.000
27	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	TPI1(2)	752631	2	2	2	0	1	1	0	0	0	0	0.450	0.693	1.000
28	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(3), ST3GAL1(1), ST3GAL4(1), ST3GAL5(2), ST6GALNAC2(2), ST8SIA1(2)	2580190	11	10	11	1	1	3	3	1	3	0	0.138	0.710	1.000
29	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), HGD(2)	1018738	3	3	3	1	1	1	1	0	0	0	0.607	0.729	1.000
30	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(2), HLA-DRA(1)	1077093	3	3	3	1	0	1	0	1	1	0	0.732	0.730	1.000
31	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	11	CCNA1(4), CCNA2(3), CCND1(2), CCNE1(3), CCNE2(3), CDK4(4), CDKN1B(2), E2F2(3), E2F4(1)	3534087	25	24	25	5	1	7	5	8	4	0	0.197	0.757	1.000
32	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(3), FDPS(2), IDI1(1)	1460995	6	6	6	2	2	3	1	0	0	0	0.481	0.758	1.000
33	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(2), EHHADH(2), HADHA(3)	2211166	7	7	7	0	0	1	1	3	2	0	0.159	0.758	1.000
34	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH6(1), ADH7(1), ADHFE1(2)	2570828	13	12	13	3	1	5	1	3	3	0	0.407	0.767	1.000
35	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYC(2), RB1(9), SP1(1), SP3(1)	3024881	13	13	13	3	0	1	1	2	9	0	0.581	0.781	1.000
36	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(7), GOT1(1), GOT2(3), TAT(1), TYR(4)	2142884	16	15	16	4	2	2	8	1	3	0	0.440	0.782	1.000
37	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIPT1(1)	695872	1	1	1	0	0	0	0	1	0	0	0.757	0.790	1.000
38	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(2), RAB1A(1), RAB3A(1), RAB5A(2)	1919717	6	6	6	0	2	2	1	1	0	0	0.115	0.795	1.000
39	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	AKT1(2), ANXA1(1), CALM1(1), CALM3(1), GNAS(6), GNB1(2), NFKB1(2), NOS3(4), NPPA(1), NR3C1(5), PIK3R1(6), RELA(1), SYT1(5)	7157306	37	31	37	4	11	8	6	8	4	0	0.0147	0.817	1.000
40	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(4), CCNE1(3), CDC34(1), CUL1(6), RB1(9), SKP2(2), TFDP1(3)	3866305	28	26	28	7	4	4	5	3	12	0	0.335	0.822	1.000
41	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	18	CSNK2A1(6), ELK1(1), EPO(2), FOS(1), JAK2(2), MAP2K1(4), MAPK8(4), PLCG1(5), PTPN6(1), RAF1(2), SHC1(1), SOS1(8), STAT5A(1), STAT5B(4)	9569935	42	37	42	4	7	7	19	1	8	0	0.00442	0.825	1.000
42	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(4), ADORA2A(1), ADORA3(2), LTB4R(2), P2RY1(4), P2RY2(2), P2RY6(2)	2718389	17	15	17	4	4	5	6	2	0	0	0.127	0.828	1.000
43	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PLCD1(2), PRKCA(2), TGM2(3)	2255806	8	8	8	1	0	3	3	2	0	0	0.172	0.833	1.000
44	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(3), CDKN1B(2), CKS1B(1), CUL1(6), NEDD8(1), RB1(9), RBX1(2), SKP2(2), TFDP1(3)	3895401	29	28	29	7	3	5	5	4	12	0	0.277	0.839	1.000
45	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(12), ARHGEF1(5), F2(2), F2RL3(3), GNA12(1), GNA13(1), GNAI1(1), GNB1(2), MAP3K7(4), PIK3R1(6), PLCB1(12), PPP1R12B(1), PRKCA(2), PTK2B(2), ROCK1(11)	10791239	65	57	65	9	11	12	25	12	5	0	0.00532	0.843	1.000
46	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(2), CD86(1), HLA-DRA(1), IFNG(1), IFNGR1(5), IFNGR2(2), IL12A(1), IL12B(4), IL12RB1(3), IL12RB2(7), IL18R1(2), IL2RA(2), IL4(1), IL4R(2)	5765533	34	31	33	5	3	9	9	6	7	0	0.0366	0.846	1.000
47	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOA(1), ALDOB(3), ALDOC(1), TPI1(2)	1785922	7	7	7	2	1	2	2	2	0	0	0.543	0.847	1.000
48	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(5), PARK2(3), SNCAIP(1), UBE2L3(1), UBE2L6(1)	2927495	11	10	11	2	1	2	2	4	2	0	0.360	0.849	1.000
49	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT2(1), ACYP1(1), ECHS1(2), EHHADH(2), GCDH(1), HADHA(3)	3564134	10	10	10	1	1	2	1	4	2	0	0.182	0.855	1.000
50	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	SNAP25(1), STX1A(3)	1483617	4	4	4	1	1	0	1	1	1	0	0.756	0.858	1.000
51	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1)	516198	1	1	1	0	0	0	1	0	0	0	0.843	0.890	1.000
52	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(1), GOT2(3), TAT(1)	1197770	5	5	5	2	1	0	3	1	0	0	0.740	0.899	1.000
53	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT2(1), HMGCL(1), OXCT1(1)	1542084	3	3	3	1	1	0	0	1	1	0	0.692	0.909	1.000
54	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(3), FDPS(2), IDI1(1)	1951946	6	6	6	2	2	3	1	0	0	0	0.482	0.915	1.000
55	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	13	AKT1(2), BAD(1), IGF1R(7), IRS1(1), MAP2K1(4), MAPK1(4), PIK3R1(6), RAF1(2), SHC1(1), SOS1(8), YWHAH(1)	7453630	37	33	34	5	8	8	11	5	5	0	0.0311	0.917	1.000
56	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(1), IFNGR1(5), IFNGR2(2), JAK1(6), JAK2(2), STAT1(5)	3727435	21	20	20	6	1	5	4	2	9	0	0.406	0.919	1.000
57	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(4), GAD1(2), HDC(2), PNMT(1), TH(2), TPH1(2)	2763324	13	13	13	3	2	1	6	1	3	0	0.476	0.926	1.000
58	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(2), CD80(5), HLA-DRA(1), IL4(1)	1807437	9	9	9	3	0	4	2	2	1	0	0.525	0.927	1.000
59	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(3), AOC2(2), AOC3(5), CES1(4), ESD(1)	2756712	15	15	15	4	1	6	6	0	2	0	0.320	0.934	1.000
60	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD28(2), CD3D(1)	1461751	3	3	3	1	0	0	1	1	1	0	0.841	0.934	1.000
61	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR2(5), MTMR6(2), NFS1(1), PHPT1(1), TPK1(3)	2920637	13	11	13	3	3	2	3	3	2	0	0.484	0.945	1.000
62	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	17	CSNK2A1(6), ELK1(1), FOS(1), IGF1R(7), IRS1(1), MAP2K1(4), MAPK8(4), PIK3R1(6), PTPN11(1), RAF1(2), SHC1(1), SOS1(8)	9163227	42	38	42	5	6	5	17	4	10	0	0.0286	0.946	1.000
63	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25B(3), CHEK1(1), NEK1(3), WEE1(1)	3132462	8	8	8	1	2	1	4	0	1	0	0.556	0.947	1.000
64	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(3), CHPT1(1), HEMK1(1), LCMT1(1), LCMT2(6), METTL2B(2), METTL6(2), PCYT1A(1), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2)	6395286	28	26	28	4	9	7	7	2	3	0	0.0385	0.947	1.000
65	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	4	ADAM17(4), DLL1(4), FURIN(1)	2369375	9	9	9	2	3	2	2	1	1	0	0.350	0.948	1.000
66	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SEC61A2(2), SRP19(2), SRP68(2), SRPR(2)	3433083	9	8	9	1	0	2	4	2	1	0	0.349	0.949	1.000
67	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	9	ACTA1(2), EPHA4(9), EPHB1(9), FYN(3), ITGA1(3), L1CAM(3), LYN(3), RAP1B(2), SELP(11)	6415962	45	36	45	8	4	8	12	13	8	0	0.108	0.949	1.000
68	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	18	CSNK2A1(6), ELK1(1), FOS(1), INSR(2), IRS1(1), MAP2K1(4), MAPK8(4), PIK3R1(6), PTPN11(1), RAF1(2), SHC1(1), SLC2A4(1), SOS1(8)	9487041	38	33	38	4	4	5	16	3	10	0	0.0213	0.951	1.000
69	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNB1(2), HTR2C(1), PLCB1(12), TUB(2)	3252404	17	17	17	4	5	3	7	2	0	0	0.298	0.951	1.000
70	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(3), ENO1(1), GPI(2), HK1(3), PFKL(4), PGAM1(1), PKLR(1), TPI1(2)	4218425	17	16	17	3	6	3	1	4	3	0	0.215	0.951	1.000
71	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(1), ACAT2(1), ECHS1(2), EHHADH(2), HADHA(3), HADHB(2)	3809273	11	11	11	2	1	1	3	4	2	0	0.369	0.957	1.000
72	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA5(3), NDUFB4(1), NDUFB6(1), NDUFS1(1), NDUFS2(1), NDUFV1(1)	3173054	8	8	8	1	1	3	2	1	1	0	0.257	0.964	1.000
73	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(8), GABRA2(7), GABRA3(4), GABRA4(3), GABRA5(5), GABRA6(2), PRKCE(2)	3578364	31	28	31	9	2	6	12	5	6	0	0.476	0.966	1.000
74	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	14	APAF1(9), BIRC2(1), BIRC3(1), CASP10(2), CASP3(1), CASP7(1), GZMB(1), PRF1(3), SCAP(1), SREBF1(3), SREBF2(4)	7763449	27	25	27	3	6	4	7	6	4	0	0.0361	0.969	1.000
75	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	17	APAF1(9), BAX(1), BCL2(1), BCL2L1(2), BID(2), BIK(1), BIRC2(1), BIRC3(1), CASP3(1), CASP6(2), CASP7(1), DIABLO(1)	5584704	23	22	23	4	4	6	5	4	4	0	0.146	0.972	1.000
76	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(3), HLA-DRA(1), IL1B(1), IL4(1), IL5(1), IL5RA(1)	2426471	8	8	8	2	0	4	4	0	0	0	0.379	0.973	1.000
77	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(1), CD34(4), CD3D(1), CD8A(2), IL3(1)	2820651	9	9	9	3	2	1	2	1	3	0	0.618	0.976	1.000
78	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), BCKDK(3), CTH(2), MUT(2)	2232722	8	7	8	2	0	4	3	0	1	0	0.464	0.978	1.000
79	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(7), ACO2(2), FH(2), IDH1(2), MDH1(1), SUCLA2(1)	4056012	15	13	15	3	1	5	6	2	1	0	0.274	0.984	1.000
80	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	MAX(1), MYC(4), SP1(1), SP3(1)	2843487	7	7	7	2	0	1	3	2	1	0	0.690	0.984	1.000
81	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CEBPB(1), CSNK2A1(6), ELK1(1), FOS(1), IL6R(4), IL6ST(2), JAK1(6), JAK2(2), JAK3(3), MAP2K1(4), PTPN11(1), RAF1(2), SHC1(1), SOS1(8), STAT3(3)	10638274	45	40	44	6	6	5	17	7	10	0	0.0295	0.985	1.000
82	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(2), FUT1(1), FUT2(2), FUT5(3), FUT6(1), ST3GAL3(1)	2320444	10	10	10	3	2	3	2	1	2	0	0.446	0.985	1.000
83	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	11	CREB1(1), FOS(1), MAPK1(4), MAPK14(1), MAPK8(4), PRKCA(2)	2972328	13	13	10	4	3	1	6	0	3	0	0.599	0.986	1.000
84	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(2), BAD(1), CHUK(3), GH1(1), GHR(4), NFKB1(2), PDPK1(2), PIK3R1(6), RELA(1), YWHAH(1)	5434076	23	21	23	4	2	9	2	6	4	0	0.137	0.987	1.000
85	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	11	AKT1(2), CAT(2), GH1(1), GHR(4), IGF1R(7), PIK3R1(6), SHC1(1), SOD2(1), SOD3(1)	4866227	25	24	25	5	5	7	6	5	2	0	0.161	0.988	1.000
86	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	14	AKT1(2), BCAR1(2), CDKN1B(2), ILK(4), MAPK1(4), PDPK1(2), PIK3R1(6), PTEN(6), PTK2(5), SHC1(1), SOS1(8)	7047668	42	36	39	8	4	7	13	6	12	0	0.143	0.990	1.000
87	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(3), POLR2A(9), POLR2B(2), POLR2D(1), POLR2G(2), POLR2H(1), POLR2L(1), POLRMT(4)	6131663	23	22	23	4	2	5	10	2	4	0	0.131	0.990	1.000
88	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALT5(1), FUT1(1), FUT2(2), FUT9(10), GBGT1(2), GLA(3), HEXA(3), NAGA(3), ST3GAL1(1), ST8SIA1(2)	4897881	28	25	28	6	1	5	13	4	5	0	0.240	0.990	1.000
89	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	AKT1(2), PIK3R1(6), PLCB1(12), PLCG1(5), PRKCA(2), VAV1(2)	4839318	29	27	29	6	3	6	13	5	2	0	0.250	0.991	1.000
90	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	8	CISH(1), IFNG(1), IFNGR1(5), JAK1(6), JAK2(2), PTPRU(6), STAT1(5)	5049247	26	24	25	6	4	7	4	2	9	0	0.168	0.992	1.000
91	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	21	CSNK2A1(6), ELK1(1), FOS(1), IL2RA(2), IL2RB(3), JAK1(6), JAK3(3), LCK(5), MAP2K1(4), MAPK8(4), RAF1(2), SHC1(1), SOS1(8), STAT5A(1), STAT5B(4), SYK(3)	10403288	54	44	54	9	7	9	21	5	12	0	0.0240	0.993	1.000
92	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	8	CISH(1), JAK1(6), JAK2(2), JAK3(3), PIAS3(3), PTPRU(6), SOAT1(3)	6077563	24	23	24	4	4	5	6	3	6	0	0.141	0.993	1.000
93	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(12), FHL5(4), FSHB(1), FSHR(5), GNAS(6), XPO1(3)	4347116	31	29	31	6	8	6	10	7	0	0	0.199	0.993	1.000
94	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	14	CUZD1(3), FOS(1), MAP2K1(4), MAPK1(4), MYC(4), NFKB1(2), PLCB1(12), PRKCA(2), RAF1(2), RELA(1)	6893555	35	35	32	8	8	6	14	4	3	0	0.143	0.993	1.000
95	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	CS(2), MDH1(1), ME1(1), PC(7), PDHA1(3), SLC25A1(1)	4234898	15	15	15	4	3	5	3	3	1	0	0.375	0.995	1.000
96	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(9), ATR(19), CHEK1(1), CHEK2(4), YWHAH(1)	6914301	34	31	34	5	2	8	8	12	4	0	0.155	0.995	1.000
97	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), DAG1(1), ITPKA(1), ITPKB(5)	2748280	8	6	8	2	2	2	2	2	0	0	0.361	0.995	1.000
98	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(3), B4GALNT1(2), GLB1(4), HEXA(3), LCT(8), SLC33A1(1), ST3GAL1(1), ST3GAL5(2), ST6GALNAC3(5), ST6GALNAC5(2), ST6GALNAC6(3), ST8SIA1(2), ST8SIA5(4)	7487856	40	35	40	8	7	10	10	9	4	0	0.0779	0.995	1.000
99	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT2(1), BDH1(1), BDH2(1), HMGCL(1), HMGCS1(2), HMGCS2(2), OXCT1(1), OXCT2(1)	3277286	10	9	10	3	3	1	2	3	1	0	0.569	0.996	1.000
100	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	15	AKT1(2), CREB1(1), MAPK1(4), MAPK7(1), MEF2A(1), MEF2B(2), MEF2C(7), NTRK1(3), PIK3R1(6), PLCG1(5), RPS6KA1(4), SHC1(1)	7426817	37	32	34	6	7	10	9	6	5	0	0.0422	0.996	1.000
101	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), CAMK1G(1), HDAC9(11), MEF2A(1), MEF2B(2), MEF2C(7), YWHAH(1)	3486563	24	22	24	7	3	5	10	3	3	0	0.440	0.996	1.000
102	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(3), KARS(2)	2143652	6	6	6	3	0	1	1	2	2	0	0.863	0.996	1.000
103	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	21	ACTA1(2), ADCY1(12), CAP1(2), CCNB1(3), GNAI1(1), GNAS(6), GNB1(2), MAPK1(4), MYT1(7), PIN1(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RPS6KA1(4), SRC(1)	9140987	53	47	50	9	18	9	15	9	2	0	0.0109	0.997	1.000
104	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(10), GNA12(1), PRKACB(2), PRKACG(1), PRKAR2B(2)	4572101	16	14	16	3	2	9	3	2	0	0	0.127	0.997	1.000
105	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(3), ANKRD1(1), DUSP14(1), EIF4EBP1(1), IFNG(1), IFRD1(2), IL1A(1), IL1R1(2), MYOG(3), NR4A3(2)	4869061	17	15	17	3	2	5	4	5	1	0	0.236	0.997	1.000
106	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(1), FUT2(2), FUT9(10), GBGT1(2), GLA(3), HEXA(3), NAGA(3), ST3GAL1(1), ST3GAL4(1), ST8SIA1(2)	4614870	28	25	28	7	1	6	12	4	5	0	0.318	0.997	1.000
107	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(4), ERBB4(15), NRG2(4), NRG3(8), PRKCA(2)	4087307	33	28	33	9	4	5	13	8	3	0	0.481	0.997	1.000
108	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(5)	2209291	5	4	5	2	1	2	1	1	0	0	0.737	0.998	1.000
109	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(2), CTH(2), GOT1(1), GOT2(3), LDHA(1), LDHB(1), LDHC(3)	3118783	13	13	13	4	4	0	7	2	0	0	0.578	0.998	1.000
110	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(5), FOS(1), IL3(1), IL3RA(3), JAK2(2), MAP2K1(4), PTPN6(1), RAF1(2), SHC1(1), SOS1(8), STAT5A(1), STAT5B(4)	7857773	33	30	33	6	5	10	11	3	4	0	0.0560	0.998	1.000
111	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(7), ACO2(2), AFMID(3), CS(2), HAO1(5), HAO2(2), MDH1(1), MTHFD1(2), MTHFD1L(3), MTHFD2(1)	6097801	28	24	28	5	3	6	9	6	4	0	0.148	0.999	1.000
112	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR1B(1), BMPR2(3)	2852136	4	4	4	1	0	1	2	1	0	0	0.693	0.999	1.000
113	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	10	AKT1(2), NTRK1(3), PIK3R1(6), PLCG1(5), PRKCA(2), SHC1(1), SOS1(8)	5901382	27	24	27	5	3	7	9	5	3	0	0.185	0.999	1.000
114	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	15	CD28(2), CD3D(1), IFNG(1), IL2RA(2), IL4(1), TGFB1(1), TGFB2(2), TGFBR1(1), TGFBR3(3), TOB2(2)	4287563	16	15	16	4	1	5	4	4	2	0	0.446	0.999	1.000
115	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(2), CDO1(1), CSAD(2), GAD1(2), GAD2(2), GGT1(1)	2616298	10	10	10	4	2	3	1	1	3	0	0.701	0.999	1.000
116	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNG(1), IL12A(1), IL12B(4), IL13(1), IL16(11), IL1A(1), IL3(1), IL4(1), IL5(1), IL9(1), LTA(1)	4526342	24	22	24	7	8	6	4	5	1	0	0.290	0.999	1.000
117	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(21), MAP2(13), PRKACB(2), PRKACG(1), PRKAR2B(2), PRKCE(2)	8254538	41	34	41	8	2	6	14	8	11	0	0.373	0.999	1.000
118	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(3), F2(2), F3(1), F5(12), F7(2), FGA(7), FGB(2), FGG(3), PROS1(5), SERPINC1(3)	7476710	40	33	40	8	2	9	16	6	7	0	0.118	0.999	1.000
119	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	12	ARNT(4), ASPH(7), COPS5(1), CREB1(1), EPO(2), HIF1A(2), LDHA(1), NOS3(4), P4HB(1)	5498088	23	23	23	5	8	4	5	3	3	0	0.202	0.999	1.000
120	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	18	AKT1(2), BAD(1), BCL2L1(2), CDC42(1), CHUK(3), ELK1(1), MAP2K1(4), NFKB1(2), PIK3R1(6), RAF1(2), RALBP1(2), RALGDS(6), RELA(1), RHOA(4)	7296671	37	30	34	7	7	9	12	3	6	0	0.114	0.999	1.000
121	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(2), B3GALT1(1), B3GALT2(1), B3GALT5(1), B3GNT5(2), FUT1(1), FUT2(2), ST3GAL3(1), ST3GAL4(1)	3283505	12	11	12	5	2	2	4	0	4	0	0.826	0.999	1.000
122	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(3), AASDHPPT(3), KARS(2)	3161374	9	9	9	4	0	1	2	3	3	0	0.830	0.999	1.000
123	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(2), LDLR(3), MBTPS1(8), MBTPS2(1), SCAP(1), SREBF1(3), SREBF2(4)	5420463	22	20	22	5	2	4	8	5	3	0	0.348	0.999	1.000
124	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(7), ACO2(2), CS(2), HAO1(5), HAO2(2), MDH1(1), MTHFD1(2), MTHFD1L(3), MTHFD2(1)	5821305	25	22	25	5	3	6	8	5	3	0	0.190	0.999	1.000
125	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ5(1), COQ6(1), COQ7(1), NDUFA12(1), NDUFA13(2)	1824339	6	6	6	4	0	2	2	1	1	0	0.934	0.999	1.000
126	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(6)	3846743	7	7	7	2	2	0	2	1	2	0	0.730	1.000	1.000
127	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), FYN(3), HLA-DRA(1), LCK(5), PTPRC(13), ZAP70(2)	4113288	25	21	25	8	2	6	5	7	5	0	0.392	1.000	1.000
128	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	7	CREB1(1), HBXIP(1), PTK2B(2), SHC1(1), SOS1(8), SRC(1)	3823592	14	13	14	4	3	2	5	2	2	0	0.565	1.000	1.000
129	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(3), CDC25B(3), CSK(1), PRKCA(2), PTPRA(4), SRC(1)	4193055	14	13	14	4	4	3	6	1	0	0	0.361	1.000	1.000
130	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(2), BAD(1), BRAF(4), CREB1(1), CREB5(5), DUSP4(1), DUSP6(3), DUSP9(1), EEF2K(4), MAP2K1(4), MAP2K2(3), MAP3K8(1), MAPK1(4), MKNK1(1), MKNK2(1), MOS(5), NFKB1(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), SHC1(1), SOS1(8), SOS2(9), TRAF3(3)	13427113	75	56	71	11	15	15	23	12	10	0	0.00453	1.000	1.000
131	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	11	EGR1(3), MAP2K1(4), MAP2K2(3), MAPK1(4), NGFR(1), RAF1(2)	3514191	17	16	14	6	7	1	4	1	4	0	0.524	1.000	1.000
132	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(2), CSF1(1), LDLR(3), LPL(2)	2422249	8	8	8	4	1	1	4	1	1	0	0.853	1.000	1.000
133	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(1), ANXA3(1), ANXA4(1), ANXA6(4), CYP11A1(2), EDNRB(3), HSD11B2(1), PLA2G4A(3), PRL(3), PTGDR(1), PTGER2(4), PTGER4(2), PTGFR(2), PTGIS(3), PTGS1(6), PTGS2(2), TBXAS1(5)	9389909	44	35	43	8	11	5	11	8	9	0	0.0441	1.000	1.000
134	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	11	FOS(1), IFNAR1(2), IFNAR2(1), MAPK8(4), NFKB1(2), RELA(1), TNFRSF11A(2), TNFSF11(1), TRAF6(1)	4773990	15	15	15	4	3	4	4	3	1	0	0.466	1.000	1.000
135	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(9), CDC25B(3), CDK4(4), CHEK1(1), MYT1(7), RB1(9), WEE1(1), YWHAH(1)	7615917	35	33	35	7	3	6	10	6	10	0	0.341	1.000	1.000
136	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	12	MDM2(2), MYC(4), PIK3R1(6), POLR1A(5), POLR1B(3), POLR1C(2), RB1(9), TBX2(2), TWIST1(1)	7400100	34	31	34	8	4	6	6	5	13	0	0.236	1.000	1.000
137	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	10	CISH(1), IL6R(4), JAK1(6), JAK2(2), JAK3(3), PIAS3(3), PTPRU(6), SRC(1), STAT3(3)	6766295	29	28	28	6	5	5	7	7	5	0	0.160	1.000	1.000
138	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(9), BAD(1), BAX(1), BCL10(1), BCL2(1), BCL2L1(2), BCL2L11(1), BID(2), CASP8AP2(3), CES1(4)	4964296	25	23	25	6	3	8	6	4	4	0	0.362	1.000	1.000
139	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(6), EGFR(14), ERBB3(7), NRG1(1)	4690084	28	25	28	8	4	6	8	7	3	0	0.420	1.000	1.000
140	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	12	CCND1(2), CDK4(4), CDKN1B(2), CFL1(2), E2F2(3), MDM2(2)	2909457	15	13	15	6	1	4	4	4	2	0	0.659	1.000	1.000
141	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(12), CFTR(7), GNAS(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), SLC9A3R1(1)	5944860	34	30	34	8	10	6	12	6	0	0	0.200	1.000	1.000
142	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(4), HS3ST2(2), HS3ST3B1(1), XYLT1(7), XYLT2(3)	3002239	17	17	17	6	3	2	6	3	3	0	0.516	1.000	1.000
143	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(4), HS3ST2(2), HS3ST3B1(1), XYLT1(7), XYLT2(3)	3002239	17	17	17	6	3	2	6	3	3	0	0.516	1.000	1.000
144	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(1), ENO3(1), FARS2(2), GOT1(1), GOT2(3), PAH(4), TAT(1), YARS(3)	3783264	16	13	16	7	1	4	5	3	3	0	0.739	1.000	1.000
145	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT2(3), B4GALT5(2), FUT8(2), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1)	3610573	11	10	11	4	2	2	2	2	3	0	0.692	1.000	1.000
146	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(2), PLCG1(5), PRKCA(2), PTK2B(2)	3053975	11	11	11	4	2	2	5	2	0	0	0.492	1.000	1.000
147	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT3(4), CHPF(4), CHST11(3), CHST12(2), CHST13(3), CHST14(1), CHSY1(2), UST(1), XYLT1(7), XYLT2(3)	6353940	30	29	30	7	6	2	12	6	4	0	0.247	1.000	1.000
148	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD8A(2), CSF1(1), EPO(2), IL3(1), IL4(1), IL5(1), IL9(1)	2773360	9	9	9	7	4	1	2	1	1	0	0.944	1.000	1.000
149	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	20	APAF1(9), BIRC2(1), BIRC3(1), CASP1(2), CASP10(2), CASP3(1), CASP4(1), CASP6(2), CASP7(1), GZMB(1), LMNB1(1), LMNB2(4), PRF1(3)	8262676	29	28	29	6	7	5	7	7	3	0	0.176	1.000	1.000
150	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	23	GH1(1), GHR(4), INSR(2), IRS1(1), JAK2(2), MAP2K1(4), MAPK1(4), PIK3R1(6), PLCG1(5), PRKCA(2), PTPN6(1), RAF1(2), RPS6KA1(4), SHC1(1), SLC2A4(1), SOS1(8), STAT5A(1), STAT5B(4)	13867482	53	46	50	8	10	15	16	6	6	0	0.00498	1.000	1.000
151	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX3(1), FADS2(2), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1)	4623164	12	11	12	4	2	1	4	2	3	0	0.599	1.000	1.000
152	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(2), GNAS(6), GNB1(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2)	4344323	20	17	20	5	8	5	5	2	0	0	0.279	1.000	1.000
153	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CALM3(1), CCL2(2), CXCL12(1), CXCR4(1), FOS(1), MAPK14(1), MAPK8(4), PLCG1(5), PRKCA(2), PTK2B(2), SYT1(5)	6275083	26	22	26	6	3	3	14	5	1	0	0.291	1.000	1.000
154	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACP2(1), ACP5(2), ACPP(1), ACPT(1), ENPP1(5), ENPP3(5), FLAD1(4), TYR(4)	4427430	24	22	24	8	2	4	13	1	4	0	0.734	1.000	1.000
155	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(3), DHRS1(1), DHRS2(3), DHRS7(1), HEMK1(1), LCMT1(1), LCMT2(6), METTL2B(2), METTL6(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2)	6838421	31	29	31	8	8	8	8	4	3	0	0.199	1.000	1.000
156	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(2), ALOX15(1), ALOX15B(2), ALOX5(2), DPEP1(2), GGT1(1), PLA2G6(1), PTGIS(3), PTGS1(6), PTGS2(2), TBXAS1(5)	6863320	27	25	27	6	5	4	9	4	5	0	0.112	1.000	1.000
157	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(3), CDC25B(3), MNAT1(2), XPO1(3)	3932458	11	11	11	4	4	3	2	2	0	0	0.593	1.000	1.000
158	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), CARM1(3), CTH(2), GGT1(1), HEMK1(1), LCMT1(1), LCMT2(6), MARS(2), MARS2(4), MAT1A(1), METTL2B(2), METTL6(2), PAPSS1(3), PAPSS2(3), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2), SEPHS1(1), SEPHS2(3)	11353289	47	39	46	8	12	13	13	5	4	0	0.0179	1.000	1.000
159	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2)	3636958	11	11	11	7	3	1	3	1	3	0	0.921	1.000	1.000
160	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2)	3636958	11	11	11	7	3	1	3	1	3	0	0.921	1.000	1.000
161	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(2), B3GNT1(1), B3GNT2(1), B3GNT3(4), B3GNT5(2), B4GALT2(3), FUT1(1), FUT2(2), FUT5(3), FUT6(1), FUT9(10), GCNT2(4), ST3GAL6(1), ST8SIA1(2)	7367361	37	33	37	9	4	12	14	3	4	0	0.120	1.000	1.000
