Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	36.0	1254.0	34.0	-0.786	0.008	1000.0	-1000.0	-0.06	-1000.0
FOXA2 and FOXA3 transcription factor networks	26.0	1211.0	46.0	-1.534	0.013	1000.0	-1000.0	-0.108	-1000.0
PDGFR-alpha signaling pathway	17.0	760.0	44.0	-0.373	0.022	1000.0	-1000.0	-0.054	-1000.0
Signaling events mediated by the Hedgehog family	10.0	550.0	52.0	-0.643	0.195	1000.0	-1000.0	-0.08	-1000.0
Glypican 1 network	9.0	433.0	48.0	-0.472	0.023	1000.0	-1000.0	-0.051	-1000.0
Signaling events regulated by Ret tyrosine kinase	8.0	729.0	82.0	-0.271	0.008	1000.0	-1000.0	-0.078	-1000.0
BMP receptor signaling	6.0	564.0	81.0	-0.769	0.014	1000.0	-1000.0	-0.093	-1000.0
Ephrin B reverse signaling	6.0	318.0	48.0	-0.254	0.018	1000.0	-1000.0	-0.06	-1000.0
Thromboxane A2 receptor signaling	5.0	602.0	105.0	-0.163	0.029	1000.0	-1000.0	-0.073	-1000.0
Reelin signaling pathway	5.0	325.0	56.0	-0.199	0.008	1000.0	-1000.0	-0.074	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	5.0	625.0	120.0	-0.561	0.218	1000.0	-1000.0	-0.079	-1000.0
HIF-1-alpha transcription factor network	4.0	367.0	76.0	-1.013	0.014	1000.0	-1000.0	-0.178	-1000.0
Endothelins	4.0	409.0	96.0	-0.615	0.017	1000.0	-1000.0	-0.094	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	4.0	325.0	68.0	-0.657	0.06	1000.0	-1000.0	-0.131	-1000.0
IL23-mediated signaling events	4.0	253.0	60.0	-0.309	0.013	1000.0	-1000.0	-0.165	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	3.0	210.0	54.0	-0.199	0.018	1000.0	-1000.0	-0.082	-1000.0
IL4-mediated signaling events	3.0	312.0	91.0	-0.497	0.287	1000.0	-1000.0	-0.181	-1000.0
amb2 Integrin signaling	3.0	303.0	82.0	-0.602	0.008	1000.0	-1000.0	-0.09	-1000.0
TCGA08_rtk_signaling	3.0	84.0	26.0	-0.371	0.02	1000.0	-1000.0	-0.023	-1000.0
FOXM1 transcription factor network	3.0	196.0	51.0	-0.346	0.016	1000.0	-1000.0	-0.201	-1000.0
ErbB2/ErbB3 signaling events	2.0	190.0	65.0	-0.115	0.015	1000.0	-1000.0	-0.067	-1000.0
Syndecan-1-mediated signaling events	2.0	87.0	34.0	-0.277	0.008	1000.0	-1000.0	-0.059	-1000.0
Circadian rhythm pathway	2.0	64.0	22.0	-0.423	0.01	1000.0	-1000.0	-0.056	-1000.0
Osteopontin-mediated events	2.0	77.0	38.0	-0.324	0.008	1000.0	-1000.0	-0.093	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	149.0	61.0	-0.371	0.064	1000.0	-1000.0	-0.066	-1000.0
IL1-mediated signaling events	2.0	154.0	62.0	-0.358	0.044	1000.0	-1000.0	-0.095	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	127.0	52.0	-0.535	0.044	1000.0	-1000.0	-0.062	-1000.0
FoxO family signaling	2.0	188.0	64.0	-0.743	0.054	1000.0	-1000.0	-0.089	-1000.0
Integrins in angiogenesis	2.0	228.0	84.0	-0.671	0.02	1000.0	-1000.0	-0.091	-1000.0
Effects of Botulinum toxin	2.0	58.0	26.0	-0.317	0.01	1000.0	-1000.0	-0.061	-1000.0
Nongenotropic Androgen signaling	2.0	135.0	52.0	-0.092	0.013	1000.0	-1000.0	-0.056	-1000.0
LPA receptor mediated events	2.0	228.0	102.0	-0.078	0.025	1000.0	-1000.0	-0.094	-1000.0
