E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.08 0.188 -9999.0 0.0 -0.488 27.0 27.0 KLHL20 -0.027 0.086 -9999.0 0.0 -0.193 23.0 23.0 CYFIP2 0.01 0.044 -9999.0 0.0 -0.403 2.0 2.0 Rac1/GDP -0.027 0.107 -9999.0 0.0 -0.232 25.0 25.0 ENAH -0.081 0.17 -9999.0 0.0 -0.429 28.0 28.0 AP1M1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.045 0.068 -9999.0 0.0 -0.24 9.0 9.0 ABI1/Sra1/Nap1 -0.041 0.054 -9999.0 0.0 -0.141 31.0 31.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.027 0.097 -9999.0 0.0 -0.204 27.0 27.0 RAPGEF1 -0.048 0.139 -9999.0 0.0 -0.342 27.0 27.0 CTNND1 0.013 0.031 -9999.0 0.0 -0.403 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.059 0.159 -9999.0 0.0 -0.419 26.0 26.0 CRK -0.058 0.15 -9999.0 0.0 -0.367 28.0 28.0 E-cadherin/gamma catenin/alpha catenin -0.069 0.131 -9999.0 0.0 -0.21 74.0 74.0 alphaE/beta7 Integrin 0.015 0.043 -9999.0 0.0 -0.21 6.0 6.0 IQGAP1 0.013 0.031 -9999.0 0.0 -0.403 1.0 1.0 NCKAP1 -0.036 0.126 -9999.0 0.0 -0.335 26.0 26.0 Rap1/GTP/I-afadin 0.004 0.061 -9999.0 0.0 -0.2 6.0 6.0 DLG1 -0.052 0.155 -9999.0 0.0 -0.402 26.0 26.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.032 0.049 -9999.0 0.0 -0.178 8.0 8.0 MLLT4 -0.032 0.115 -9999.0 0.0 -0.306 26.0 26.0 ARF6/GTP/NME1/Tiam1 0.002 0.067 -9999.0 0.0 -0.201 10.0 10.0 PI3K -0.04 0.063 -9999.0 0.0 -0.229 8.0 8.0 ARF6 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.086 0.146 -9999.0 0.0 -0.252 71.0 71.0 TIAM1 -0.036 0.124 -9999.0 0.0 -0.324 27.0 27.0 E-cadherin(dimer)/Ca2+ -0.027 0.094 -9999.0 0.0 -0.195 29.0 29.0 AKT1 -0.022 0.037 -9999.0 0.0 -0.145 5.0 5.0 PIK3R1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.094 0.165 -9999.0 0.0 -0.333 56.0 56.0 RhoA/GDP -0.027 0.107 -9999.0 0.0 -0.232 25.0 25.0 actin cytoskeleton organization -0.019 0.065 -9999.0 0.0 -0.142 23.0 23.0 CDC42/GDP -0.027 0.107 -9999.0 0.0 -0.225 29.0 29.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.055 0.113 -9999.0 0.0 -0.232 44.0 44.0 ITGB7 0.01 0.044 -9999.0 0.0 -0.403 2.0 2.0 RAC1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.028 0.1 -9999.0 0.0 -0.208 29.0 29.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.034 0.092 -9999.0 0.0 -0.201 28.0 28.0 mol:GDP -0.039 0.12 -9999.0 0.0 -0.262 30.0 30.0 CDC42/GTP/IQGAP1 0.019 0.019 -9999.0 0.0 -0.229 1.0 1.0 JUP -0.033 0.133 -9999.0 0.0 -0.397 21.0 21.0 p120 catenin/RhoA/GDP -0.027 0.108 -9999.0 0.0 -0.239 21.0 21.0 RAC1/GTP/IQGAP1 0.019 0.019 -9999.0 0.0 -0.229 1.0 1.0 PIP5K1C/AP1M1 0.023 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.003 0.069 -9999.0 0.0 -0.403 5.0 5.0 positive regulation of S phase of mitotic cell cycle -0.018 0.06 -9999.0 0.0 -0.128 29.0 29.0 NME1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.085 0.168 -9999.0 0.0 -0.436 27.0 27.0 regulation of cell-cell adhesion -0.04 0.06 -9999.0 0.0 -0.211 9.0 9.0 WASF2 -0.02 0.029 -9999.0 0.0 -0.107 2.0 2.0 Rap1/GTP -0.027 0.096 -9999.0 0.0 -0.252 12.0 12.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.048 0.119 -9999.0 0.0 -0.215 45.0 45.0 CCND1 -0.022 0.072 -9999.0 0.0 -0.157 29.0 29.0 VAV2 -0.078 0.191 -9999.0 0.0 -0.437 32.0 32.0 RAP1/GDP -0.029 0.098 -9999.0 0.0 -0.257 12.0 12.0 adherens junction assembly -0.083 0.163 -9999.0 0.0 -0.422 27.0 27.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.041 0.113 -9999.0 0.0 -0.351 9.0 9.0 E-cadherin/beta catenin -0.048 0.109 -9999.0 0.0 -0.296 25.0 25.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.067 0.158 -9999.0 0.0 -0.371 32.0 32.0 PIK3CA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.076 0.112 -9999.0 0.0 -0.307 24.0 24.0 E-cadherin/beta catenin/alpha catenin -0.041 0.108 -9999.0 0.0 -0.224 33.0 33.0 ITGAE 0.009 0.043 -9999.0 0.0 -0.277 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.061 0.162 -9999.0 0.0 -0.428 26.0 26.0