162	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(3), DNAJC3(1), EIF2S1(1), EIF2S2(2), MAP3K14(2), NFKB1(2), RELA(1)	4100676	12	11	12	5	2	3	2	2	3	0	0.828	1.000	1.000
163	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(3), ALPP(1), ALPPL2(4), DHFR(3), FPGS(2)	2971869	15	13	15	6	2	1	9	2	1	0	0.682	1.000	1.000
164	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	20	AKT1(2), EIF4A1(1), EIF4B(2), EIF4EBP1(1), EIF4G1(14), EIF4G2(2), EIF4G3(4), MKNK1(1), PDPK1(2), PIK3R1(6), PTEN(6), RPS6KB1(3), TSC1(2), TSC2(3)	11622216	49	41	48	8	0	12	19	5	13	0	0.0882	1.000	1.000
165	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(15), GZMA(1), GZMB(1), HMGB2(1), PRF1(3), SET(1)	4837360	22	21	22	7	3	4	8	5	2	0	0.581	1.000	1.000
166	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(15), ASAH1(1), CASP3(1), CERK(2), CREB1(1), CREB5(5), CXCL2(1), DAG1(1), EPHB2(2), FOS(1), ITPKA(1), ITPKB(5), MAP2K4(1), MAPK1(4), MAPK10(3), MAPK8(4), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(5), MAPK9(4)	12987964	62	50	59	10	12	13	20	8	9	0	0.0154	1.000	1.000
167	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	8	HSD17B3(1), HSD17B4(3), HSD3B1(2), HSD3B2(2)	3068995	8	8	8	5	1	3	2	1	1	0	0.859	1.000	1.000
168	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACO1(7), ACO2(2), ACSS1(5), ACSS2(2), FH(2), IDH1(2), MDH1(1), SUCLA2(1)	6056947	22	19	22	6	2	6	7	3	4	0	0.403	1.000	1.000
169	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	23	ADCY1(12), AKT1(2), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CREB1(1), GNAS(6), MAPK1(4), MAPK14(1), PIK3R1(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), RPS6KA1(4), RPS6KA5(4), SOS1(8)	11855351	64	54	61	11	13	15	18	10	8	0	0.0186	1.000	1.000
170	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	19	F2(2), F2RL3(3), GNAI1(1), GNB1(2), ITGA1(3), MAP2K1(4), MAPK1(4), PLA2G4A(3), PLCB1(12), PRKCA(2), PTGS1(6), PTK2(5), RAF1(2), SRC(1), SYK(3), TBXAS1(5)	10124655	58	50	55	12	11	5	22	11	9	0	0.112	1.000	1.000
171	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(3), MAP3K14(2), MAPK14(1), MAPK8(4), NFKB1(2), RELA(1), TNFRSF13B(2), TNFRSF13C(2), TNFSF13(1), TNFSF13B(1), TRAF2(1), TRAF3(3), TRAF5(1), TRAF6(1)	6641117	25	25	24	7	2	5	10	1	7	0	0.598	1.000	1.000
172	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(2), ALDH18A1(2), ARG2(1), CKB(3), CKM(2), CKMT1B(1), CPS1(11), GATM(2), GLUD1(2), NAGS(2), ODC1(1), OTC(1), PYCR1(1), SMS(2)	7984329	33	31	33	7	7	9	10	7	0	0	0.105	1.000	1.000
173	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	GPD2(2), SDHA(5), SDHC(1), UQCRC1(1)	3015547	9	8	9	4	0	1	4	3	1	0	0.794	1.000	1.000
174	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	20	ADCY1(12), AKT1(2), ASAH1(1), GNAI1(1), GNB1(2), ITGAV(2), ITGB3(5), MAPK1(4), PDGFRA(6), PIK3R1(6), PLCB1(12), PRKCA(2), PTK2(5), SMPD1(1), SMPD2(1), SRC(1)	11310688	63	59	60	13	12	10	23	9	9	0	0.0610	1.000	1.000
175	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(9), CDC25B(3), CHEK1(1), MYT1(7), WEE1(1), YWHAH(1)	6259861	22	21	22	5	3	2	9	6	2	0	0.549	1.000	1.000
176	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	12	ACTR2(1), ARPC1B(1), ARPC2(2), ARPC4(1), CDC42(1), PAK1(1), PDGFRA(6), PIK3R1(6), WASL(1)	4903636	20	20	20	8	2	4	5	5	4	0	0.838	1.000	1.000
177	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(4), CYP2A13(2), CYP2A7(2), NAT1(1), XDH(3)	3638553	12	11	12	5	1	2	4	3	2	0	0.753	1.000	1.000
178	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	15	KLRC2(1), KLRC3(2), KLRC4(1), LAT(3), MAP2K1(4), PAK1(1), PIK3R1(6), PTK2B(2), PTPN6(1), SYK(3), VAV1(2)	6042192	26	22	26	7	5	1	6	7	7	0	0.559	1.000	1.000
179	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(4), ADSS(2), DHFR(3), HPRT1(1), IMPDH1(3), MTHFD2(1), OAZ1(1), POLB(1), POLD1(3), POLG(2), PRPS2(1), RRM1(1)	5688117	23	21	23	6	5	3	12	0	3	0	0.292	1.000	1.000
180	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(2), CSF1(1), IL1B(1), MST1(5), MST1R(5)	2968399	14	13	13	6	3	3	7	0	1	0	0.706	1.000	1.000
181	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(2), HADHA(3), HADHB(2), HSD17B4(3), PPT1(1), PPT2(1)	3860702	13	13	13	5	0	2	3	6	2	0	0.728	1.000	1.000
182	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(1), EIF2AK4(6), EIF2B5(2), EIF2S1(1), EIF2S2(2), EIF5(2), GSK3B(1)	5274480	15	14	15	8	3	3	5	0	4	0	0.953	1.000	1.000
183	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	11	APC(15), CDH1(4), CREBBP(15), MAP2K1(4), MAP3K7(4), SKIL(4), TGFB1(1), TGFB2(2), TGFBR1(1)	8909934	50	42	50	11	6	8	21	8	7	0	0.339	1.000	1.000
184	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	CKM(2), LDHA(1), LDHB(1), LDHC(3), MAPK14(1), NCL(3)	4092084	11	11	11	6	2	0	4	3	2	0	0.935	1.000	1.000
185	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CALM3(1), CAMK1(1), CAMK1G(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CAMKK1(1), CAMKK2(5), CREB1(1), SYT1(5)	5260732	22	22	22	7	3	4	7	5	3	0	0.605	1.000	1.000
186	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BRAF(4), CREB1(1), CREB5(5), MAPK1(4), RAF1(2), SRC(1)	5080555	18	15	15	5	4	2	8	1	3	0	0.563	1.000	1.000
187	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(1), CALM3(1), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), PLCG1(5), PRKCA(2), SP1(1), SP3(1), SYT1(5)	9559825	37	32	37	8	10	7	10	7	3	0	0.0781	1.000	1.000
188	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(1), IL13RA2(1), IL4R(2), JAK1(6), JAK2(2), TYK2(2)	4776708	15	14	15	6	3	4	4	1	3	0	0.694	1.000	1.000
189	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(1), IL13RA2(1), IL4R(2), JAK1(6), JAK2(2), TYK2(2)	4776708	15	14	15	6	3	4	4	1	3	0	0.694	1.000	1.000
190	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(6), JAK2(2), JAK3(3), MAPK1(4), STAT3(3), TYK2(2)	5322868	20	18	16	7	4	3	4	5	4	0	0.637	1.000	1.000
191	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(3), KHK(2), LCT(8), MPI(3), PGM1(3), PYGL(4), PYGM(3), TPI1(2)	6059784	28	26	28	9	7	5	6	5	5	0	0.411	1.000	1.000
192	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), MIOX(2), UGDH(3)	3873966	12	12	12	6	3	1	3	3	2	0	0.824	1.000	1.000
193	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), EPO(2), FLT3(4), IL1A(1), IL3(1), IL9(1), TGFB1(1), TGFB2(2)	3766855	13	11	13	6	4	1	5	2	1	0	0.767	1.000	1.000
194	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(2), FARSB(4), GOT1(1), GOT2(3), PAH(4), TAT(1), YARS(3), YARS2(3)	3964861	21	19	21	7	2	7	7	4	1	0	0.423	1.000	1.000
195	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK1(3), HK2(5), HK3(4), IMPA1(1), PGM1(3), PGM3(1), TGDS(2)	4651478	21	20	21	7	4	4	7	3	3	0	0.574	1.000	1.000
196	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(2), CS(2), FH(2), MDH1(1), OGDH(6), SDHA(5), SUCLA2(1)	4286283	19	18	19	7	1	2	10	4	2	0	0.812	1.000	1.000
197	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), IL10RA(3), IL10RB(1), IL1A(1), JAK1(6), STAT1(5), STAT3(3), STAT5A(1)	5548120	22	20	21	8	1	7	6	4	4	0	0.463	1.000	1.000
198	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(2), EHHADH(2), HADHA(3), HSD17B4(3), SIRT1(1), SIRT5(1), VNN2(1)	5399408	13	13	13	7	0	3	3	4	3	0	0.938	1.000	1.000
199	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), CTH(2), GGT1(1), MARS(2), MARS2(4), MAT1A(1), PAPSS1(3), PAPSS2(3), SEPHS1(1)	5637988	18	17	17	5	4	5	5	3	1	0	0.366	1.000	1.000
200	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	CSNK2A1(6), ELK1(1), FOS(1), JAK1(6), MAP2K1(4), MAP2K4(1), MAP3K1(3), MAPK8(4), PDGFRA(6), PIK3R1(6), PLCG1(5), PRKCA(2), RAF1(2), SHC1(1), SOS1(8), STAT1(5), STAT3(3), STAT5A(1)	13760303	65	54	64	12	8	9	24	8	16	0	0.0666	1.000	1.000
201	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), ECHS1(2), EHHADH(2), HADHA(3)	5540691	18	17	18	7	3	2	4	4	5	0	0.718	1.000	1.000
202	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	19	CSNK2A1(6), FOS(1), JAK2(2), MAP2K1(4), MPL(2), PIK3R1(6), PLCG1(5), PRKCA(2), RAF1(2), SHC1(1), SOS1(8), STAT1(5), STAT3(3), STAT5A(1), STAT5B(4)	11519570	52	46	51	10	6	11	18	6	11	0	0.0658	1.000	1.000
203	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(3), UBE2D2(1), UBE2E1(1), UBE2J1(1), UBE2J2(1), UBE2L3(1), UBE2L6(1), UBE3A(4)	4805613	14	14	14	6	2	5	5	0	2	0	0.778	1.000	1.000
204	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GALNS(1), GLB1(4), GNS(1), GUSB(1), HEXA(3), IDS(3), IDUA(3), LCT(8), NAGLU(1)	6522401	26	25	26	8	5	6	7	7	1	0	0.431	1.000	1.000
205	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(3), ARFGAP3(2), ARFGEF2(5), CLTA(1), COPA(7), GBF1(6), GPLD1(3)	7390021	27	25	27	7	5	7	9	3	3	0	0.278	1.000	1.000
206	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(2), APAF1(9), BCL2(1), CASP3(1), FAS(1), FASLG(2), IL1A(1), MAPKAPK3(2)	5153734	19	18	19	6	3	5	4	5	2	0	0.507	1.000	1.000
207	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(1), CLOCK(4), CRY1(3), CRY2(1), CSNK1E(3), PER1(5)	3886607	17	17	17	7	3	3	6	4	1	0	0.735	1.000	1.000
208	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), IL4(1), IL4R(2), IRS1(1), JAK1(6), JAK3(3), RPS6KB1(3), SHC1(1), STAT6(2)	6720228	21	20	21	5	4	6	6	3	2	0	0.226	1.000	1.000
209	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	19	AKT1(2), CCND1(2), CCNE1(3), CDK4(4), CDK6(1), CDKN1B(2), MAPK1(4), NFKB1(2), PAK1(1), PIK3R1(6), RAF1(2), RB1(9), RELA(1), TFDP1(3)	7828394	42	40	39	10	6	9	5	7	15	0	0.158	1.000	1.000
210	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(2), AGPAT2(1), AGPAT3(1), AGPAT4(2), AGPS(4), CHPT1(1), ENPP2(6), ENPP6(3), PAFAH2(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLD1(7), PLD2(1), PPAP2B(1)	10583122	39	36	39	9	4	10	11	8	6	0	0.157	1.000	1.000
211	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	14	BCL2(1), CREBBP(15), FYN(3), IL7R(3), JAK1(6), JAK3(3), LCK(5), NMI(5), PIK3R1(6), PTK2B(2), STAT5A(1), STAT5B(4)	9477350	54	43	54	12	3	14	15	13	9	0	0.0773	1.000	1.000
212	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2)	6029403	22	19	22	9	3	7	4	4	4	0	0.715	1.000	1.000
213	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(2), CDO1(1), CTH(2), GOT1(1), GOT2(3), LDHA(1), LDHAL6B(4), LDHB(1), LDHC(3), SULT1B1(2), SULT1C2(2), SULT4A1(1)	5707741	23	21	23	8	5	3	9	3	3	0	0.595	1.000	1.000
214	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(6), EGFR(14), MAP2K1(4), MAP3K1(3), MAPK14(1), NCOR2(11), RARA(2), RXRA(4), THRA(4), THRB(1)	7874705	50	45	50	12	8	8	18	9	7	0	0.152	1.000	1.000
215	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(3), CAPNS1(1), CAPNS2(2), CSNK1A1(1), GSK3B(1), MAPT(6)	4192884	14	13	14	5	2	3	7	1	1	0	0.620	1.000	1.000
216	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(3), ALOX15(1), ALOX5(2), CYP1A2(4), CYP2C18(1), CYP2C19(3), CYP2C8(3), CYP2C9(5), CYP2E1(5), CYP2J2(4), CYP3A4(3), CYP3A43(1), CYP3A5(1), CYP3A7(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), RDH11(1), RDH12(3)	10897024	50	42	50	10	7	9	22	7	5	0	0.0534	1.000	1.000
217	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	35	BTK(5), CALM1(1), CALM3(1), ELK1(1), FCER1A(2), FOS(1), LYN(3), MAP2K1(4), MAP2K4(1), MAP3K1(3), MAPK1(4), MAPK8(4), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), PAK2(5), PIK3R1(6), PLA2G4A(3), PLCG1(5), RAF1(2), SHC1(1), SOS1(8), SYK(3), SYT1(5), VAV1(2)	18404402	91	70	88	17	19	15	28	15	14	0	0.0219	1.000	1.000
218	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(3), IKBKB(5), MAP3K1(3), MAP3K14(2), NFKB1(2), RELA(1), TNFAIP3(3), TRAF3(3), TRAF6(1)	8277422	23	22	23	9	3	5	5	4	6	0	0.699	1.000	1.000
219	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1)	6849510	23	21	23	9	4	5	7	3	4	0	0.721	1.000	1.000
220	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1)	6849510	23	21	23	9	4	5	7	3	4	0	0.721	1.000	1.000
221	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1)	6849510	23	21	23	9	4	5	7	3	4	0	0.721	1.000	1.000
222	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX3(1), ELOVL5(1), ELOVL6(1), FADS2(2), FASN(4), HADHA(3), HSD17B12(1), SCD(1)	6543336	14	13	14	6	1	2	5	2	4	0	0.823	1.000	1.000
223	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(1), GOSR1(3), SEC22B(1), SNAP25(1), STX11(3), STX17(1), STX18(2), STX19(1), STX4(4), STX5(1), STX7(2), STX8(2), TSNARE1(1), USE1(1), VAMP1(1), VAMP5(1)	7593036	26	25	26	7	4	7	8	2	5	0	0.302	1.000	1.000
224	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	CSNK2A1(6), EGF(6), EGFR(14), ELK1(1), FOS(1), JAK1(6), MAP2K1(4), MAP2K4(1), MAP3K1(3), MAPK8(4), PIK3R1(6), PLCG1(5), PRKCA(2), RAF1(2), SHC1(1), SOS1(8), STAT1(5), STAT3(3), STAT5A(1)	14926918	79	65	78	16	9	13	27	13	17	0	0.0599	1.000	1.000
225	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ATM(9), ATR(19), CCNA1(4), CCND1(2), CCNE1(3), CDK4(4), CDK6(1), CDKN1B(2), DHFR(3), GSK3B(1), RB1(9), SKP2(2), TFDP1(3), TGFB1(1), TGFB2(2)	13105421	65	57	65	14	5	14	15	15	16	0	0.132	1.000	1.000
226	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(3), ALDOC(1), FBP2(1), G6PD(2), GPI(2), PFKL(4), PFKM(2), PFKP(4), PGD(2), PGM1(3), PGM3(1), PRPS1(3), PRPS1L1(4), PRPS2(1), RBKS(2), RPE(1), RPIA(1), TKT(1), TKTL1(3), TKTL2(7)	11046189	49	46	49	12	7	5	18	12	7	0	0.288	1.000	1.000
227	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT2(3), FBP2(1), G6PC(2), GAA(3), GALK2(1), GALT(1), GANAB(1), GCK(2), GLA(3), GLB1(4), HK1(3), HK2(5), HK3(4), LALBA(1), LCT(8), MGAM(18), PFKM(2), PFKP(4), PGM1(3), PGM3(1)	14813090	72	62	72	15	13	17	21	10	11	0	0.0249	1.000	1.000
228	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	27	EGFR(14), ELK1(1), GNAS(6), GNB1(2), IGF1R(7), MAP2K1(4), MAP2K2(3), MAPK1(4), MKNK1(1), MKNK2(1), MYC(4), NGFR(1), PDGFRA(6), PTPRR(4), RAF1(2), RPS6KA1(4), RPS6KA5(4), SHC1(1), SOS1(8), SRC(1), STAT3(3)	14045836	81	64	77	17	18	11	29	14	9	0	0.0572	1.000	1.000
229	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDFT1(3), FDPS(2), HMGCR(3), IDI1(1), LSS(3), PMVK(1)	5046464	14	12	14	9	5	5	2	1	1	0	0.871	1.000	1.000
230	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(12), AKT1(2), BAD(1), BAX(1), BCL2(1), BCL2L1(2), CSF2RB(5), IGF1R(7), IL3(1), IL3RA(3), KIT(5), PIK3R1(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), YWHAH(1)	8998052	55	46	55	14	10	15	14	11	5	0	0.108	1.000	1.000
231	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	33	ADCY1(12), CALM1(1), CALM3(1), CREB1(1), ELK1(1), FOS(1), GNAI1(1), GNAS(6), GNB1(2), MAP2K1(4), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), PLCG1(5), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), RAF1(2), RPS6KA3(3), SYT1(5)	15670785	76	58	76	14	22	14	23	12	5	0	0.00682	1.000	1.000
232	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(2), AKR1B10(3), B4GALT2(3), G6PC(2), G6PC2(3), GAA(3), GALK2(1), GALT(1), GANC(3), GCK(2), GLA(3), GLB1(4), HK1(3), HK2(5), HK3(4), LALBA(1), LCT(8), MGAM(18), PFKL(4), PFKM(2), PFKP(4), PGM1(3), PGM3(1), RDH11(1), RDH12(3), UGP2(1)	17569991	88	72	88	18	16	18	29	13	12	0	0.0155	1.000	1.000
233	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(4), PSMA2(1), PSMA6(1), PSMB2(1), PSMB4(2), PSMB5(2), PSMB6(1), PSMB7(1), PSMC2(4), PSMC3(1), PSMD1(1), PSMD11(1), PSMD2(3)	7279642	23	23	23	8	2	3	11	4	3	0	0.779	1.000	1.000
234	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCR1(1), CCR2(2), CCR3(3), CCR4(1), CCR7(1), CD28(2), CXCR3(1), CXCR4(1), IFNG(1), IFNGR1(5), IFNGR2(2), IL12A(1), IL12B(4), IL12RB1(3), IL12RB2(7), IL18R1(2), IL4(1), IL4R(2), IL5(1), TGFB1(1), TGFB2(2)	9102244	45	38	44	12	7	9	12	8	9	0	0.168	1.000	1.000
235	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(4), EPO(2), HIF1A(2), JAK2(2), NFKB1(2), RELA(1), SOD2(1)	5790559	14	14	14	6	2	5	3	3	1	0	0.672	1.000	1.000
236	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(6), AGT(2), AGTR2(2), EDNRB(3), EGF(6), EGFR(14), FOS(1), MYC(4), NFKB1(2), PLCG1(5), PRKCA(2), RELA(1)	9172461	48	44	48	13	5	10	19	10	4	0	0.213	1.000	1.000
237	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	31	ACTA1(2), CRK(1), CRKL(1), DOCK1(8), ELK1(1), FOS(1), GAB1(2), HGF(8), ITGA1(3), MAP2K1(4), MAP2K2(3), MAP4K1(2), MAPK1(4), MAPK8(4), MET(1), PAK1(1), PIK3R1(6), PTEN(6), PTK2(5), PTK2B(2), PTPN11(1), PXN(1), RAF1(2), RAP1B(2), SOS1(8), SRC(1), STAT3(3)	17162334	83	67	78	19	12	10	29	18	14	0	0.169	1.000	1.000
238	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	20	AKT1(2), BCL2(1), BCR(1), CRKL(1), FOS(1), JAK2(2), MAP2K1(4), MAP2K4(1), MAP3K1(3), MAPK8(4), MYC(4), PIK3R1(6), RAF1(2), SOS1(8), STAT1(5), STAT5A(1), STAT5B(4)	11628028	50	44	50	12	5	13	18	5	9	0	0.170	1.000	1.000
239	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	38	CALM1(1), CALM3(1), CD3D(1), ELK1(1), FOS(1), FYN(3), LAT(3), LCK(5), MAP2K1(4), MAP2K4(1), MAP3K1(3), MAPK8(4), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NFKB1(2), PIK3R1(6), PLCG1(5), PRKCA(2), PTPN7(2), RAF1(2), RELA(1), SHC1(1), SOS1(8), SYT1(5), VAV1(2), ZAP70(2)	19486584	87	66	87	16	17	16	28	14	12	0	0.0130	1.000	1.000
240	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), FOS(1), OPRK1(2), POLR2A(9), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2)	5865799	21	19	21	9	2	7	9	2	1	0	0.729	1.000	1.000
241	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3D(1), CXCR3(1), ETV5(3), IFNG(1), IL12A(1), IL12B(4), IL12RB1(3), IL12RB2(7), IL18R1(2), JAK2(2), MAP2K6(1), MAPK14(1), MAPK8(4), STAT4(3), TYK2(2)	8497800	36	32	36	10	2	9	14	5	6	0	0.438	1.000	1.000
242	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(2), ATF1(2), CDC42(1), CREB1(1), CREB5(5), DUSP10(2), EEF2K(4), ELK1(1), IL1R1(2), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAP3K10(4), MAP3K4(5), MAP3K5(5), MAP3K7(4), MAPK1(4), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPKAPK5(1), MKNK1(1), MKNK2(1), MYEF2(3), NFKB1(2), NR2C2(1), TRAF6(1)	15189407	64	53	61	14	11	14	17	13	9	0	0.0695	1.000	1.000
243	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(4), CCNB1(3), CCND1(2), CCNE1(3), CDK4(4), CDK6(1), CDKN1B(2), RB1(9), RBL1(8), TFDP1(3)	7042429	39	37	39	11	3	8	8	7	13	0	0.356	1.000	1.000
244	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(4), CA1(1), CA12(1), CA14(2), CA2(1), CA3(3), CA4(4), CA5A(1), CA5B(1), CA6(3), CA8(3), CPS1(11), CTH(2), GLS(1), GLS2(1), GLUD1(2), GLUL(2), HAL(2)	8653411	45	40	45	12	8	13	10	12	2	0	0.236	1.000	1.000
245	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	AKT1(2), AP2A1(2), AP2M1(3), BAD(1), BTK(5), EEA1(8), GSK3B(1), LYN(3), PDPK1(2), PFKL(4), PFKM(2), PFKP(4), PLCG1(5), PRKCE(2), PRKCZ(3), RAB5A(2), RPS6KB1(3), VAV2(1)	11198108	53	44	53	13	4	15	20	7	7	0	0.134	1.000	1.000
246	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), CTH(2), DNMT1(4), DNMT3A(8), DNMT3B(5), MARS(2), MARS2(4), MAT1A(1), MTAP(3), MTFMT(3), MTR(4), TAT(1)	9453517	38	31	37	10	7	9	14	5	3	0	0.173	1.000	1.000
247	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	AKT1(2), CREB1(1), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K6(1), MAP3K1(3), MAPK1(4), MAPK14(1), NFKB1(2), PIK3R1(6), RB1(9), RELA(1), SP1(1)	7841103	41	38	38	11	8	6	8	5	14	0	0.502	1.000	1.000
248	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	21	AKT1(2), EIF4A1(1), EIF4EBP1(1), EIF4G1(14), EIF4G2(2), EIF4G3(4), GHR(4), IRS1(1), MAPK1(4), MAPK14(1), MKNK1(1), PDPK1(2), PIK3R1(6), PRKCA(2), PTEN(6), RPS6KB1(3)	11857455	54	44	50	11	3	15	17	7	12	0	0.135	1.000	1.000
249	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	32	AKT1(2), BAD(1), BCL2(1), BCL2L1(2), CBL(2), CFLAR(2), CRKL(1), FOS(1), IL2RA(2), IL2RB(3), IRS1(1), JAK1(6), JAK3(3), MAPK1(4), MYC(4), NMI(5), PIK3R1(6), PTPN6(1), RAF1(2), RPS6KB1(3), SHC1(1), SOS1(8), STAT5A(1), STAT5B(4), SYK(3)	15257870	69	59	66	15	12	18	20	10	9	0	0.0260	1.000	1.000
250	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(3), ALDOC(1), FBP2(1), G6PD(2), GPI(2), PFKM(2), PFKP(4), PGD(2), PGM1(3), PGM3(1), PRPS1(3), PRPS1L1(4), PRPS2(1), RBKS(2), RPE(1), RPIA(1), TAL1(2), TKT(1)	9302962	37	37	37	11	6	4	13	9	5	0	0.440	1.000	1.000
251	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(12), GNAS(6), GNB1(2), PRKAA1(3), PRKAA2(2), PRKAB1(3), PRKACB(2), PRKACG(1), PRKAG2(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2)	6953378	38	33	38	11	11	6	12	7	2	0	0.411	1.000	1.000
252	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	ALOX12(2), ALOX12B(4), ALOX15(1), ALOX15B(2), ALOX5(2), CBR3(1), CYP2B6(3), CYP2C18(1), CYP2C19(3), CYP2C8(3), CYP2C9(5), CYP2E1(5), CYP2J2(4), CYP2U1(1), CYP4A11(8), CYP4A22(6), CYP4F2(3), CYP4F3(1), DHRS4(2), EPHX2(4), GGT1(1), GPX2(2), GPX4(2), GPX5(1), GPX6(1), GPX7(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PTGES2(1), PTGIS(3), PTGS1(6), PTGS2(2), TBXAS1(5)	17719710	95	75	95	21	13	22	31	15	14	0	0.0175	1.000	1.000
253	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	18	AKT1(2), EIF2B5(2), EIF2S1(1), EIF2S2(2), EIF4EBP1(1), GSK3B(1), IGF1R(7), INPPL1(4), PDPK1(2), PIK3R1(6), PTEN(6), RPS6KB1(3)	7996833	37	32	36	10	6	8	11	4	8	0	0.346	1.000	1.000
254	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(9), BCL2(1), BID(2), BIRC2(1), BIRC3(1), CASP10(2), CASP3(1), CASP6(2), CASP7(1), CFLAR(2), CHUK(3), FADD(1), GAS2(1), MAP3K14(2), NFKB1(2), RELA(1), RIPK1(2), SPTAN1(11), TNFRSF10A(1), TNFRSF10B(1), TNFRSF25(2), TRAF2(1)	14699598	50	43	50	10	12	11	13	7	7	0	0.0472	1.000	1.000
255	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	32	BLNK(3), BTK(5), CALM1(1), CALM3(1), ELK1(1), FOS(1), LYN(3), MAP2K1(4), MAP3K1(3), MAPK14(1), MAPK8(4), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), PLCG1(5), PRKCA(2), RAF1(2), SHC1(1), SOS1(8), SYK(3), SYT1(5), VAV1(2)	17035931	76	61	76	18	15	12	27	12	10	0	0.115	1.000	1.000
256	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	16	CBL(2), EGF(6), EGFR(14), MAP2K1(4), MAPK1(4), PTPRB(11), RAF1(2), SHC1(1), SOS1(8), SPRY1(1), SPRY2(2), SPRY3(1), SPRY4(1), SRC(1)	10244571	58	52	55	16	9	11	20	11	7	0	0.301	1.000	1.000
257	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(12), CD3D(1), CREBBP(15), CSK(1), GNAS(6), GNB1(2), HLA-DRA(1), LCK(5), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PTPRC(13), ZAP70(2)	10440262	66	50	66	19	12	16	19	12	7	0	0.199	1.000	1.000
258	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(12), CD3D(1), CREBBP(15), CSK(1), GNAS(6), GNB1(2), HLA-DRA(1), LCK(5), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PTPRC(13), ZAP70(2)	10440262	66	50	66	19	12	16	19	12	7	0	0.199	1.000	1.000
259	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(9), ATR(19), BRCA1(9), BRCA2(11), CHEK1(1), CHEK2(4), FANCA(4), FANCC(2), FANCD2(3), FANCG(2), HUS1(2), MRE11A(1), RAD17(3), RAD50(5), RAD51(1), TREX1(2)	19690872	78	67	78	15	6	23	17	21	11	0	0.0781	1.000	1.000
260	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(3), GABBR1(2), GPRC5B(2), GPRC5C(2), GRM1(16), GRM2(4), GRM3(14), GRM4(2), GRM5(7), GRM7(8), GRM8(12)	9519867	72	59	72	23	16	15	26	13	2	0	0.123	1.000	1.000
261	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	11	ADAM17(4), APC(15), AXIN1(5), BTRC(1), CTNNB1(2), DLL1(4), DVL1(2), FZD1(3), GSK3B(1), WNT1(1)	7914816	38	28	38	11	5	10	11	7	4	1	0.409	1.000	1.000
262	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	188	ACTB(2), ACTG1(2), ACTN1(2), ACTN2(6), ACTN3(6), ACTN4(3), AKT1(2), AKT2(3), AKT3(4), ARHGAP5(6), BAD(1), BCAR1(2), BCL2(1), BIRC2(1), BIRC3(1), BRAF(4), CAPN2(4), CCND1(2), CDC42(1), CHAD(3), COL11A1(38), COL11A2(6), COL1A1(6), COL1A2(13), COL2A1(4), COL3A1(12), COL4A1(6), COL4A2(4), COL4A4(10), COL4A6(2), COL5A1(9), COL5A2(11), COL5A3(6), COL6A1(5), COL6A2(6), COL6A3(13), COL6A6(17), CRK(1), CRKL(1), CTNNB1(2), DIAPH1(6), DOCK1(8), EGF(6), EGFR(14), ELK1(1), ERBB2(8), FARP2(1), FLNA(8), FLNB(4), FLNC(7), FLT1(10), FN1(14), FYN(3), GRLF1(12), GSK3B(1), HGF(8), IBSP(1), IGF1R(7), ILK(4), ITGA1(3), ITGA10(5), ITGA11(5), ITGA2(4), ITGA2B(3), ITGA3(3), ITGA4(6), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(12), ITGA9(1), ITGAV(2), ITGB3(5), ITGB4(3), ITGB5(1), ITGB6(4), ITGB7(1), ITGB8(3), KDR(5), LAMA1(22), LAMA2(32), LAMA3(8), LAMA4(18), LAMA5(9), LAMB1(5), LAMB3(2), LAMB4(11), LAMC1(6), LAMC2(4), LAMC3(5), MAP2K1(4), MAPK1(4), MAPK10(3), MAPK8(4), MAPK9(4), MET(1), MYL7(1), MYL9(2), MYLK(4), MYLK2(2), MYLPF(2), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PARVG(2), PDGFC(1), PDGFD(4), PDGFRA(6), PDGFRB(6), PDPK1(2), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PIP5K1C(2), PPP1R12A(3), PRKCA(2), PRKCG(7), PTEN(6), PTK2(5), PXN(1), RAC2(1), RAC3(2), RAF1(2), RAP1B(2), RAPGEF1(2), RELN(37), RHOA(4), ROCK1(11), ROCK2(6), SHC1(1), SHC2(3), SHC3(3), SHC4(3), SOS1(8), SOS2(9), SPP1(1), SRC(1), THBS1(7), THBS2(7), THBS4(5), TLN1(13), TLN2(7), TNC(8), TNN(15), TNR(7), TNXB(10), VASP(1), VAV1(2), VAV2(1), VAV3(1), VCL(6), VEGFC(3), VTN(2), VWF(6), ZYX(2)	167019727	876	252	866	270	116	192	303	146	117	2	0.0710	1.000	1.000