EGFR-dependent Endothelin signaling events	2.0	46.0	21.0	-0.061	0.008	1000.0	-1000.0	-0.066	-1000.0
Syndecan-4-mediated signaling events	2.0	141.0	67.0	-0.357	0.053	1000.0	-1000.0	-0.097	-1000.0
Plasma membrane estrogen receptor signaling	2.0	213.0	86.0	-0.063	0.04	1000.0	-1000.0	-0.087	-1000.0
E-cadherin signaling in keratinocytes	2.0	97.0	43.0	-0.274	0.031	1000.0	-1000.0	-0.063	-1000.0
Coregulation of Androgen receptor activity	1.0	99.0	76.0	-0.131	0.036	1000.0	-1000.0	-0.057	-1000.0
ErbB4 signaling events	1.0	123.0	69.0	-0.105	0.018	1000.0	-1000.0	-0.084	-1000.0
Visual signal transduction: Cones	1.0	45.0	38.0	-0.114	0.008	1000.0	-1000.0	-0.066	-1000.0
Noncanonical Wnt signaling pathway	1.0	42.0	26.0	-0.106	0.021	1000.0	-1000.0	-0.07	-1000.0
Syndecan-2-mediated signaling events	1.0	136.0	69.0	-0.602	0.029	1000.0	-1000.0	-0.048	-1000.0
Signaling events mediated by PTP1B	1.0	113.0	76.0	-0.507	0.023	1000.0	-1000.0	-0.078	-1000.0
p75(NTR)-mediated signaling	1.0	197.0	125.0	-0.409	0.019	1000.0	-1000.0	-0.093	-1000.0
Fc-epsilon receptor I signaling in mast cells	1.0	183.0	97.0	-0.124	0.022	1000.0	-1000.0	-0.085	-1000.0
Glucocorticoid receptor regulatory network	1.0	202.0	114.0	-0.365	0.112	1000.0	-1000.0	-0.064	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	60.0	37.0	-0.154	0.01	1000.0	-1000.0	-0.075	-1000.0
FAS signaling pathway (CD95)	1.0	75.0	47.0	-0.286	0.051	1000.0	-1000.0	-0.042	-1000.0
Syndecan-3-mediated signaling events	1.0	47.0	35.0	-0.13	0.008	1000.0	-1000.0	-0.066	-1000.0
Signaling mediated by p38-alpha and p38-beta	1.0	63.0	44.0	-0.221	0.031	1000.0	-1000.0	-0.06	-1000.0
TCR signaling in naïve CD8+ T cells	1.0	103.0	93.0	-0.105	0.044	1000.0	-1000.0	-0.083	-1000.0
IL6-mediated signaling events	1.0	131.0	75.0	-0.184	0.039	1000.0	-1000.0	-0.094	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	1.0	126.0	74.0	-0.31	0.043	1000.0	-1000.0	-0.085	-1000.0
Angiopoietin receptor Tie2-mediated signaling	1.0	161.0	88.0	-0.231	0.029	1000.0	-1000.0	-0.11	-1000.0
Visual signal transduction: Rods	1.0	94.0	52.0	-0.114	0.008	1000.0	-1000.0	-0.077	-1000.0
Signaling events mediated by PRL	1.0	34.0	34.0	-0.059	0.012	1000.0	-1000.0	-0.052	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.019	-1000.0	1000.0	-1000.0	-0.014	-1000.0
E-cadherin signaling events	1.0	6.0	5.0	-0.021	0.008	1000.0	-1000.0	-0.047	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	1.0	100.0	78.0	-0.381	0.026	1000.0	-1000.0	-0.084	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	28.0	17.0	-0.059	0.009	1000.0	-1000.0	-0.045	-1000.0
LPA4-mediated signaling events	0.0	7.0	12.0	-0.053	0.013	1000.0	-1000.0	-0.031	-1000.0
Caspase cascade in apoptosis	0.0	14.0	74.0	-0.025	0.033	1000.0	-1000.0	-0.051	-1000.0
Regulation of nuclear SMAD2/3 signaling	0.0	120.0	136.0	-0.359	0.095	1000.0	-1000.0	-0.082	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	0.0	23.0	0.0	0.031	1000.0	-1000.0	-0.069	-1000.0
