Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	209.0	7122.0	34.0	-0.516	0.029	1000.0	-1000.0	-0.058	-1000.0
HIF-1-alpha transcription factor network	158.0	12018.0	76.0	-1.097	0.045	1000.0	-1000.0	-0.147	-1000.0
TCGA08_p53	142.0	995.0	7.0	-0.422	0.221	1000.0	-1000.0	-0.014	-1000.0
TCR signaling in naïve CD8+ T cells	129.0	12074.0	93.0	-0.438	0.202	1000.0	-1000.0	-0.084	-1000.0
FOXA2 and FOXA3 transcription factor networks	112.0	5187.0	46.0	-1.12	0.036	1000.0	-1000.0	-0.111	-1000.0
PDGFR-alpha signaling pathway	98.0	4350.0	44.0	-0.224	0.036	1000.0	-1000.0	-0.058	-1000.0
TCGA08_retinoblastoma	96.0	774.0	8.0	-0.578	0.16	1000.0	-1000.0	-0.011	-1000.0
Aurora B signaling	84.0	5677.0	67.0	-0.265	0.041	1000.0	-1000.0	-0.06	-1000.0
IL12-mediated signaling events	82.0	7216.0	87.0	-0.459	0.117	1000.0	-1000.0	-0.118	-1000.0
Syndecan-4-mediated signaling events	81.0	5455.0	67.0	-0.44	0.09	1000.0	-1000.0	-0.063	-1000.0
EGFR-dependent Endothelin signaling events	79.0	1672.0	21.0	-0.571	0.042	1000.0	-1000.0	-0.06	-1000.0
Glypican 1 network	76.0	3684.0	48.0	-0.411	0.046	1000.0	-1000.0	-0.038	-1000.0
amb2 Integrin signaling	76.0	6278.0	82.0	-0.472	0.038	1000.0	-1000.0	-0.059	-1000.0
FOXM1 transcription factor network	74.0	3791.0	51.0	-0.565	0.03	1000.0	-1000.0	-0.108	-1000.0
Aurora C signaling	64.0	448.0	7.0	-0.266	0.028	1000.0	-1000.0	-0.022	-1000.0
BMP receptor signaling	61.0	4986.0	81.0	-0.523	0.054	1000.0	-1000.0	-0.081	-1000.0
IL4-mediated signaling events	59.0	5400.0	91.0	-0.788	0.491	1000.0	-1000.0	-0.098	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	58.0	1926.0	33.0	-0.571	0.057	1000.0	-1000.0	-0.045	-1000.0
Glypican 2 network	55.0	223.0	4.0	-0.04	-1000.0	1000.0	-1000.0	-0.005	-1000.0
Caspase cascade in apoptosis	52.0	3856.0	74.0	-0.289	0.093	1000.0	-1000.0	-0.053	-1000.0
JNK signaling in the CD4+ TCR pathway	49.0	833.0	17.0	-0.226	0.029	1000.0	-1000.0	-0.053	-1000.0
Fc-epsilon receptor I signaling in mast cells	47.0	4584.0	97.0	-0.221	0.041	1000.0	-1000.0	-0.081	-1000.0
Syndecan-1-mediated signaling events	40.0	1361.0	34.0	-0.25	0.029	1000.0	-1000.0	-0.064	-1000.0
HIF-2-alpha transcription factor network	38.0	1656.0	43.0	-0.528	0.242	1000.0	-1000.0	-0.065	-1000.0
Effects of Botulinum toxin	36.0	936.0	26.0	-0.241	0.04	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by the Hedgehog family	35.0	1845.0	52.0	-0.287	0.068	1000.0	-1000.0	-0.058	-1000.0
Arf6 signaling events	35.0	2217.0	62.0	-0.571	0.066	1000.0	-1000.0	-0.051	-1000.0
Reelin signaling pathway	35.0	2008.0	56.0	-0.171	0.079	1000.0	-1000.0	-0.057	-1000.0
Calcium signaling in the CD4+ TCR pathway	35.0	1102.0	31.0	-0.384	0.029	1000.0	-1000.0	-0.066	-1000.0
IL23-mediated signaling events	33.0	2016.0	60.0	-0.27	0.029	1000.0	-1000.0	-0.082	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	32.0	1752.0	54.0	-0.443	0.041	1000.0	-1000.0	-0.085	-1000.0
PLK1 signaling events	31.0	2638.0	85.0	-0.201	0.042	1000.0	-1000.0	-0.05	-1000.0
p75(NTR)-mediated signaling	30.0	3760.0	125.0	-0.32	0.077	1000.0	-1000.0	-0.104	-1000.0
