Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.127 0.19 -9999.0 0.0 -0.512 10.0 10.0 IHH -0.08 0.137 -9999.0 0.0 -0.297 17.0 17.0 SHH Np/Cholesterol/GAS1 0.029 0.045 -9999.0 0.0 -9999.0 0.0 0.0 LRPAP1 0.044 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.029 0.045 -9999.0 0.0 -9999.0 0.0 0.0 SMO/beta Arrestin2 -0.051 0.168 -9999.0 0.0 -0.442 5.0 5.0 SMO -0.079 0.159 -9999.0 0.0 -0.434 7.0 7.0 AKT1 -0.031 0.17 -9999.0 0.0 -0.591 5.0 5.0 ARRB2 0.041 0.013 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.03 0.078 -9999.0 0.0 -0.42 2.0 2.0 ADRBK1 0.044 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.078 0.158 -9999.0 0.0 -0.428 7.0 7.0 STIL -0.042 0.106 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH2 0.047 0.063 -9999.0 0.0 -0.297 2.0 2.0 DHH N/PTCH1 -0.069 0.122 -9999.0 0.0 -0.276 10.0 10.0 PIK3CA 0.043 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.03 0.078 -9999.0 0.0 -0.42 2.0 2.0 PTHLH -0.208 0.338 -9999.0 0.0 -0.932 11.0 11.0 determination of left/right symmetry -0.078 0.158 -9999.0 0.0 -0.428 7.0 7.0 PIK3R1 0.01 0.114 -9999.0 0.0 -0.396 5.0 5.0 skeletal system development -0.205 0.334 -9999.0 0.0 -0.919 11.0 11.0 IHH N/Hhip -0.056 0.137 -9999.0 0.0 -0.273 15.0 15.0 DHH N/Hhip 0.011 0.129 -9999.0 0.0 -0.266 11.0 11.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.078 0.158 -9999.0 0.0 -0.428 7.0 7.0 pancreas development -0.013 0.134 -9999.0 0.0 -0.321 11.0 11.0 HHAT 0.04 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.037 0.09 -9999.0 0.0 -0.278 5.0 5.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.029 0.07 -9999.0 0.0 -0.299 3.0 3.0 somite specification -0.078 0.158 -9999.0 0.0 -0.428 7.0 7.0 SHH Np/Cholesterol/PTCH1 -0.055 0.099 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH2 0.037 0.025 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Megalin 0.006 0.088 -9999.0 0.0 -0.225 8.0 8.0 SHH 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process -0.083 0.123 -9999.0 0.0 -0.297 11.0 11.0 SMO/Vitamin D3 -0.064 0.13 -9999.0 0.0 -0.369 3.0 3.0 SHH Np/Cholesterol/Hhip 0.011 0.074 -9999.0 0.0 -0.225 2.0 2.0 LRP2 -0.025 0.162 -9999.0 0.0 -0.42 10.0 10.0 receptor-mediated endocytosis -0.08 0.157 -9999.0 0.0 -0.372 10.0 10.0 SHH Np/Cholesterol/BOC 0.029 0.051 -9999.0 0.0 -0.225 2.0 2.0 SHH Np/Cholesterol/CDO 0.017 0.079 -9999.0 0.0 -0.242 5.0 5.0 mesenchymal cell differentiation -0.011 0.074 0.224 2.0 -9999.0 0.0 2.0 mol:Vitamin D3 -0.043 0.116 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH2 -0.015 0.092 -9999.0 0.0 -0.189 5.0 5.0 CDON -0.007 0.144 -9999.0 0.0 -0.405 8.0 8.0 IHH N/PTCH1 -0.08 0.13 -9999.0 0.0 -0.298 11.0 11.0 Megalin/LRPAP1 0.009 0.126 -9999.0 0.0 -0.297 10.0 10.0 PTCH2 0.04 0.013 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.022 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 -0.083 0.124 -9999.0 0.0 -0.297 11.0 11.0 HHIP -0.013 0.134 -9999.0 0.0 -0.321 11.0 11.0