263	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	242	ACVR1B(4), ACVR1C(3), AKT1(2), AKT2(3), AKT3(4), ARRB1(2), ARRB2(1), ATF2(1), ATF4(1), BDNF(2), BRAF(4), CACNA1A(7), CACNA1B(4), CACNA1C(11), CACNA1D(15), CACNA1E(17), CACNA1F(6), CACNA1G(12), CACNA1H(6), CACNA1I(7), CACNA1S(11), CACNA2D1(12), CACNA2D3(2), CACNA2D4(3), CACNB1(5), CACNB2(4), CACNB3(2), CACNB4(1), CACNG1(1), CACNG2(2), CACNG4(2), CACNG5(3), CACNG6(4), CACNG7(1), CACNG8(4), CASP3(1), CD14(1), CDC25B(3), CDC42(1), CHUK(3), CRK(1), CRKL(1), DUSP10(2), DUSP14(1), DUSP16(2), DUSP2(1), DUSP3(1), DUSP4(1), DUSP5(3), DUSP6(3), DUSP7(1), DUSP9(1), ECSIT(1), EGF(6), EGFR(14), ELK1(1), ELK4(3), FAS(1), FASLG(2), FGF1(2), FGF10(2), FGF12(2), FGF13(2), FGF17(1), FGF19(2), FGF2(1), FGF20(1), FGF21(1), FGF23(4), FGF5(3), FGF6(1), FGF7(1), FGF8(1), FGFR1(1), FGFR2(2), FGFR3(6), FGFR4(3), FLNA(8), FLNB(4), FLNC(7), FOS(1), GADD45G(1), GNA12(1), GNG12(1), IKBKB(5), IL1A(1), IL1B(1), IL1R1(2), IL1R2(1), KRAS(1), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K4(1), MAP2K5(2), MAP2K6(1), MAP3K1(3), MAP3K10(4), MAP3K12(6), MAP3K13(8), MAP3K14(2), MAP3K3(1), MAP3K4(5), MAP3K5(5), MAP3K6(3), MAP3K7(4), MAP3K8(1), MAP4K1(2), MAP4K2(1), MAP4K3(5), MAP4K4(2), MAPK1(4), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK7(1), MAPK8(4), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(5), MAPK9(4), MAPKAPK3(2), MAPKAPK5(1), MAPT(6), MAX(1), MEF2C(7), MKNK1(1), MKNK2(1), MOS(5), MYC(4), NF1(10), NFATC2(6), NFATC4(2), NFKB1(2), NFKB2(1), NLK(1), NRAS(1), NTF3(1), NTRK1(3), NTRK2(1), PAK1(1), PAK2(5), PDGFRA(6), PDGFRB(6), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PPM1A(3), PPP5C(1), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCG(7), PRKX(1), PTPN7(2), PTPRR(4), RAC2(1), RAC3(2), RAF1(2), RAP1B(2), RAPGEF2(2), RASA2(6), RASGRF1(9), RASGRF2(5), RASGRP1(5), RASGRP2(3), RASGRP3(3), RASGRP4(3), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA4(3), RPS6KA5(4), RPS6KA6(4), RRAS2(1), SOS1(8), SOS2(9), STK3(1), TAOK1(4), TAOK2(9), TAOK3(2), TGFB1(1), TGFB2(2), TGFBR1(1), TRAF2(1), TRAF6(1), ZAK(2)	127638576	610	238	604	198	114	126	191	102	77	0	0.0749	1.000	1.000
264	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	166	ADCY1(12), ADCY3(6), ADCY4(5), ADCY7(2), ADCY8(13), ADCY9(4), ADORA2A(1), ADRA1A(4), ADRA1B(1), ADRB1(1), ADRB3(2), ATP2A1(2), ATP2A2(4), ATP2A3(3), ATP2B1(3), ATP2B2(2), ATP2B3(8), ATP2B4(4), AVPR1A(5), AVPR1B(4), BDKRB1(1), BST1(2), CACNA1A(7), CACNA1B(4), CACNA1C(11), CACNA1D(15), CACNA1E(17), CACNA1F(6), CACNA1G(12), CACNA1H(6), CACNA1I(7), CACNA1S(11), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CCKAR(4), CCKBR(3), CD38(2), CHRM2(4), CHRM3(5), CHRM5(1), CHRNA7(1), CYSLTR1(1), CYSLTR2(2), DRD1(1), EDNRB(3), EGFR(14), ERBB2(8), ERBB3(7), ERBB4(15), GNA15(2), GNAL(2), GNAS(6), GRIN2A(14), GRIN2C(4), GRIN2D(3), GRM1(16), GRM5(7), GRPR(1), HRH1(1), HRH2(1), HTR2A(3), HTR2B(1), HTR2C(1), HTR4(1), HTR5A(3), HTR6(2), HTR7(3), ITPKA(1), ITPKB(5), ITPR1(9), ITPR2(11), ITPR3(5), LHCGR(2), LTB4R2(1), MYLK(4), MYLK2(2), NOS1(3), NOS3(4), NTSR1(2), OXTR(2), P2RX1(4), P2RX2(1), P2RX3(1), PDE1A(3), PDE1B(2), PDE1C(9), PDGFRA(6), PDGFRB(6), PHKA1(1), PHKA2(9), PHKB(2), PHKG2(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PLCD1(2), PLCD4(2), PLCE1(12), PLCG1(5), PLCG2(4), PLCZ1(3), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCG(7), PRKX(1), PTGER3(2), PTGFR(2), PTK2B(2), RYR1(16), RYR2(44), RYR3(23), SLC25A6(1), SLC8A1(8), SLC8A2(4), SLC8A3(10), SPHK2(1), TACR1(2), TACR2(2), TACR3(5), TBXA2R(1), TRHR(4), TRPC1(4)	120884599	637	234	635	233	131	137	204	106	58	1	0.162	1.000	1.000
265	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	199	ABI2(2), ACTN1(2), ACTN2(6), ACTN3(6), ACTN4(3), APC(15), APC2(3), ARHGEF1(5), ARHGEF12(8), ARHGEF4(2), ARHGEF6(3), ARHGEF7(1), ARPC1B(1), ARPC2(2), ARPC4(1), BCAR1(2), BDKRB1(1), BRAF(4), C3orf10(1), CD14(1), CDC42(1), CFL1(2), CHRM2(4), CHRM3(5), CHRM5(1), CRK(1), CRKL(1), CSK(1), CYFIP1(5), CYFIP2(5), DIAPH1(6), DIAPH2(6), DIAPH3(9), DOCK1(8), EGF(6), EGFR(14), F2(2), FGD1(10), FGD3(4), FGF1(2), FGF10(2), FGF12(2), FGF13(2), FGF17(1), FGF19(2), FGF2(1), FGF20(1), FGF21(1), FGF23(4), FGF5(3), FGF6(1), FGF7(1), FGF8(1), FGFR1(1), FGFR2(2), FGFR3(6), FGFR4(3), FN1(14), GIT1(1), GNA12(1), GNA13(1), GNG12(1), GRLF1(12), GSN(5), IQGAP1(5), IQGAP2(4), IQGAP3(7), ITGA1(3), ITGA10(5), ITGA11(5), ITGA2(4), ITGA2B(3), ITGA3(3), ITGA4(6), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(12), ITGA9(1), ITGAD(3), ITGAE(3), ITGAL(3), ITGAM(3), ITGAV(2), ITGAX(5), ITGB2(2), ITGB3(5), ITGB4(3), ITGB5(1), ITGB6(4), ITGB7(1), ITGB8(3), KRAS(1), LIMK1(5), LIMK2(3), MAP2K1(4), MAP2K2(3), MAPK1(4), MOS(5), MSN(3), MYH10(17), MYH14(3), MYH9(12), MYL7(1), MYL9(2), MYLK(4), MYLK2(2), MYLPF(2), NCKAP1(5), NCKAP1L(5), NRAS(1), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PDGFRA(6), PDGFRB(6), PFN4(1), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PIP4K2B(2), PIP4K2C(2), PIP5K1A(4), PIP5K1B(4), PIP5K1C(2), PPP1R12A(3), PPP1R12B(1), PTK2(5), PXN(1), RAC2(1), RAC3(2), RAF1(2), RHOA(4), ROCK1(11), ROCK2(6), RRAS2(1), SCIN(2), SLC9A1(4), SOS1(8), SOS2(9), SSH1(3), SSH2(4), SSH3(1), TIAM1(7), TIAM2(9), TMSB4Y(1), VAV1(2), VAV2(1), VAV3(1), VCL(6), WASF1(3), WASF2(2), WASL(1)	123541042	597	233	589	207	101	126	188	105	76	1	0.426	1.000	1.000
266	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	231	ADCYAP1R1(3), ADORA1(4), ADORA2A(1), ADORA3(2), ADRA1A(4), ADRA1B(1), ADRA2B(1), ADRA2C(1), ADRB1(1), ADRB3(2), AGTR2(2), AVPR1A(5), AVPR1B(4), AVPR2(1), BDKRB1(1), BRS3(2), C3AR1(2), C5AR1(1), CALCR(4), CALCRL(1), CCKAR(4), CCKBR(3), CGA(1), CHRM2(4), CHRM3(5), CHRM5(1), CNR1(3), CRHR2(4), CTSG(1), CYSLTR1(1), CYSLTR2(2), DRD1(1), DRD2(2), DRD3(4), DRD4(1), DRD5(7), EDNRB(3), F2(2), F2RL1(1), F2RL2(1), F2RL3(3), FPR1(3), FSHB(1), FSHR(5), GABBR1(2), GABBR2(4), GABRA1(8), GABRA2(7), GABRA3(4), GABRA4(3), GABRA5(5), GABRA6(2), GABRB1(5), GABRB2(7), GABRE(2), GABRG1(4), GABRG2(6), GABRG3(2), GABRP(4), GABRQ(5), GABRR1(2), GABRR2(2), GALR1(2), GALR2(3), GH1(1), GH2(2), GHR(4), GHRHR(2), GHSR(3), GIPR(1), GLP1R(1), GLP2R(3), GLRA1(2), GLRA2(3), GLRA3(2), GLRB(3), GPR156(2), GPR50(1), GPR63(4), GRIA1(9), GRIA2(10), GRIA3(5), GRIA4(7), GRID1(11), GRIK1(4), GRIK2(4), GRIK3(5), GRIK4(4), GRIK5(6), GRIN2A(14), GRIN2B(15), GRIN2C(4), GRIN2D(3), GRIN3A(10), GRM1(16), GRM2(4), GRM3(14), GRM4(2), GRM5(7), GRM6(3), GRM7(8), GRM8(12), GRPR(1), GZMA(1), HCRTR1(2), HCRTR2(5), HRH1(1), HRH2(1), HRH3(1), HRH4(3), HTR1A(7), HTR1B(3), HTR1E(7), HTR1F(4), HTR2A(3), HTR2B(1), HTR2C(1), HTR4(1), HTR5A(3), HTR6(2), HTR7(3), LEP(1), LEPR(11), LHB(1), LHCGR(2), LTB4R(2), LTB4R2(1), MAS1(3), MC2R(7), MC3R(3), MC4R(3), MC5R(5), MCHR1(1), MCHR2(4), MLNR(2), MTNR1A(2), MTNR1B(2), NMBR(2), NMUR1(3), NMUR2(1), NPBWR1(1), NPBWR2(1), NPFFR2(8), NPY1R(5), NPY2R(3), NR3C1(5), NTSR1(2), NTSR2(5), OPRD1(2), OPRK1(2), OPRL1(1), OXTR(2), P2RX1(4), P2RX2(1), P2RX3(1), P2RY1(4), P2RY10(5), P2RY13(2), P2RY2(2), P2RY6(2), PARD3(10), PPYR1(1), PRL(3), PRLHR(2), PRLR(4), PRSS3(1), PTGDR(1), PTGER2(4), PTGER3(2), PTGER4(2), PTGFR(2), PTH2R(6), RXFP1(4), RXFP2(4), SSTR1(5), SSTR2(1), SSTR3(5), SSTR4(6), TAAR1(2), TAAR2(2), TAAR6(1), TACR1(2), TACR2(2), TACR3(5), TBXA2R(1), THRA(4), THRB(1), TRHR(4), TRPV1(5), TSHR(2), UTS2R(1), VIPR2(3)	98570089	658	223	657	238	109	118	247	120	64	0	0.148	1.000	1.000
267	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(2), ACTG1(2), CHAD(3), COL11A1(38), COL11A2(6), COL17A1(7), COL1A1(6), COL1A2(13), COL2A1(4), COL3A1(12), COL4A1(6), COL4A2(4), COL4A4(10), COL4A6(2), COL5A1(9), COL5A2(11), COL5A3(6), COL6A1(5), COL6A2(6), COL6A3(13), COL6A6(17), DES(1), DSC1(1), DSC2(1), DSG1(4), DSG2(2), DSG3(2), DSG4(1), FN1(14), GJA1(1), GJA10(3), GJA3(1), GJA5(2), GJA8(6), GJA9(2), GJB3(1), GJC1(1), GJC3(1), GJD2(1), GJD4(1), IBSP(1), ITGA6(3), ITGB4(3), KRT1(2), KRT10(4), KRT12(3), KRT13(2), KRT14(6), KRT15(1), KRT16(1), KRT18(1), KRT2(3), KRT23(1), KRT24(5), KRT25(5), KRT27(2), KRT28(2), KRT31(3), KRT32(1), KRT33A(1), KRT33B(2), KRT34(3), KRT35(1), KRT36(4), KRT38(5), KRT39(4), KRT4(6), KRT40(2), KRT5(8), KRT6A(2), KRT6B(1), KRT6C(3), KRT7(2), KRT71(1), KRT72(1), KRT73(3), KRT74(2), KRT75(1), KRT76(1), KRT77(2), KRT78(6), KRT79(2), KRT83(3), KRT85(2), KRT86(2), KRT9(1), LAMA1(22), LAMA2(32), LAMA3(8), LAMA4(18), LAMA5(9), LAMB1(5), LAMB3(2), LAMB4(11), LAMC1(6), LAMC2(4), LAMC3(5), LMNB1(1), LMNB2(4), NES(7), RELN(37), SPP1(1), THBS1(7), THBS2(7), THBS4(5), TNC(8), TNN(15), TNR(7), TNXB(10), VIM(2), VTN(2), VWF(6)	113623912	589	216	587	176	87	118	211	91	81	1	0.0504	1.000	1.000
268	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	120	ABLIM1(4), ABLIM2(3), ABLIM3(2), ARHGEF12(8), CDC42(1), CFL1(2), CXCL12(1), CXCR4(1), DCC(19), DPYSL2(2), DPYSL5(2), EFNA5(2), EFNB1(2), EFNB2(1), EPHA1(6), EPHA3(12), EPHA4(9), EPHA5(12), EPHA6(10), EPHA7(11), EPHA8(3), EPHB1(9), EPHB2(2), EPHB3(5), EPHB4(3), EPHB6(4), FES(4), FYN(3), GNAI1(1), GNAI3(1), GSK3B(1), KRAS(1), L1CAM(3), LIMK1(5), LIMK2(3), MAPK1(4), MET(1), NCK1(4), NCK2(3), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NGEF(1), NRAS(1), NRP1(4), NTN1(1), NTNG1(1), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PLXNA1(16), PLXNA2(6), PLXNA3(9), PLXNB1(3), PLXNB2(14), PLXNB3(5), PLXNC1(7), PTK2(5), RAC2(1), RAC3(2), RGS3(2), RHOA(4), RHOD(1), ROBO1(7), ROBO2(11), ROBO3(2), ROCK1(11), ROCK2(6), SEMA3A(10), SEMA3B(1), SEMA3C(4), SEMA3D(1), SEMA3E(8), SEMA3F(3), SEMA4A(3), SEMA4B(3), SEMA4C(1), SEMA4D(1), SEMA4F(3), SEMA4G(2), SEMA5B(8), SEMA6A(2), SEMA6B(2), SEMA6C(1), SEMA6D(4), SEMA7A(1), SLIT1(3), SLIT2(15), SLIT3(3), SRGAP1(6), SRGAP2(1), SRGAP3(2), UNC5A(3), UNC5B(4), UNC5C(12), UNC5D(14)	85101463	455	209	446	149	71	102	143	88	51	0	0.122	1.000	1.000
269	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	84	AGRN(2), CD44(1), CHAD(3), COL11A1(38), COL11A2(6), COL1A1(6), COL1A2(13), COL2A1(4), COL3A1(12), COL4A1(6), COL4A2(4), COL4A4(10), COL4A6(2), COL5A1(9), COL5A2(11), COL5A3(6), COL6A1(5), COL6A2(6), COL6A3(13), COL6A6(17), DAG1(1), FN1(14), FNDC1(7), FNDC3A(5), FNDC4(1), FNDC5(1), GP5(3), GP6(1), GP9(1), HMMR(1), HSPG2(11), IBSP(1), ITGA1(3), ITGA10(5), ITGA11(5), ITGA2(4), ITGA2B(3), ITGA3(3), ITGA4(6), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(12), ITGA9(1), ITGAV(2), ITGB3(5), ITGB4(3), ITGB5(1), ITGB6(4), ITGB7(1), ITGB8(3), LAMA1(22), LAMA2(32), LAMA3(8), LAMA4(18), LAMA5(9), LAMB1(5), LAMB3(2), LAMB4(11), LAMC1(6), LAMC2(4), LAMC3(5), RELN(37), SDC1(2), SDC2(2), SDC3(1), SDC4(1), SPP1(1), SV2A(3), SV2B(3), SV2C(3), THBS1(7), THBS2(7), THBS4(5), TNC(8), TNN(15), TNR(7), TNXB(10), VTN(2), VWF(6)	101537613	533	207	531	162	76	113	181	94	69	0	0.103	1.000	1.000
270	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY1(12), ADCY3(6), ADCY4(5), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(13), ADCY9(4), ADRA1A(4), ADRA1B(1), ADRB1(1), ADRB3(2), ANXA6(4), ARRB1(2), ARRB2(1), ATP1A4(4), ATP1B3(3), ATP2A2(4), ATP2A3(3), ATP2B1(3), ATP2B2(2), ATP2B3(8), CACNA1A(7), CACNA1B(4), CACNA1C(11), CACNA1D(15), CACNA1E(17), CACNA1S(11), CACNB1(5), CACNB3(2), CALM1(1), CALM3(1), CALR(2), CAMK1(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CASQ1(1), CASQ2(2), CHRM2(4), CHRM3(5), CHRM5(1), GJA1(1), GJA5(2), GJB3(1), GNAI3(1), GNAO1(2), GNAZ(2), GNB1(2), GNB2(3), GNB3(3), GNB4(1), GNB5(1), GNG12(1), GNG2(1), GRK5(5), ITPR1(9), ITPR2(11), ITPR3(5), KCNB1(3), KCNJ3(4), KCNJ5(3), MIB1(5), NME7(2), PEA15(1), PKIG(1), PLCB3(5), PRKACA(4), PRKACB(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(4), PRKCE(2), PRKCG(7), PRKCH(3), PRKCQ(5), PRKCZ(3), PRKD1(10), RGS1(3), RGS11(1), RGS14(1), RGS16(1), RGS17(5), RGS18(1), RGS19(1), RGS2(1), RGS20(2), RGS3(2), RGS4(1), RGS5(1), RGS6(5), RGS7(13), RGS9(5), RYR1(16), RYR2(44), RYR3(23), SFN(5), SLC8A1(8), SLC8A3(10), USP5(4), YWHAB(1), YWHAH(1), YWHAQ(1)	84204815	466	202	463	167	95	106	132	80	52	1	0.233	1.000	1.000
271	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTB(2), ACTG1(2), ACTN1(2), ACTN2(6), ACTN3(6), ACTN4(3), AKT1(2), AKT2(3), AKT3(4), AMOTL1(2), ASH1L(11), CASK(1), CDC42(1), CDK4(4), CGN(3), CLDN10(2), CLDN15(2), CLDN16(1), CLDN18(3), CLDN2(2), CLDN22(1), CLDN23(1), CLDN6(1), CLDN9(1), CRB3(2), CSDA(1), CSNK2A1(6), CSNK2A2(1), CSNK2B(2), CTNNA1(5), CTNNA2(19), CTNNA3(6), CTNNB1(2), CTTN(4), EPB41L1(5), EPB41L2(7), EPB41L3(16), EXOC3(1), EXOC4(10), F11R(1), GNAI1(1), GNAI3(1), HCLS1(2), IGSF5(3), INADL(7), KRAS(1), LLGL2(3), MAGI1(3), MAGI2(10), MAGI3(6), MLLT4(5), MPDZ(8), MPP5(5), MYH1(11), MYH10(17), MYH11(11), MYH13(16), MYH14(3), MYH15(9), MYH2(16), MYH3(8), MYH4(13), MYH6(10), MYH7(9), MYH7B(5), MYH8(18), MYH9(12), MYL7(1), MYL9(2), MYLPF(2), NRAS(1), PARD3(10), PARD6A(1), PARD6B(1), PARD6G(2), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2B(3), PPP2R3A(5), PPP2R3B(3), PPP2R4(1), PRKCA(2), PRKCD(4), PRKCE(2), PRKCG(7), PRKCH(3), PRKCI(2), PRKCQ(5), PRKCZ(3), PTEN(6), RAB13(1), RHOA(4), RRAS2(1), SPTAN1(11), SRC(1), SYMPK(4), TJAP1(1), TJP1(9), TJP2(4), TJP3(5), VAPA(1), YES1(1), ZAK(2)	88086992	485	199	481	154	77	108	166	75	57	2	0.146	1.000	1.000
272	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ACTA1(2), ACTA2(1), ADCY1(12), ADCY3(6), ADCY4(5), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(13), ADCY9(4), ARRB1(2), ARRB2(1), ATF1(2), ATF2(1), ATF4(1), ATF5(2), ATP2A2(4), ATP2A3(3), CACNB3(2), CALCA(1), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CNN1(1), CNN2(1), CORIN(2), DGKZ(4), ETS2(5), FOS(1), GABPA(2), GBA2(3), GJA1(1), GNB1(2), GNB2(3), GNB3(3), GNB4(1), GNB5(1), GNG12(1), GNG2(1), GRK5(5), GSTO1(2), GUCY1A3(4), IGFBP1(2), IGFBP3(1), IGFBP4(1), IL1B(1), ITPR1(9), ITPR2(11), ITPR3(5), MIB1(5), MYLK2(2), NFKB1(2), NOS1(3), NOS3(4), OXTR(2), PDE4B(4), PDE4D(5), PKIG(1), PLCB3(5), PLCD1(2), PLCG1(5), PLCG2(4), PRKACA(4), PRKACB(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(4), PRKCE(2), PRKCH(3), PRKCQ(5), PRKCZ(3), PRKD1(10), RGS1(3), RGS11(1), RGS14(1), RGS16(1), RGS17(5), RGS18(1), RGS19(1), RGS2(1), RGS20(2), RGS3(2), RGS4(1), RGS5(1), RGS6(5), RGS7(13), RGS9(5), RYR1(16), RYR2(44), RYR3(23), SFN(5), SLC8A1(8), SP1(1), TNXB(10), USP5(4), YWHAB(1), YWHAH(1), YWHAQ(1)	77731935	394	189	393	129	74	99	107	68	45	1	0.103	1.000	1.000
273	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	140	ADA(1), ADCY1(12), ADCY3(6), ADCY4(5), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(13), ADCY9(4), ADK(1), ADSL(4), ADSS(2), ADSSL1(2), AK1(1), AK2(1), AK3L1(1), AK5(5), AK7(2), ALLC(1), AMPD1(1), AMPD2(2), AMPD3(1), ATIC(2), CANT1(1), DCK(2), ENPP1(5), ENPP3(5), ENTPD1(2), ENTPD3(1), ENTPD4(4), ENTPD5(2), ENTPD6(1), GART(3), GDA(4), GMPR2(1), GMPS(4), GUCY1A2(5), GUCY1A3(4), GUCY1B3(4), GUCY2C(4), GUCY2D(5), GUCY2F(8), HPRT1(1), IMPDH1(3), IMPDH2(1), ITPA(3), NME7(2), NPR1(1), NPR2(5), NT5C1A(1), NT5C1B(4), NT5C2(1), NT5C3(2), NUDT2(1), NUDT5(1), NUDT9(1), PAPSS1(3), PAPSS2(3), PDE10A(12), PDE11A(2), PDE1A(3), PDE1C(9), PDE2A(1), PDE3B(1), PDE4A(3), PDE4B(4), PDE4C(2), PDE4D(5), PDE5A(7), PDE7A(3), PDE8B(7), PDE9A(2), PFAS(12), PKLR(1), PKM2(3), PNPT1(4), POLA1(2), POLA2(1), POLD1(3), POLD2(1), POLD3(3), POLE(8), POLE2(1), POLR1A(5), POLR1B(3), POLR1C(2), POLR2A(9), POLR2B(2), POLR2D(1), POLR2G(2), POLR2H(1), POLR2L(1), POLR3A(8), POLR3B(2), POLR3G(1), POLR3H(1), PPAT(2), PRPS1(3), PRPS1L1(4), PRPS2(1), RFC5(2), RRM1(1), RRM2(1), RRM2B(1), XDH(3)	72982877	331	183	329	106	59	68	112	52	40	0	0.261	1.000	1.000
274	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(2), ACTA2(1), ACTN2(6), ACTN3(6), ACTN4(3), DES(1), DMD(33), FAM48A(2), MYBPC1(11), MYBPC2(3), MYBPC3(3), MYH3(8), MYH6(10), MYH7(9), MYH8(18), MYL1(1), MYL9(2), MYOM1(11), NEB(26), TNNI2(1), TNNI3(1), TNNT1(2), TNNT3(1), TPM1(1), TTN(248), VIM(2)	62136330	412	181	410	110	44	98	161	62	44	3	0.200	1.000	1.000
275	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	129	ACACA(11), ACACB(12), AKT1(2), AKT2(3), AKT3(4), BAD(1), BRAF(4), CALM1(1), CALM3(1), CBL(2), CBLB(2), CRK(1), CRKL(1), EIF4EBP1(1), ELK1(1), EXOC7(1), FASN(4), FBP2(1), FLOT1(1), FLOT2(3), FOXO1(3), G6PC(2), G6PC2(3), GCK(2), GSK3B(1), GYS1(5), GYS2(5), IKBKB(5), INPP5D(7), INSR(2), IRS1(1), IRS2(2), IRS4(10), KRAS(1), LIPE(3), MAP2K1(4), MAP2K2(3), MAPK1(4), MAPK10(3), MAPK8(4), MAPK9(4), MKNK1(1), MKNK2(1), NRAS(1), PCK2(3), PDE3A(13), PDE3B(1), PDPK1(2), PFKL(4), PFKM(2), PFKP(4), PHKA1(1), PHKA2(9), PHKB(2), PHKG2(1), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PKLR(1), PKM2(3), PPARGC1A(3), PPP1R3A(7), PPP1R3B(3), PPP1R3C(1), PPP1R3D(3), PRKAA1(3), PRKAA2(2), PRKAB1(3), PRKACA(4), PRKACB(2), PRKACG(1), PRKAG2(2), PRKAG3(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCI(2), PRKCZ(3), PRKX(1), PTPN1(2), PTPRF(10), PYGB(3), PYGL(4), PYGM(3), RAF1(2), RAPGEF1(2), RHOQ(1), RPS6KB1(3), RPS6KB2(1), SH2B2(1), SHC1(1), SHC2(3), SHC3(3), SHC4(3), SLC2A4(1), SOCS4(1), SORBS1(2), SOS1(8), SOS2(9), SREBF1(3), TRIP10(5), TSC1(2), TSC2(3)	71724310	336	177	333	104	73	64	106	58	34	1	0.117	1.000	1.000
276	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	249	ACVR1(5), ACVR1B(4), ACVR2A(2), AMHR2(1), BMP2(3), BMP7(3), BMPR1B(1), BMPR2(3), CCL1(3), CCL15(1), CCL2(2), CCL20(1), CCL23(2), CCL25(2), CCL28(1), CCL3(1), CCL7(1), CCL8(2), CCR1(1), CCR2(2), CCR3(3), CCR4(1), CCR6(1), CCR7(1), CD27(1), CD40(4), CD40LG(3), CSF1(1), CSF2RA(1), CSF2RB(5), CSF3R(2), CX3CL1(1), CX3CR1(1), CXCL1(1), CXCL10(2), CXCL12(1), CXCL13(1), CXCL2(1), CXCL3(1), CXCL9(1), CXCR3(1), CXCR4(1), EDA(4), EDAR(1), EGF(6), EGFR(14), EPO(2), FAS(1), FASLG(2), FLT1(10), FLT3(4), FLT3LG(1), FLT4(6), GDF5(3), GH1(1), GH2(2), GHR(4), HGF(8), IFNA16(2), IFNA17(1), IFNA21(1), IFNA4(2), IFNA6(1), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(1), IFNGR1(5), IFNGR2(2), IFNK(1), IFNW1(1), IL10RA(3), IL10RB(1), IL12A(1), IL12B(4), IL12RB1(3), IL12RB2(7), IL13(1), IL13RA1(1), IL17A(1), IL17RA(2), IL17RB(1), IL18R1(2), IL18RAP(2), IL19(1), IL1A(1), IL1B(1), IL1R1(2), IL1R2(1), IL1RAP(4), IL21R(1), IL22(1), IL22RA1(2), IL23R(1), IL24(2), IL25(2), IL26(2), IL28A(1), IL28B(1), IL28RA(1), IL2RA(2), IL2RB(3), IL3(1), IL3RA(3), IL4(1), IL4R(2), IL5(1), IL5RA(1), IL6R(4), IL6ST(2), IL7R(3), IL9(1), IL9R(4), INHBA(1), INHBB(2), INHBC(3), INHBE(1), KDR(5), KIT(5), LEP(1), LEPR(11), LIF(2), LIFR(9), LTA(1), LTBR(2), MET(1), MPL(2), NGFR(1), OSMR(3), PDGFC(1), PDGFRA(6), PDGFRB(6), PF4V1(1), PLEKHO2(2), PPBP(2), PRL(3), PRLR(4), RELT(3), TGFB1(1), TGFB2(2), TGFBR1(1), TNFRSF10A(1), TNFRSF10B(1), TNFRSF11A(2), TNFRSF11B(2), TNFRSF13B(2), TNFRSF13C(2), TNFRSF19(3), TNFRSF21(2), TNFRSF25(2), TNFRSF4(2), TNFRSF6B(2), TNFRSF8(1), TNFRSF9(1), TNFSF11(1), TNFSF13(1), TNFSF13B(1), TNFSF14(2), TNFSF18(1), TNFSF4(2), TNFSF8(2), TPO(10), VEGFC(3), XCL1(1), XCL2(1), XCR1(2)	80162356	380	175	376	128	56	75	136	72	41	0	0.353	1.000	1.000
277	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	141	APC(15), APC2(3), AXIN1(5), AXIN2(5), BTRC(1), CACYBP(2), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CCND1(2), CHD8(7), CREBBP(15), CSNK1A1(1), CSNK1E(3), CSNK2A1(6), CSNK2A2(1), CSNK2B(2), CTBP1(1), CTBP2(2), CTNNB1(2), CUL1(6), CXXC4(1), DAAM1(6), DAAM2(6), DKK1(3), DKK2(3), DVL1(2), DVL2(1), DVL3(4), FZD1(3), FZD10(1), FZD2(2), FZD3(2), FZD4(1), FZD5(1), FZD6(2), FZD8(1), GSK3B(1), LEF1(2), LRP5(3), LRP6(12), MAP3K7(4), MAPK10(3), MAPK8(4), MAPK9(4), MMP7(1), MYC(4), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NKD1(5), NKD2(1), NLK(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PORCN(2), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2B(3), PRICKLE1(4), PRICKLE2(5), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCG(7), PRKX(1), RAC2(1), RAC3(2), RBX1(2), RHOA(4), ROCK1(11), ROCK2(6), SENP2(2), SFRP1(1), SFRP4(8), SFRP5(1), SIAH1(1), SKP1(1), SMAD2(3), SMAD3(2), SMAD4(8), SOX17(1), TBL1X(4), TBL1XR1(3), TBL1Y(2), TCF7(2), TCF7L1(1), VANGL1(1), VANGL2(2), WNT1(1), WNT10A(2), WNT10B(1), WNT11(1), WNT16(1), WNT2(3), WNT3(4), WNT3A(1), WNT4(1), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(1), WNT8A(1), WNT8B(2), WNT9A(3), WNT9B(1)	70764443	359	174	356	114	63	80	120	51	44	1	0.0798	1.000	1.000
278	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	90	ADCY1(12), ADCY3(6), ADCY4(5), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(13), ADCY9(4), ADRB1(1), DRD1(1), DRD2(2), EGF(6), EGFR(14), GJA1(1), GJD2(1), GNAI1(1), GNAI3(1), GNAS(6), GRM1(16), GRM5(7), GUCY1A2(5), GUCY1A3(4), GUCY1B3(4), GUCY2C(4), GUCY2D(5), GUCY2F(8), HTR2A(3), HTR2B(1), HTR2C(1), ITPR1(9), ITPR2(11), ITPR3(5), KRAS(1), MAP2K1(4), MAP2K2(3), MAP2K5(2), MAPK1(4), MAPK7(1), NPR1(1), NPR2(5), NRAS(1), PDGFC(1), PDGFD(4), PDGFRA(6), PDGFRB(6), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCG(7), PRKG1(3), PRKG2(1), PRKX(1), RAF1(2), SOS1(8), SOS2(9), SRC(1), TJP1(9), TUBA1B(3), TUBA3C(6), TUBA3D(2), TUBA3E(3), TUBA4A(1), TUBA8(2), TUBAL3(3), TUBB1(1), TUBB2C(1), TUBB3(2), TUBB4(3), TUBB4Q(4), TUBB6(3), TUBB8(1)	58867559	321	174	316	99	60	69	104	54	34	0	0.0506	1.000	1.000
279	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	160	ADORA1(4), ADORA2A(1), ADORA3(2), ADRA1A(4), ADRA1B(1), ADRA2C(1), ADRB1(1), ADRB3(2), AGTR2(2), AVPR1A(5), AVPR1B(4), AVPR2(1), BDKRB1(1), BRS3(2), C3AR1(2), CCBP2(2), CCKAR(4), CCKBR(3), CCR1(1), CCR10(1), CCR2(2), CCR3(3), CCR4(1), CCR6(1), CCR7(1), CCRL1(1), CCRL2(1), CHML(3), CHRM2(4), CHRM3(5), CHRM5(1), CMKLR1(4), CNR1(3), CX3CR1(1), CXCR3(1), CXCR4(1), DRD1(1), DRD2(2), DRD3(4), DRD4(1), DRD5(7), EDNRB(3), F2RL1(1), F2RL2(1), F2RL3(3), FPR1(3), FSHR(5), GALR1(2), GALR2(3), GALT(1), GHSR(3), GNB2L1(1), GPR17(1), GPR174(2), GPR27(2), GPR3(2), GPR37(5), GPR37L1(2), GPR50(1), GPR6(4), GPR63(4), GPR77(2), GRPR(1), HCRTR1(2), HCRTR2(5), HRH1(1), HRH2(1), HRH3(1), HTR1A(7), HTR1B(3), HTR1E(7), HTR1F(4), HTR2A(3), HTR2B(1), HTR2C(1), HTR4(1), HTR5A(3), HTR6(2), HTR7(3), LHCGR(2), LTB4R(2), MAS1(3), MC3R(3), MC4R(3), MC5R(5), MLNR(2), MTNR1A(2), MTNR1B(2), NMBR(2), NMUR1(3), NMUR2(1), NPY1R(5), NPY2R(3), NTSR1(2), NTSR2(5), OPRD1(2), OPRK1(2), OPRL1(1), OR10A5(2), OR11A1(1), OR12D3(2), OR1C1(3), OR1Q1(2), OR2H1(3), OR5V1(4), OR7A5(3), OR8B8(1), OXTR(2), P2RY1(4), P2RY10(5), P2RY13(2), P2RY2(2), P2RY6(2), PPYR1(1), PTGDR(1), PTGER2(4), PTGER4(2), PTGFR(2), RGR(3), RHO(3), RRH(1), SSTR1(5), SSTR2(1), SSTR3(5), SSTR4(6), SUCNR1(1), TBXA2R(1), TRHR(4)	54565865	317	172	316	132	61	57	125	53	21	0	0.465	1.000	1.000