IL27-mediated signaling events	30.0	1530.0	51.0	-0.588	0.057	1000.0	-1000.0	-0.058	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	30.0	2107.0	68.0	-0.331	0.062	1000.0	-1000.0	-0.099	-1000.0
IL2 signaling events mediated by STAT5	30.0	671.0	22.0	-0.311	0.035	1000.0	-1000.0	-0.056	-1000.0
LPA4-mediated signaling events	28.0	337.0	12.0	-0.104	0.011	1000.0	-1000.0	-0.029	-1000.0
Ephrin A  reverse signaling	28.0	202.0	7.0	-0.023	0.008	1000.0	-1000.0	-0.02	-1000.0
Coregulation of Androgen receptor activity	27.0	2101.0	76.0	-0.858	0.054	1000.0	-1000.0	-0.025	-1000.0
S1P1 pathway	27.0	973.0	36.0	-0.246	0.029	1000.0	-1000.0	-0.057	-1000.0
BCR signaling pathway	25.0	2568.0	99.0	-0.223	0.056	1000.0	-1000.0	-0.083	-1000.0
Integrins in angiogenesis	24.0	2035.0	84.0	-0.264	0.068	1000.0	-1000.0	-0.067	-1000.0
IL2 signaling events mediated by PI3K	23.0	1377.0	58.0	-0.309	0.049	1000.0	-1000.0	-0.055	-1000.0
EPO signaling pathway	22.0	1214.0	55.0	-0.171	0.035	1000.0	-1000.0	-0.077	-1000.0
Glucocorticoid receptor regulatory network	22.0	2590.0	114.0	-0.353	0.146	1000.0	-1000.0	-0.085	-1000.0
Signaling events mediated by PTP1B	21.0	1610.0	76.0	-0.574	0.064	1000.0	-1000.0	-0.06	-1000.0
Ceramide signaling pathway	20.0	1577.0	76.0	-0.571	0.205	1000.0	-1000.0	-0.059	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	20.0	930.0	45.0	-0.381	0.077	1000.0	-1000.0	-0.08	-1000.0
Wnt signaling	20.0	140.0	7.0	-0.048	0.028	1000.0	-1000.0	-0.03	-1000.0
Regulation of Telomerase	20.0	2135.0	102.0	-0.572	0.061	1000.0	-1000.0	-0.08	-1000.0
VEGFR1 specific signals	20.0	1154.0	56.0	-0.319	0.033	1000.0	-1000.0	-0.075	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	20.0	1612.0	78.0	-0.243	0.048	1000.0	-1000.0	-0.06	-1000.0
FoxO family signaling	19.0	1234.0	64.0	-0.556	0.095	1000.0	-1000.0	-0.06	-1000.0
Angiopoietin receptor Tie2-mediated signaling	19.0	1734.0	88.0	-0.206	0.05	1000.0	-1000.0	-0.074	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	18.0	2190.0	120.0	-0.115	0.083	1000.0	-1000.0	-0.069	-1000.0
Visual signal transduction: Rods	18.0	963.0	52.0	-0.155	0.041	1000.0	-1000.0	-0.066	-1000.0
Noncanonical Wnt signaling pathway	17.0	449.0	26.0	-0.102	0.028	1000.0	-1000.0	-0.063	-1000.0
Syndecan-2-mediated signaling events	17.0	1201.0	69.0	-0.472	0.064	1000.0	-1000.0	-0.04	-1000.0
Thromboxane A2 receptor signaling	16.0	1761.0	105.0	-0.571	0.049	1000.0	-1000.0	-0.063	-1000.0
Endothelins	16.0	1560.0	96.0	-0.331	0.048	1000.0	-1000.0	-0.061	-1000.0
Signaling mediated by p38-alpha and p38-beta	15.0	684.0	44.0	-0.04	0.054	1000.0	-1000.0	-0.042	-1000.0
IL6-mediated signaling events	15.0	1155.0	75.0	-0.209	0.062	1000.0	-1000.0	-0.065	-1000.0
Regulation of nuclear SMAD2/3 signaling	14.0	1999.0	136.0	-0.296	0.098	1000.0	-1000.0	-0.061	-1000.0
Presenilin action in Notch and Wnt signaling	14.0	865.0	61.0	-0.138	0.084	1000.0	-1000.0	-0.063	-1000.0
LPA receptor mediated events	14.0	1441.0	102.0	-0.245	0.052	1000.0	-1000.0	-0.08	-1000.0
