Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.036 0.139 -9999.0 0.0 -9999.0 0.0 0.0 IHH -0.084 0.269 -9999.0 0.0 -0.674 13.0 13.0 SHH Np/Cholesterol/GAS1 -0.001 0.084 -9999.0 0.0 -0.389 3.0 3.0 LRPAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.001 0.083 0.386 3.0 -9999.0 0.0 3.0 SMO/beta Arrestin2 -0.028 0.186 -9999.0 0.0 -0.441 10.0 10.0 SMO -0.052 0.174 -9999.0 0.0 -0.459 10.0 10.0 AKT1 -0.033 0.159 -9999.0 0.0 -0.656 3.0 3.0 ARRB2 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.051 0.171 -9999.0 0.0 -0.453 10.0 10.0 STIL -0.022 0.135 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH2 0.023 0.086 -9999.0 0.0 -0.493 2.0 2.0 DHH N/PTCH1 -0.04 0.157 -9999.0 0.0 -0.354 15.0 15.0 PIK3CA 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.003 0.109 -9999.0 0.0 -0.649 2.0 2.0 PTHLH -0.052 0.17 -9999.0 0.0 -9999.0 0.0 0.0 determination of left/right symmetry -0.051 0.171 -9999.0 0.0 -0.453 10.0 10.0 PIK3R1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.052 0.169 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/Hhip -0.077 0.215 -9999.0 0.0 -0.461 18.0 18.0 DHH N/Hhip -0.012 0.153 -9999.0 0.0 -0.493 7.0 7.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.051 0.171 -9999.0 0.0 -0.453 10.0 10.0 pancreas development -0.02 0.167 -9999.0 0.0 -0.648 5.0 5.0 HHAT 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.038 0.011 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.001 0.132 -9999.0 0.0 -0.649 3.0 3.0 somite specification -0.051 0.171 -9999.0 0.0 -0.453 10.0 10.0 SHH Np/Cholesterol/PTCH1 -0.036 0.123 -9999.0 0.0 -0.316 10.0 10.0 SHH Np/Cholesterol/PTCH2 0.014 0.049 -9999.0 0.0 -0.394 1.0 1.0 SHH Np/Cholesterol/Megalin -0.041 0.146 -9999.0 0.0 -0.394 11.0 11.0 SHH -0.018 0.056 -9999.0 0.0 -0.494 1.0 1.0 catabolic process -0.044 0.156 -9999.0 0.0 -0.385 13.0 13.0 SMO/Vitamin D3 -0.044 0.151 -9999.0 0.0 -0.41 8.0 8.0 SHH Np/Cholesterol/Hhip -0.013 0.105 -9999.0 0.0 -0.364 6.0 6.0 LRP2 -0.062 0.229 -9999.0 0.0 -0.649 10.0 10.0 receptor-mediated endocytosis -0.082 0.205 -9999.0 0.0 -0.648 6.0 6.0 SHH Np/Cholesterol/BOC 0.014 0.048 -9999.0 0.0 -0.394 1.0 1.0 SHH Np/Cholesterol/CDO 0.015 0.05 -9999.0 0.0 -0.394 1.0 1.0 mesenchymal cell differentiation 0.013 0.105 0.361 6.0 -9999.0 0.0 6.0 mol:Vitamin D3 -0.007 0.153 0.359 1.0 -0.319 10.0 11.0 IHH N/PTCH2 -0.039 0.18 -9999.0 0.0 -0.434 13.0 13.0 CDON 0.03 0.017 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.037 0.161 -9999.0 0.0 -0.389 13.0 13.0 Megalin/LRPAP1 -0.031 0.179 -9999.0 0.0 -0.491 10.0 10.0 PTCH2 0.026 0.013 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.006 0.046 -9999.0 0.0 -0.389 1.0 1.0 PTCH1 -0.044 0.156 -9999.0 0.0 -0.386 13.0 13.0 HHIP -0.02 0.167 -9999.0 0.0 -0.649 5.0 5.0