Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.017 0.098 -9999.0 0.0 -0.233 10.0 10.0 epithelial cell differentiation 0.011 0.106 -9999.0 0.0 -0.21 9.0 9.0 CYFIP2 0.029 0.057 -9999.0 0.0 -0.42 1.0 1.0 ENAH 0.015 0.156 0.543 2.0 -0.29 4.0 6.0 EGFR -0.024 0.15 -9999.0 0.0 -0.365 11.0 11.0 EPHA2 0.029 0.069 -9999.0 0.0 -0.36 2.0 2.0 MYO6 0.036 0.145 0.272 8.0 -0.226 8.0 16.0 CTNNB1 0.033 0.02 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.055 0.06 -9999.0 0.0 -0.25 1.0 1.0 AQP5 0.02 0.152 -9999.0 0.0 -0.642 2.0 2.0 CTNND1 0.024 0.094 -9999.0 0.0 -0.42 3.0 3.0 mol:PI-4-5-P2 0.034 0.142 0.27 8.0 -9999.0 0.0 8.0 regulation of calcium-dependent cell-cell adhesion -0.025 0.163 0.208 7.0 -0.297 11.0 18.0 EGF -0.125 0.194 -9999.0 0.0 -0.338 31.0 31.0 NCKAP1 0.037 0.042 -9999.0 0.0 -0.299 1.0 1.0 AQP3 -0.018 0.2 -9999.0 0.0 -0.633 5.0 5.0 cortical microtubule organization 0.011 0.106 -9999.0 0.0 -0.21 9.0 9.0 GO:0000145 0.021 0.136 0.22 14.0 -9999.0 0.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.015 0.11 -9999.0 0.0 -0.212 9.0 9.0 MLLT4 0.032 0.057 -9999.0 0.0 -0.42 1.0 1.0 ARF6/GDP -0.043 0.103 -9999.0 0.0 -0.368 4.0 4.0 ARF6 0.042 0.012 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.057 0.121 -9999.0 0.0 -0.288 6.0 6.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.008 0.115 0.212 5.0 -0.304 1.0 6.0 PVRL2 0.044 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.02 0.115 0.21 6.0 -9999.0 0.0 6.0 ARF6/GTP 0.065 0.119 -9999.0 0.0 -0.398 2.0 2.0 CDH1 -0.021 0.151 -9999.0 0.0 -0.365 11.0 11.0 EGFR/EGFR/EGF/EGF -0.088 0.142 -9999.0 0.0 -0.338 10.0 10.0 RhoA/GDP 0.014 0.104 -9999.0 0.0 -0.2 9.0 9.0 actin cytoskeleton organization 0.018 0.113 0.192 7.0 -0.381 1.0 8.0 IGF-1R heterotetramer 0.038 0.055 -9999.0 0.0 -0.42 1.0 1.0 GIT1 0.041 0.013 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.038 0.055 -9999.0 0.0 -0.42 1.0 1.0 IGF1 -0.016 0.138 -9999.0 0.0 -0.332 11.0 11.0 DIAPH1 0.011 0.194 -9999.0 0.0 -0.653 2.0 2.0 Wnt receptor signaling pathway -0.011 0.106 0.21 9.0 -9999.0 0.0 9.0 RHOA 0.035 0.019 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.044 0.103 -9999.0 0.0 -0.367 4.0 4.0 CTNNA1 0.035 0.018 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.018 0.115 0.193 7.0 -0.39 1.0 8.0 EFNA1 -0.007 0.139 -9999.0 0.0 -0.42 7.0 7.0 LPP -0.009 0.132 0.206 5.0 -0.337 3.0 8.0 Ephrin A1/EPHA2 -0.015 0.126 -9999.0 0.0 -0.356 4.0 4.0 SEC6/SEC8 -0.019 0.076 -9999.0 0.0 -0.341 1.0 1.0 MGAT3 -0.026 0.165 0.21 7.0 -0.302 11.0 18.0 HGF/MET -0.008 0.101 -9999.0 0.0 -0.257 1.0 1.0 HGF 0.02 0.088 -9999.0 0.0 -0.329 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.017 0.099 -9999.0 0.0 -0.234 10.0 10.0 actin cable formation 0.049 0.179 0.327 10.0 -0.354 3.0 13.0 KIAA1543 0.011 0.111 0.197 7.0 -9999.0 0.0 7.0 KIFC3 0.024 0.118 0.21 7.0 -9999.0 0.0 7.0 NCK1 0.036 0.056 -9999.0 0.0 -0.42 1.0 1.0 EXOC3 0.034 0.056 -9999.0 0.0 -0.42 1.0 1.0 ACTN1 0.002 0.138 0.21 6.0 -0.317 4.0 10.0 NCK1/GIT1 0.054 0.048 -9999.0 0.0 -0.31 1.0 1.0 mol:GDP 0.011 0.106 -9999.0 0.0 -0.21 9.0 9.0 EXOC4 0.041 0.013 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.016 0.131 0.21 7.0 -0.245 9.0 16.0 PIP5K1C 0.035 0.143 0.272 8.0 -9999.0 0.0 8.0 LIMA1 0.017 0.096 -9999.0 0.0 -0.323 5.0 5.0 ABI1 0.042 0.012 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.031 0.174 0.483 3.0 -0.325 4.0 7.0 adherens junction assembly 0.044 0.156 0.951 1.0 -9999.0 0.0 1.0 IGF-1R heterotetramer/IGF1 -0.012 0.124 -9999.0 0.0 -0.32 5.0 5.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.052 0.048 -9999.0 0.0 -0.297 1.0 1.0 MET 0.029 0.069 -9999.0 0.0 -0.36 2.0 2.0 PLEKHA7 0.024 0.118 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.054 0.119 -9999.0 0.0 -0.286 6.0 6.0 establishment of epithelial cell apical/basal polarity 0.036 0.149 0.384 4.0 -0.493 1.0 5.0 cortical actin cytoskeleton stabilization -0.017 0.098 -9999.0 0.0 -0.233 10.0 10.0 regulation of cell-cell adhesion 0.018 0.113 0.192 7.0 -0.381 1.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.017 0.099 -9999.0 0.0 -0.234 10.0 10.0