280	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	127	ALCAM(3), CADM1(2), CADM3(1), CD2(1), CD22(1), CD226(3), CD28(2), CD34(4), CD40(4), CD40LG(3), CD6(1), CD80(5), CD86(1), CD8A(2), CD8B(1), CDH1(4), CDH15(2), CDH2(5), CDH3(6), CDH4(1), CDH5(4), CLDN10(2), CLDN15(2), CLDN16(1), CLDN18(3), CLDN2(2), CLDN22(1), CLDN23(1), CLDN6(1), CLDN9(1), CNTN1(7), CNTN2(4), CNTNAP1(6), CNTNAP2(21), CTLA4(1), ESAM(1), F11R(1), GLG1(3), HLA-C(3), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-F(3), ICAM1(2), ICAM2(2), ICAM3(1), ICOS(1), ITGA4(6), ITGA6(3), ITGA8(12), ITGA9(1), ITGAL(3), ITGAM(3), ITGAV(2), ITGB2(2), ITGB7(1), ITGB8(3), L1CAM(3), MAG(1), MPZL1(2), NCAM1(1), NCAM2(7), NEGR1(2), NEO1(1), NFASC(3), NLGN1(12), NLGN2(3), NRCAM(9), NRXN1(20), NRXN2(9), NRXN3(14), PDCD1(1), PTPRC(13), PTPRF(10), PTPRM(14), PVR(2), PVRL2(3), PVRL3(4), SDC1(2), SDC2(2), SDC3(1), SDC4(1), SELE(4), SELL(2), SELP(11), SIGLEC1(10), SPN(2), VCAM1(3), VCAN(15)	65774616	355	171	355	138	63	62	117	63	49	1	0.671	1.000	1.000
281	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	149	AKT1(2), AKT2(3), AKT3(4), BCL2L1(2), CBL(2), CBLB(2), CCND1(2), CISH(1), CREBBP(15), CSF2RA(1), CSF2RB(5), CSF3R(2), EPO(2), GH1(1), GH2(2), GHR(4), IFNA16(2), IFNA17(1), IFNA21(1), IFNA4(2), IFNA6(1), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(1), IFNGR1(5), IFNGR2(2), IFNK(1), IFNW1(1), IL10RA(3), IL10RB(1), IL12A(1), IL12B(4), IL12RB1(3), IL12RB2(7), IL13(1), IL13RA1(1), IL13RA2(1), IL19(1), IL21R(1), IL22(1), IL22RA1(2), IL23R(1), IL24(2), IL26(2), IL28A(1), IL28B(1), IL28RA(1), IL2RA(2), IL2RB(3), IL3(1), IL3RA(3), IL4(1), IL4R(2), IL5(1), IL5RA(1), IL6R(4), IL6ST(2), IL7R(3), IL9(1), IL9R(4), IRF9(2), JAK1(6), JAK2(2), JAK3(3), LEP(1), LEPR(11), LIF(2), LIFR(9), MPL(2), MYC(4), OSMR(3), PIAS2(1), PIAS3(3), PIAS4(2), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PIM1(2), PRL(3), PRLR(4), PTPN11(1), PTPN6(1), SOCS4(1), SOCS5(5), SOCS7(2), SOS1(8), SOS2(9), SPRED1(2), SPRED2(1), SPRY1(1), SPRY2(2), SPRY3(1), SPRY4(1), STAM(2), STAM2(2), STAT1(5), STAT2(3), STAT3(3), STAT4(3), STAT5A(1), STAT5B(4), STAT6(2), TPO(10), TYK2(2)	62996130	300	170	297	100	35	72	94	63	35	1	0.371	1.000	1.000
282	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	72	ACP1(1), ACTB(2), ACTG1(2), ACTN1(2), ACTN2(6), ACTN3(6), ACTN4(3), ACVR1B(4), ACVR1C(3), CDC42(1), CDH1(4), CREBBP(15), CSNK2A1(6), CSNK2A2(1), CSNK2B(2), CTNNA1(5), CTNNA2(19), CTNNA3(6), CTNNB1(2), CTNND1(4), EGFR(14), ERBB2(8), FARP2(1), FER(2), FGFR1(1), FYN(3), IGF1R(7), INSR(2), IQGAP1(5), LEF1(2), LMO7(6), MAP3K7(4), MAPK1(4), MET(1), MLLT4(5), NLK(1), PARD3(10), PTPN1(2), PTPN6(1), PTPRB(11), PTPRF(10), PTPRJ(6), PTPRM(14), PVRL2(3), PVRL3(4), PVRL4(2), RAC2(1), RAC3(2), RHOA(4), SMAD2(3), SMAD3(2), SMAD4(8), SNAI2(1), SORBS1(2), SRC(1), SSX2IP(2), TCF7(2), TCF7L1(1), TGFBR1(1), TJP1(9), VCL(6), WASF1(3), WASF2(2), WASF3(2), WASL(1), YES1(1)	51543760	277	165	270	84	39	63	86	52	36	1	0.175	1.000	1.000
283	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	93	ADCY1(12), ADCY3(6), ADCY4(5), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(13), ADCY9(4), ATF4(1), CACNA1C(11), CACNA1D(15), CACNA1F(6), CACNA1S(11), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CDC42(1), CGA(1), EGFR(14), ELK1(1), FSHB(1), GNAS(6), ITPR1(9), ITPR2(11), ITPR3(5), KRAS(1), LHB(1), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAP3K1(3), MAP3K3(1), MAP3K4(5), MAPK1(4), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK7(1), MAPK8(4), MAPK9(4), MMP14(2), MMP2(2), NRAS(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PLD1(7), PLD2(1), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCD(4), PRKX(1), PTK2B(2), RAF1(2), SOS1(8), SOS2(9), SRC(1)	56463296	285	161	282	84	52	64	84	52	33	0	0.0320	1.000	1.000
284	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	90	ADCY1(12), ADCY3(6), ADCY4(5), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(13), ADCY9(4), AKAP1(5), AKAP10(3), AKAP11(6), AKAP12(10), AKAP2(1), AKAP3(5), AKAP4(5), AKAP5(2), AKAP6(14), AKAP7(1), AKAP8(2), AKAP9(21), ARHGEF1(5), CALM1(1), CALM3(1), CHMP1B(2), GNA12(1), GNA13(1), GNA15(2), GNAI3(1), GNAL(2), GNAO1(2), GNAZ(2), GNB1(2), GNB2(3), GNB3(3), GNB5(1), GNG12(1), ITPR1(9), KCNJ3(4), KRAS(1), NRAS(1), PDE1A(3), PDE1B(2), PDE1C(9), PDE4A(3), PDE4B(4), PDE4C(2), PDE4D(5), PDE7A(3), PDE8B(7), PLCB3(5), PRKACA(4), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(4), PRKCE(2), PRKCG(7), PRKCH(3), PRKCI(2), PRKCQ(5), PRKCZ(3), PRKD1(10), PRKD3(9), RHOA(4), SLC9A1(4), USP5(4)	51951630	284	160	280	78	60	61	75	47	41	0	0.0314	1.000	1.000
285	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	109	ADA(1), ADCY1(12), ADCY3(6), ADCY4(5), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(13), ADK(1), ADSL(4), ADSS(2), AK1(1), AK2(1), AK5(5), ALLC(1), AMPD1(1), AMPD2(2), AMPD3(1), ATIC(2), ATP5F1(1), ATP5G2(1), ATP5G3(1), CANT1(1), DCK(2), ENPP1(5), ENPP3(5), ENTPD1(2), GART(3), GDA(4), GMPS(4), GUCY1A2(5), GUCY1A3(4), GUCY1B3(4), GUCY2C(4), GUCY2D(5), GUCY2F(8), HPRT1(1), IMPDH1(3), IMPDH2(1), ITPA(3), NPR1(1), NPR2(5), NUDT2(1), PAPSS1(3), PAPSS2(3), PDE1A(3), PDE4A(3), PDE4B(4), PDE4C(2), PDE4D(5), PDE5A(7), PDE6C(2), PDE9A(2), PFAS(12), PKLR(1), PKM2(3), POLB(1), POLD1(3), POLD2(1), POLE(8), POLG(2), POLL(5), POLQ(16), POLR1B(3), POLR2A(9), POLR2B(2), POLR2D(1), POLR2G(2), POLR2H(1), POLR2L(1), POLRMT(4), PPAT(2), PRPS1(3), PRPS1L1(4), PRPS2(1), RRM1(1), RRM2(1)	57387511	263	160	261	80	46	52	93	39	33	0	0.131	1.000	1.000
286	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(5), AMY2A(2), AMY2B(6), ASCC3(5), DDX18(1), DDX19A(3), DDX23(1), DDX4(3), DDX41(2), DDX50(1), DDX51(2), DDX52(4), DDX54(4), DDX55(3), DDX56(3), DHX58(2), ENPP1(5), ENPP3(5), ENTPD7(3), EP400(8), ERCC2(2), ERCC3(4), G6PC(2), G6PC2(3), GAA(3), GANC(3), GBA(2), GBA3(5), GCK(2), GPI(2), GUSB(1), GYS1(5), GYS2(5), HK1(3), HK2(5), HK3(4), IFIH1(5), MGAM(18), MOV10L1(3), NUDT5(1), NUDT8(1), PGM1(3), PGM3(1), PYGB(3), PYGL(4), PYGM(3), RAD54B(2), RAD54L(4), RUVBL2(2), SETX(8), SI(40), SKIV2L2(3), SMARCA2(8), SMARCA5(1), UGDH(3), UGP2(1), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2A1(4), UGT2A3(4), UGT2B10(11), UGT2B11(7), UGT2B15(2), UGT2B28(3), UGT2B4(8), UGT2B7(3), UXS1(1)	56297057	286	159	285	90	32	56	108	59	31	0	0.530	1.000	1.000
287	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	83	ABL2(7), AKT1(2), AKT2(3), AKT3(4), BAD(1), BRAF(4), BTC(2), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CBL(2), CBLB(2), CDKN1B(2), CRK(1), CRKL(1), EGF(6), EGFR(14), EIF4EBP1(1), ELK1(1), ERBB2(8), ERBB3(7), ERBB4(15), GAB1(2), GSK3B(1), KRAS(1), MAP2K1(4), MAP2K2(3), MAP2K4(1), MAPK1(4), MAPK10(3), MAPK8(4), MAPK9(4), MYC(4), NCK1(4), NCK2(3), NRAS(1), NRG1(1), NRG2(4), NRG3(8), NRG4(2), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLCG1(5), PLCG2(4), PRKCA(2), PRKCG(7), PTK2(5), RAF1(2), RPS6KB1(3), RPS6KB2(1), SHC1(1), SHC2(3), SHC3(3), SHC4(3), SOS1(8), SOS2(9), SRC(1), STAT5A(1), STAT5B(4)	45681117	256	155	252	82	35	57	89	47	27	1	0.337	1.000	1.000
288	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	107	ACTN1(2), ACTN2(6), ACTN3(6), ACTN4(3), ARHGAP5(6), BCAR1(2), CDC42(1), CDH5(4), CLDN10(2), CLDN15(2), CLDN16(1), CLDN18(3), CLDN2(2), CLDN22(1), CLDN23(1), CLDN6(1), CLDN9(1), CTNNA1(5), CTNNA2(19), CTNNA3(6), CTNNB1(2), CTNND1(4), CXCL12(1), CXCR4(1), CYBB(1), ESAM(1), F11R(1), GNAI1(1), GNAI3(1), GRLF1(12), ICAM1(2), ITGA4(6), ITGAL(3), ITGAM(3), ITGB2(2), ITK(1), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MLLT4(5), MMP2(2), MSN(3), MYL7(1), MYL9(2), MYLPF(2), NCF2(4), NCF4(1), NOX1(5), NOX3(4), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLCG1(5), PLCG2(4), PRKCA(2), PRKCG(7), PTK2(5), PTK2B(2), PTPN11(1), PXN(1), RAC2(1), RAP1B(2), RAPGEF3(5), RASSF5(1), RHOA(4), ROCK1(11), ROCK2(6), SIPA1(1), THY1(1), TXK(3), VASP(1), VAV1(2), VAV2(1), VAV3(1), VCAM1(3), VCL(6)	54644192	261	154	257	104	32	47	87	53	40	2	0.937	1.000	1.000
289	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	72	CALM1(1), CALM3(1), CDIPT(1), CDS1(1), CDS2(3), DGKA(2), DGKB(6), DGKD(4), DGKE(3), DGKH(4), DGKI(8), DGKQ(5), DGKZ(4), FN3K(2), IMPA1(1), IMPA2(2), INPP1(2), INPP4A(4), INPP4B(7), INPP5B(3), INPP5D(7), INPPL1(4), ITPK1(2), ITPKA(1), ITPKB(5), ITPR1(9), ITPR2(11), ITPR3(5), OCRL(4), PI4KA(5), PIK3C2A(4), PIK3C2B(7), PIK3C2G(7), PIK3C3(2), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PIP4K2B(2), PIP4K2C(2), PIP5K1A(4), PIP5K1B(4), PIP5K1C(2), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PLCD1(2), PLCD4(2), PLCE1(12), PLCG1(5), PLCG2(4), PLCZ1(3), PRKCA(2), PRKCG(7), PTEN(6), PTPMT1(2), SYNJ1(6), SYNJ2(4)	55603636	269	153	268	83	39	56	80	55	38	1	0.104	1.000	1.000
290	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	106	ANAPC1(5), ANAPC2(1), ANAPC5(1), ANAPC7(1), ATM(9), ATR(19), BUB1(2), BUB1B(4), CCNA1(4), CCNA2(3), CCNB1(3), CCNB3(5), CCND1(2), CCNE1(3), CCNE2(3), CDC14A(2), CDC16(1), CDC20(2), CDC23(1), CDC25B(3), CDC27(5), CDC6(2), CDC7(1), CDK4(4), CDK6(1), CDKN1B(2), CHEK1(1), CHEK2(4), CREBBP(15), CUL1(6), E2F2(3), ESPL1(9), FZR1(2), GADD45G(1), GSK3B(1), MAD1L1(4), MAD2L2(1), MCM2(4), MCM3(2), MCM4(4), MCM5(2), MCM6(3), MCM7(5), MDM2(2), ORC2L(1), ORC4L(1), ORC5L(1), ORC6L(1), PKMYT1(1), PLK1(2), PRKDC(15), RB1(9), RBL1(8), RBL2(3), RBX1(2), SFN(5), SKP1(1), SKP2(2), SMAD2(3), SMAD3(2), SMAD4(8), SMC1A(3), SMC1B(5), TFDP1(3), TGFB1(1), TGFB2(2), WEE1(1), YWHAB(1), YWHAE(2), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(2)	59056609	246	151	246	75	26	57	67	51	45	0	0.349	1.000	1.000
291	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(5), ACVR1B(4), ACVRL1(3), AKT1(2), AURKB(3), BMPR2(3), BUB1(2), CDIPT(1), CDKL1(1), CDKL2(2), CDS1(1), CDS2(3), CLK1(3), CLK2(5), COL4A3BP(4), CSNK2A1(6), CSNK2A2(1), CSNK2B(2), DGKA(2), DGKB(6), DGKD(4), DGKE(3), DGKH(4), DGKQ(5), DGKZ(4), IMPA1(1), INPP1(2), INPP4A(4), INPP4B(7), INPPL1(4), ITPKA(1), ITPKB(5), MAP3K10(4), MOS(5), NEK1(3), NEK3(1), OCRL(4), PAK4(1), PIK3C2A(4), PIK3C2B(7), PIK3C2G(7), PIK3CB(5), PIK3CG(8), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PLCD1(2), PLCG1(5), PLCG2(4), PLK3(1), PRKACA(4), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(4), PRKCE(2), PRKCG(7), PRKCH(3), PRKCQ(5), PRKCZ(3), PRKD1(10), PRKG1(3), RAF1(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA4(3), RPS6KB1(3), STK11(2), TGFBR1(1), VRK1(1)	50362156	268	151	266	78	55	48	78	51	35	1	0.0845	1.000	1.000
292	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	65	ADCY1(12), ADCY8(13), ATF4(1), BRAF(4), CACNA1C(11), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CREBBP(15), GRIA1(9), GRIA2(10), GRIN2A(14), GRIN2B(15), GRIN2C(4), GRIN2D(3), GRM1(16), GRM5(7), ITPR1(9), ITPR2(11), ITPR3(5), KRAS(1), MAP2K1(4), MAP2K2(3), MAPK1(4), NRAS(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PPP1R12A(3), PPP1R1A(1), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCG(7), PRKX(1), RAF1(2), RAP1B(2), RAPGEF3(5), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA6(4)	42697829	255	145	252	84	43	59	80	49	24	0	0.164	1.000	1.000
293	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	96	ADCY1(12), ADCY3(6), ADCY4(5), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(13), ADCY9(4), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CREB1(1), CREB3L1(2), CREB3L2(2), CREB3L3(3), CREB3L4(1), CREBBP(15), CTNNB1(2), DCT(1), DVL1(2), DVL2(1), DVL3(4), EDNRB(3), FZD1(3), FZD10(1), FZD2(2), FZD3(2), FZD4(1), FZD5(1), FZD6(2), FZD8(1), GNAI1(1), GNAI3(1), GNAO1(2), GNAS(6), GSK3B(1), KIT(5), KRAS(1), LEF1(2), MAP2K1(4), MAP2K2(3), MAPK1(4), MITF(4), NRAS(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), POMC(1), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCG(7), PRKX(1), RAF1(2), TCF7(2), TCF7L1(1), TYR(4), TYRP1(1), WNT1(1), WNT10A(2), WNT10B(1), WNT11(1), WNT16(1), WNT2(3), WNT3(4), WNT3A(1), WNT4(1), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(1), WNT8A(1), WNT8B(2), WNT9A(3), WNT9B(1)	46091683	228	144	225	76	53	40	71	41	22	1	0.173	1.000	1.000
294	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	88	AKT1(2), AKT3(4), BCAR1(2), CAPN10(3), CAPN11(1), CAPN2(4), CAPN3(3), CAPN5(1), CAPN6(2), CAPN7(1), CAPN9(3), CAPNS1(1), CDC42(1), CRK(1), CSK(1), DOCK1(8), FYN(3), GIT2(1), ILK(4), ITGA10(5), ITGA11(5), ITGA2(4), ITGA2B(3), ITGA3(3), ITGA4(6), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(12), ITGA9(1), ITGAD(3), ITGAE(3), ITGAL(3), ITGAM(3), ITGAV(2), ITGAX(5), ITGB2(2), ITGB3(5), ITGB4(3), ITGB5(1), ITGB6(4), ITGB7(1), ITGB8(3), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K6(1), MAPK10(3), MAPK12(1), MAPK4(6), MAPK6(3), MAPK7(1), MYLK2(2), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PDPK1(2), PIK3R2(3), PTK2(5), PXN(1), RAC2(1), RAC3(2), RAP1B(2), RAPGEF1(2), RHO(3), ROCK1(11), ROCK2(6), SDCCAG8(3), SHC1(1), SHC3(3), SORBS1(2), SOS1(8), SRC(1), TLN1(13), TNS1(5), VASP(1), VAV2(1), VAV3(1), VCL(6), ZYX(2)	60052477	255	144	254	85	34	58	90	38	35	0	0.319	1.000	1.000
295	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	90	AKT1(2), AKT2(3), AKT3(4), BCL10(1), CARD11(4), CBL(2), CBLB(2), CD247(1), CD28(2), CD3D(1), CD40LG(3), CD8A(2), CD8B(1), CDC42(1), CDK4(4), CHUK(3), CTLA4(1), FOS(1), FYN(3), GRAP2(1), ICOS(1), IFNG(1), IKBKB(5), IL4(1), IL5(1), ITK(1), KRAS(1), LAT(3), LCK(5), LCP2(1), MALT1(3), MAP3K14(2), MAP3K8(1), NCK1(4), NCK2(3), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NFKB1(2), NFKB2(1), NFKBIB(1), NRAS(1), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PDCD1(1), PDK1(1), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLCG1(5), PRKCQ(5), PTPN6(1), PTPRC(13), RASGRP1(5), RHOA(4), SOS1(8), SOS2(9), TEC(2), VAV1(2), VAV2(1), VAV3(1), ZAP70(2)	45123169	217	142	214	70	34	47	62	40	33	1	0.362	1.000	1.000
296	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	76	ACTN1(2), ACTR2(1), AKT1(2), AKT2(3), AKT3(4), ANGPTL2(2), ARHGEF6(3), ARHGEF7(1), BCAR1(2), BRAF(4), CDC42(1), CRK(1), CSE1L(2), DOCK1(8), EPHB2(2), FYN(3), GRB7(2), GRLF1(12), ILK(4), ITGA1(3), ITGA10(5), ITGA11(5), ITGA2(4), ITGA3(3), ITGA4(6), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(12), ITGA9(1), ITGB3BP(1), MAP2K4(1), MAP3K11(1), MAPK1(4), MAPK10(3), MAPK8(4), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(5), MAPK9(4), MYLK(4), MYLK2(2), P4HB(1), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PIK3CB(5), PKLR(1), PLCG1(5), PLCG2(4), PTEN(6), PTK2(5), RAF1(2), RHO(3), ROCK1(11), ROCK2(6), SHC1(1), SOS1(8), SOS2(9), SRC(1), TLN1(13), TLN2(7), VASP(1), ZYX(2)	54458645	250	141	246	77	34	47	94	39	36	0	0.298	1.000	1.000
297	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	121	BID(2), BRAF(4), CASP3(1), CD247(1), CD48(1), FAS(1), FASLG(2), FCGR3A(4), FCGR3B(3), FYN(3), GZMB(1), HLA-C(3), ICAM1(2), ICAM2(2), IFNA16(2), IFNA17(1), IFNA21(1), IFNA4(2), IFNA6(1), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(1), IFNGR1(5), IFNGR2(2), ITGAL(3), ITGB2(2), KIR2DL1(3), KIR2DL3(1), KIR3DL1(7), KLRC2(1), KLRC3(2), KRAS(1), LAT(3), LCK(5), LCP2(1), MAP2K1(4), MAP2K2(3), MAPK1(4), MICB(3), NCR1(5), NCR2(3), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NRAS(1), PAK1(1), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLCG1(5), PLCG2(4), PRF1(3), PRKCA(2), PRKCG(7), PTK2B(2), PTPN11(1), PTPN6(1), RAC2(1), RAC3(2), RAF1(2), SH2D1A(4), SH2D1B(2), SH3BP2(1), SHC1(1), SHC2(3), SHC3(3), SHC4(3), SOS1(8), SOS2(9), SYK(3), TNFRSF10A(1), TNFRSF10B(1), ULBP1(1), ULBP2(1), VAV1(2), VAV2(1), VAV3(1), ZAP70(2)	49658192	239	139	234	87	48	43	68	44	34	2	0.618	1.000	1.000
298	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	86	ACVR1(5), ACVR1B(4), ACVR1C(3), ACVR2A(2), ACVRL1(3), AMHR2(1), BMP2(3), BMP4(2), BMP5(2), BMP6(2), BMP7(3), BMP8B(3), BMPR1B(1), BMPR2(3), CHRD(6), CREBBP(15), CUL1(6), DCN(2), E2F4(1), E2F5(4), FST(1), GDF5(3), GDF6(1), ID1(1), IFNG(1), INHBA(1), INHBB(2), INHBC(3), INHBE(1), LEFTY1(1), LEFTY2(1), LTBP1(15), MAPK1(4), MYC(4), PITX2(1), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2B(3), RBL1(8), RBL2(3), RBX1(2), RHOA(4), ROCK1(11), ROCK2(6), RPS6KB1(3), RPS6KB2(1), SKP1(1), SMAD1(2), SMAD2(3), SMAD3(2), SMAD4(8), SMAD5(2), SMAD9(2), SMURF1(2), SMURF2(4), SP1(1), TFDP1(3), TGFB1(1), TGFB2(2), TGFBR1(1), THBS1(7), THBS2(7), THBS4(5), ZFYVE16(3), ZFYVE9(5)	42324429	220	138	214	44	25	46	70	40	39	0	0.000540	1.000	1.000
299	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	72	BRAF(4), C7orf16(1), CACNA1A(7), GNA12(1), GNA13(1), GNAI1(1), GNAI3(1), GNAO1(2), GNAS(6), GNAZ(2), GRIA1(9), GRIA2(10), GRIA3(5), GRM1(16), GRM5(7), GUCY1A2(5), GUCY1A3(4), GUCY1B3(4), GUCY2C(4), GUCY2D(5), GUCY2F(8), IGF1R(7), ITPR1(9), ITPR2(11), ITPR3(5), KRAS(1), LYN(3), MAP2K1(4), MAP2K2(3), MAPK1(4), NOS1(3), NOS3(4), NPR1(1), NPR2(5), NRAS(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2B(3), PRKCA(2), PRKCG(7), PRKG1(3), PRKG2(1), RAF1(2), RYR1(16)	48844601	244	138	239	81	44	51	81	46	22	0	0.308	1.000	1.000
300	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	53	ASH1L(11), ASH2L(2), C17orf79(1), CARM1(3), CTCFL(2), DOT1L(3), EED(2), EHMT1(6), EHMT2(6), EZH1(3), EZH2(1), FBXO11(6), HCFC1(6), JMJD4(2), JMJD6(2), KDM6A(8), MEN1(2), MLL(15), MLL3(25), MLL4(7), MLL5(7), OGT(3), PAXIP1(2), PRDM2(4), PRDM7(1), PRDM9(22), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2), SATB1(5), SETD1A(6), SETD2(8), SETD7(2), SETD8(1), SETDB1(6), SETMAR(1), SMYD3(1), STK38(2), SUV39H1(2), SUV420H1(4), SUV420H2(2), SUZ12(1), WHSC1(11), WHSC1L1(1)	47117902	213	132	208	57	20	44	71	30	48	0	0.267	1.000	1.000
301	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(4), ALG1(2), ALG10(2), ALG10B(3), ALG12(2), ALG13(2), ALG2(2), ALG3(1), ALG6(2), ALG9(1), B3GNT1(1), B3GNT2(1), B3GNT6(1), B3GNT7(1), B4GALT2(3), B4GALT5(2), C1GALT1(3), C1GALT1C1(2), CHPF(4), CHST1(3), CHST11(3), CHST12(2), CHST13(3), CHST14(1), CHST2(2), CHST4(3), CHST6(6), CHSY1(2), DPAGT1(1), EXT1(2), EXT2(2), EXTL1(2), EXTL2(2), EXTL3(2), FUT8(2), GALNT1(2), GALNT10(2), GALNT11(2), GALNT12(3), GALNT13(7), GALNT14(5), GALNT2(3), GALNT3(3), GALNT4(2), GALNT5(3), GALNT6(3), GALNT8(5), GALNTL1(3), GALNTL2(3), GALNTL4(1), GALNTL5(4), GANAB(1), GCNT1(1), GCNT4(2), HS2ST1(4), HS3ST2(2), HS3ST3B1(1), HS3ST5(6), HS6ST1(2), HS6ST2(1), HS6ST3(1), MAN1B1(3), MAN1C1(3), MAN2A1(2), MGAT1(1), MGAT2(1), MGAT3(4), MGAT4B(2), MGAT5(1), MGAT5B(2), NDST1(1), NDST2(2), NDST3(4), NDST4(7), OGT(3), RPN1(1), RPN2(2), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1), ST6GALNAC1(4), STT3B(2), UST(1), WBSCR17(8), XYLT1(7), XYLT2(3)	50282171	216	132	216	92	45	32	78	33	28	0	0.934	1.000	1.000
302	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(6), ABCA10(12), ABCA12(12), ABCA13(24), ABCA2(8), ABCA3(4), ABCA4(9), ABCA5(3), ABCA6(7), ABCA7(4), ABCA8(5), ABCA9(7), ABCB1(11), ABCB11(6), ABCB4(9), ABCB5(5), ABCB6(5), ABCB7(4), ABCB8(3), ABCC10(5), ABCC11(4), ABCC12(5), ABCC2(4), ABCC3(4), ABCC5(4), ABCC6(2), ABCC8(11), ABCC9(15), ABCD1(2), ABCD2(6), ABCD3(3), ABCD4(3), ABCG1(3), ABCG2(2), ABCG4(4), ABCG8(8), CFTR(7), TAP1(3), TAP2(5)	53812685	244	132	243	79	32	59	79	39	35	0	0.115	1.000	1.000
303	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	95	AKT1(2), AKT2(3), AKT3(4), CCL3(1), CD14(1), CD40(4), CD80(5), CD86(1), CHUK(3), CXCL10(2), CXCL9(1), FADD(1), FOS(1), IFNA16(2), IFNA17(1), IFNA21(1), IFNA4(2), IFNA6(1), IFNA8(2), IFNAR1(2), IFNAR2(1), IKBKB(5), IKBKE(2), IL12A(1), IL12B(4), IL1B(1), IRAK1(2), IRAK4(3), IRF3(1), IRF5(1), IRF7(2), LBP(7), LY96(1), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAP3K7(4), MAP3K8(1), MAPK1(4), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK8(4), MAPK9(4), NFKB1(2), NFKB2(1), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), RELA(1), RIPK1(2), SPP1(1), STAT1(5), TBK1(1), TICAM1(4), TLR1(1), TLR2(1), TLR3(1), TLR4(7), TLR5(1), TLR6(3), TLR7(4), TLR8(2), TLR9(2), TRAF3(3), TRAF6(1)	39183290	186	131	183	56	31	38	60	34	22	1	0.157	1.000	1.000
304	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(3), CDC40(2), CLK2(5), CLK3(3), COL2A1(4), CPSF1(3), CPSF2(3), CSTF1(1), CSTF2(2), CSTF2T(1), CSTF3(1), DDX1(3), DDX20(3), DHX15(1), DHX16(4), DHX38(1), DHX8(3), DHX9(5), DICER1(7), DNAJC8(2), FUS(2), GIPC1(1), LOC440563(2), LSM2(1), METTL3(2), NCBP1(4), NCBP2(3), NONO(2), NUDT21(2), NXF1(3), PABPN1(2), PAPOLA(2), PHF5A(1), POLR2A(9), PRPF4(1), PRPF4B(4), PRPF8(6), PTBP2(1), RBM17(1), RBM5(6), RNGTT(1), RNMT(2), RNPS1(1), SF3A1(1), SF3A2(1), SF3B1(3), SF3B2(1), SF3B5(1), SF4(1), SFRS12(2), SFRS14(2), SFRS16(5), SFRS2(2), SFRS4(3), SFRS5(3), SFRS6(4), SFRS7(3), SFRS8(5), SFRS9(1), SNRPA(2), SNRPA1(1), SNRPB(1), SNRPB2(1), SNRPD2(2), SNRPN(5), SNURF(1), SPOP(4), SRPK2(5), SRRM1(3), SUPT5H(3), U2AF1(4), XRN2(5)	48212981	191	126	190	64	24	49	58	33	27	0	0.682	1.000	1.000
305	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	79	ATM(9), BUB1(2), BUB1B(4), CCNA1(4), CCNA2(3), CCNB1(3), CCNB3(5), CCNE1(3), CCNE2(3), CDAN1(7), CDC14A(2), CDC20(2), CDC25B(3), CDC6(2), CDC7(1), CDH1(4), CDK4(4), CHEK1(1), CHEK2(4), DTX4(3), E2F2(3), E2F4(1), E2F5(4), E2F6(1), ESPL1(9), GSK3B(1), HDAC3(1), HDAC4(3), HDAC5(1), HDAC6(5), HDAC8(1), MAD1L1(4), MAD2L2(1), MCM2(4), MCM3(2), MCM4(4), MCM5(2), MCM6(3), MCM7(5), MDM2(2), MPEG1(1), MPL(2), ORC2L(1), ORC4L(1), ORC5L(1), ORC6L(1), PLK1(2), PRKDC(15), PTPRA(4), RB1(9), RBL1(8), SKP2(2), SMAD4(8), TBC1D8(2), TFDP1(3), TGFB1(1), WEE1(1)	47156157	188	123	188	64	25	42	53	32	36	0	0.552	1.000	1.000
306	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	82	ATF2(1), BRAF(4), CHUK(3), CREB1(1), ELK1(1), FOS(1), IKBKB(5), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K4(1), MAP2K5(2), MAP2K6(1), MAP3K1(3), MAP3K10(4), MAP3K11(1), MAP3K12(6), MAP3K13(8), MAP3K14(2), MAP3K3(1), MAP3K4(5), MAP3K5(5), MAP3K6(3), MAP3K7(4), MAP3K8(1), MAP3K9(2), MAP4K1(2), MAP4K2(1), MAP4K3(5), MAP4K4(2), MAP4K5(1), MAPK1(4), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK4(6), MAPK6(3), MAPK7(1), MAPK8(4), MAPK9(4), MAPKAPK3(2), MAPKAPK5(1), MAX(1), MEF2A(1), MEF2B(2), MEF2C(7), MKNK1(1), MKNK2(1), MYC(4), NFKB1(2), PAK1(1), PAK2(5), RAF1(2), RELA(1), RIPK1(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA4(3), RPS6KA5(4), RPS6KB1(3), RPS6KB2(1), SHC1(1), SP1(1), STAT1(5), TGFB1(1), TGFB2(2), TGFBR1(1), TRAF2(1)	43022297	185	122	181	56	29	36	66	26	28	0	0.329	1.000	1.000
307	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	90	ACTB(2), BAD(1), BCL2(1), CABIN1(7), CALM1(1), CALM3(1), CAMK2B(2), CD69(1), CEBPB(1), CNR1(3), CREBBP(15), CSNK2A1(6), CSNK2B(2), CTLA4(1), EGR2(1), FCER1A(2), FCGR3A(4), FOS(1), GATA3(6), GRLF1(12), GSK3B(1), ICOS(1), IFNG(1), IL13(1), IL1B(1), IL2RA(2), IL3(1), IL4(1), ITK(1), JUNB(1), KPNA5(1), MAPK14(1), MAPK8(4), MAPK9(4), MEF2A(1), MEF2B(2), MYF5(4), NCK2(3), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NFKB2(1), NFKBIB(1), NPPB(1), NUP214(8), OPRD1(2), PAK1(1), PIN1(1), PTPRC(13), RELA(1), RPL13A(1), SFN(5), SLA(1), SP1(1), SP3(1), TGFB1(1), TRAF2(1), TRPV6(4), VAV1(2), VAV2(1), VAV3(1), XPO5(1)	39096074	176	121	176	65	24	37	53	37	25	0	0.639	1.000	1.000
308	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(12), ACSL1(2), ACSL3(1), ACSL4(6), ACSL5(4), ACSL6(1), ADIPOQ(1), ADIPOR1(2), ADIPOR2(3), AKT1(2), AKT2(3), AKT3(4), CAMKK1(1), CAMKK2(5), CHUK(3), CPT1A(4), CPT1B(3), CPT1C(5), CPT2(2), G6PC(2), G6PC2(3), IKBKB(5), IRS1(1), IRS2(2), IRS4(10), JAK1(6), JAK2(2), JAK3(3), LEP(1), LEPR(11), MAPK10(3), MAPK8(4), MAPK9(4), NFKB1(2), NFKB2(1), NFKBIB(1), NPY(2), PCK2(3), POMC(1), PPARGC1A(3), PRKAA1(3), PRKAA2(2), PRKAB1(3), PRKAG2(2), PRKAG3(2), PRKCQ(5), PTPN11(1), RELA(1), RXRA(4), RXRB(2), RXRG(6), SLC2A1(3), SLC2A4(1), STAT3(3), STK11(2), TRAF2(1), TYK2(2)	37823107	177	120	176	56	26	36	59	31	25	0	0.320	1.000	1.000
309	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	65	A2M(3), BDKRB1(1), C1QC(1), C1R(3), C1S(3), C3(7), C3AR1(2), C4BPA(1), C4BPB(2), C5(5), C5AR1(1), C7(5), C8A(6), C8B(4), C8G(1), C9(5), CD46(1), CFB(1), CFH(9), CFI(5), CPB2(3), CR1(8), CR2(5), F10(3), F11(2), F12(1), F2(2), F3(1), F5(12), F7(2), F8(4), F9(5), FGA(7), FGB(2), FGG(3), KLKB1(5), KNG1(3), MASP1(4), MASP2(4), MBL2(2), PLAT(2), PLAU(1), PLG(8), PROS1(5), SERPINA1(4), SERPINA5(4), SERPINC1(3), SERPIND1(4), SERPINE1(4), SERPING1(3), THBD(2), VWF(6)	39788954	190	117	190	81	14	48	64	30	33	1	0.949	1.000	1.000
