Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
TCGA08_retinoblastoma	35.0	280.0	8.0	-0.069	0.046	1000.0	-1000.0	-0.004	-1000.0
E-cadherin signaling events	34.0	173.0	5.0	-0.094	0.015	1000.0	-1000.0	-0.003	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	32.0	1101.0	34.0	-0.12	0.015	1000.0	-1000.0	-0.009	-1000.0
LPA receptor mediated events	32.0	3341.0	102.0	-0.17	0.015	1000.0	-1000.0	-0.047	-1000.0
IL4-mediated signaling events	30.0	2763.0	91.0	-0.636	0.575	1000.0	-1000.0	-0.115	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	30.0	3851.0	125.0	-0.215	0.023	1000.0	-1000.0	-0.045	-1000.0
Thromboxane A2 receptor signaling	28.0	3001.0	105.0	-0.205	0.089	1000.0	-1000.0	-0.034	-1000.0
Endothelins	28.0	2738.0	96.0	-0.26	0.072	1000.0	-1000.0	-0.04	-1000.0
Angiopoietin receptor Tie2-mediated signaling	28.0	2529.0	88.0	-0.285	0.044	1000.0	-1000.0	-0.051	-1000.0
Osteopontin-mediated events	27.0	1058.0	38.0	-0.176	0.019	1000.0	-1000.0	-0.03	-1000.0
Syndecan-2-mediated signaling events	27.0	1927.0	69.0	-0.111	0.021	1000.0	-1000.0	-0.018	-1000.0
Nectin adhesion pathway	26.0	1646.0	63.0	-0.156	0.019	1000.0	-1000.0	-0.038	-1000.0
Wnt signaling	26.0	185.0	7.0	-0.072	0.015	1000.0	-1000.0	-0.01	-1000.0
Integrins in angiogenesis	25.0	2183.0	84.0	-0.165	0.023	1000.0	-1000.0	-0.044	-1000.0
Ephrin B reverse signaling	24.0	1197.0	48.0	-0.113	0.078	1000.0	-1000.0	-0.027	-1000.0
Syndecan-4-mediated signaling events	23.0	1595.0	67.0	-0.181	0.021	1000.0	-1000.0	-0.022	-1000.0
amb2 Integrin signaling	22.0	1815.0	82.0	-0.137	0.021	1000.0	-1000.0	-0.027	-1000.0
EPHB forward signaling	22.0	1873.0	85.0	-0.116	0.087	1000.0	-1000.0	-0.044	-1000.0
Syndecan-1-mediated signaling events	21.0	732.0	34.0	-0.124	0.015	1000.0	-1000.0	-0.022	-1000.0
Fc-epsilon receptor I signaling in mast cells	21.0	2132.0	97.0	-0.18	0.034	1000.0	-1000.0	-0.041	-1000.0
Nongenotropic Androgen signaling	21.0	1128.0	52.0	-0.17	0.031	1000.0	-1000.0	-0.023	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	21.0	1582.0	74.0	-0.101	0.029	1000.0	-1000.0	-0.038	-1000.0
p75(NTR)-mediated signaling	20.0	2621.0	125.0	-0.145	0.045	1000.0	-1000.0	-0.046	-1000.0
EGFR-dependent Endothelin signaling events	20.0	433.0	21.0	-0.092	0.023	1000.0	-1000.0	-0.034	-1000.0
IL23-mediated signaling events	20.0	1226.0	60.0	-0.449	0.015	1000.0	-1000.0	-0.071	-1000.0
BMP receptor signaling	19.0	1590.0	81.0	-0.121	0.031	1000.0	-1000.0	-0.05	-1000.0
Syndecan-3-mediated signaling events	19.0	676.0	35.0	-0.113	0.045	1000.0	-1000.0	-0.021	-1000.0
E-cadherin signaling in keratinocytes	19.0	834.0	43.0	-0.093	0.018	1000.0	-1000.0	-0.017	-1000.0
S1P1 pathway	18.0	650.0	36.0	-0.099	0.015	1000.0	-1000.0	-0.036	-1000.0
Coregulation of Androgen receptor activity	17.0	1347.0	76.0	-0.181	0.031	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by the Hedgehog family	17.0	918.0	52.0	-0.063	0.038	1000.0	-1000.0	-0.013	-1000.0
Noncanonical Wnt signaling pathway	17.0	467.0	26.0	-0.078	0.015	1000.0	-1000.0	-0.022	-1000.0
LPA4-mediated signaling events	16.0	200.0	12.0	-0.06	0.01	1000.0	-1000.0	-0.009	-1000.0
Cellular roles of Anthrax toxin	16.0	656.0	39.0	-0.117	0.015	1000.0	-1000.0	-0.01	-1000.0
Glypican 1 network	16.0	790.0	48.0	-0.128	0.027	1000.0	-1000.0	-0.009	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	16.0	1118.0	68.0	-0.266	0.132	1000.0	-1000.0	-0.046	-1000.0
E-cadherin signaling in the nascent adherens junction	16.0	1269.0	76.0	-0.094	0.023	1000.0	-1000.0	-0.041	-1000.0
HIF-1-alpha transcription factor network	15.0	1161.0	76.0	-0.177	0.022	1000.0	-1000.0	-0.047	-1000.0
Arf6 signaling events	15.0	954.0	62.0	-0.113	0.019	1000.0	-1000.0	-0.014	-1000.0
Signaling events mediated by PTP1B	15.0	1156.0	76.0	-0.133	0.032	1000.0	-1000.0	-0.032	-1000.0
Glucocorticoid receptor regulatory network	15.0	1800.0	114.0	-0.328	0.217	1000.0	-1000.0	-0.033	-1000.0