Canonical NF-kappaB pathway	0.0	0.0	39.0	-0.002	0.057	1000.0	-1000.0	-0.081	-1000.0
Signaling events mediated by HDAC Class II	0.0	12.0	75.0	-0.059	0.027	1000.0	-1000.0	-0.067	-1000.0
IL12-mediated signaling events	0.0	24.0	87.0	-0.105	0.053	1000.0	-1000.0	-0.122	-1000.0
BARD1 signaling events	0.0	22.0	57.0	-0.011	0.038	1000.0	-1000.0	-0.077	-1000.0
Sphingosine 1-phosphate (S1P) pathway	0.0	3.0	28.0	-0.005	0.023	1000.0	-1000.0	-0.05	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	0.005	0.012	1000.0	-1000.0	-0.018	-1000.0
Ephrin A  reverse signaling	0.0	5.0	7.0	-0.012	0.001	1000.0	-1000.0	-0.029	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	15.0	17.0	-0.059	0.035	1000.0	-1000.0	-0.059	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.0	0.008	1000.0	-1000.0	-0.041	-1000.0
Cellular roles of Anthrax toxin	0.0	31.0	39.0	-0.079	0.013	1000.0	-1000.0	-0.027	-1000.0
Arf6 signaling events	0.0	38.0	62.0	-0.046	0.034	1000.0	-1000.0	-0.073	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	0.0	26.0	85.0	-0.032	0.041	1000.0	-1000.0	-0.064	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	41.0	65.0	-0.097	0.052	1000.0	-1000.0	-0.071	-1000.0
Aurora A signaling	0.0	3.0	60.0	-0.034	0.018	1000.0	-1000.0	-0.055	-1000.0
Arf6 downstream pathway	0.0	0.0	43.0	-0.021	0.021	1000.0	-1000.0	-0.04	-1000.0
Aurora C signaling	0.0	0.0	7.0	-0.014	0.0	1000.0	-1000.0	-0.043	-1000.0
EPO signaling pathway	0.0	9.0	55.0	-0.097	0.053	1000.0	-1000.0	-0.088	-1000.0
PLK1 signaling events	0.0	0.0	85.0	-0.048	0.012	1000.0	-1000.0	-0.063	-1000.0
Insulin-mediated glucose transport	0.0	13.0	32.0	-0.172	0.021	1000.0	-1000.0	-0.074	-1000.0
mTOR signaling pathway	0.0	0.0	53.0	-0.0	0.023	1000.0	-1000.0	-0.056	-1000.0
IFN-gamma pathway	0.0	57.0	68.0	-0.226	0.046	1000.0	-1000.0	-0.091	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	13.0	68.0	-0.172	0.033	1000.0	-1000.0	-0.07	-1000.0
Nectin adhesion pathway	0.0	45.0	63.0	-0.046	0.03	1000.0	-1000.0	-0.074	-1000.0
Ceramide signaling pathway	0.0	10.0	76.0	-0.063	0.03	1000.0	-1000.0	-0.058	-1000.0
Signaling events mediated by HDAC Class III	0.0	14.0	40.0	-0.073	0.015	1000.0	-1000.0	-0.046	-1000.0
TRAIL signaling pathway	0.0	16.0	48.0	-0.021	0.03	1000.0	-1000.0	-0.06	-1000.0
S1P5 pathway	0.0	3.0	17.0	-0.005	0.017	1000.0	-1000.0	-0.053	-1000.0
ceramide signaling pathway	0.0	4.0	49.0	-0.019	0.033	1000.0	-1000.0	-0.058	-1000.0
HIF-2-alpha transcription factor network	0.0	8.0	43.0	-0.123	0.126	1000.0	-1000.0	-0.097	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	78.0	83.0	-0.222	0.067	1000.0	-1000.0	-0.083	-1000.0
S1P1 pathway	0.0	4.0	36.0	-0.004	0.033	1000.0	-1000.0	-0.061	-1000.0
Signaling events mediated by HDAC Class I	0.0	2.0	104.0	-0.008	0.038	1000.0	-1000.0	-0.072	-1000.0
TCGA08_p53	0.0	0.0	7.0	-0.078	0.048	1000.0	-1000.0	-0.015	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	11.0	15.0	-0.003	0.02	1000.0	-1000.0	-0.038	-1000.0