310	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	27	BRAF(4), CPEB1(4), EGFR(14), ERBB2(8), ERBB4(15), ETS1(2), ETS2(5), ETV6(4), ETV7(1), FMN2(21), KRAS(1), MAP2K1(4), MAPK1(4), NOTCH2(13), NOTCH3(14), NOTCH4(5), PIWIL1(8), PIWIL2(4), PIWIL3(3), PIWIL4(2), RAF1(2), SOS1(8), SOS2(9), SPIRE1(4)	21971044	159	116	153	41	26	31	55	24	23	0	0.247	1.000	1.000
311	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	61	AKT1(2), AKT2(3), AKT3(4), BAD(1), BCL2L1(2), CDC42(1), CDKN1B(2), CREB1(1), CREB5(5), ERBB4(15), F2RL2(1), GAB1(2), GSK3B(1), IGFBP1(2), INPPL1(4), IRS1(1), IRS2(2), IRS4(10), MET(1), MYC(4), NOLC1(3), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PARD3(10), PARD6A(1), PDK1(1), PIK3CD(2), PPP1R13B(1), PREX1(6), PTEN(6), PTK2(5), PTPN1(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KB1(3), SFN(5), SHC1(1), SLC2A4(1), SOS1(8), SOS2(9), TSC1(2), TSC2(3), YWHAB(1), YWHAE(2), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(2)	33990785	170	116	169	51	17	40	55	29	29	0	0.200	1.000	1.000
312	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	71	AKT1(2), AKT2(3), AKT3(4), BTK(5), FCER1A(2), FYN(3), GAB2(2), IL13(1), IL3(1), IL4(1), IL5(1), INPP5D(7), KRAS(1), LAT(3), LCP2(1), LYN(3), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAPK1(4), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK8(4), MAPK9(4), MS4A2(2), NRAS(1), PDK1(1), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLCG1(5), PLCG2(4), PRKCA(2), PRKCD(4), PRKCE(2), RAC2(1), RAC3(2), RAF1(2), SOS1(8), SOS2(9), SYK(3), VAV1(2), VAV2(1), VAV3(1)	31462599	166	114	163	54	26	33	54	31	21	1	0.481	1.000	1.000
313	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	46	FN3K(2), IMPA1(1), IMPA2(2), INPP1(2), INPP4A(4), INPP4B(7), INPP5B(3), INPPL1(4), IPMK(2), ISYNA1(2), ITPK1(2), ITPKA(1), ITPKB(5), MIOX(2), OCRL(4), PI4KA(5), PIK3C3(2), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIP4K2B(2), PIP4K2C(2), PIP5K1A(4), PIP5K1B(4), PIP5K1C(2), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PLCD1(2), PLCD4(2), PLCE1(12), PLCG1(5), PLCG2(4), PLCZ1(3), PTEN(6), PTPMT1(2), SYNJ1(6), SYNJ2(4)	32831248	155	110	154	56	28	26	52	30	18	1	0.448	1.000	1.000
314	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	77	AIFM1(1), AKT1(2), AKT2(3), AKT3(4), APAF1(9), ATM(9), BAD(1), BAX(1), BCL2(1), BCL2L1(2), BID(2), BIRC2(1), BIRC3(1), CAPN2(4), CASP10(2), CASP3(1), CASP6(2), CASP7(1), CFLAR(2), CHUK(3), CSF2RB(5), FADD(1), FAS(1), FASLG(2), IKBKB(5), IL1A(1), IL1B(1), IL1R1(2), IL1RAP(4), IL3(1), IL3RA(3), IRAK1(2), IRAK2(2), IRAK3(4), IRAK4(3), MAP3K14(2), NFKB1(2), NFKB2(1), NTRK1(3), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PRKACA(4), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RELA(1), RIPK1(2), TNFRSF10A(1), TNFRSF10B(1), TRAF2(1)	36170479	148	108	148	46	28	39	31	31	18	1	0.222	1.000	1.000
315	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	66	AKT1(2), AKT2(3), AKT3(4), BAD(1), CDC42(1), KDR(5), KRAS(1), MAP2K1(4), MAP2K2(3), MAPK1(4), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPKAPK3(2), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NOS3(4), NRAS(1), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLCG1(5), PLCG2(4), PRKCA(2), PRKCG(7), PTGS2(2), PTK2(5), PXN(1), RAC2(1), RAC3(2), RAF1(2), SHC2(3), SPHK2(1), SRC(1)	31459937	146	107	143	57	35	28	42	25	15	1	0.614	1.000	1.000
316	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	59	AKT1(2), AKT2(3), AKT3(4), BCL10(1), BLNK(3), BTK(5), CARD11(4), CD19(2), CD22(1), CD72(1), CHUK(3), CR2(5), FCGR2B(1), FOS(1), GSK3B(1), IFITM1(3), IKBKB(5), INPP5D(7), KRAS(1), LILRB3(5), LYN(3), MALT1(3), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NFKB1(2), NFKB2(1), NFKBIB(1), NRAS(1), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLCG2(4), PTPN6(1), RAC2(1), RAC3(2), RASGRP3(3), SYK(3), VAV1(2), VAV2(1), VAV3(1)	32611025	146	107	145	57	29	33	37	27	19	1	0.656	1.000	1.000
317	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(5), AMY2A(2), AMY2B(6), ENPP1(5), ENPP3(5), G6PC(2), GAA(3), GANAB(1), GBA3(5), GCK(2), GPI(2), GUSB(1), GYS1(5), GYS2(5), HK1(3), HK2(5), HK3(4), MGAM(18), PGM1(3), PGM3(1), PYGB(3), PYGL(4), PYGM(3), SI(40), UCHL3(1), UGDH(3), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2B15(2), UGT2B4(8), UXS1(1)	25874629	158	107	157	55	21	28	55	35	19	0	0.736	1.000	1.000
318	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	82	CD14(1), CD19(2), CD1A(4), CD1B(1), CD1C(2), CD1D(4), CD2(1), CD22(1), CD33(2), CD34(4), CD38(2), CD3D(1), CD44(1), CD7(2), CD8A(2), CD8B(1), CD9(1), CR1(8), CR2(5), CSF1(1), CSF2RA(1), CSF3R(2), EPO(2), FCER2(2), FCGR1A(1), FLT3(4), FLT3LG(1), GP5(3), GP9(1), GYPA(3), HLA-DRA(1), IL1A(1), IL1B(1), IL1R1(2), IL1R2(1), IL2RA(2), IL3(1), IL3RA(3), IL4(1), IL4R(2), IL5(1), IL5RA(1), IL6R(4), IL7R(3), IL9R(4), ITGA1(3), ITGA2(4), ITGA2B(3), ITGA3(3), ITGA4(6), ITGA5(1), ITGA6(3), ITGAM(3), ITGB3(5), KIT(5), MME(11), MS4A1(2), TFRC(3), TPO(10)	36829029	156	104	155	62	25	32	56	27	16	0	0.854	1.000	1.000
319	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	64	AGTR2(2), ATP8A1(9), AVPR1A(5), AVPR1B(4), AVPR2(1), BDKRB1(1), BRS3(2), C3AR1(2), CCKAR(4), CCKBR(3), CCR1(1), CCR10(1), CCR2(2), CCR3(3), CCR4(1), CCR6(1), CCR7(1), CX3CR1(1), CXCR3(1), CXCR4(1), EDNRB(3), FPR1(3), FSHR(5), GALR1(2), GALR2(3), GALT(1), GHSR(3), GNB2L1(1), GPR77(2), GRPR(1), LHCGR(2), MC2R(7), MC3R(3), MC4R(3), MC5R(5), NMBR(2), NPY1R(5), NPY2R(3), NTSR1(2), NTSR2(5), OPRD1(2), OPRK1(2), OPRL1(1), OXTR(2), PPYR1(1), SSTR1(5), SSTR2(1), SSTR3(5), SSTR4(6), TACR1(2), TACR2(2), TACR3(5), TRHR(4), TSHR(2)	23099743	147	104	147	60	28	34	51	16	18	0	0.351	1.000	1.000
320	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(2), ALG6(2), CCKBR(3), CCR2(2), CCR3(3), CELSR1(9), CELSR2(18), CELSR3(12), CHRM2(4), CHRM3(5), CXCR3(1), DRD4(1), EMR2(2), EMR3(2), FSHR(5), GHRHR(2), GPR116(4), GPR132(2), GPR133(7), GPR143(1), GPR17(1), GPR18(1), GPR55(1), GPR77(2), GPR84(2), GRM1(16), GRPR(1), HRH4(3), LGR6(5), LPHN2(8), LPHN3(14), LTB4R2(1), NTSR1(2), OR2M4(4), OR8G2(3), P2RY13(2), PTGFR(2), SMO(1), SSTR2(1), TSHR(2), VN1R1(1)	30291802	160	103	160	62	25	45	51	27	12	0	0.337	1.000	1.000
321	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	AICDA(3), CAD(2), CANT1(1), CDA(1), CTPS(1), DCK(2), DHODH(4), DPYD(8), DPYS(5), ENTPD1(2), ENTPD3(1), ENTPD4(4), ENTPD5(2), ENTPD6(1), ITPA(3), NME7(2), NT5C1A(1), NT5C1B(4), NT5C2(1), NT5C3(2), NUDT2(1), PNPT1(4), POLA1(2), POLA2(1), POLD1(3), POLD2(1), POLD3(3), POLE(8), POLE2(1), POLR1A(5), POLR1B(3), POLR1C(2), POLR2A(9), POLR2B(2), POLR2D(1), POLR2G(2), POLR2H(1), POLR2L(1), POLR3A(8), POLR3B(2), POLR3G(1), POLR3H(1), RFC5(2), RRM1(1), RRM2(1), RRM2B(1), TXNRD1(3), TXNRD2(1), TYMS(1), UCK1(2), UCK2(4), UMPS(1), UPB1(1), UPP1(1), UPP2(4), UPRT(2)	36498221	137	100	137	58	25	25	49	21	17	0	0.929	1.000	1.000
322	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADL(2), ACADM(3), ACOX2(1), ACOX3(1), ACSL1(2), ACSL3(1), ACSL4(6), ACSL5(4), ACSL6(1), ADIPOQ(1), ANGPTL4(3), APOA2(1), APOA5(2), CPT1A(4), CPT1B(3), CPT1C(5), CPT2(2), CYP27A1(2), CYP4A11(8), CYP4A22(6), CYP7A1(2), CYP8B1(3), DBI(2), EHHADH(2), FABP1(1), FABP2(1), FABP3(1), FABP4(2), FABP5(1), FABP6(2), FABP7(1), FADS2(2), GK(1), GK2(7), HMGCS2(2), ILK(4), LPL(2), ME1(1), MMP1(4), OLR1(1), PCK2(3), PDPK1(2), RXRA(4), RXRB(2), RXRG(6), SCD(1), SLC27A1(1), SLC27A2(2), SLC27A4(2), SLC27A5(2), SLC27A6(5), SORBS1(2), UBC(4)	29828246	136	99	136	42	21	27	49	16	23	0	0.252	1.000	1.000
323	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	43	ACTR2(1), AKT1(2), AKT2(3), AKT3(4), ANGPTL2(2), ARHGAP1(2), ARHGAP4(5), ARHGEF11(3), BTK(5), CDC42(1), CFL1(2), GDI1(2), GDI2(2), INPPL1(4), ITPR1(9), ITPR2(11), ITPR3(5), LIMK1(5), MYLK(4), MYLK2(2), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PDK1(1), PIK3CD(2), PIK3CG(8), PIK3R1(6), PITX2(1), PPP1R13B(1), PTEN(6), RACGAP1(3), RHO(3), ROCK1(11), ROCK2(6), WASF1(3), WASL(1)	30883269	144	99	143	55	18	40	39	26	20	1	0.633	1.000	1.000
324	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(2), AKT2(3), AKT3(4), ASAH1(1), BRAF(4), DAG1(1), DRD2(2), EGFR(14), EPHB2(2), ITPKA(1), ITPKB(5), ITPR1(9), ITPR2(11), ITPR3(5), KCNJ3(4), KCNJ5(3), KCNJ9(1), MAPK1(4), PI3(1), PIK3CB(5), PITX2(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), RAF1(2), RGS20(2), SHC1(1), SOS1(8), SOS2(9), SRC(1), STAT3(3)	26560548	139	99	135	43	21	29	42	33	14	0	0.240	1.000	1.000
325	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	APAF1(9), ATM(9), ATR(19), BAI1(4), BAX(1), BID(2), CASP3(1), CCNB1(3), CCNB3(5), CCND1(2), CCNE1(3), CCNE2(3), CCNG1(1), CCNG2(2), CDK4(4), CDK6(1), CHEK1(1), CHEK2(4), DDB2(2), EI24(1), FAS(1), GADD45G(1), GTSE1(4), IGFBP3(1), LRDD(3), MDM2(2), MDM4(1), PERP(1), PMAIP1(2), PPM1D(2), PTEN(6), RCHY1(1), RFWD2(1), RRM2(1), RRM2B(1), SERPINE1(4), SESN3(1), SFN(5), SIAH1(1), STEAP3(2), THBS1(7), TNFRSF10B(1), TSC2(3)	28630402	129	97	129	33	13	29	30	35	22	0	0.126	1.000	1.000
326	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(3), ADAM17(4), ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V0D2(3), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), CASP3(1), CDC42(1), CHUK(3), CSK(1), CXCL1(1), EGFR(14), F11R(1), GIT1(1), IGSF5(3), IKBKB(5), LYN(3), MAP2K4(1), MAP3K14(2), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK8(4), MAPK9(4), MET(1), NFKB1(2), NFKB2(1), NOD1(5), PAK1(1), PLCG1(5), PLCG2(4), PTPN11(1), PTPRZ1(6), RELA(1), SRC(1), TCIRG1(7), TJP1(9)	31835220	132	96	132	44	12	30	46	27	17	0	0.590	1.000	1.000
327	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(1), AANAT(1), ABP1(3), ACAT2(1), ACMSD(4), AFMID(3), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), AOC2(2), AOC3(5), AOX1(5), ASMT(2), CARM1(3), CAT(2), CYP1A2(4), CYP1B1(1), DDC(7), ECHS1(2), EHHADH(2), GCDH(1), HADHA(3), HEMK1(1), HSD17B4(3), KMO(1), KYNU(6), LCMT1(1), LCMT2(6), MAOA(1), MAOB(1), METTL2B(2), METTL6(2), NFX1(2), OGDH(6), OGDHL(9), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2), TDO2(2), TPH1(2), TPH2(4), WARS2(5)	27547564	124	95	124	38	20	26	36	18	24	0	0.343	1.000	1.000
328	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP2(3), BMP4(2), BMP5(2), BMP6(2), BMP7(3), BMP8B(3), BTRC(1), CSNK1A1(1), CSNK1E(3), CSNK1G1(1), GLI1(5), GLI2(8), GLI3(5), GSK3B(1), HHIP(2), LRP2(26), PRKACA(4), PRKACB(2), PRKACG(1), PRKX(1), PTCH1(11), PTCH2(5), RAB23(2), SMO(1), STK36(4), SUFU(1), WNT1(1), WNT10A(2), WNT10B(1), WNT11(1), WNT16(1), WNT2(3), WNT3(4), WNT3A(1), WNT4(1), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(1), WNT8A(1), WNT8B(2), WNT9A(3), WNT9B(1), ZIC2(5)	27678560	132	95	132	47	29	22	50	17	14	0	0.542	1.000	1.000
329	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(2), AKT2(3), AKT3(4), BAD(1), BCL2(1), BCR(1), BLNK(3), BTK(5), CD19(2), CD22(1), CR2(5), CSK(1), DAG1(1), FLOT1(1), FLOT2(3), GSK3B(1), INPP5D(7), ITPR1(9), ITPR2(11), ITPR3(5), LYN(3), MAP4K1(2), MAPK1(4), NFATC1(7), NFATC2(6), NR0B2(1), PDK1(1), PIK3CD(2), PIK3R1(6), PLCG2(4), PPP1R13B(1), PTPRC(13), RAF1(2), SHC1(1), SOS1(8), SOS2(9), SYK(3), VAV1(2)	32669101	142	95	139	57	21	35	34	30	22	0	0.681	1.000	1.000
330	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	47	AKT1(2), AKT2(3), AKT3(4), BRD4(5), CAP1(2), CBL(2), CDC42(1), F2RL2(1), FLOT1(1), FLOT2(3), GSK3B(1), IGFBP1(2), INPPL1(4), IRS1(1), IRS2(2), IRS4(10), LNPEP(2), MAPK1(4), PARD3(10), PARD6A(1), PDK1(1), PIK3CD(2), PIK3R1(6), PPYR1(1), PTEN(6), PTPN1(2), RAF1(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KB1(3), SERPINB6(3), SFN(5), SHC1(1), SLC2A4(1), SORBS1(2), SOS1(8), SOS2(9), YWHAB(1), YWHAE(2), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(2)	25887359	132	95	128	39	23	28	42	22	17	0	0.208	1.000	1.000
331	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	62	ATM(9), CCNA1(4), CCNB1(3), CCND1(2), CCNE1(3), CCNE2(3), CCNG2(2), CDK4(4), CDKN1B(2), CREB3L1(2), CREB3L3(3), CREB3L4(1), E2F2(3), E2F4(1), E2F5(4), E2F6(1), GBA2(3), MCM2(4), MCM3(2), MCM4(4), MCM5(2), MCM6(3), MCM7(5), MDM2(2), MNAT1(2), MYC(4), MYT1(7), NACA(3), ORC2L(1), ORC4L(1), ORC5L(1), ORC6L(1), POLA2(1), POLE(8), POLE2(1), RB1(9), RBL1(8), RPA1(4), TFDP1(3), TFDP2(1), TNXB(10), WEE1(1)	34511048	138	94	137	50	17	29	45	25	22	0	0.732	1.000	1.000
332	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	41	ADAM17(4), APH1A(2), CREBBP(15), CTBP1(1), CTBP2(2), DLL1(4), DLL3(1), DLL4(2), DTX1(5), DTX2(1), DTX3(2), DTX3L(1), DTX4(3), DVL1(2), DVL2(1), DVL3(4), JAG1(6), JAG2(4), LFNG(2), MAML1(1), MAML2(2), MAML3(1), NCOR2(11), NCSTN(1), NOTCH2(13), NOTCH3(14), NOTCH4(5), NUMB(2), PTCRA(2), RBPJ(2), RBPJL(2), RFNG(2), SNW1(2)	27500704	122	93	120	49	24	25	34	17	22	0	0.778	1.000	1.000
333	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ABP1(3), ACAT2(1), ACMSD(4), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), AOC2(2), AOC3(5), AOX1(5), ASMT(2), CAT(2), CYP19A1(1), CYP1A2(4), CYP2A13(2), CYP2A7(2), CYP2B6(3), CYP2C18(1), CYP2C19(3), CYP2C8(3), CYP2C9(5), CYP2D6(1), CYP2E1(5), CYP2F1(2), CYP2J2(4), CYP3A4(3), CYP3A5(1), CYP3A7(1), CYP4B1(2), CYP4F8(3), CYP51A1(1), DDC(7), ECHS1(2), EHHADH(2), GCDH(1), HADHA(3), KMO(1), KYNU(6), MAOA(1), MAOB(1), TDO2(2), TPH1(2), WARS2(5)	25058904	116	90	116	34	18	23	37	17	21	0	0.205	1.000	1.000
334	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	APC(15), AXIN1(5), CCND1(2), CSNK1E(3), CTNNB1(2), DVL1(2), DVL2(1), DVL3(4), FZD1(3), FZD10(1), FZD2(2), FZD3(2), FZD5(1), FZD6(2), FZD8(1), GSK3B(1), LDLR(3), MAPK10(3), MAPK9(4), MYC(4), PLAU(1), PPP2R5C(2), PPP2R5E(1), PRKCA(2), PRKCD(4), PRKCE(2), PRKCG(7), PRKCH(3), PRKCI(2), PRKCQ(5), PRKCZ(3), PRKD1(10), RHOA(4), SFRP4(8), TCF7(2), WNT1(1), WNT10A(2), WNT10B(1), WNT11(1), WNT16(1), WNT2(3), WNT3(4), WNT4(1), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(1)	27149849	136	90	133	52	18	26	56	24	11	1	0.739	1.000	1.000
335	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(3), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH3B1(1), ALDH3B2(2), AOC2(2), AOC3(5), AOX1(5), CARM1(3), DBH(4), DCT(1), DDC(7), ESCO1(3), ESCO2(3), FAH(1), GOT1(1), GOT2(3), HEMK1(1), HGD(2), HPD(1), LCMT1(1), LCMT2(6), MAOA(1), MAOB(1), METTL2B(2), METTL6(2), MYST3(4), MYST4(6), PNMT(1), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2), SH3GLB1(2), TAT(1), TH(2), TPO(10), TYR(4), TYRP1(1)	27085348	118	89	117	39	21	30	37	13	17	0	0.418	1.000	1.000
336	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	43	CBL(2), CD28(2), CD3D(1), CSK(1), CTLA4(1), DAG1(1), EPHB2(2), GRAP2(1), ITK(1), ITPKA(1), ITPKB(5), LAT(3), LCK(5), LCP2(1), MAPK1(4), NCK1(4), NFAT5(5), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PLCG1(5), PTPRC(13), RAF1(2), RASGRP1(5), RASGRP2(3), RASGRP3(3), RASGRP4(3), SOS1(8), SOS2(9), VAV1(2), ZAP70(2)	24704887	118	89	115	37	18	24	35	18	23	0	0.367	1.000	1.000
337	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	57	ALG2(2), BAX(1), BTK(5), CAD(2), CASP10(2), CASP3(1), CASP8AP2(3), CD7(2), CSNK1A1(1), DEDD(1), DEDD2(2), DIABLO(1), EGFR(14), EPHB2(2), FADD(1), FAF1(1), IL1A(1), MAP2K4(1), MAP3K1(3), MAP3K5(5), MAPK1(4), MAPK10(3), MAPK8(4), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(5), MAPK9(4), MET(1), NFAT5(5), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), NR0B2(1), PTPN13(9), RALBP1(2), RIPK1(2), ROCK1(11), SMPD1(1), TNFRSF6B(2), TPX2(4), TRAF2(1)	32291864	120	88	117	39	19	26	41	17	17	0	0.458	1.000	1.000
338	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), AGK(1), AGPAT1(2), AGPAT2(1), AGPAT3(1), AGPAT4(2), AKR1B1(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), CEL(1), DAK(3), DGAT2(1), DGKA(2), DGKB(6), DGKD(4), DGKE(3), DGKH(4), DGKI(8), DGKQ(5), DGKZ(4), GK(1), GK2(7), GLA(3), GLB1(4), GPAM(3), LCT(8), LIPA(1), LIPC(3), LIPG(1), LPL(2), PNLIP(2), PNLIPRP1(5), PNLIPRP2(6), PPAP2B(1)	26704718	119	87	119	32	17	28	29	26	19	0	0.0611	1.000	1.000
339	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	49	ACTA1(2), AGT(2), AKT1(2), CALM1(1), CALM3(1), CALR(2), CAMK1(1), CAMK1G(1), CREBBP(15), CSNK1A1(1), F2(2), FGF2(1), GSK3B(1), HAND2(2), LIF(2), MAP2K1(4), MAPK1(4), MAPK14(1), MAPK8(4), MEF2C(7), MYH2(16), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NKX2-5(1), NPPA(1), PIK3R1(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RAF1(2), RPS6KB1(3), SYT1(5)	21932228	119	86	116	38	24	27	36	17	15	0	0.230	1.000	1.000
340	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(2), AKT1(2), CALM1(1), CALM3(1), FLT1(10), FLT4(6), KDR(5), NOS3(4), PDE2A(1), PDE3A(13), PDE3B(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKG1(3), PRKG2(1), RYR2(44), SLC7A1(2), SYT1(5)	18432057	109	86	109	41	20	26	36	18	8	1	0.646	1.000	1.000
341	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(2), ALPL(3), ALPP(1), ALPPL2(4), ASCC3(5), DDX18(1), DDX19A(3), DDX23(1), DDX4(3), DDX41(2), DDX50(1), DDX51(2), DDX52(4), DDX54(4), DDX55(3), DDX56(3), DHFR(3), DHX58(2), ENTPD7(3), EP400(8), ERCC2(2), ERCC3(4), FPGS(2), IFIH1(5), MOV10L1(3), NUDT5(1), NUDT8(1), RAD54B(2), RAD54L(4), RUVBL2(2), SETX(8), SKIV2L2(3), SMARCA2(8), SMARCA5(1)	28632935	104	85	104	31	12	21	39	20	12	0	0.389	1.000	1.000
342	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	43	AKT1(2), AKT2(3), AKT3(4), BRAF(4), EIF4B(2), EIF4EBP1(1), HIF1A(2), MAPK1(4), PDPK1(2), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PRKAA1(3), PRKAA2(2), RICTOR(7), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA6(4), RPS6KB1(3), RPS6KB2(1), STK11(2), TSC1(2), TSC2(3), ULK1(5), ULK2(2), VEGFC(3)	23184866	105	85	102	32	23	21	28	18	14	1	0.313	1.000	1.000
343	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	AKT1(2), APC(15), AR(4), ASAH1(1), BRAF(4), CCL15(1), DAG1(1), EGFR(14), GNA15(2), GNAI1(1), ITPKA(1), ITPKB(5), ITPR1(9), ITPR2(11), ITPR3(5), KCNJ3(4), KCNJ5(3), KCNJ9(1), MAPK1(4), MAPK10(3), MAPK14(1), PHKA2(9), PIK3CD(2), PIK3R1(6), PITX2(1), PTX3(2), RAF1(2), SRC(1)	23165352	115	85	111	38	20	23	35	21	16	0	0.372	1.000	1.000
344	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(5), ACSS2(2), ACYP1(1), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(2), ALDH7A1(2), ALDH9A1(2), ALDOA(1), ALDOB(3), ALDOC(1), DLAT(2), ENO1(1), ENO3(1), FBP2(1), G6PC(2), G6PC2(3), GAPDHS(1), GCK(2), GPI(2), HK1(3), HK2(5), HK3(4), LDHA(1), LDHAL6B(4), LDHB(1), LDHC(3), PDHA1(3), PDHA2(5), PFKL(4), PFKM(2), PFKP(4), PGAM1(1), PGAM4(1), PGK2(3), PGM1(3), PGM3(1), PKLR(1), PKM2(3), TPI1(2)	26472566	107	84	107	40	20	21	28	17	21	0	0.688	1.000	1.000
345	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(6), ADCY4(5), ADCY6(4), ADCY8(13), CACNA1A(7), CACNA1B(4), GNAS(6), GNAT3(3), GNB1(2), GNB3(3), GRM4(2), ITPR3(5), KCNB1(3), PDE1A(3), PLCB2(4), PRKACA(4), PRKACB(2), PRKACG(1), PRKX(1), SCNN1A(3), SCNN1B(1), SCNN1G(4), TAS1R1(2), TAS1R2(2), TAS1R3(2), TAS2R1(1), TAS2R13(1), TAS2R14(1), TAS2R16(3), TAS2R3(1), TAS2R38(2), TAS2R39(1), TAS2R40(4), TAS2R42(1), TAS2R43(1), TAS2R46(2), TAS2R60(1), TAS2R7(2), TAS2R8(3), TRPM5(3)	25874670	119	84	119	60	34	18	28	26	13	0	0.943	1.000	1.000
346	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	48	APOA2(1), CPT1B(3), CREBBP(15), EHHADH(2), FABP1(1), HSD17B4(3), LPL(2), MAPK1(4), ME1(1), MYC(4), NCOA1(4), NCOR1(12), NCOR2(11), NR0B2(1), NR2F1(2), NRIP1(3), PIK3R1(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PTGS2(2), RB1(9), RELA(1), RXRA(4), SP1(1), STAT5A(1), STAT5B(4)	25603695	107	83	102	33	11	27	31	17	21	0	0.317	1.000	1.000
347	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3L1(1), CAD(2), CANT1(1), CDA(1), CTPS(1), DCK(2), DHODH(4), DPYD(8), DPYS(5), ENTPD1(2), ITPA(3), NUDT2(1), POLB(1), POLD1(3), POLD2(1), POLE(8), POLG(2), POLL(5), POLQ(16), POLR1B(3), POLR2A(9), POLR2B(2), POLR2D(1), POLR2G(2), POLR2H(1), POLR2L(1), POLRMT(4), RRM1(1), RRM2(1), TXNRD1(3), TYMS(1), UCK1(2), UCK2(4), UMPS(1), UNG(1), UPB1(1), UPP1(1)	26116929	106	82	106	37	16	20	40	14	16	0	0.493	1.000	1.000
348	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	50	ACTG1(2), APAF1(9), BAG4(4), BCL2(1), BID(2), BIRC2(1), BIRC3(1), CASP3(1), CASP6(2), CASP7(1), CFLAR(2), CHUK(3), CRADD(1), FADD(1), GSN(5), LMNB1(1), LMNB2(4), MAP3K1(3), MAP3K14(2), MAP3K5(5), MAPK8(4), MDM2(2), NFKB1(2), NUMA1(4), PAK2(5), PRKCD(4), PRKDC(15), PTK2(5), RB1(9), RELA(1), RIPK1(2), SPTAN1(11), TRAF2(1)	30103025	116	81	116	39	16	23	32	17	28	0	0.566	1.000	1.000
349	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	41	AKT1(2), ASAH1(1), ATF1(2), BRAF(4), CREB1(1), CREB5(5), CREBBP(15), CRKL(1), DAG1(1), EGR1(3), EGR2(1), ELK1(1), MAP1B(12), MAP2K4(1), MAPK1(4), MAPK10(3), MAPK8(4), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(5), MAPK9(4), NTRK1(3), OPN1LW(2), PIK3C2G(7), PIK3CD(2), PIK3R1(6), PTPN11(1), RPS6KA3(3), SHC1(1), SRC(1), TH(2)	22417691	103	81	100	29	15	23	34	15	16	0	0.241	1.000	1.000
350	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(2), AKR1D1(2), ARSD(1), ARSE(1), CARM1(3), CYP11B1(4), CYP11B2(3), CYP19A1(1), HEMK1(1), HSD11B2(1), HSD17B12(1), HSD17B3(1), HSD17B8(1), HSD3B1(2), HSD3B2(2), LCMT1(1), LCMT2(6), METTL2B(2), METTL6(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2), SRD5A2(2), STS(1), SULT1E1(3), SULT2A1(2), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2A1(4), UGT2A3(4), UGT2B10(11), UGT2B11(7), UGT2B15(2), UGT2B28(3), UGT2B4(8), UGT2B7(3)	22848351	108	80	108	37	18	20	43	18	9	0	0.588	1.000	1.000
351	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), AKR1C4(2), ALDH3B1(1), ALDH3B2(2), CYP1A2(4), CYP1B1(1), CYP2B6(3), CYP2C18(1), CYP2C19(3), CYP2C8(3), CYP2C9(5), CYP2E1(5), CYP2F1(2), CYP2S1(1), CYP3A4(3), CYP3A43(1), CYP3A5(1), CYP3A7(1), EPHX1(1), GSTA1(2), GSTA2(2), GSTA3(2), GSTA5(2), GSTK1(1), GSTM2(2), GSTM4(1), GSTT1(1), MGST1(1), MGST3(1), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2A1(4), UGT2A3(4), UGT2B10(11), UGT2B11(7), UGT2B15(2), UGT2B28(3), UGT2B4(8), UGT2B7(3)	26186719	122	80	121	42	13	26	49	24	10	0	0.514	1.000	1.000
352	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(2), AGPAT1(2), AGPAT2(1), AGPAT3(1), AGPAT4(2), CDIPT(1), CDS1(1), CDS2(3), CHAT(6), CHPT1(1), CRLS1(1), DGKA(2), DGKB(6), DGKD(4), DGKE(3), DGKH(4), DGKI(8), DGKQ(5), DGKZ(4), ESCO1(3), ESCO2(3), ETNK2(1), GNPAT(3), GPAM(3), GPD1(1), GPD2(2), LCAT(2), MYST3(4), MYST4(6), PCYT1A(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLD1(7), PLD2(1), PPAP2B(1), PTDSS1(5), PTDSS2(1), SH3GLB1(2)	29766289	112	79	112	36	12	22	35	21	22	0	0.430	1.000	1.000
353	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ACTB(2), ACTG1(2), ARHGEF2(1), CD14(1), CDC42(1), CDH1(4), CTNNB1(2), CTTN(4), FYN(3), HCLS1(2), KRT18(1), LY96(1), NCK1(4), NCK2(3), NCL(3), PRKCA(2), RHOA(4), ROCK1(11), ROCK2(6), TLR4(7), TLR5(1), TUBA1B(3), TUBA3C(6), TUBA3D(2), TUBA3E(3), TUBA4A(1), TUBA8(2), TUBAL3(3), TUBB1(1), TUBB2C(1), TUBB3(2), TUBB4(3), TUBB4Q(4), TUBB6(3), TUBB8(1), WASL(1), YWHAQ(1), YWHAZ(2)	23144073	104	79	101	41	21	22	37	10	13	1	0.670	1.000	1.000
354	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ACTB(2), ACTG1(2), ARHGEF2(1), CD14(1), CDC42(1), CDH1(4), CTNNB1(2), CTTN(4), FYN(3), HCLS1(2), KRT18(1), LY96(1), NCK1(4), NCK2(3), NCL(3), PRKCA(2), RHOA(4), ROCK1(11), ROCK2(6), TLR4(7), TLR5(1), TUBA1B(3), TUBA3C(6), TUBA3D(2), TUBA3E(3), TUBA4A(1), TUBA8(2), TUBAL3(3), TUBB1(1), TUBB2C(1), TUBB3(2), TUBB4(3), TUBB4Q(4), TUBB6(3), TUBB8(1), WASL(1), YWHAQ(1), YWHAZ(2)	23144073	104	79	101	41	21	22	37	10	13	1	0.670	1.000	1.000
355	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(1), INPP1(2), INPP4A(4), INPP4B(7), INPPL1(4), ITPKA(1), ITPKB(5), MIOX(2), OCRL(4), PIK3C2A(4), PIK3C2B(7), PIK3C2G(7), PIK3CB(5), PIK3CG(8), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PLCD1(2), PLCG1(5), PLCG2(4)	19401948	102	79	101	26	21	16	31	21	12	1	0.102	1.000	1.000
