Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.027 0.095 -9999.0 0.0 -0.213 30.0 30.0 epithelial cell differentiation -0.029 0.092 -9999.0 0.0 -0.194 29.0 29.0 CYFIP2 0.01 0.044 -9999.0 0.0 -0.403 2.0 2.0 ENAH -0.049 0.098 -9999.0 0.0 -0.242 21.0 21.0 EGFR -0.032 0.115 -9999.0 0.0 -0.343 21.0 21.0 EPHA2 -0.062 0.145 -9999.0 0.0 -0.332 39.0 39.0 MYO6 -0.037 0.1 -9999.0 0.0 -0.197 35.0 35.0 CTNNB1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.002 0.079 -9999.0 0.0 -0.181 28.0 28.0 AQP5 -0.05 0.092 -9999.0 0.0 -0.371 7.0 7.0 CTNND1 0.013 0.031 -9999.0 0.0 -0.403 1.0 1.0 mol:PI-4-5-P2 -0.024 0.085 -9999.0 0.0 -0.177 29.0 29.0 regulation of calcium-dependent cell-cell adhesion -0.046 0.112 -9999.0 0.0 -0.226 37.0 37.0 EGF -0.092 0.163 -9999.0 0.0 -0.332 55.0 55.0 NCKAP1 -0.036 0.126 -9999.0 0.0 -0.335 26.0 26.0 AQP3 -0.026 0.104 -9999.0 0.0 -0.383 6.0 6.0 cortical microtubule organization -0.029 0.092 -9999.0 0.0 -0.194 29.0 29.0 GO:0000145 -0.025 0.08 -9999.0 0.0 -0.169 29.0 29.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.027 0.094 -9999.0 0.0 -0.195 29.0 29.0 MLLT4 -0.032 0.115 -9999.0 0.0 -0.306 26.0 26.0 ARF6/GDP -0.066 0.081 -9999.0 0.0 -0.228 22.0 22.0 ARF6 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.016 0.09 -9999.0 0.0 -0.206 21.0 21.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.013 0.08 -9999.0 0.0 -0.325 2.0 2.0 PVRL2 -0.004 0.086 -9999.0 0.0 -0.403 8.0 8.0 ZYX -0.025 0.086 -9999.0 0.0 -0.18 29.0 29.0 ARF6/GTP -0.008 0.083 -9999.0 0.0 -0.185 21.0 21.0 CDH1 -0.094 0.165 -9999.0 0.0 -0.333 56.0 56.0 EGFR/EGFR/EGF/EGF -0.101 0.112 -9999.0 0.0 -0.287 32.0 32.0 RhoA/GDP -0.024 0.085 -9999.0 0.0 -0.178 29.0 29.0 actin cytoskeleton organization -0.033 0.098 -9999.0 0.0 -0.196 32.0 32.0 IGF-1R heterotetramer -0.022 0.115 -9999.0 0.0 -0.373 17.0 17.0 GIT1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.022 0.115 -9999.0 0.0 -0.373 17.0 17.0 IGF1 -0.036 0.126 -9999.0 0.0 -0.343 25.0 25.0 DIAPH1 -0.041 0.159 -9999.0 0.0 -0.58 14.0 14.0 Wnt receptor signaling pathway 0.029 0.092 0.194 29.0 -9999.0 0.0 29.0 RHOA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.066 0.081 -9999.0 0.0 -0.228 22.0 22.0 CTNNA1 0.003 0.069 -9999.0 0.0 -0.403 5.0 5.0 VCL -0.033 0.1 -9999.0 0.0 -0.2 32.0 32.0 EFNA1 -0.009 0.081 -9999.0 0.0 -0.277 15.0 15.0 LPP -0.019 0.082 -9999.0 0.0 -0.333 2.0 2.0 Ephrin A1/EPHA2 -0.08 0.095 -9999.0 0.0 -0.201 55.0 55.0 SEC6/SEC8 -0.059 0.085 -9999.0 0.0 -0.27 15.0 15.0 MGAT3 -0.047 0.114 -9999.0 0.0 -0.229 37.0 37.0 HGF/MET -0.084 0.097 -9999.0 0.0 -0.198 59.0 59.0 HGF -0.07 0.157 -9999.0 0.0 -0.349 42.0 42.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.027 0.095 -9999.0 0.0 -0.214 30.0 30.0 actin cable formation -0.025 0.089 -9999.0 0.0 -0.235 12.0 12.0 KIAA1543 -0.038 0.102 -9999.0 0.0 -0.272 15.0 15.0 KIFC3 -0.033 0.095 -9999.0 0.0 -0.192 32.0 32.0 NCK1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.025 0.086 -9999.0 0.0 -0.18 29.0 29.0 NCK1/GIT1 0.023 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.029 0.092 -9999.0 0.0 -0.194 29.0 29.0 EXOC4 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.025 0.086 -9999.0 0.0 -0.18 29.0 29.0 PIP5K1C -0.025 0.086 -9999.0 0.0 -0.18 29.0 29.0 LIMA1 0.01 0.044 -9999.0 0.0 -0.403 2.0 2.0 ABI1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.033 0.092 -9999.0 0.0 -0.264 9.0 9.0 adherens junction assembly -0.034 0.114 -9999.0 0.0 -0.317 13.0 13.0 IGF-1R heterotetramer/IGF1 -0.077 0.099 -9999.0 0.0 -0.246 29.0 29.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.023 0.099 -9999.0 0.0 -0.224 33.0 33.0 MET -0.009 0.085 -9999.0 0.0 -0.319 12.0 12.0 PLEKHA7 -0.035 0.097 -9999.0 0.0 -0.201 34.0 34.0 mol:GTP -0.017 0.089 -9999.0 0.0 -0.205 21.0 21.0 establishment of epithelial cell apical/basal polarity -0.028 0.1 -9999.0 0.0 -0.256 15.0 15.0 cortical actin cytoskeleton stabilization -0.027 0.095 -9999.0 0.0 -0.213 30.0 30.0 regulation of cell-cell adhesion -0.033 0.098 -9999.0 0.0 -0.196 32.0 32.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.027 0.095 -9999.0 0.0 -0.214 30.0 30.0