Class I PI3K signaling events	14.0	1036.0	73.0	-0.32	0.08	1000.0	-1000.0	-0.059	-1000.0
Aurora A signaling	13.0	817.0	60.0	-0.149	0.063	1000.0	-1000.0	-0.048	-1000.0
IFN-gamma pathway	13.0	938.0	68.0	-0.248	0.042	1000.0	-1000.0	-0.079	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	13.0	491.0	37.0	-0.178	0.055	1000.0	-1000.0	-0.053	-1000.0
S1P5 pathway	13.0	232.0	17.0	-0.077	0.029	1000.0	-1000.0	-0.025	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	13.0	994.0	74.0	-0.571	0.105	1000.0	-1000.0	-0.091	-1000.0
Canonical Wnt signaling pathway	12.0	632.0	51.0	-0.138	0.098	1000.0	-1000.0	-0.068	-1000.0
Nongenotropic Androgen signaling	12.0	624.0	52.0	-0.112	0.046	1000.0	-1000.0	-0.043	-1000.0
Plasma membrane estrogen receptor signaling	12.0	1035.0	86.0	-0.143	0.054	1000.0	-1000.0	-0.086	-1000.0
S1P3 pathway	12.0	510.0	42.0	-0.243	0.051	1000.0	-1000.0	-0.042	-1000.0
PLK2 and PLK4 events	11.0	34.0	3.0	0.005	0.025	1000.0	-1000.0	-0.017	-1000.0
Signaling events regulated by Ret tyrosine kinase	11.0	974.0	82.0	-0.026	0.031	1000.0	-1000.0	-0.092	-1000.0
S1P4 pathway	11.0	278.0	25.0	-0.077	0.038	1000.0	-1000.0	-0.046	-1000.0
Regulation of Androgen receptor activity	11.0	816.0	70.0	-0.926	0.053	1000.0	-1000.0	-0.062	-1000.0
Sphingosine 1-phosphate (S1P) pathway	10.0	306.0	28.0	-0.077	0.048	1000.0	-1000.0	-0.039	-1000.0
FAS signaling pathway (CD95)	10.0	516.0	47.0	-0.295	0.049	1000.0	-1000.0	-0.055	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	10.0	1287.0	125.0	-0.243	0.043	1000.0	-1000.0	-0.083	-1000.0
TCGA08_rtk_signaling	10.0	279.0	26.0	-0.224	0.057	1000.0	-1000.0	-0.015	-1000.0
E-cadherin signaling events	10.0	51.0	5.0	0.007	0.025	1000.0	-1000.0	-0.012	-1000.0
ErbB4 signaling events	9.0	648.0	69.0	-0.162	0.095	1000.0	-1000.0	-0.072	-1000.0
a4b1 and a4b7 Integrin signaling	9.0	48.0	5.0	0.007	0.029	1000.0	-1000.0	-0.007	-1000.0
ceramide signaling pathway	8.0	412.0	49.0	-0.066	0.045	1000.0	-1000.0	-0.064	-1000.0
Canonical NF-kappaB pathway	6.0	253.0	39.0	-0.123	0.056	1000.0	-1000.0	-0.065	-1000.0
Visual signal transduction: Cones	6.0	263.0	38.0	-0.017	0.045	1000.0	-1000.0	-0.021	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	6.0	539.0	85.0	-0.036	0.083	1000.0	-1000.0	-0.062	-1000.0
mTOR signaling pathway	6.0	320.0	53.0	-0.063	0.054	1000.0	-1000.0	-0.056	-1000.0
Signaling events mediated by PRL	6.0	219.0	34.0	-0.043	0.066	1000.0	-1000.0	-0.046	-1000.0
E-cadherin signaling in keratinocytes	6.0	261.0	43.0	-0.221	0.043	1000.0	-1000.0	-0.053	-1000.0
Signaling events mediated by HDAC Class III	5.0	200.0	40.0	-0.053	0.054	1000.0	-1000.0	-0.023	-1000.0
IL1-mediated signaling events	5.0	340.0	62.0	-0.044	0.067	1000.0	-1000.0	-0.083	-1000.0
Ephrin B reverse signaling	5.0	277.0	48.0	-0.049	0.054	1000.0	-1000.0	-0.046	-1000.0
E-cadherin signaling in the nascent adherens junction	5.0	448.0	76.0	-0.034	0.051	1000.0	-1000.0	-0.081	-1000.0
PDGFR-beta signaling pathway	5.0	487.0	97.0	-0.018	0.088	1000.0	-1000.0	-0.072	-1000.0