356	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(21), B3GALT4(3), CDR1(3), DGKI(8), IL6ST(2), MRPL19(1), PIGK(4), RPL10(2), RPL12(1), RPL13A(1), RPL18(2), RPL22(2), RPL23(1), RPL26(1), RPL28(1), RPL31(1), RPL36(2), RPL37(1), RPL3L(1), RPL4(1), RPL6(2), RPLP0(2), RPLP2(1), RPS10(1), RPS13(2), RPS15(1), RPS19(1), RPS20(1), RPS21(1), RPS23(1), RPS27A(1), RPS28(1), RPS3(1), RPS5(1), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA6(4), RPS6KB1(3), RPS6KB2(1), SLC36A2(1), TBC1D10C(3), TSPAN9(1), UBA52(2), UBB(1), UBC(4)	23815448	107	79	106	46	12	21	45	13	16	0	0.969	1.000	1.000
357	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(2), ACTG2(3), ACTR2(1), AKT1(2), ANGPTL2(2), CDC42(1), CFL1(2), FLNA(8), FLNC(7), FSCN1(1), FSCN3(5), GDI1(2), GDI2(2), LIMK1(5), MYH2(16), MYLK(4), MYLK2(2), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), RHO(3), ROCK1(11), ROCK2(6), VASP(1), WASF1(3), WASL(1)	21807472	108	79	108	38	15	35	28	19	11	0	0.310	1.000	1.000
358	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT1(2), AKT2(3), AKT3(4), BAD(1), BCR(1), BLNK(3), BTK(5), CD19(2), CSK(1), DAG1(1), EPHB2(2), ITPKA(1), ITPKB(5), LYN(3), MAP2K1(4), MAP2K2(3), MAPK1(4), NFAT5(5), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), PI3(1), PIK3CD(2), PIK3R1(6), PLCG2(4), PPP1R13B(1), RAF1(2), SERPINA4(5), SHC1(1), SOS1(8), SOS2(9), SYK(3), VAV1(2)	23092362	99	79	96	38	18	22	27	16	16	0	0.670	1.000	1.000
359	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	31	AKT1(2), AKT2(3), AKT3(4), BCR(1), BTK(5), CD19(2), FLOT1(1), FLOT2(3), GAB1(2), ITPR1(9), ITPR2(11), ITPR3(5), LYN(3), NR0B2(1), PDK1(1), PITX2(1), PLCG2(4), PPP1R13B(1), PREX1(6), PTEN(6), PTPRC(13), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KB1(3), SYK(3), TEC(2), VAV1(2)	23808098	105	78	105	40	11	29	23	22	20	0	0.552	1.000	1.000
360	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	46	AADAT(1), AASDHPPT(3), ACAT2(1), AKR1B10(3), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), BBOX1(1), DLST(4), DOT1L(3), ECHS1(2), EHHADH(2), EHMT1(6), EHMT2(6), GCDH(1), HADHA(3), HSD17B4(3), OGDH(6), OGDHL(9), PIPOX(1), PLOD1(3), PLOD2(7), PLOD3(4), RDH11(1), RDH12(3), SETD1A(6), SETD7(2), SETDB1(6), SHMT1(1), SHMT2(2), SPCS3(1), SUV39H1(2), TMLHE(2)	23926013	102	77	102	43	18	21	32	19	12	0	0.859	1.000	1.000
361	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH6(1), ADH7(1), ADHFE1(2), AGPAT1(2), AGPAT2(1), AGPAT3(1), AGPAT4(2), AKR1B1(2), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), CEL(1), DGKA(2), DGKB(6), DGKD(4), DGKE(3), DGKH(4), DGKQ(5), DGKZ(4), GK(1), GLA(3), GLB1(4), LCT(8), LIPC(3), LIPG(1), LPL(2), PNLIP(2), PNLIPRP1(5), PNLIPRP2(6), PPAP2B(1)	21937918	97	76	97	27	15	22	20	21	19	0	0.0891	1.000	1.000
362	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(11), ACACB(12), ACAT2(1), ACOT12(2), ACSS1(5), ACSS2(2), ACYP1(1), AKR1B1(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), DLAT(2), GLO1(1), HAGH(1), LDHA(1), LDHAL6B(4), LDHB(1), LDHC(3), LDHD(3), MDH1(1), ME1(1), ME2(1), ME3(6), PC(7), PCK2(3), PDHA1(3), PDHA2(5), PKLR(1), PKM2(3)	21292840	90	76	90	36	25	17	26	15	7	0	0.781	1.000	1.000
363	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	BCL2(1), CHUK(3), EGF(6), EGFR(14), ETS1(2), ETS2(5), FOS(1), HOXA7(2), IKBKB(5), MAP2K1(4), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAP3K1(3), MAP3K14(2), MAP3K5(5), MAPK1(4), MAPK13(3), MAPK14(1), MAPK8(4), NFKB1(2), PRKCA(2), PRKCD(4), PRKCE(2), PRKCG(7), PRKCH(3), PRKCQ(5), RAF1(2), RELA(1), RIPK1(2), SP1(1), TRAF2(1)	22179930	102	76	99	38	20	18	31	16	17	0	0.723	1.000	1.000
364	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	24	BRCA1(9), CARM1(3), CCND1(2), CREBBP(15), ERCC3(4), ESR1(3), GRIP1(5), GTF2A1(2), GTF2E1(5), GTF2F1(3), HDAC3(1), HDAC4(3), HDAC5(1), HDAC6(5), MEF2C(7), NCOR2(11), NR0B1(3), NRIP1(3), PELP1(1), POLR2A(9), TBP(1)	18680679	96	75	96	37	7	23	36	16	14	0	0.789	1.000	1.000
365	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	64	APAF1(9), BAD(1), BAX(1), BCL2(1), BCL2L1(2), BCL2L11(1), BID(2), BIRC2(1), BIRC3(1), CASP1(2), CASP10(2), CASP3(1), CASP4(1), CASP6(2), CASP7(1), CHUK(3), FADD(1), FAS(1), FASLG(2), GZMB(1), HELLS(4), IKBKB(5), IRF1(5), IRF2(3), IRF3(1), IRF4(2), IRF5(1), IRF6(4), IRF7(2), LTA(1), MAP2K4(1), MAP3K1(3), MAPK10(3), MDM2(2), MYC(4), NFKB1(2), NFKBIB(1), PLEKHG5(4), PRF1(3), RELA(1), RIPK1(2), TNFRSF10B(1), TNFRSF21(2), TNFRSF25(2), TRAF2(1), TRAF3(3)	25286744	99	74	99	27	19	24	24	16	16	0	0.164	1.000	1.000
366	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(6), ATP4A(3), ATP4B(2), ATP5F1(1), ATP5G2(1), ATP5G3(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V0D2(3), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), COX10(1), COX15(2), COX17(2), COX5B(1), COX7B2(1), COX8A(1), LHPP(1), NDUFA12(1), NDUFA13(2), NDUFA2(1), NDUFA3(1), NDUFA5(3), NDUFA7(1), NDUFA9(1), NDUFB10(1), NDUFB3(2), NDUFB4(1), NDUFB6(1), NDUFB9(1), NDUFS1(1), NDUFS2(1), NDUFS3(1), NDUFS4(1), NDUFS7(1), NDUFS8(1), NDUFV1(1), PPA1(1), SDHA(5), SDHC(1), TCIRG1(7), UQCRC1(1), UQCRFS1(3)	25453896	90	73	90	31	10	23	27	17	13	0	0.480	1.000	1.000
367	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(6), COL4A2(4), COL4A3(7), COL4A4(10), COL4A5(7), COL4A6(2), F10(3), F11(2), F12(1), F2(2), F5(12), F8(4), F9(5), FGA(7), FGB(2), FGG(3), KLKB1(5), PROS1(5), SERPINC1(3), SERPING1(3)	20236242	93	73	93	25	6	28	32	13	14	0	0.322	1.000	1.000
368	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(1), ACADL(2), ACADM(3), ACADS(2), ACADSB(2), ACADVL(4), ACAT2(1), ACOX3(1), ACSL1(2), ACSL3(1), ACSL4(6), ACSL5(4), ACSL6(1), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), CPT1A(4), CPT1B(3), CPT1C(5), CPT2(2), CYP4A11(8), CYP4A22(6), DCI(1), ECHS1(2), EHHADH(2), GCDH(1), HADHA(3), HADHB(2), HSD17B4(3), PECI(1)	22294292	95	72	95	29	9	25	26	21	14	0	0.345	1.000	1.000
369	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(2), AKT2(3), AKT3(4), ARHGEF11(3), BCL2(1), CDC42(1), DLG4(1), GNA13(1), LPA(8), MAP2K4(1), MAP3K1(3), MAP3K5(5), MAPK8(4), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), PDK1(1), PHKA2(9), PI3(1), PIK3CB(5), PLD1(7), PLD2(1), PLD3(1), PTK2(5), ROCK1(11), ROCK2(6), SERPINA4(5), TBXA2R(1)	22402792	95	71	95	35	9	26	29	15	16	0	0.720	1.000	1.000
370	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	A1BG(4), AKT1(2), AKT2(3), AKT3(4), BAD(1), BTK(5), GSK3B(1), IARS(7), IGFBP1(2), INPP5D(7), PDK1(1), PPP1R13B(1), PTEN(6), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KB1(3), SFN(5), SHC1(1), SOS1(8), SOS2(9), TEC(2), YWHAB(1), YWHAE(2), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(2)	15160750	91	71	91	28	8	23	34	17	9	0	0.402	1.000	1.000
371	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	35	CALM1(1), CALM3(1), CAMK1(1), CAMK1G(1), ELK1(1), FPR1(3), GNA15(2), GNB1(2), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K6(1), MAP3K1(3), MAPK1(4), MAPK14(1), NCF2(4), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NFKB1(2), PAK1(1), PIK3C2G(7), PLCB1(12), RAF1(2), RELA(1), SYT1(5)	17034759	86	70	83	25	23	12	29	13	9	0	0.265	1.000	1.000
372	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(2), ALDH9A1(2), ALDOA(1), ALDOB(3), ALDOC(1), DLAT(2), ENO1(1), ENO3(1), FBP2(1), G6PC(2), GCK(2), GPI(2), HK1(3), HK2(5), HK3(4), LDHA(1), LDHB(1), LDHC(3), PDHA1(3), PDHA2(5), PFKM(2), PFKP(4), PGAM1(1), PGM1(3), PGM3(1), PKLR(1), PKM2(3), TPI1(2)	22234026	86	70	86	36	16	18	21	14	17	0	0.846	1.000	1.000
373	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(2), AGPAT1(2), AGPAT2(1), AGPAT3(1), AGPAT4(2), AGPS(4), CDIPT(1), CDS1(1), CDS2(3), CHAT(6), CLC(2), CPT1B(3), DGKA(2), DGKB(6), DGKD(4), DGKE(3), DGKH(4), DGKQ(5), DGKZ(4), GNPAT(3), GPD1(1), GPD2(2), LCAT(2), LGALS13(1), PAFAH2(1), PCYT1A(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLCB2(4), PLCG1(5), PLCG2(4), PPAP2B(1)	22761376	87	70	87	26	10	13	25	19	20	0	0.265	1.000	1.000
374	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(2), ALDH9A1(2), ALDOA(1), ALDOB(3), ALDOC(1), DLAT(2), ENO1(1), ENO3(1), FBP2(1), G6PC(2), GCK(2), GPI(2), HK1(3), HK2(5), HK3(4), LDHA(1), LDHB(1), LDHC(3), PDHA1(3), PDHA2(5), PFKM(2), PFKP(4), PGAM1(1), PGM1(3), PGM3(1), PKLR(1), PKM2(3), TPI1(2)	22234026	86	70	86	36	16	18	21	14	17	0	0.846	1.000	1.000
375	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(2), AKT2(3), AKT3(4), ANKRD6(2), APC(15), AXIN1(5), AXIN2(5), CSNK1A1(1), CTNNB1(2), DACT1(3), DKK1(3), DKK2(3), DKK3(2), DVL1(2), FSTL1(3), GSK3B(1), LRP1(17), MVP(3), NKD1(5), NKD2(1), PIN1(1), PTPRA(4), SENP2(2), SFRP1(1)	18399429	90	70	90	32	10	30	22	18	9	1	0.398	1.000	1.000
376	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	70	CALR(2), CD74(3), CD8A(2), CD8B(1), CIITA(7), CREB1(1), CTSS(3), HLA-C(3), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-F(3), HSP90AA1(6), HSP90AB1(7), HSPA5(3), IFNA16(2), IFNA17(1), IFNA21(1), IFNA4(2), IFNA6(1), IFNA8(2), KIR2DL1(3), KIR2DL3(1), KIR2DS4(1), KIR3DL1(7), KIR3DL3(2), KLRC2(1), KLRC3(2), KLRC4(1), LGMN(3), LTA(1), NFYC(2), PSME1(1), PSME2(1), RFX5(4), RFXAP(1), TAP1(3), TAP2(5), TAPBP(1)	20384956	96	69	95	34	9	25	26	18	17	1	0.457	1.000	1.000
377	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(3), ALDOC(1), DLAT(2), ENO1(1), ENO3(1), FBP2(1), G6PC(2), GAPDHS(1), GCK(2), GOT1(1), GOT2(3), GPI(2), HK1(3), HK2(5), HK3(4), LDHA(1), LDHAL6B(4), LDHB(1), LDHC(3), MDH1(1), PC(7), PDHA1(3), PDHA2(5), PDHX(4), PFKL(4), PFKM(2), PFKP(4), PGAM1(1), PGK2(3), PKLR(1), PKM2(3), TNFAIP1(2), TPI1(2)	19321716	84	67	84	32	21	14	24	14	11	0	0.637	1.000	1.000
378	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	33	ACTA1(2), ACTN1(2), ACTN2(6), ACTN3(6), BCAR1(2), BCR(1), CAPNS1(1), CAPNS2(2), CRKL(1), CSK(1), FYN(3), ITGA1(3), MAP2K1(4), MAP2K2(3), MAPK1(4), MAPK8(4), PPP1R12B(1), PTK2(5), PXN(1), RAF1(2), ROCK1(11), SHC1(1), SOS1(8), SRC(1), TLN1(13), VCL(6), ZYX(2)	20496513	96	67	93	25	14	18	40	16	8	0	0.202	1.000	1.000
379	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(2), ATF2(1), CDC42(1), DUSP10(2), DUSP4(1), GAB1(2), GCK(2), IL1R1(2), MAP2K4(1), MAP2K5(2), MAP3K1(3), MAP3K10(4), MAP3K11(1), MAP3K12(6), MAP3K13(8), MAP3K3(1), MAP3K4(5), MAP3K5(5), MAP3K7(4), MAP3K9(2), MAPK10(3), MAPK7(1), MAPK8(4), MAPK9(4), MYEF2(3), NFATC3(6), NR2C2(1), PAPPA(9), SHC1(1), TRAF6(1), ZAK(2)	22621392	90	67	90	25	11	23	31	13	12	0	0.261	1.000	1.000
380	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(2), AKR1B10(3), ALDOA(1), ALDOB(3), ALDOC(1), FBP2(1), FPGT(3), FUK(1), GMDS(1), GMPPA(1), HK1(3), HK2(5), HK3(4), KHK(2), LHPP(1), MPI(3), MTMR2(5), MTMR6(2), PFKFB1(4), PFKFB2(4), PFKFB4(2), PFKL(4), PFKM(2), PFKP(4), PGM2(1), PHPT1(1), RDH11(1), RDH12(3), SORD(1), TPI1(2), TSTA3(2)	16906477	73	66	73	19	17	9	25	12	10	0	0.154	1.000	1.000
381	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	ABO(2), B3GALT1(1), B3GALT2(1), B3GALT4(3), B3GALT5(1), B3GNT1(1), B3GNT2(1), B3GNT3(4), B3GNT5(2), B4GALNT1(2), B4GALT2(3), B4GALT6(2), FUT1(1), FUT2(2), FUT5(3), FUT6(1), FUT9(10), GBGT1(2), GCNT2(4), PIGA(1), PIGB(2), PIGC(1), PIGG(1), PIGK(4), PIGN(2), PIGO(2), PIGS(1), PIGT(1), PIGZ(1), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1), ST3GAL5(2), ST3GAL6(1), ST6GALNAC3(5), ST6GALNAC5(2), ST6GALNAC6(3), ST8SIA1(2), ST8SIA5(4), UGCG(1)	22103183	85	66	85	32	11	21	29	13	11	0	0.512	1.000	1.000
382	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(8), AR(4), ESR1(3), ESR2(1), ESRRA(4), HNF4A(2), NPM1(1), NR0B1(3), NR1D1(1), NR1D2(2), NR1I2(2), NR2C2(1), NR2E1(3), NR2F1(2), NR2F2(4), NR3C1(5), NR4A2(2), NR5A2(2), PGR(2), RARA(2), RARB(2), RARG(5), ROR1(5), RORA(1), RORC(2), RXRA(4), RXRB(2), RXRG(6), THRA(4), THRB(1), VDR(1)	19120352	87	66	85	32	18	13	30	11	15	0	0.669	1.000	1.000
383	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(1), ARHGAP1(2), ARHGAP4(5), ARHGAP5(6), ARHGAP6(6), ARHGEF1(5), ARHGEF11(3), ARHGEF5(3), ARPC1B(1), ARPC2(2), ARPC4(1), CFL1(2), DIAPH1(6), GSN(5), LIMK1(5), MYLK(4), PIP5K1A(4), PIP5K1B(4), PPP1R12B(1), ROCK1(11), SRC(1), TLN1(13), VCL(6)	20642161	97	66	97	37	11	26	32	22	6	0	0.727	1.000	1.000
384	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	22	ADRB1(1), AKT1(2), APC(15), ASAH1(1), DAG1(1), DLG4(1), EPHB2(2), GNAI1(1), ITPR1(9), ITPR2(11), ITPR3(5), KCNJ3(4), KCNJ5(3), KCNJ9(1), MAPK1(4), PITX2(1), PTX3(2), RHO(3), RYR1(16)	20572470	83	66	80	34	20	20	20	12	11	0	0.612	1.000	1.000
385	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(3), ACY3(3), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(2), ALDH7A1(2), ALDH9A1(2), AMDHD1(2), AOC2(2), AOC3(5), ASPA(1), CARM1(3), CNDP1(3), DDC(7), FTCD(1), HAL(2), HARS2(1), HDC(2), HEMK1(1), LCMT1(1), LCMT2(6), MAOA(1), MAOB(1), METTL2B(2), METTL6(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2), PRPS1(3), PRPS2(1), UROC1(3)	18011757	77	65	77	20	16	22	24	5	10	0	0.0515	1.000	1.000
386	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(2), ALAS2(4), BLVRA(2), COX10(1), COX15(2), CP(4), CPOX(1), EARS2(1), EPRS(2), FECH(1), FTMT(4), GUSB(1), HCCS(2), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2A1(4), UGT2A3(4), UGT2B10(11), UGT2B11(7), UGT2B15(2), UGT2B28(3), UGT2B4(8), UGT2B7(3), UROD(1), UROS(3)	19248154	83	65	83	35	7	14	40	20	2	0	0.932	1.000	1.000
387	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	ACTR2(1), AKT1(2), ANGPTL2(2), DAG1(1), DGKA(2), ETFA(2), GCA(1), ITGA9(1), ITPKA(1), ITPKB(5), ITPR1(9), ITPR2(11), ITPR3(5), MAP2K1(4), MAPK1(4), PAK1(1), PDE3A(13), PDE3B(1), PI3(1), PIK3C2G(7), PIK3CD(2), PIK3R1(6), PLDN(2), PSME1(1), SGCB(3), VASP(1)	21095391	89	65	86	25	14	18	24	15	18	0	0.246	1.000	1.000
388	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	20	ATM(9), ATR(19), BRCA1(9), CCNB1(3), CDC25B(3), CDC34(1), CHEK1(1), CHEK2(4), MDM2(2), MYT1(7), PRKDC(15), RPS6KA1(4), WEE1(1), YWHAH(1), YWHAQ(1)	16478112	80	64	80	19	9	16	23	20	12	0	0.250	1.000	1.000
389	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	30	AGT(2), ATF2(1), CALM1(1), CALM3(1), EGFR(14), ELK1(1), MAP2K1(4), MAP2K2(3), MAP2K4(1), MAP3K1(3), MAPK1(4), MAPK8(4), MEF2A(1), MEF2B(2), MEF2C(7), PAK1(1), PRKCA(2), PTK2(5), PTK2B(2), RAF1(2), SHC1(1), SOS1(8), SRC(1), SYT1(5)	14513970	76	63	73	22	11	11	31	14	9	0	0.425	1.000	1.000
390	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	CASP10(2), CASP3(1), CASP6(2), CASP7(1), CFLAR(2), FADD(1), FAF1(1), LMNB1(1), LMNB2(4), MAP2K4(1), MAP3K1(3), MAP3K7(4), MAPK8(4), PAK1(1), PAK2(5), PRKDC(15), PTPN13(9), RB1(9), RIPK2(1), SPTAN1(11)	18064122	78	63	78	22	14	14	22	9	19	0	0.448	1.000	1.000
391	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(2), GTF2A2(1), GTF2B(1), GTF2E1(5), GTF2F1(3), GTF2H1(2), GTF2H3(1), GTF2H4(1), GTF2I(3), GTF2IRD1(3), TAF1(8), TAF10(4), TAF1L(13), TAF2(5), TAF4(2), TAF4B(4), TAF5(5), TAF5L(1), TAF6(3), TAF7(1), TAF7L(2), TAF9(2), TBPL1(2), TBPL2(1)	16412255	75	63	75	25	6	20	24	13	12	0	0.620	1.000	1.000
392	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	31	ACVR1(5), APC(15), ATF2(1), AXIN1(5), BMP10(1), BMP2(3), BMP4(2), BMP5(2), BMP7(3), BMPR2(3), CHRD(6), CTNNB1(2), DVL1(2), FZD1(3), GSK3B(1), MAP3K7(4), MEF2C(7), NKX2-5(1), NPPA(1), NPPB(1), RFC1(2), TGFB1(1), TGFB2(2), TGFBR1(1), TGFBR3(3), WNT1(1)	16089237	78	62	78	20	7	21	26	15	8	1	0.163	1.000	1.000
393	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	36	AGT(2), AGTR2(2), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), F2(2), FYN(3), GNAI1(1), GNB1(2), JAK2(2), MAP2K1(4), MAP2K2(3), MAPK1(4), MAPK14(1), MAPK8(4), MAPT(6), MYLK(4), PLCG1(5), PRKCA(2), PTK2B(2), RAF1(2), SHC1(1), SOS1(8), STAT1(5), STAT3(3), STAT5A(1), SYT1(5)	18723969	82	62	78	23	13	16	30	14	9	0	0.206	1.000	1.000
394	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(4), AKT1(2), AKT2(3), AKT3(4), DAG1(1), ITPKA(1), ITPKB(5), ITPR1(9), ITPR2(11), ITPR3(5), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), PDK1(1), PHKA2(9), PIK3CB(5), PITX2(1), PLD1(7), PLD2(1), PLD3(1), VN1R1(1)	20370491	76	62	76	32	8	26	15	14	13	0	0.688	1.000	1.000
395	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	46	APAF1(9), BAD(1), BAX(1), BCL2(1), BCL2A1(1), BCL2L1(2), CASP1(2), CASP10(2), CASP3(1), CASP4(1), CASP6(2), CASP7(1), CD40(4), CD40LG(3), CRADD(1), FADD(1), FAS(1), FASLG(2), IKBKE(2), LTA(1), MCL1(1), NFKB1(2), NGFR(1), NR3C1(5), NTRK1(3), PTPN13(9), RIPK1(2), SFRS2IP(5), TFG(1), TRAF2(1), TRAF3(3), TRAF6(1)	19294570	73	61	73	22	16	16	16	15	10	0	0.307	1.000	1.000
396	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(5), ACACA(11), ACACB(12), ACADM(3), ACAT2(1), ACSS1(5), ACSS2(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), ECHS1(2), EHHADH(2), HADHA(3), HIBCH(1), LDHA(1), LDHAL6B(4), LDHB(1), LDHC(3), MLYCD(1), MUT(2), PCCA(5), PCCB(1), SUCLA2(1), SUCLG2(3)	18088116	76	61	76	26	16	15	23	12	10	0	0.601	1.000	1.000
397	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(11), ACAT2(1), ACYP1(1), ADH5(2), AKR1B1(2), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), DLAT(2), GLO1(1), HAGH(1), LDHA(1), LDHB(1), LDHC(3), LDHD(3), MDH1(1), ME1(1), ME2(1), ME3(6), PC(7), PDHA1(3), PDHA2(5), PKLR(1), PKM2(3)	16825998	68	61	68	25	20	13	16	14	5	0	0.591	1.000	1.000
398	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(3), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH6(1), ADH7(1), ADHFE1(2), ALDH3B1(1), ALDH3B2(2), AOC2(2), AOC3(5), AOX1(5), DBH(4), DCT(1), DDC(7), FAH(1), GOT1(1), GOT2(3), HGD(2), HPD(1), MAOA(1), MAOB(1), PNMT(1), TAT(1), TH(2), TPO(10), TYR(4)	14444053	71	61	70	27	12	19	22	7	11	0	0.554	1.000	1.000
399	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	20	CCR3(3), CFL1(2), GNAS(6), GNB1(2), LIMK1(5), MAP2K1(4), MAPK1(4), NOX1(5), PIK3C2G(7), PLCB1(12), PPP1R12B(1), PRKCA(2), PTK2(5), RAF1(2), ROCK2(6)	11249653	66	60	63	19	15	13	23	6	9	0	0.438	1.000	1.000
400	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(1), AADAC(2), ABAT(5), ACADS(2), ACAT2(1), ACSM1(2), AKR1B10(3), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), BDH1(1), BDH2(1), DDHD1(2), ECHS1(2), EHHADH(2), GAD1(2), GAD2(2), HADHA(3), HMGCL(1), HMGCS1(2), HMGCS2(2), HSD17B4(3), ILVBL(3), L2HGDH(4), OXCT1(1), OXCT2(1), PDHA1(3), PDHA2(5), PLA1A(5), PRDX6(1), RDH11(1), RDH12(3)	18485529	73	60	73	33	11	16	24	14	8	0	0.906	1.000	1.000
401	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), AARS2(3), CARS(2), DARS(2), DARS2(1), EARS2(1), EPRS(2), FARS2(2), FARSB(4), GARS(1), HARS2(1), IARS(7), KARS(2), LARS2(1), MARS(2), MARS2(4), MTFMT(3), NARS(2), NARS2(1), PARS2(3), QARS(1), RARS(1), RARS2(3), SARS(1), SARS2(2), TARS(3), TARS2(1), VARS(5), VARS2(1), WARS2(5), YARS(3), YARS2(3)	24731006	74	60	73	28	8	15	30	15	6	0	0.788	1.000	1.000
402	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(4), ADRA1B(1), ADRA2C(1), ADRB1(1), ADRB3(2), CHRM2(4), CHRM3(5), CHRM5(1), DRD1(1), DRD2(2), DRD3(4), DRD4(1), DRD5(7), HRH1(1), HRH2(1), HTR1A(7), HTR1B(3), HTR1E(7), HTR1F(4), HTR2A(3), HTR2B(1), HTR2C(1), HTR4(1), HTR5A(3), HTR6(2), HTR7(3)	11657802	71	60	71	34	16	10	25	16	4	0	0.718	1.000	1.000
403	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(2), BCL2(1), EGFR(14), IGF1R(7), MYC(4), POLR2A(9), PRKCA(2), RB1(9), TEP1(8), TERF1(3), TERT(1), TNKS(4), XRCC5(2)	12493643	66	60	66	24	8	14	21	12	11	0	0.485	1.000	1.000
404	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	19	ARHGAP5(6), DIAPH1(6), FYN(3), GSN(5), ITGA1(3), MAP2K1(4), MAPK1(4), MYLK(4), PIK3R1(6), PTK2(5), PXN(1), RAF1(2), ROCK1(11), SHC1(1), SRC(1), TLN1(13)	15035733	75	59	72	20	10	13	23	21	8	0	0.341	1.000	1.000
405	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(6), ADRBK2(4), ARRB2(1), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CLCA1(5), CLCA2(2), CLCA4(2), CNGA3(4), CNGA4(3), CNGB1(9), GNAL(2), PDC(1), PDE1C(9), PRKACA(4), PRKACB(2), PRKACG(1), PRKG1(3), PRKG2(1), PRKX(1)	13896049	68	59	68	27	13	13	18	16	8	0	0.653	1.000	1.000
406	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(2), AKT2(3), AKT3(4), CISH(1), IARS(7), IL13RA1(1), IL4(1), IL4R(2), INPP5D(7), JAK1(6), JAK2(2), JAK3(3), NR0B2(1), PI3(1), PPP1R13B(1), RPS6KB1(3), SERPINA4(5), SHC1(1), SOS1(8), SOS2(9), SRC(1), STAT6(2), TYK2(2)	15801041	73	59	73	29	8	19	28	13	5	0	0.753	1.000	1.000
407	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	19	F10(3), F11(2), F12(1), F2(2), F5(12), F7(2), F8(4), F9(5), FGA(7), FGB(2), FGG(3), LPA(8), PLAT(2), PLAU(1), PLG(8), SERPINB2(1), SERPINE1(4), VWF(6)	15461994	73	58	73	19	6	17	24	13	13	0	0.158	1.000	1.000
408	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(2), CDC7(1), CDT1(1), DIAPH2(6), GMNN(1), MCM10(1), MCM2(4), MCM3(2), MCM4(4), MCM5(2), MCM6(3), MCM7(5), NACA(3), ORC2L(1), ORC4L(1), ORC5L(1), ORC6L(1), POLA2(1), POLD1(3), POLD2(1), POLD3(3), POLE(8), POLE2(1), RFC1(2), RFC2(2), RFC3(1), RFC4(4), RFC5(2), RPA1(4), RPS27A(1), UBA52(2), UBB(1), UBC(4)	23074021	79	58	78	38	8	20	34	7	10	0	0.984	1.000	1.000
409	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACP2(1), ACP5(2), ACPP(1), ACPT(1), ALPI(2), ALPL(3), ALPP(1), ALPPL2(4), CYP19A1(1), CYP1A2(4), CYP2A13(2), CYP2A7(2), CYP2B6(3), CYP2C18(1), CYP2C19(3), CYP2C8(3), CYP2C9(5), CYP2D6(1), CYP2E1(5), CYP2F1(2), CYP2J2(4), CYP3A4(3), CYP3A5(1), CYP3A7(1), CYP4B1(2), CYP4F8(3), CYP51A1(1), PON1(6)	13347882	69	58	69	20	10	11	28	13	7	0	0.273	1.000	1.000
410	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	BAG4(4), CASP3(1), CRADD(1), FADD(1), LMNB1(1), LMNB2(4), MADD(6), MAP2K4(1), MAP3K1(3), MAP3K7(4), MAPK8(4), PAK1(1), PAK2(5), PRKDC(15), RB1(9), RIPK1(2), SPTAN1(11), TRAF2(1)	17178194	74	58	74	20	13	11	26	8	16	0	0.391	1.000	1.000
411	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	ARNT(4), EIF1(2), EIF2B2(1), EIF2B3(3), EIF2B5(2), EIF2S1(1), EIF2S2(2), ELAVL1(1), FLT1(10), FLT4(6), HIF1A(2), KDR(5), NOS3(4), PIK3R1(6), PLCG1(5), PRKCA(2), PTK2(5), PXN(1), SHC1(1)	14281196	63	58	63	22	15	12	22	7	7	0	0.648	1.000	1.000
412	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(1), AZIN1(1), BTG1(1), CBX3(1), CEBPB(1), CLOCK(4), CRY1(3), CRY2(1), DAZAP2(1), DNAJA1(1), EIF4G2(2), ETV6(4), G0S2(1), GFRA1(6), HERPUD1(3), HSPA8(3), IDI1(1), KLF9(1), MYF6(1), NCKAP1(5), NCOA4(2), NR1D2(2), PER1(5), PER2(2), PPP1R3C(1), PPP2CB(1), TUBB3(2), UCP3(3), UGP2(1), VAPA(1), ZFR(3)	16654955	65	57	65	25	9	13	27	10	6	0	0.818	1.000	1.000
413	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(1), B4GALT5(2), C1GALT1(3), C1GALT1C1(2), GALNT1(2), GALNT10(2), GALNT11(2), GALNT12(3), GALNT13(7), GALNT14(5), GALNT2(3), GALNT3(3), GALNT4(2), GALNT5(3), GALNT6(3), GALNT8(5), GALNTL1(3), GALNTL2(3), GALNTL4(1), GALNTL5(4), GCNT1(1), GCNT4(2), OGT(3), ST3GAL1(1), ST6GALNAC1(4), WBSCR17(8)	14694128	78	57	78	27	14	16	23	11	14	0	0.585	1.000	1.000
414	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(6), ATP4B(2), ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), ATP7A(8), ATP7B(4), COX10(1), COX5B(1), COX8A(1), NDUFA5(3), NDUFB4(1), NDUFB6(1), NDUFS1(1), NDUFS2(1), NDUFV1(1), SDHA(5), SHMT1(1), UQCRC1(1), UQCRFS1(3)	17384861	63	57	63	21	6	18	17	15	7	0	0.420	1.000	1.000
415	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	23	POLA1(2), POLA2(1), POLB(1), POLD1(3), POLD2(1), POLD3(3), POLE(8), POLE2(1), POLG(2), POLG2(1), POLH(2), POLI(2), POLK(3), POLL(5), POLM(1), POLQ(16), REV1(1), REV3L(11), RFC5(2)	18056685	66	56	66	23	9	18	18	9	12	0	0.600	1.000	1.000
416	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(3), AASDHPPT(3), ACAT2(1), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), BBOX1(1), DLST(4), DOT1L(3), ECHS1(2), EHHADH(2), EHMT1(6), EHMT2(6), GCDH(1), HADHA(3), PLOD1(3), PLOD2(7), PLOD3(4), SHMT1(1), SHMT2(2), TMLHE(2)	16863752	66	56	66	31	13	13	17	12	11	0	0.887	1.000	1.000
