Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.034 0.151 -9999.0 0.0 -0.465 12.0 12.0 IHH -0.014 0.082 -9999.0 0.0 -0.359 6.0 6.0 SHH Np/Cholesterol/GAS1 -0.032 0.095 -9999.0 0.0 -0.223 25.0 25.0 LRPAP1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.032 0.094 0.222 25.0 -9999.0 0.0 25.0 SMO/beta Arrestin2 -0.046 0.137 -9999.0 0.0 -0.366 11.0 11.0 SMO -0.056 0.142 -9999.0 0.0 -0.349 16.0 16.0 AKT1 -0.007 0.07 -9999.0 0.0 -0.253 2.0 2.0 ARRB2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.012 0.031 -9999.0 0.0 -0.277 2.0 2.0 ADRBK1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.055 0.14 -9999.0 0.0 -0.345 16.0 16.0 STIL -0.032 0.118 -9999.0 0.0 -0.32 12.0 12.0 DHH N/PTCH2 0.011 0.052 -9999.0 0.0 -0.226 8.0 8.0 DHH N/PTCH1 -0.034 0.135 -9999.0 0.0 -0.261 39.0 39.0 PIK3CA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.002 0.074 -9999.0 0.0 -0.34 8.0 8.0 PTHLH -0.039 0.174 -9999.0 0.0 -0.584 11.0 11.0 determination of left/right symmetry -0.055 0.14 -9999.0 0.0 -0.345 16.0 16.0 PIK3R1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.039 0.172 -9999.0 0.0 -0.579 11.0 11.0 IHH N/Hhip -0.054 0.119 -9999.0 0.0 -0.25 45.0 45.0 DHH N/Hhip -0.044 0.111 -9999.0 0.0 -0.225 47.0 47.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.055 0.14 -9999.0 0.0 -0.345 16.0 16.0 pancreas development -0.063 0.144 -9999.0 0.0 -0.323 41.0 41.0 HHAT 0.01 0.044 -9999.0 0.0 -0.403 2.0 2.0 PI3K 0.023 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.051 0.138 -9999.0 0.0 -0.334 33.0 33.0 somite specification -0.055 0.14 -9999.0 0.0 -0.345 16.0 16.0 SHH Np/Cholesterol/PTCH1 -0.036 0.124 -9999.0 0.0 -0.294 18.0 18.0 SHH Np/Cholesterol/PTCH2 0.002 0.061 -9999.0 0.0 -0.16 21.0 21.0 SHH Np/Cholesterol/Megalin -0.024 0.09 -9999.0 0.0 -0.182 40.0 40.0 SHH -0.009 0.08 -9999.0 0.0 -0.225 21.0 21.0 catabolic process -0.038 0.141 -9999.0 0.0 -0.279 42.0 42.0 SMO/Vitamin D3 -0.048 0.132 -9999.0 0.0 -0.309 20.0 20.0 SHH Np/Cholesterol/Hhip -0.038 0.099 -9999.0 0.0 -0.223 29.0 29.0 LRP2 -0.034 0.123 -9999.0 0.0 -0.348 23.0 23.0 receptor-mediated endocytosis -0.054 0.136 -9999.0 0.0 -0.341 18.0 18.0 SHH Np/Cholesterol/BOC 0.0 0.064 -9999.0 0.0 -0.206 11.0 11.0 SHH Np/Cholesterol/CDO -0.013 0.082 -9999.0 0.0 -0.221 18.0 18.0 mesenchymal cell differentiation 0.038 0.099 0.222 29.0 -9999.0 0.0 29.0 mol:Vitamin D3 -0.035 0.126 -9999.0 0.0 -0.295 18.0 18.0 IHH N/PTCH2 0.007 0.046 -9999.0 0.0 -0.225 4.0 4.0 CDON -0.015 0.096 -9999.0 0.0 -0.307 17.0 17.0 IHH N/PTCH1 -0.036 0.143 -9999.0 0.0 -0.28 42.0 42.0 Megalin/LRPAP1 -0.012 0.087 -9999.0 0.0 -0.233 23.0 23.0 PTCH2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.006 0.06 -9999.0 0.0 -0.167 21.0 21.0 PTCH1 -0.038 0.141 -9999.0 0.0 -0.28 42.0 42.0 HHIP -0.063 0.145 -9999.0 0.0 -0.323 41.0 41.0