Retinoic acid receptors-mediated signaling	0.0	0.0	58.0	-0.003	0.037	1000.0	-1000.0	-0.072	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	24.0	36.0	-0.154	0.015	1000.0	-1000.0	-0.069	-1000.0
Atypical NF-kappaB pathway	0.0	16.0	31.0	-0.032	0.018	1000.0	-1000.0	-0.062	-1000.0
IL2 signaling events mediated by PI3K	0.0	25.0	58.0	-0.03	0.033	1000.0	-1000.0	-0.084	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	14.0	45.0	-0.016	0.046	1000.0	-1000.0	-0.082	-1000.0
Canonical Wnt signaling pathway	0.0	29.0	51.0	-0.141	0.07	1000.0	-1000.0	-0.073	-1000.0
EPHB forward signaling	0.0	45.0	85.0	-0.032	0.042	1000.0	-1000.0	-0.083	-1000.0
Regulation of p38-alpha and p38-beta	0.0	5.0	54.0	-0.032	0.03	1000.0	-1000.0	-0.062	-1000.0
Glypican 2 network	0.0	0.0	4.0	-0.01	-1000.0	1000.0	-1000.0	-0.035	-1000.0
Calcium signaling in the CD4+ TCR pathway	0.0	4.0	31.0	-0.031	0.04	1000.0	-1000.0	-0.089	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	0.0	16.0	125.0	-0.023	0.061	1000.0	-1000.0	-0.084	-1000.0
IL27-mediated signaling events	0.0	48.0	51.0	-0.188	0.04	1000.0	-1000.0	-0.092	-1000.0
Wnt signaling	0.0	4.0	7.0	-0.022	0.008	1000.0	-1000.0	-0.026	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	58.0	76.0	-0.021	0.029	1000.0	-1000.0	-0.081	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.0	0.019	1000.0	-1000.0	-0.058	-1000.0
IL2 signaling events mediated by STAT5	0.0	7.0	22.0	-0.032	0.025	1000.0	-1000.0	-0.058	-1000.0
Class I PI3K signaling events	0.0	10.0	73.0	-0.097	0.029	1000.0	-1000.0	-0.081	-1000.0
Arf6 trafficking events	0.0	11.0	71.0	-0.116	0.029	1000.0	-1000.0	-0.078	-1000.0
TCGA08_retinoblastoma	0.0	0.0	8.0	-0.125	0.028	1000.0	-1000.0	-0.019	-1000.0
Regulation of Telomerase	0.0	59.0	102.0	-0.376	0.031	1000.0	-1000.0	-0.11	-1000.0
BCR signaling pathway	0.0	34.0	99.0	-0.097	0.025	1000.0	-1000.0	-0.09	-1000.0
IGF1 pathway	0.0	1.0	57.0	-0.06	0.023	1000.0	-1000.0	-0.093	-1000.0
Insulin Pathway	0.0	18.0	74.0	-0.032	0.026	1000.0	-1000.0	-0.082	-1000.0
VEGFR1 specific signals	0.0	5.0	56.0	-0.011	0.046	1000.0	-1000.0	-0.072	-1000.0
S1P3 pathway	0.0	11.0	42.0	-0.009	0.03	1000.0	-1000.0	-0.056	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	14.0	33.0	-0.122	0.024	1000.0	-1000.0	-0.066	-1000.0
Rapid glucocorticoid signaling	0.0	0.0	20.0	-0.052	0.008	1000.0	-1000.0	-0.037	-1000.0
PDGFR-beta signaling pathway	0.0	12.0	97.0	-0.031	0.042	1000.0	-1000.0	-0.075	-1000.0
S1P4 pathway	0.0	3.0	25.0	-0.005	0.023	1000.0	-1000.0	-0.052	-1000.0
p38 MAPK signaling pathway	0.0	0.0	44.0	-0.077	0.018	1000.0	-1000.0	-0.061	-1000.0
Arf1 pathway	0.0	0.0	54.0	-0.001	0.023	1000.0	-1000.0	-0.039	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.008	1000.0	-1000.0	-0.065	-1000.0
Regulation of Androgen receptor activity	0.0	53.0	70.0	-0.117	0.022	1000.0	-1000.0	-0.076	-1000.0
Aurora B signaling	0.0	36.0	67.0	-0.323	0.02	1000.0	-1000.0	-0.07	-1000.0
Total	219	15393	7203	-25.2411085541	-1995.68387963	131000	-131000	-9.37222317268	-131000