417	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	22	ACTA1(2), CAPN2(4), CAPNS1(1), CAPNS2(2), CXCR3(1), EGF(6), EGFR(14), ITGA1(3), MAPK1(4), MYLK(4), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PTK2(5), PXN(1), TLN1(13)	13899193	68	56	65	27	12	11	24	13	8	0	0.794	1.000	1.000
418	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(5), ACAA2(1), ACADM(3), ACADS(2), ACAT2(1), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), AOX1(5), AUH(1), BCAT2(1), BCKDHA(1), BCKDHB(1), DBT(5), ECHS1(2), EHHADH(2), HADHA(3), HADHB(2), HIBADH(1), HIBCH(1), HMGCL(1), HMGCS1(2), HMGCS2(2), HSD17B4(3), IVD(1), MCCC1(1), MCCC2(3), MUT(2), OXCT1(1), OXCT2(1), PCCA(5), PCCB(1)	19616344	67	55	67	24	12	18	18	11	8	0	0.638	1.000	1.000
419	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(9), BMPR1B(1), CDK4(4), CDKN1B(2), CEBPB(1), DMC1(2), EGR1(3), ESR2(1), FSHR(5), INHA(1), LHCGR(2), MLH1(4), MSH5(1), NCOR1(12), NRIP1(3), PGR(2), PRLR(4), PTGER2(4), SMPD1(1), VDR(1), ZP2(4)	15955331	67	55	65	18	7	15	24	13	8	0	0.277	1.000	1.000
420	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(5), ACACA(11), ACADL(2), ACADM(3), ACADSB(2), ACAT2(1), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), ECHS1(2), EHHADH(2), HADHA(3), LDHA(1), LDHB(1), LDHC(3), MLYCD(1), MUT(2), PCCA(5), PCCB(1), SUCLA2(1), SUCLG2(3)	15097273	60	55	60	17	13	11	18	9	9	0	0.360	1.000	1.000
421	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(3), CALCR(4), CALCRL(1), CD97(1), CRHR2(4), ELTD1(6), EMR1(5), EMR2(2), GHRHR(2), GIPR(1), GLP1R(1), GLP2R(3), GPR64(5), LPHN1(5), LPHN2(8), LPHN3(14), VIPR2(3)	12129177	68	54	68	22	7	7	24	22	8	0	0.506	1.000	1.000
422	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), AARS2(3), ABAT(5), ACY3(3), ADSL(4), ADSS(2), ADSSL1(2), AGXT2(2), ASNS(4), ASPA(1), ASRGL1(1), ASS1(1), CAD(2), DARS(2), DARS2(1), DLAT(2), GAD1(2), GAD2(2), GOT1(1), GOT2(3), GPT2(2), NARS(2), NARS2(1), PC(7), PDHA1(3), PDHA2(5)	17243718	64	54	64	29	12	18	21	8	5	0	0.824	1.000	1.000
423	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(3), ALDH3B1(1), ALDH3B2(2), AOC2(2), AOC3(5), DDC(7), EPX(5), ESCO1(3), ESCO2(3), GOT1(1), GOT2(3), HPD(1), MAOA(1), MAOB(1), MPO(5), MYST3(4), MYST4(6), PRDX6(1), SH3GLB1(2), TAT(1), TPO(10)	15581425	67	54	66	32	13	13	27	5	9	0	0.931	1.000	1.000
424	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(2), ACTG2(3), ADCY3(6), ADCY9(4), AK1(1), ARF4(1), ARF6(2), ARL4D(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V0D2(3), ATP6V1A(1), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), ERO1L(2), GNAS(6), PLCG1(5), PLCG2(4), PRKCA(2), SEC61A1(3), SEC61A2(2), SEC61B(1), TRIM23(1)	16815893	68	54	68	20	13	13	22	11	9	0	0.232	1.000	1.000
425	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	ERCC3(4), GTF2A2(1), GTF2B(1), GTF2E1(5), GTF2H1(2), GTF2H4(1), ILK(4), MNAT1(2), POLR1A(5), POLR1B(3), POLR2A(9), POLR2B(2), POLR2G(2), POLR2H(1), POLR3B(2), POLR3D(1), POLR3E(1), POLR3H(1), TAF5(5), TAF6(3), TAF7(1), TAF9(2), TBP(1)	15971986	59	54	59	24	8	15	17	7	12	0	0.782	1.000	1.000
426	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	31	MAP2K4(1), MAPK1(4), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK8(4), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(5), MAPK9(4), MAPKAPK5(1), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), PIK3CD(2), PIK3R1(6), SYT1(5), TRAF2(1), TRAF3(3), TRAF5(1), TRAF6(1)	14336108	58	54	55	19	13	8	18	9	10	0	0.453	1.000	1.000
427	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(2), EEF2(1), EEF2K(4), EIF2AK1(6), EIF2AK3(1), EIF2B2(1), EIF2B3(3), EIF2B5(2), EIF2S1(1), EIF2S2(2), EIF4A1(1), EIF4EBP1(1), EIF4G1(14), EIF4G3(4), EIF5(2), EIF5B(3), ETF1(2), GSPT2(4), KIAA0664(4), PABPC3(7), PAIP1(4)	19913415	69	54	66	20	8	10	23	12	16	0	0.699	1.000	1.000
428	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(3), AGMAT(1), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH4A1(1), ALDH9A1(2), AOC2(2), AOC3(5), ARG2(1), CKB(3), CKM(2), CKMT1B(1), CPS1(11), GATM(2), GLUD1(2), GOT1(1), GOT2(3), MAOA(1), MAOB(1), NOS1(3), NOS3(4), ODC1(1), OTC(1), P4HA1(1), P4HA2(1), P4HA3(1), P4HB(1), PYCR1(1), RARS(1), SMS(2)	20123489	68	53	68	26	17	16	18	11	6	0	0.577	1.000	1.000
429	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	22	ATF2(1), BCR(1), BLNK(3), ELK1(1), FOS(1), LYN(3), MAP2K1(4), MAP3K1(3), MAPK1(4), MAPK8IP3(5), PAPPA(9), RPS6KA1(4), RPS6KA3(3), SHC1(1), SOS1(8), SYK(3), VAV1(2), VAV2(1), VAV3(1)	14224894	58	53	55	17	14	9	16	8	11	0	0.409	1.000	1.000
430	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(15), AXIN1(5), BTRC(1), CCND1(2), CREBBP(15), CSNK1A1(1), CSNK2A1(6), CTBP1(1), CTNNB1(2), DVL1(2), FZD1(3), GSK3B(1), MAP3K7(4), MYC(4), NLK(1), TLE1(4), WNT1(1)	13396234	68	53	68	21	4	16	24	10	13	1	0.520	1.000	1.000
431	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	AKT1(2), AVP(1), CABIN1(7), CALM1(1), CALM3(1), CAMK1(1), CAMK1G(1), HDAC5(1), IGF1R(7), INSR(2), MAP2K6(1), MAPK14(1), MAPK7(1), MEF2A(1), MEF2B(2), MEF2C(7), NFATC1(7), NFATC2(6), PIK3R1(6), SYT1(5), YWHAH(1)	14886501	62	52	62	25	10	14	18	14	6	0	0.620	1.000	1.000
432	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), GUSB(1), RPE(1), UGDH(3), UGP2(1), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2A1(4), UGT2A3(4), UGT2B10(11), UGT2B11(7), UGT2B15(2), UGT2B28(3), UGT2B4(8), UGT2B7(3), XYLB(2)	12441231	62	52	62	23	7	10	27	16	2	0	0.793	1.000	1.000
433	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	37	ATF2(1), CDC42(1), CREB1(1), ELK1(1), MAP2K4(1), MAP2K6(1), MAP3K1(3), MAP3K5(5), MAP3K7(4), MAP3K9(2), MAPK14(1), MAPKAPK5(1), MAX(1), MEF2A(1), MEF2B(2), MEF2C(7), MKNK1(1), MYC(4), PLA2G4A(3), RIPK1(2), RPS6KA5(4), SHC1(1), STAT1(5), TGFB1(1), TGFB2(2), TGFBR1(1), TRAF2(1)	16271579	58	52	58	23	7	14	21	6	10	0	0.790	1.000	1.000
434	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	20	CFL1(2), CHN1(3), LIMK1(5), MAP3K1(3), MYLK(4), NCF2(4), PAK1(1), PDGFRA(6), PIK3R1(6), PLD1(7), PPP1R12B(1), RALBP1(2), RPS6KB1(3), TRIO(10), VAV1(2), WASF1(3)	14729949	62	52	62	33	7	17	24	8	6	0	0.987	1.000	1.000
435	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(5), ABP1(3), ACADL(2), ACADM(3), ACADSB(2), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), AOC2(2), AOC3(5), CNDP1(3), DPYD(8), DPYS(5), ECHS1(2), EHHADH(2), GAD1(2), GAD2(2), HADHA(3), MLYCD(1), SMS(2), UPB1(1)	13246982	64	51	64	20	10	17	18	9	10	0	0.361	1.000	1.000
436	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	25	AKT1(2), APC(15), AXIN1(5), CCND1(2), CD14(1), CTNNB1(2), DVL1(2), FZD1(3), GJA1(1), GNAI1(1), GSK3B(1), IRAK1(2), LBP(7), LEF1(2), LY96(1), NFKB1(2), PDPK1(2), PIK3R1(6), RELA(1), TLR4(7), WNT1(1)	13050542	66	51	66	23	8	18	19	13	7	1	0.509	1.000	1.000
437	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	14	ACTA1(2), ACTN1(2), ACTN2(6), ACTN3(6), CAPNS1(1), CAPNS2(2), ITGA1(3), ITGB3(5), PTK2(5), PXN(1), SPTAN1(11), SRC(1), TLN1(13)	12004985	58	51	58	17	10	7	27	10	4	0	0.479	1.000	1.000
438	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(2), APAF1(9), ATM(9), BAD(1), BAX(1), BCL2(1), BCL2L1(2), BID(2), CASP3(1), CASP6(2), CASP7(1), EIF2S1(1), PRKCA(2), PTK2(5), PXN(1), STAT1(5), TLN1(13)	12104801	58	50	58	21	7	13	19	11	8	0	0.739	1.000	1.000
439	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(3), AGXT2(2), ALAS2(4), AOC2(2), AOC3(5), CHDH(2), CPT1B(3), CTH(2), DMGDH(2), GARS(1), GATM(2), GCAT(3), GLDC(3), MAOA(1), MAOB(1), PLCB2(4), PLCG1(5), PLCG2(4), SARDH(5), SARS(1), SHMT1(1), SHMT2(2), TARS(3)	19087059	61	50	61	29	12	12	25	5	7	0	0.845	1.000	1.000
440	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(4), GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2F1(3), HDAC3(1), NCOA1(4), NCOA2(3), NCOA3(5), NCOR2(11), POLR2A(9), RARA(2), RXRA(4), TBP(1)	11377258	55	50	55	17	7	12	22	8	6	0	0.464	1.000	1.000
441	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	26	AKT1(2), AKT2(3), AKT3(4), BAD(1), BCL2(1), GSK3B(1), IL4R(2), IRS1(1), IRS2(2), JAK1(6), JAK3(3), MAP4K1(2), MAPK1(4), PDK1(1), PIK3CD(2), PIK3R1(6), PPP1R13B(1), RAF1(2), SHC1(1), SOS1(8), SOS2(9), STAT6(2)	15667205	64	50	61	23	10	15	21	12	6	0	0.565	1.000	1.000
442	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(5), ADC(1), ALDH4A1(1), CAD(2), CPS1(11), EARS2(1), EPRS(2), GAD1(2), GAD2(2), GCLM(1), GFPT1(2), GFPT2(2), GLS(1), GLS2(1), GLUD1(2), GLUD2(4), GLUL(2), GMPS(4), GNPNAT1(1), GOT1(1), GOT2(3), GPT2(2), GSS(2), NADSYN1(2), PPAT(2), QARS(1)	18015965	60	49	60	30	12	14	17	14	3	0	0.942	1.000	1.000
443	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(2), CS(2), DLAT(2), DLST(4), FH(2), IDH3B(1), IDH3G(1), MDH1(1), OGDH(6), PC(7), PDHA1(3), PDHA2(5), PDHX(4), PDK1(1), PDK4(4), SDHA(5), SDHC(1), SUCLA2(1), SUCLG2(3)	12919449	55	49	55	22	7	11	21	9	7	0	0.778	1.000	1.000
444	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(5), DLG4(1), EPHB2(2), F2(2), F2RL1(1), F2RL2(1), F2RL3(3), MAP2K5(2), MAPK1(4), MAPK7(1), MAPK8(4), MYEF2(3), PLD1(7), PLD2(1), PLD3(1), PTK2(5), RAF1(2), RASAL1(5), SRC(1), TEC(2), VAV1(2)	12511791	55	49	52	18	7	10	18	8	12	0	0.532	1.000	1.000
445	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), CHUK(3), ELK1(1), FOS(1), IKBKB(5), IRAK1(2), LY96(1), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAP3K1(3), MAP3K14(2), MAP3K7(4), MAPK14(1), MAPK8(4), NFKB1(2), RELA(1), TLR2(1), TLR3(1), TLR4(7), TLR6(3), TLR7(4), TLR9(2), TRAF6(1)	16629202	55	49	55	21	8	8	24	8	7	0	0.797	1.000	1.000
446	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(1), ACADL(2), ACADM(3), ACADS(2), ACADSB(2), ACAT2(1), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), AOX1(5), BCKDHA(1), BCKDHB(1), ECHS1(2), EHHADH(2), HADHA(3), HADHB(2), HIBADH(1), HMGCL(1), IVD(1), MCCC1(1), MCCC2(3), MUT(2), OXCT1(1), PCCA(5), PCCB(1)	16411285	54	49	54	20	8	12	16	8	10	0	0.723	1.000	1.000
447	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACO1(7), ACO2(2), CS(2), DLST(4), FH(2), IDH1(2), IDH3B(1), IDH3G(1), MDH1(1), OGDH(6), OGDHL(9), PC(7), PCK2(3), SDHA(5), SDHC(1), SUCLA2(1), SUCLG2(3)	13606372	57	48	57	19	8	11	18	13	7	0	0.482	1.000	1.000
448	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(1), ACAD8(3), ACAD9(2), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), AKR1B10(3), AKR1C4(2), AKR1D1(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), BAAT(2), CEL(1), CYP27A1(2), CYP7A1(2), HADHB(2), LIPA(1), RDH11(1), RDH12(3), SLC27A5(2), SOAT1(3), SOAT2(2), SRD5A2(2)	14411602	58	47	58	20	9	14	22	8	5	0	0.514	1.000	1.000
449	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(3), AGXT2(2), AKR1B10(3), ALAS2(4), AOC2(2), AOC3(5), CHDH(2), CTH(2), DMGDH(2), GARS(1), GATM(2), GCAT(3), GLDC(3), MAOA(1), MAOB(1), PHGDH(1), PIPOX(1), RDH11(1), RDH12(3), SARDH(5), SARS(1), SARS2(2), SHMT1(1), SHMT2(2), TARS(3), TARS2(1)	19401255	57	47	57	25	11	12	25	3	6	0	0.746	1.000	1.000
450	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(5), ABP1(3), ACADM(3), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), AOC2(2), AOC3(5), CNDP1(3), DPYD(8), DPYS(5), ECHS1(2), EHHADH(2), GAD1(2), GAD2(2), HADHA(3), HIBCH(1), MLYCD(1), SMS(2), UPB1(1)	12311011	57	47	57	19	9	17	15	9	7	0	0.410	1.000	1.000
451	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	ARSB(1), FUCA1(1), GALNS(1), GBA(2), GLB1(4), GNS(1), GUSB(1), HEXA(3), HGSNAT(2), HPSE(2), HPSE2(3), HYAL1(1), HYAL2(2), IDS(3), IDUA(3), LCT(8), MAN2B1(2), MAN2B2(1), MAN2C1(2), MANBA(2), NAGLU(1), NEU1(1), NEU2(1), SPAM1(2)	15650075	50	47	50	20	10	10	12	11	7	0	0.654	1.000	1.000
452	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), CALM3(1), DLG4(1), GRIN2A(14), GRIN2B(15), GRIN2C(4), GRIN2D(3), NOS1(3), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), SYT1(5)	11640690	57	47	57	23	11	15	18	10	3	0	0.588	1.000	1.000
453	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(1), ALDOB(3), ALDOC(1), FBP2(1), FPGT(3), GCK(2), GMDS(1), GMPPA(1), HK1(3), HK2(5), HK3(4), KHK(2), MPI(3), PFKFB1(4), PFKFB4(2), PFKM(2), PFKP(4), SORD(1), TPI1(2)	10869121	47	46	47	15	9	7	17	7	7	0	0.419	1.000	1.000
454	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	39	APAF1(9), BAX(1), BCL2(1), BCL2L1(2), BID(2), BIRC2(1), BIRC3(1), CASP3(1), CASP6(2), CASP7(1), FADD(1), FAS(1), FASLG(2), GZMB(1), MAP2K4(1), MAP3K1(3), MAP3K14(2), MAPK10(3), MCL1(1), MDM2(2), MYC(4), NFKB1(2), PARP1(3), PRF1(3), RELA(1), RIPK1(2), TRAF2(1)	16178980	54	45	54	16	11	10	15	11	7	0	0.341	1.000	1.000
455	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(2), ALG10(2), ALG10B(3), ALG12(2), ALG13(2), ALG2(2), ALG3(1), ALG5(1), ALG6(2), ALG9(1), B4GALT2(3), DHDDS(2), DOLPP1(1), DPAGT1(1), DPM1(2), FUT8(2), GANAB(1), MAN1B1(3), MAN1C1(3), MAN2A1(2), MGAT1(1), MGAT2(1), MGAT3(4), MGAT4B(2), MGAT5(1), MGAT5B(2), RFT1(1), RPN1(1), RPN2(2), STT3B(2)	19334839	55	45	55	25	10	7	21	9	8	0	0.893	1.000	1.000
456	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(1), ARSE(1), ASAH1(1), B4GALT6(2), CERK(2), DEGS1(1), DEGS2(1), ENPP7(4), GAL3ST1(1), GALC(2), GBA(2), GLA(3), GLB1(4), LCT(8), NEU1(1), NEU2(1), PPAP2B(1), SGMS1(1), SGMS2(1), SGPP1(2), SMPD1(1), SMPD2(1), SMPD3(1), SMPD4(3), SPHK2(1), SPTLC1(1), SPTLC2(2), UGCG(1)	16282181	51	45	51	19	10	12	12	10	7	0	0.467	1.000	1.000
457	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	20	CHUK(3), CREBBP(15), IKBKB(5), IL1B(1), MAP2K3(3), MAP2K6(1), MAP3K14(2), MAP3K7(4), MAPK11(2), MAPK14(1), NFKB1(2), NR3C1(5), RELA(1), TGFBR1(1), TLR2(1)	10761404	47	45	47	15	4	10	18	8	7	0	0.633	1.000	1.000
458	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(2), ACTN2(6), ACTN3(6), BCAR1(2), CSK(1), CTNNA1(5), CTNNA2(19), CTNNB1(2), PTK2(5), PXN(1), SRC(1), VCL(6)	8727281	56	44	56	23	5	11	23	8	8	1	0.870	1.000	1.000
459	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	21	BCAR1(2), CRK(1), CXCL12(1), CXCR4(1), GNAI1(1), GNB1(2), MAP2K1(4), MAPK1(4), NFKB1(2), PIK3C2G(7), PIK3R1(6), PLCG1(5), PRKCA(2), PTK2(5), PTK2B(2), PXN(1), RAF1(2), RELA(1)	11412455	49	44	46	17	11	8	14	7	9	0	0.653	1.000	1.000
460	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	16	ACE(5), ACE2(1), AGT(2), AGTR2(2), CMA1(3), CPA3(2), CTSG(1), ENPEP(11), LNPEP(2), MAS1(3), MME(11), NLN(2), REN(3)	9310203	48	44	48	19	8	4	23	8	5	0	0.788	1.000	1.000
461	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(3), ALDH3B1(1), ALDH3B2(2), AOC2(2), AOC3(5), DDC(7), EPX(5), GOT1(1), GOT2(3), HPD(1), MAOA(1), MAOB(1), MPO(5), PRDX2(1), PRDX6(1), TAT(1), TPO(10)	10002009	50	44	49	23	12	10	19	3	6	0	0.716	1.000	1.000
462	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX12(2), ALOX15(1), ALOX5(2), CBR3(1), CYP4F2(3), CYP4F3(1), EPX(5), GGT1(1), MPO(5), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PRDX2(1), PRDX6(1), PTGES2(1), PTGIS(3), PTGS1(6), PTGS2(2), TBXAS1(5), TPO(10)	12736158	56	44	55	25	13	10	19	8	6	0	0.719	1.000	1.000
463	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(6), COL4A2(4), COL4A3(7), COL4A4(10), COL4A5(7), COL4A6(2), P4HB(1), SLC23A1(3), SLC23A2(5), SLC2A1(3), SLC2A3(2)	11395523	50	44	50	21	4	19	16	6	5	0	0.869	1.000	1.000
464	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	11	ACE2(1), AGT(2), AGTR2(2), CMA1(3), COL4A1(6), COL4A2(4), COL4A3(7), COL4A4(10), COL4A5(7), COL4A6(2), REN(3)	11167264	47	43	47	21	4	16	18	4	5	0	0.956	1.000	1.000
465	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(2), AKR1D1(2), ARSB(1), ARSD(1), ARSE(1), CYP11B1(4), CYP11B2(3), HSD11B2(1), HSD17B3(1), HSD17B8(1), HSD3B1(2), HSD3B2(2), SRD5A2(2), STS(1), SULT1E1(3), SULT2A1(2), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2B15(2), UGT2B4(8)	12401080	49	43	49	24	9	8	19	10	3	0	0.930	1.000	1.000
466	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(5), ALDH4A1(1), CAD(2), CPS1(11), EPRS(2), GAD1(2), GAD2(2), GCLM(1), GFPT1(2), GLS(1), GLS2(1), GLUD1(2), GLUL(2), GMPS(4), GOT1(1), GOT2(3), GPT2(2), GSS(2), NADSYN1(2), PPAT(2), QARS(1)	15140759	51	43	51	23	9	13	13	13	3	0	0.859	1.000	1.000
467	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ARG2(1), ASS1(1), CKB(3), CKM(2), CKMT1B(1), CPS1(11), EPRS(2), GATM(2), GLUD1(2), GLUD2(4), GOT1(1), GOT2(3), LAP3(1), NOS1(3), NOS3(4), OTC(1), P4HA1(1), P4HA2(1), P4HA3(1), PARS2(3), PRODH(1), PYCR1(1), RARS(1), RARS2(3)	16376141	55	43	55	17	15	9	15	15	1	0	0.402	1.000	1.000
468	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(4), ASRGL1(1), CA1(1), CA12(1), CA14(2), CA2(1), CA3(3), CA4(4), CA5A(1), CA5B(1), CA6(3), CA8(3), CPS1(11), CTH(2), GLS(1), GLS2(1), GLUD1(2), GLUD2(4), GLUL(2), HAL(2)	9675351	50	43	50	15	11	13	12	12	2	0	0.352	1.000	1.000
469	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(3), IKBKB(5), IL1A(1), IL1B(1), IL1R1(2), IL1RAP(4), IRAK1(2), IRAK2(2), IRAK3(4), MAP2K3(3), MAP2K6(1), MAP3K1(3), MAP3K14(2), MAP3K7(4), MAPK14(1), MAPK8(4), NFKB1(2), RELA(1), TGFB1(1), TGFB2(2), TRAF6(1)	13545349	49	43	49	14	9	11	14	7	8	0	0.366	1.000	1.000
470	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	26	BCAR1(2), CALM1(1), CALM3(1), CRKL(1), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K4(1), MAP3K1(3), MAPK1(4), MAPK14(1), MAPK8(4), PAK1(1), PLCG1(5), PRKCA(2), PTK2B(2), RAF1(2), SHC1(1), SOS1(8), SRC(1), SYT1(5)	12589092	55	43	52	16	13	7	20	8	7	0	0.442	1.000	1.000
471	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	13	APC(15), AXIN1(5), CREBBP(15), CTNNB1(2), DVL1(2), FZD1(3), GSK3B(1), LDB1(1), LEF1(2), PITX2(1), TRRAP(10), WNT1(1)	12878986	58	42	58	18	6	16	18	11	6	1	0.379	1.000	1.000
472	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), DAG1(1), ITPKA(1), ITPKB(5), ITPR1(9), ITPR2(11), ITPR3(5), NFAT5(5), PDE6A(1), PDE6C(2), SLC6A13(3), TF(3)	16196113	52	42	52	21	5	18	12	10	7	0	0.636	1.000	1.000
473	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CALM3(1), CHUK(3), EGR2(1), MAP3K1(3), MYC(4), NFATC1(7), NFATC2(6), NFKB1(2), PLCG1(5), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RELA(1), SYT1(5), VIP(1), VIPR2(3)	12742226	51	42	51	19	12	9	15	12	3	0	0.521	1.000	1.000
474	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(3), ACY1(2), ADC(1), AGMAT(1), ALDH18A1(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), AOC2(2), AOC3(5), ARG2(1), ASS1(1), CPS1(11), GATM(2), MAOA(1), MAOB(1), NAGS(2), ODC1(1), OTC(1), SAT1(3), SAT2(1), SMS(2)	13395037	50	41	50	15	11	14	14	6	5	0	0.261	1.000	1.000
475	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	37	ANAPC1(5), ANAPC2(1), ANAPC5(1), ANAPC7(1), BTRC(1), CDC16(1), CDC20(2), CDC23(1), CDC27(5), CUL1(6), CUL2(1), FZR1(2), ITCH(5), RBX1(2), SKP1(1), SKP2(2), SMURF1(2), SMURF2(4), TCEB1(1), UBE2D2(1), UBE2E1(1), WWP1(3), WWP2(2)	16777614	51	41	51	17	6	15	10	12	8	0	0.638	1.000	1.000
476	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(6), ARHGEF1(5), GNA12(1), GNA13(1), GNB1(2), MYLK(4), PLCB1(12), PPP1R12B(1), PRKCA(2), ROCK1(11)	9422362	45	41	45	13	7	10	15	9	4	0	0.436	1.000	1.000
477	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(6), APOC1(1), CETP(2), CYP7A1(2), HMGCR(3), LCAT(2), LDLR(3), LIPC(3), LPL(2), LRP1(17), SCARB1(1), SOAT1(3)	12484942	45	41	45	13	5	10	15	9	6	0	0.353	1.000	1.000
478	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ATM(9), BRCA1(9), CHEK1(1), CHEK2(4), MAPK8(4), MDM2(2), MRE11A(1), NFKB1(2), RAD50(5), RAD51(1), RBBP8(6), RELA(1)	13212544	45	40	45	15	4	13	14	9	5	0	0.692	1.000	1.000
479	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(3), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(2), ALDH9A1(2), AOC2(2), AOC3(5), ASPA(1), CNDP1(3), DDC(7), HAL(2), HDC(2), MAOA(1), MAOB(1), PRPS1(3), PRPS2(1)	11101012	45	40	45	13	8	11	14	4	8	0	0.234	1.000	1.000
480	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIA(1), CHIT1(2), CTBS(1), CYB5R1(1), CYB5R3(2), GFPT1(2), GFPT2(2), GNE(1), GNPDA1(1), GNPNAT1(1), HEXA(3), HK1(3), HK2(5), HK3(4), LHPP(1), MTMR2(5), MTMR6(2), NANS(2), PGM3(1), PHPT1(1), RENBP(3), UAP1(2)	13065355	47	40	47	16	10	11	12	5	9	0	0.549	1.000	1.000
481	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	14	ATN1(9), CASP1(2), CASP3(1), CASP7(1), INSR(2), ITCH(5), MAGI1(3), MAGI2(10), RERE(6), WWP1(3), WWP2(2)	10392138	44	40	43	17	5	14	12	7	6	0	0.801	1.000	1.000
482	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(1), ABAT(5), ACADS(2), ACAT2(1), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), ECHS1(2), EHHADH(2), GAD1(2), GAD2(2), HADHA(3), HMGCL(1), L2HGDH(4), OXCT1(1), PDHA1(3), PDHA2(5)	11758995	45	39	45	21	7	11	11	6	10	0	0.875	1.000	1.000
483	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(2), ABP1(3), AOC2(2), AOC3(5), CES1(4), CES7(2), DDHD1(2), ESCO1(3), ESCO2(3), LIPA(1), MYST3(4), MYST4(6), PLA1A(5), PRDX6(1), SH3GLB1(2)	11562887	45	39	45	17	4	11	18	7	5	0	0.811	1.000	1.000
484	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), ABAT(5), ADSL(4), ADSS(2), AGXT2(2), ASNS(4), ASPA(1), CAD(2), DARS(2), GAD1(2), GAD2(2), GOT1(1), GOT2(3), GPT2(2), NARS(2), PC(7)	11884905	42	38	42	17	9	10	14	6	3	0	0.624	1.000	1.000
485	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(3), ALDOC(1), FBP2(1), GOT1(1), GOT2(3), GPT2(2), MDH1(1), ME1(1), ME3(6), PGK2(3), PKLR(1), PKM2(3), RPE(1), RPIA(1), TKT(1), TKTL1(3), TKTL2(7), TPI1(2)	9208910	42	38	42	15	10	7	15	6	4	0	0.573	1.000	1.000
486	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(5), BST1(2), CD38(2), ENPP1(5), ENPP3(5), NADSYN1(2), NMNAT1(3), NMNAT2(2), NNMT(1), NNT(3), NT5C1A(1), NT5C1B(4), NT5C2(1), NT5C3(2), NUDT12(3)	9826266	41	38	41	19	5	6	18	8	4	0	0.930	1.000	1.000
487	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	15	AKT1(2), AKT2(3), AKT3(4), BPNT1(1), ILK(4), MAPK1(4), PDK1(1), PIK3CD(2), PTEN(6), PTK2B(2), RBL2(3), SHC1(1), SOS1(8)	8320144	41	38	38	12	6	7	16	6	6	0	0.359	1.000	1.000
488	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(2), EGF(6), EGFR(14), MET(1), PDGFRA(6), PRKCA(2), SH3GLB1(2), SH3KBP1(6), SRC(1)	8839014	40	37	40	13	4	8	14	8	6	0	0.457	1.000	1.000
489	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(2), EXT2(2), EXTL1(2), EXTL2(2), EXTL3(2), HS2ST1(4), HS3ST2(2), HS3ST3B1(1), HS3ST5(6), HS6ST1(2), HS6ST2(1), HS6ST3(1), NDST1(1), NDST2(2), NDST3(4), NDST4(7)	9435294	41	37	41	19	10	7	15	6	3	0	0.836	1.000	1.000
490	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), CYP2C19(3), CYP2C9(5), DHRS1(1), DHRS2(3), DHRS7(1), ECHS1(2), EHHADH(2), ESCO1(3), ESCO2(3), HADHA(3), MYST3(4), MYST4(6), SH3GLB1(2), YOD1(1)	14092645	48	37	48	21	4	9	19	10	6	0	0.927	1.000	1.000
491	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), CARS(2), DARS(2), EPRS(2), FARS2(2), GARS(1), IARS(7), KARS(2), LARS2(1), MARS(2), MARS2(4), NARS(2), QARS(1), RARS(1), SARS(1), TARS(3), WARS2(5), YARS(3)	14571823	42	36	41	17	5	6	19	10	2	0	0.862	1.000	1.000
492	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(1), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH6(1), ADH7(1), ADHFE1(2), AKR1C4(2), AKR1D1(2), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), BAAT(2), CEL(1), CYP27A1(2), CYP7A1(2), HADHB(2), SOAT2(2), SRD5A2(2)	10577856	42	36	42	17	6	10	14	6	6	0	0.749	1.000	1.000
493	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	17	CSF1(1), DDX20(3), E2F4(1), ETS1(2), ETS2(5), FOS(1), HDAC5(1), NCOR2(11), RBL1(8), RBL2(3), SIN3A(2), SIN3B(5)	11664609	43	36	43	16	7	13	13	5	5	0	0.430	1.000	1.000
494	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(1), ACP2(1), ACP5(2), ACP6(4), ACPP(1), ACPT(1), ALPI(2), ALPL(3), ALPP(1), ALPPL2(4), CMBL(2), CYP3A4(3), CYP3A43(1), CYP3A5(1), CYP3A7(1), DHRS1(1), DHRS2(3), DHRS7(1), PON1(6), PON2(1), PON3(3)	8202193	43	36	43	19	8	5	15	10	5	0	0.857	1.000	1.000
495	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GALNS(1), GLB1(4), GNS(1), GUSB(1), HEXA(3), HGSNAT(2), HPSE(2), HPSE2(3), HYAL1(1), HYAL2(2), IDS(3), IDUA(3), LCT(8), NAGLU(1), SPAM1(2)	9290213	38	36	38	12	7	7	10	10	4	0	0.507	1.000	1.000
496	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(2), BLVRA(2), CP(4), CPOX(1), EPRS(2), FECH(1), GUSB(1), HCCS(2), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2B15(2), UGT2B4(8), UROD(1), UROS(3)	12503061	39	36	39	21	4	8	15	11	1	0	0.969	1.000	1.000
