Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.091 0.136 0.244 72.0 -9999.0 0.0 72.0 KIRREL -0.12 0.173 -9999.0 0.0 -0.34 66.0 66.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.091 0.136 -9999.0 0.0 -0.245 72.0 72.0 PLCG1 0.005 0.057 -9999.0 0.0 -0.298 6.0 6.0 ARRB2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.063 0.109 -9999.0 0.0 -0.227 41.0 41.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.049 0.103 -9999.0 0.0 -0.221 40.0 40.0 FYN -0.063 0.1 -9999.0 0.0 -0.218 41.0 41.0 mol:Ca2+ -0.068 0.108 -9999.0 0.0 -0.223 45.0 45.0 mol:DAG -0.068 0.109 -9999.0 0.0 -0.224 45.0 45.0 NPHS2 -0.032 0.086 -9999.0 0.0 -0.326 13.0 13.0 mol:IP3 -0.068 0.109 -9999.0 0.0 -0.224 45.0 45.0 regulation of endocytosis -0.05 0.097 -9999.0 0.0 -0.199 41.0 41.0 Nephrin/NEPH1/podocin/Cholesterol -0.07 0.105 -9999.0 0.0 -0.206 52.0 52.0 establishment of cell polarity -0.091 0.136 -9999.0 0.0 -0.244 72.0 72.0 Nephrin/NEPH1/podocin/NCK1-2 -0.048 0.099 -9999.0 0.0 -0.195 41.0 41.0 Nephrin/NEPH1/beta Arrestin2 -0.05 0.098 -9999.0 0.0 -0.201 41.0 41.0 NPHS1 -0.025 0.09 -9999.0 0.0 -0.381 10.0 10.0 Nephrin/NEPH1/podocin -0.062 0.102 -9999.0 0.0 -0.219 41.0 41.0 TJP1 -0.061 0.148 -9999.0 0.0 -0.345 37.0 37.0 NCK1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.068 0.11 -9999.0 0.0 -0.224 45.0 45.0 CD2AP 0.013 0.031 -9999.0 0.0 -0.403 1.0 1.0 Nephrin/NEPH1/podocin/GRB2 -0.062 0.107 -9999.0 0.0 -0.222 41.0 41.0 GRB2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.079 0.101 -9999.0 0.0 -0.211 49.0 49.0 cytoskeleton organization -0.053 0.112 -9999.0 0.0 -0.235 40.0 40.0 Nephrin/NEPH1 -0.06 0.094 -9999.0 0.0 -0.21 37.0 37.0 Nephrin/NEPH1/ZO-1 -0.107 0.136 -9999.0 0.0 -0.252 67.0 67.0