p38 MAPK signaling pathway	5.0	226.0	44.0	-0.069	0.055	1000.0	-1000.0	-0.056	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	92.0	17.0	-0.01	0.055	1000.0	-1000.0	-0.033	-1000.0
ErbB2/ErbB3 signaling events	4.0	271.0	65.0	-0.126	0.044	1000.0	-1000.0	-0.069	-1000.0
Cellular roles of Anthrax toxin	4.0	194.0	39.0	-0.01	0.039	1000.0	-1000.0	-0.029	-1000.0
Insulin-mediated glucose transport	4.0	142.0	32.0	-0.039	0.056	1000.0	-1000.0	-0.05	-1000.0
Syndecan-3-mediated signaling events	4.0	148.0	35.0	-0.013	0.077	1000.0	-1000.0	-0.055	-1000.0
EPHB forward signaling	4.0	376.0	85.0	-0.052	0.078	1000.0	-1000.0	-0.096	-1000.0
Regulation of p38-alpha and p38-beta	4.0	234.0	54.0	-0.022	0.066	1000.0	-1000.0	-0.061	-1000.0
Class IB PI3K non-lipid kinase events	4.0	12.0	3.0	-0.024	0.024	1000.0	-1000.0	-0.005	-1000.0
BARD1 signaling events	3.0	186.0	57.0	-0.105	0.076	1000.0	-1000.0	-0.069	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	237.0	65.0	-0.007	0.106	1000.0	-1000.0	-0.066	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	3.0	168.0	52.0	-0.012	0.097	1000.0	-1000.0	-0.051	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	54.0	15.0	-0.0	0.032	1000.0	-1000.0	-0.036	-1000.0
Arf6 trafficking events	3.0	224.0	71.0	-0.118	0.064	1000.0	-1000.0	-0.054	-1000.0
Insulin Pathway	3.0	270.0	74.0	-0.032	0.079	1000.0	-1000.0	-0.085	-1000.0
Osteopontin-mediated events	2.0	78.0	38.0	0.0	0.091	1000.0	-1000.0	-0.055	-1000.0
Arf6 downstream pathway	2.0	114.0	43.0	-0.047	0.048	1000.0	-1000.0	-0.036	-1000.0
Class I PI3K signaling events mediated by Akt	2.0	168.0	68.0	-0.039	0.056	1000.0	-1000.0	-0.055	-1000.0
Nectin adhesion pathway	2.0	151.0	63.0	-0.0	0.06	1000.0	-1000.0	-0.062	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	211.0	83.0	-0.039	0.073	1000.0	-1000.0	-0.067	-1000.0
Signaling events mediated by HDAC Class II	1.0	95.0	75.0	-0.04	0.061	1000.0	-1000.0	-0.045	-1000.0
Signaling events mediated by HDAC Class I	1.0	173.0	104.0	-0.056	0.076	1000.0	-1000.0	-0.049	-1000.0
Retinoic acid receptors-mediated signaling	1.0	98.0	58.0	-0.013	0.053	1000.0	-1000.0	-0.05	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	67.0	36.0	-0.05	0.055	1000.0	-1000.0	-0.057	-1000.0
Atypical NF-kappaB pathway	1.0	51.0	31.0	-0.0	0.039	1000.0	-1000.0	-0.043	-1000.0
IGF1 pathway	1.0	109.0	57.0	-0.049	0.076	1000.0	-1000.0	-0.077	-1000.0
Arf1 pathway	1.0	69.0	54.0	-0.0	0.048	1000.0	-1000.0	-0.027	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	16.0	23.0	-0.024	0.055	1000.0	-1000.0	-0.043	-1000.0
Circadian rhythm pathway	0.0	18.0	22.0	-0.014	0.069	1000.0	-1000.0	-0.046	-1000.0
TRAIL signaling pathway	0.0	28.0	48.0	-0.0	0.072	1000.0	-1000.0	-0.061	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.0	0.069	1000.0	-1000.0	-0.057	-1000.0
Rapid glucocorticoid signaling	0.0	6.0	20.0	-0.01	0.036	1000.0	-1000.0	-0.012	-1000.0
Alternative NF-kappaB pathway	0.0	8.0	13.0	-0.0	0.06	1000.0	-1000.0	-0.019	-1000.0
Total	3371	184798	7203	-30.0720821196	-991.530476565	131000	-131000	-7.54673710517	-131000