497	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(2), CHUK(3), CRADD(1), IKBKB(5), LTA(1), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAP3K1(3), MAP3K14(2), MAP4K2(1), MAPK14(1), MAPK8(4), NFKB1(2), RELA(1), RIPK1(2), TANK(2), TRAF2(1)	11015915	36	36	36	11	6	6	13	6	5	0	0.523	1.000	1.000
498	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(5), CR1(8), CR2(5), FCGR2B(1), HLA-DRA(1), ICAM1(2), ITGAL(3), ITGB2(2), PTPRC(13)	6927972	40	35	40	22	3	11	8	8	10	0	0.956	1.000	1.000
499	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(6), IL13(1), IL4(1), IL5(1), JUNB(1), MAF(1), MAP2K3(3), MAPK14(1), NFATC1(7), NFATC2(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2)	5525405	36	35	36	15	10	8	7	7	4	0	0.467	1.000	1.000
500	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(3), ACAD9(2), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), DHRS1(1), DHRS2(3), DHRS7(1), ESCO1(3), ESCO2(3), MYST3(4), MYST4(6), SH3GLB1(2)	11377238	43	35	43	17	4	11	12	10	6	0	0.833	1.000	1.000
501	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(7), AP2A1(2), AP2M1(3), BIN1(1), CALM1(1), CALM3(1), DNM1(1), EPN1(4), EPS15(2), PICALM(3), SYNJ1(6), SYNJ2(4), SYT1(5)	9847906	40	35	40	17	5	6	16	9	4	0	0.888	1.000	1.000
502	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(3), FADD(1), IKBKB(5), IL1A(1), IL1R1(2), IRAK1(2), MAP3K1(3), MAP3K14(2), MAP3K7(4), NFKB1(2), RELA(1), RIPK1(2), TLR4(7), TNFAIP3(3), TRAF6(1)	11126084	39	35	39	16	7	8	14	7	3	0	0.738	1.000	1.000
503	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(11), AKT1(2), ATM(9), BAX(1), CPB2(3), CSNK1A1(1), FHL2(1), HIC1(1), HIF1A(2), IGFBP3(1), MAPK8(4), MDM2(2), NFKBIB(1)	9096261	39	35	39	14	4	7	15	7	6	0	0.803	1.000	1.000
504	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(2), CHAT(6), DBH(4), DDC(7), GAD1(2), GAD2(2), HDC(2), MAOA(1), PAH(4), PNMT(1), SLC18A3(3), TH(2), TPH1(2)	6571771	39	34	39	16	5	9	11	5	9	0	0.656	1.000	1.000
505	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	12	CARM1(3), CREB1(1), CREBBP(15), NCOA3(5), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RARA(2), RXRA(4)	7156486	38	34	38	15	7	10	11	4	6	0	0.773	1.000	1.000
506	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	12	C1R(3), C1S(3), C3(7), C5(5), C7(5), C8A(6), C8B(4), C9(5), MASP1(4)	8617438	42	34	42	19	1	14	14	7	6	0	0.853	1.000	1.000
507	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	13	C1R(3), C1S(3), C3(7), C5(5), C7(5), C8A(6), C9(5), MASP1(4), MASP2(4), MBL2(2)	8851628	44	34	44	17	1	15	13	9	6	0	0.697	1.000	1.000
508	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(3), POLD2(1), POLE(8), POLG(2), POLL(5), POLQ(16)	7617736	36	34	36	14	6	8	8	5	9	0	0.573	1.000	1.000
509	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(8), EGF(6), EGFR(14), HGS(1), RAB5A(2), TF(3), TFRC(3)	5847123	37	34	37	12	3	10	13	7	4	0	0.587	1.000	1.000
510	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	14	C3(7), C5(5), C7(5), ICAM1(2), IL1A(1), ITGA4(6), ITGAL(3), ITGB2(2), SELP(11), VCAM1(3)	9649479	45	34	45	23	2	10	17	9	7	0	0.948	1.000	1.000
511	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(11), CPT1A(4), LEP(1), LEPR(11), PRKAA1(3), PRKAA2(2), PRKAB1(3), PRKAG2(2)	6592726	37	34	37	17	5	6	13	8	5	0	0.932	1.000	1.000
512	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	17	CABIN1(7), CALM1(1), CALM3(1), CAPN2(4), CAPNS1(1), CAPNS2(2), NFATC1(7), NFATC2(6), PRKCA(2), SYT1(5)	8886084	36	34	36	16	7	6	9	10	4	0	0.747	1.000	1.000
513	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(9), ATM(9), BAX(1), BCL2(1), CCND1(2), CCNE1(3), CDK4(4), MDM2(2), RB1(9)	7872697	40	34	40	11	3	9	7	10	11	0	0.465	1.000	1.000
514	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	11	CREBBP(15), PAX3(4), PML(1), RARA(2), RB1(9), SIRT1(1), SP100(2)	8083600	34	34	34	17	1	6	12	3	12	0	0.969	1.000	1.000
515	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(7), ACO2(2), CS(2), DLST(4), FH(2), IDH1(2), IDH3B(1), IDH3G(1), MDH1(1), PC(7), SDHA(5), SUCLA2(1), SUCLG2(3)	9387222	38	33	38	13	5	9	13	8	3	0	0.445	1.000	1.000
516	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP2(1), ACP5(2), ACP6(4), ACPP(1), ACPT(1), ENPP1(5), ENPP3(5), FLAD1(4), LHPP(1), MTMR2(5), MTMR6(2), PHPT1(1), TYR(4)	6851614	37	32	37	12	7	4	16	3	7	0	0.752	1.000	1.000
517	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(5), POLR1B(3), POLR1C(2), POLR2A(9), POLR2B(2), POLR2D(1), POLR2G(2), POLR2H(1), POLR2L(1), POLR3A(8), POLR3B(2), POLR3G(1), POLR3H(1)	10695384	38	32	38	12	5	10	11	4	8	0	0.445	1.000	1.000
518	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC2(4), ABCG2(2), BCHE(5), CES1(4), CES2(7), CYP3A4(3), CYP3A5(1), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2)	10406050	36	32	36	23	6	6	15	5	4	0	0.983	1.000	1.000
519	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(3), ACADS(2), ACADVL(4), ACSL1(2), ACSL3(1), ACSL4(6), CPT1A(4), CPT2(2), DCI(1), EHHADH(2), HADHA(3), SLC25A20(1)	7655447	33	32	33	11	4	7	9	8	5	0	0.574	1.000	1.000
520	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(12), GNAS(6), PLCE1(12), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RAP2B(1)	6702553	39	32	39	12	10	7	15	4	3	0	0.423	1.000	1.000
521	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD1(1), DRD2(2), GRM1(16), PLCB1(12), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2)	7259989	39	31	39	15	6	10	15	8	0	0	0.528	1.000	1.000
522	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(1), GABRA1(8), GABRA2(7), GABRA3(4), GABRA4(3), GABRA5(5), GABRA6(2), GPHN(1), NSF(1), SRC(1), UBQLN1(2)	5449046	35	31	35	14	2	8	14	4	7	0	0.791	1.000	1.000
523	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSB(1), ARSD(1), ARSE(1), ASAH1(1), GAL3ST1(1), GALC(2), GBA(2), GLA(3), GLB1(4), LCT(8), NEU1(1), NEU2(1), PPAP2B(1), SMPD1(1), SMPD2(1), SPTLC1(1), SPTLC2(2), UGCG(1)	10965422	33	31	33	15	5	9	8	5	6	0	0.770	1.000	1.000
524	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT2(1), ACOT11(2), ACYP1(1), DHRS1(1), DHRS2(3), DHRS7(1), ECHS1(2), EHHADH(2), ESCO1(3), ESCO2(3), FN3K(2), GCDH(1), HADHA(3), MYST3(4), MYST4(6), SH3GLB1(2), YOD1(1)	11846896	38	31	38	16	3	7	12	11	5	0	0.884	1.000	1.000
525	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	14	CHUK(3), CREBBP(15), FADD(1), HDAC3(1), IKBKB(5), NFKB1(2), RELA(1), RIPK1(2), TRAF6(1)	7970800	31	31	31	13	3	8	12	5	3	0	0.791	1.000	1.000
526	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(1), IFNG(1), IFNGR1(5), IFNGR2(2), IKBKB(5), JAK2(2), LIN7A(2), NFKB1(2), RB1(9), RELA(1), USH1C(2)	7912106	32	31	31	15	2	6	9	3	12	0	0.862	1.000	1.000
527	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	CD2(1), CD33(2), CD7(2), IFNG(1), IL12A(1), IL12B(4), IL13(1), IL3(1), IL4(1), IL5(1), ITGAX(5), TLR2(1), TLR4(7), TLR7(4), TLR9(2)	8478474	34	30	34	16	5	5	12	8	4	0	0.842	1.000	1.000
528	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	G6PD(2), GCLM(1), GGT1(1), GPX2(2), GPX4(2), GPX5(1), GPX6(1), GPX7(1), GSS(2), GSTA1(2), GSTA2(2), GSTA3(2), GSTA5(2), GSTK1(1), GSTM2(2), GSTM4(1), GSTT1(1), IDH1(2), MGST1(1), MGST3(1), OPLAH(2)	10041415	32	30	31	15	4	9	10	7	2	0	0.757	1.000	1.000
529	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT2(1), COASY(1), DPYD(8), DPYS(5), ENPP1(5), ENPP3(5), ILVBL(3), PANK2(1), PANK4(1), PPCS(2), UPB1(1), VNN1(2)	7897888	35	30	35	17	4	5	16	7	3	0	0.955	1.000	1.000
530	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	20	BAD(1), BAX(1), BCL2(1), FADD(1), MAP2K1(4), MAP2K4(1), MAP3K1(3), MAPK1(4), MAPK8(4), NFKB1(2), NSMAF(3), RAF1(2), RELA(1), RIPK1(2), SMPD1(1), TRAF2(1)	8841555	32	29	29	10	10	3	12	3	4	0	0.533	1.000	1.000
531	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(3), F2(2), FGA(7), FGB(2), FGG(3), PLAT(2), PLAU(1), PLG(8), SERPINB2(1), SERPINE1(4)	6104274	33	29	33	11	4	6	12	4	7	0	0.569	1.000	1.000
532	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(11), ACACB(12), FASN(4), MCAT(1), OLAH(2), OXSM(2)	7231847	32	29	32	13	7	8	10	6	1	0	0.615	1.000	1.000
533	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(6), ATIC(2), DHFR(3), FTCD(1), GART(3), MTFMT(3), MTHFD1(2), MTHFD1L(3), MTHFD2(1), MTHFR(1), MTHFS(2), MTR(4), SHMT1(1), SHMT2(2), TYMS(1)	8616231	35	29	35	14	4	6	17	4	4	0	0.788	1.000	1.000
534	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	10	CD44(1), ICAM1(2), ITGA4(6), ITGAL(3), ITGAM(3), ITGB2(2), SELE(4), SELL(2), SELP(11)	6467596	34	29	34	17	2	5	11	8	8	0	0.941	1.000	1.000
535	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(3), ESR2(1), ITPKA(1), PDE1A(3), PDE1B(2), PLCB1(12), PLCB2(4), PRL(3), TRH(2), VIP(1)	5059206	32	29	32	14	4	3	17	5	3	0	0.812	1.000	1.000
536	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(3), DYRK1B(5), GLI2(8), GLI3(5), GSK3B(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), SMO(1), SUFU(1)	7572285	32	29	32	13	5	8	11	6	2	0	0.678	1.000	1.000
537	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	AKT1(2), BAD(1), CHRNG(4), MUSK(6), PIK3R1(6), PTK2(5), PTK2B(2), SRC(1), TERT(1), YWHAH(1)	6472934	29	28	29	12	3	6	7	7	6	0	0.696	1.000	1.000
538	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CYB5R3(2), GCK(2), GFPT1(2), GNE(1), GNPDA1(1), HEXA(3), HK1(3), HK2(5), HK3(4), PGM3(1), RENBP(3), UAP1(2)	7717229	29	28	29	10	7	7	7	4	4	0	0.536	1.000	1.000
539	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(3), ALDOC(1), FBP2(1), GOT1(1), GOT2(3), GPT2(2), MDH1(1), ME1(1), ME2(1), ME3(6), PKLR(1), PKM2(3), RPE(1), RPIA(1), TKT(1), TPI1(2)	8239345	30	28	30	11	9	5	11	4	1	0	0.559	1.000	1.000
540	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	10	C1R(3), C1S(3), C3(7), C5(5), C7(5), C8A(6), C9(5)	7115627	34	28	34	16	1	13	12	5	3	0	0.853	1.000	1.000
541	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	BECN1(1), IFNA16(2), IFNA17(1), IFNA21(1), IFNA4(2), IFNA6(1), IFNA8(2), IFNG(1), PIK3C3(2), PIK3R4(7), PRKAA1(3), PRKAA2(2), ULK1(5), ULK2(2)	9628879	32	28	32	19	5	4	14	8	1	0	0.985	1.000	1.000
542	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(3), IL22(1), IL22RA1(2), JAK1(6), JAK2(2), JAK3(3), STAT1(5), STAT3(3), STAT5A(1), STAT5B(4), TYK2(2)	8357068	32	28	31	14	2	11	9	5	5	0	0.665	1.000	1.000
543	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(11), ABCB11(6), ABCB4(9), ABCC3(4)	6520323	30	28	30	15	3	8	12	2	5	0	0.818	1.000	1.000
544	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(2), GALNT10(2), GALNT2(3), GALNT3(3), GALNT4(2), GALNT6(3), GALNT8(5), GCNT1(1), ST3GAL1(1), ST3GAL4(1), WBSCR17(8)	6580765	31	28	31	14	5	7	10	2	7	0	0.800	1.000	1.000
545	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), GUSB(1), RPE(1), UCHL3(1), UGDH(3), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2B15(2), UGT2B4(8)	8010556	28	28	28	15	6	3	8	10	1	0	0.932	1.000	1.000
546	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CALM3(1), CAMK1(1), CAMK1G(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), ESRRA(4), HDAC5(1), MEF2A(1), MEF2B(2), MEF2C(7), SLC2A4(1), SYT1(5), YWHAH(1)	9228378	32	28	31	10	2	9	12	7	2	0	0.426	1.000	1.000
547	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	6	CREBBP(15), LPL(2), NCOA1(4), NCOA2(3), RXRA(4)	6174443	28	28	28	12	3	4	12	6	3	0	0.886	1.000	1.000
548	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	13	AKT1(2), AKT2(3), AKT3(4), ELK1(1), MAP2K1(4), MAP2K2(3), NGFR(1), NTRK1(3), PIK3CD(2), SHC1(1), SOS1(8)	6162139	32	28	32	11	6	6	11	7	2	0	0.547	1.000	1.000
549	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), CYSLTR2(2), GPR109B(4), GPR161(3), GPR171(2), GPR18(1), GPR34(1), GPR39(4), GPR45(3), GPR68(1), GPR75(4), GPR81(2)	4478212	28	27	28	13	8	7	6	6	1	0	0.638	1.000	1.000
550	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(6), ATIC(2), DHFR(3), GART(3), MTHFD1(2), MTHFD1L(3), MTHFD2(1), MTHFR(1), MTHFS(2), MTR(4), SHMT1(1), SHMT2(2), TYMS(1)	8139038	31	27	31	14	4	5	15	4	3	0	0.870	1.000	1.000
551	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(3), IKBKB(5), LTA(1), MAP3K1(3), MAP3K14(2), NFKB1(2), RELA(1), RIPK1(2), TANK(2), TNFAIP3(3), TRAF2(1), TRAF3(3)	10244486	28	27	28	10	4	5	7	6	6	0	0.591	1.000	1.000
552	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), CHUK(3), IFNG(1), IKBKB(5), IL4(1), MAP3K1(3), MAP3K5(5), MAP4K5(1), MAPK14(1), MAPK8(4), NFKB1(2), RELA(1), TNFRSF9(1), TRAF2(1)	8870258	30	26	30	13	4	5	11	5	5	0	0.867	1.000	1.000
553	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT2(1), IARS(7), ILVBL(3), LARS2(1), PDHA1(3), PDHA2(5), VARS(5), VARS2(1)	8506475	26	26	26	16	0	7	11	5	3	0	0.981	1.000	1.000
554	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(2), CAT(2), EPX(5), MPO(5), MTHFR(1), PRDX6(1), SHMT1(1), SHMT2(2), TPO(10)	5297708	29	26	28	14	11	3	12	2	1	0	0.807	1.000	1.000
555	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(1), CLOCK(4), CRY1(3), CRY2(1), CSNK1E(3), NPAS2(1), NR1D1(1), PER1(5), PER2(2), PER3(8)	7772119	29	26	29	11	6	6	9	6	2	0	0.624	1.000	1.000
556	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(2), CAT(2), EPX(5), MPO(5), PRDX2(1), PRDX6(1), SHMT1(1), SHMT2(2), TPO(10)	5381448	29	26	28	14	10	3	12	3	1	0	0.807	1.000	1.000
557	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	COASY(1), DPYD(8), DPYS(5), ENPP1(5), ENPP3(5), PANK2(1), PANK4(1), PPCS(2), UPB1(1)	6363188	29	26	29	13	4	4	13	6	2	0	0.914	1.000	1.000
558	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	26	BAG4(4), BIRC2(1), BIRC3(1), CASP3(1), CFLAR(2), FADD(1), MAP2K4(1), MAP3K3(1), MAP3K7(4), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), NR2C2(1), RALBP1(2), RIPK1(2), TNFAIP3(3), TRAF2(1)	11922181	30	26	30	13	6	10	9	1	4	0	0.663	1.000	1.000
559	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(5), GBA3(5), MPO(5), PRDX2(1), PRDX6(1), TPO(10), TYR(4)	4402726	31	26	30	15	7	2	16	4	2	0	0.879	1.000	1.000
560	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	G6PD(2), GCLM(1), GGT1(1), GPX2(2), GPX4(2), GPX5(1), GSS(2), GSTA1(2), GSTA2(2), GSTA3(2), GSTM2(2), GSTM4(1), GSTT1(1), IDH1(2), MGST1(1), MGST3(1), PGD(2)	8229452	27	25	26	10	5	7	6	6	3	0	0.540	1.000	1.000
561	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), CTH(2), DNMT1(4), DNMT3A(8), DNMT3B(5), MARS(2), MARS2(4), MAT1A(1), MTR(4)	7926355	31	25	30	10	6	7	12	5	1	0	0.383	1.000	1.000
562	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(5), CD38(2), ENPP1(5), ENPP3(5), NADSYN1(2), NMNAT1(3), NMNAT2(2), NNMT(1), NNT(3)	6643280	28	25	28	12	2	5	14	4	3	0	0.881	1.000	1.000
563	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD28(2), CD3D(1), CD8A(2), ICAM1(2), ITGAL(3), ITGB2(2), PTPRC(13), THY1(1)	4902911	27	25	27	16	3	3	4	7	10	0	0.940	1.000	1.000
564	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	17	ACTA1(2), ACTR2(1), ARPC1B(1), ARPC2(2), ARPC4(1), NCK1(4), NCKAP1(5), NTRK1(3), PIR(1), WASF1(3), WASF2(2), WASF3(2), WASL(1)	6752678	28	24	28	14	6	8	6	7	1	0	0.887	1.000	1.000
565	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	FUCA1(1), GLB1(4), HEXA(3), LCT(8), MAN2B1(2), MAN2B2(1), MAN2C1(2), MANBA(2), NEU1(1), NEU2(1)	9258084	25	24	25	13	7	4	5	5	4	0	0.827	1.000	1.000
566	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(2), HK1(3), HK2(5), HK3(4), IMPA1(1), IMPA2(2), ISYNA1(2), PGM1(3), PGM3(1), TGDS(2)	5308888	25	24	25	10	5	5	8	3	4	0	0.646	1.000	1.000
567	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPS7(1), RPL10L(4), RPL12(1), RPL13A(1), RPL18(2), RPL26(1), RPL28(1), RPL31(1), RPL37(1), RPL37A(1), RPL3L(1), RPL6(2), RPS10(1), RPS13(2), RPS20(1), RPS21(1), RPS23(1), RPS28(1), RPS3(1), RPS5(1)	10315877	26	24	25	10	4	6	11	1	4	0	0.829	1.000	1.000
568	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD2(1), CD3D(1), CXCR3(1), IFNG(1), IL12A(1), IL12B(4), IL12RB1(3), IL12RB2(7), JAK2(2), STAT4(3), TYK2(2)	6687738	26	24	26	10	1	7	8	5	5	0	0.656	1.000	1.000
569	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	5	C3(7), C5(5), C7(5), C8A(6), C9(5)	4858899	28	23	28	12	1	9	11	5	2	0	0.832	1.000	1.000
570	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(5), GBA(2), GBA3(5), MPO(5), PRDX6(1), TPO(10)	3820579	28	23	27	13	7	4	13	3	1	0	0.773	1.000	1.000
571	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(1), B4GALT2(3), B4GALT5(2), DPAGT1(1), DPM1(2), FUT8(2), MAN1B1(3), MGAT1(1), MGAT2(1), MGAT3(4), MGAT4B(2), MGAT5(1), RPN1(1), RPN2(2)	9135403	27	23	27	10	5	4	6	7	5	0	0.586	1.000	1.000
572	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	6	CREBBP(15), ESR1(3), MAPK1(4), PELP1(1), SRC(1)	4457931	24	23	21	11	3	4	9	4	4	0	0.853	1.000	1.000
573	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), FDXR(3), SHMT1(1)	7291311	26	23	26	10	5	5	9	3	4	0	0.725	1.000	1.000
574	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(2), CNR1(3), DNMT1(4), MTNR1A(2), MTNR1B(2), PTGDR(1), PTGER2(4), PTGER4(2), PTGFR(2), TBXA2R(1)	5099081	23	23	23	12	5	4	11	2	1	0	0.693	1.000	1.000
575	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD28(2), CD3D(1), ICAM1(2), ITGAL(3), ITGB2(2), PTPRC(13), THY1(1)	5143284	25	23	25	17	2	3	4	7	9	0	0.975	1.000	1.000
576	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), ESR1(3), GREB1(11), MTA1(4), MTA3(3), PDZK1(2), TUBA8(2)	4996950	26	22	26	12	7	0	10	6	3	0	0.820	1.000	1.000
577	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(5), CD44(1), CSF1(1), FCGR3A(4), IL1B(1), IL6R(4), SELL(2), SPN(2), TGFB1(1), TGFB2(2), TNFRSF8(1), TNFSF8(2)	6006613	26	22	26	11	6	6	6	6	2	0	0.567	1.000	1.000
578	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	7	IFNAR1(2), JAK1(6), PTPRU(6), STAT1(5), STAT2(3), TYK2(2)	5537181	24	22	24	10	4	7	5	2	6	0	0.639	1.000	1.000
579	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B3GNT2(1), B3GNT7(1), B4GALT2(3), CHST1(3), CHST2(2), CHST4(3), CHST6(6), FUT8(2), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1)	5735233	25	21	25	14	10	3	8	1	3	0	0.891	1.000	1.000
580	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(3), PGAP1(3), PIGA(1), PIGB(2), PIGC(1), PIGG(1), PIGK(4), PIGN(2), PIGO(2), PIGS(1), PIGT(1), PIGZ(1)	10844023	23	21	23	22	4	4	7	4	4	0	0.999	1.000	1.000
581	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	FUCA1(1), GLB1(4), HEXA(3), LCT(8), MAN2C1(2), MANBA(2), NEU1(1), NEU2(1)	7511162	22	21	22	10	6	3	5	5	3	0	0.757	1.000	1.000
582	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), AKR1D1(2), CYP11A1(2), CYP11B1(4), CYP11B2(3), CYP21A2(2), HSD11B2(1), HSD3B1(2), HSD3B2(2)	4183404	20	20	20	11	4	4	8	2	2	0	0.865	1.000	1.000
583	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), AKR1D1(2), CYP11A1(2), CYP11B1(4), CYP11B2(3), CYP21A2(2), HSD11B2(1), HSD3B1(2), HSD3B2(2)	4183404	20	20	20	11	4	4	8	2	2	0	0.865	1.000	1.000
584	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(1), DHRS2(3), DHRS7(1), ESCO1(3), ESCO2(3), MYST3(4), MYST4(6), SH3GLB1(2)	7553221	23	20	23	14	1	4	10	5	3	0	0.992	1.000	1.000
585	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	7	ACE(5), AGT(2), AGTR2(2), KNG1(3), NOS3(4), REN(3)	4170177	19	19	19	12	5	4	6	1	3	0	0.887	1.000	1.000
586	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(1), CYP51A1(1), DHCR7(1), FDFT1(3), FDPS(2), GGCX(3), HMGCR(3), IDI1(1), LSS(3), PMVK(1), SC4MOL(1), TM7SF2(1)	8797914	21	19	21	12	6	5	4	1	5	0	0.919	1.000	1.000
587	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(3), DHRS1(1), DHRS2(3), DHRS7(1), PON1(6), PON2(1), PON3(3), RDH11(1), RDH12(3)	4102728	22	19	22	12	1	3	8	9	1	0	0.934	1.000	1.000
588	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	8	CD44(1), ICAM1(2), ITGA4(6), ITGAL(3), ITGB2(2), SELE(4), SELL(2)	4737430	20	19	20	15	2	3	4	5	6	0	0.990	1.000	1.000
589	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNAR2(1), JAK1(6), STAT1(5), STAT2(3), TYK2(2)	4935436	19	18	19	11	2	6	4	2	5	0	0.907	1.000	1.000
590	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHAT(6), PCYT1A(1), PDHA1(3), PDHA2(5), SLC18A3(3)	3189313	20	17	20	14	2	4	7	4	3	0	0.976	1.000	1.000
591	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(1), ICAM1(2), ITGAL(3), ITGAM(3), ITGB2(2), SELE(4), SELL(2)	4720160	17	17	17	15	1	2	4	4	6	0	0.996	1.000	1.000
592	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(2), PLCB1(12), PRKCA(2), RELA(1)	3759828	17	17	17	7	3	3	8	3	0	0	0.733	1.000	1.000
593	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(2), ALAS2(4), CPO(2), FECH(1), GATA1(1), HBA2(2), UROD(1), UROS(3)	3556541	16	16	16	7	2	3	7	4	0	0	0.760	1.000	1.000
594	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(1), DHCR7(1), FDFT1(3), FDPS(2), HMGCR(3), HMGCS1(2), IDI1(1), LSS(3), PMVK(1), SC4MOL(1)	6015011	18	16	18	10	5	5	2	3	3	0	0.897	1.000	1.000
595	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	IARS(7), LARS2(1), PDHA1(3), PDHA2(5)	4561919	16	16	16	12	0	4	7	4	1	0	0.996	1.000	1.000
596	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CSF1(1), HLA-DRA(1), IFNG(1), IL12A(1), IL12B(4), IL13(1), IL1A(1), IL3(1), IL4(1), IL5(1), LTA(1), TGFB1(1), TGFB2(2)	6055633	17	15	17	12	4	4	2	5	2	0	0.960	1.000	1.000
597	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	CPS1(11), GLS(1), GLUD1(2), GOT1(1)	3554471	15	15	15	5	3	3	3	6	0	0	0.596	1.000	1.000
598	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSS(2), NFKB1(2), NOX1(5), RELA(1), XDH(3)	4517257	13	13	13	10	2	3	3	3	2	0	0.959	1.000	1.000
599	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	8	CD3D(1), GZMB(1), ICAM1(2), ITGAL(3), ITGB2(2), PRF1(3)	3543058	12	12	12	10	3	1	2	2	4	0	0.961	1.000	1.000
600	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(2), ALAS2(4), CPOX(1), FECH(1), UROD(1), UROS(3)	3442046	12	12	12	6	1	3	4	4	0	0	0.835	1.000	1.000
601	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GBA(2), GBA3(5), GGT1(1), SHMT1(1), SHMT2(2)	2504290	12	12	12	5	3	2	4	3	0	0	0.767	1.000	1.000
602	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	11	ACTA1(2), ACTR2(1), ARPC1B(1), ARPC2(2), ARPC4(1), CDC42(1), WASF1(3), WASL(1)	3503238	12	12	12	9	3	5	1	3	0	0	0.954	1.000	1.000
603	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(2), CYP11A1(2), CYP11B2(3), HSD11B2(1), HSD3B1(2), HSD3B2(2)	3147790	12	11	12	11	2	1	6	1	2	0	0.978	1.000	1.000
604	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	8	MMP14(2), MMP2(2), RECK(6), TIMP1(1)	3219935	11	11	11	10	0	5	3	3	0	0	0.970	1.000	1.000
605	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(5), GGT1(1), SHMT1(1), SHMT2(2)	1887272	9	9	9	5	2	0	4	3	0	0	0.927	1.000	1.000
606	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(1), CASP7(1), GZMB(1), HMGB1(1), HMGB2(1), TOP2A(2), TOP2B(2)	4030067	9	9	9	4	1	3	3	2	0	0	0.804	1.000	1.000
607	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLS2(1), GLUD1(2), GLUD2(4)	2078035	8	8	8	4	2	2	2	2	0	0	0.859	1.000	1.000
608	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BAG4(4), BIRC3(1), FADD(1), RIPK1(2), TRAF2(1)	3296555	9	8	9	5	2	3	4	0	0	0	0.768	1.000	1.000
609	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(2), APOBEC1(1), APOBEC2(1), APOBEC3B(3)	3342125	7	7	7	6	1	1	2	3	0	0	0.974	1.000	1.000
610	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(3), HLA-DRA(1), IL3(1), IL5(1)	1379968	6	6	6	4	1	3	2	0	0	0	0.856	1.000	1.000
611	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	5	BCL2(1), CASP3(1), CFL1(2), CFLAR(2)	1233220	6	6	6	4	2	4	0	0	0	0	0.723	1.000	1.000
612	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), GLS(1), GLUD1(2), PRODH(1)	2521890	5	5	5	3	1	1	0	3	0	0	0.843	1.000	1.000
613	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(3), SUCLA2(1)	959652	4	4	4	3	0	0	4	0	0	0	0.925	1.000	1.000
614	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(1), SPCS3(1)	1392715	2	2	2	2	0	1	1	0	0	0	0.894	1.000	1.000
615	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(2)	779493	2	2	2	3	0	1	1	0	0	0	0.962	1.000	1.000
616	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1		328481	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