Effects of Botulinum toxin	15.0	401.0	26.0	-0.093	0.015	1000.0	-1000.0	-0.012	-1000.0
Plasma membrane estrogen receptor signaling	15.0	1350.0	86.0	-0.128	0.056	1000.0	-1000.0	-0.046	-1000.0
S1P3 pathway	15.0	634.0	42.0	-0.093	0.021	1000.0	-1000.0	-0.031	-1000.0
Signaling events regulated by Ret tyrosine kinase	14.0	1177.0	82.0	-0.082	0.015	1000.0	-1000.0	-0.043	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	14.0	1689.0	120.0	-0.168	0.075	1000.0	-1000.0	-0.038	-1000.0
IL12-mediated signaling events	13.0	1185.0	87.0	-0.175	0.032	1000.0	-1000.0	-0.08	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	13.0	1135.0	85.0	-0.117	0.015	1000.0	-1000.0	-0.035	-1000.0
IGF1 pathway	13.0	780.0	57.0	-0.086	0.031	1000.0	-1000.0	-0.045	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	13.0	1086.0	78.0	-0.106	0.038	1000.0	-1000.0	-0.049	-1000.0
IL1-mediated signaling events	12.0	749.0	62.0	-0.121	0.059	1000.0	-1000.0	-0.046	-1000.0
Signaling mediated by p38-alpha and p38-beta	12.0	529.0	44.0	-0.091	0.015	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by PRL	12.0	426.0	34.0	-0.047	0.023	1000.0	-1000.0	-0.014	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	11.0	440.0	37.0	-0.168	0.035	1000.0	-1000.0	-0.016	-1000.0
Reelin signaling pathway	11.0	624.0	56.0	-0.079	0.045	1000.0	-1000.0	-0.039	-1000.0
TCGA08_p53	11.0	83.0	7.0	-0.052	0.044	1000.0	-1000.0	-0.003	-1000.0
Caspase cascade in apoptosis	10.0	765.0	74.0	-0.198	0.036	1000.0	-1000.0	-0.023	-1000.0
HIF-2-alpha transcription factor network	10.0	462.0	43.0	-0.182	0.083	1000.0	-1000.0	-0.047	-1000.0
Retinoic acid receptors-mediated signaling	10.0	630.0	58.0	-0.131	0.031	1000.0	-1000.0	-0.042	-1000.0
Canonical Wnt signaling pathway	10.0	560.0	51.0	-0.12	0.027	1000.0	-1000.0	-0.026	-1000.0
Visual signal transduction: Rods	10.0	536.0	52.0	-0.085	0.015	1000.0	-1000.0	-0.036	-1000.0
FOXM1 transcription factor network	10.0	512.0	51.0	-0.216	0.028	1000.0	-1000.0	-0.116	-1000.0
Regulation of nuclear SMAD2/3 signaling	9.0	1305.0	136.0	-0.199	0.088	1000.0	-1000.0	-0.025	-1000.0
Visual signal transduction: Cones	9.0	356.0	38.0	-0.044	0.015	1000.0	-1000.0	-0.005	-1000.0
S1P5 pathway	9.0	153.0	17.0	-0.071	0.027	1000.0	-1000.0	-0.014	-1000.0
Paxillin-dependent events mediated by a4b1	9.0	341.0	36.0	-0.168	0.039	1000.0	-1000.0	-0.028	-1000.0
TCR signaling in naïve CD8+ T cells	9.0	896.0	93.0	-0.066	0.025	1000.0	-1000.0	-0.042	-1000.0
Glypican 2 network	9.0	39.0	4.0	-0.001	0.002	1000.0	-1000.0	-0.002	-1000.0
Calcium signaling in the CD4+ TCR pathway	9.0	303.0	31.0	-0.091	0.015	1000.0	-1000.0	-0.038	-1000.0
VEGFR1 specific signals	9.0	540.0	56.0	-0.071	0.015	1000.0	-1000.0	-0.026	-1000.0
PDGFR-beta signaling pathway	9.0	931.0	97.0	-0.107	0.035	1000.0	-1000.0	-0.038	-1000.0
Sphingosine 1-phosphate (S1P) pathway	8.0	234.0	28.0	-0.094	0.037	1000.0	-1000.0	-0.015	-1000.0
Presenilin action in Notch and Wnt signaling	8.0	547.0	61.0	-0.12	0.045	1000.0	-1000.0	-0.018	-1000.0
Ceramide signaling pathway	8.0	638.0	76.0	-0.103	0.045	1000.0	-1000.0	-0.019	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	8.0	445.0	52.0	-0.122	0.026	1000.0	-1000.0	-0.03	-1000.0
PLK2 and PLK4 events	7.0	22.0	3.0	-0.006	0.015	1000.0	-1000.0	-0.009	-1000.0
Ephrin A  reverse signaling	7.0	51.0	7.0	-0.008	0.002	1000.0	-1000.0	-0.003	-1000.0
Hedgehog signaling events mediated by Gli proteins	7.0	469.0	65.0	-0.072	0.038	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by HDAC Class III	7.0	294.0	40.0	-0.146	0.033	1000.0	-1000.0	-0.007	-1000.0
Signaling events mediated by HDAC Class II	6.0	478.0	75.0	-0.072	0.034	1000.0	-1000.0	-0.02	-1000.0
ErbB4 signaling events	6.0	417.0	69.0	-0.159	0.029	1000.0	-1000.0	-0.043	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	6.0	368.0	54.0	-0.079	0.027	1000.0	-1000.0	-0.045	-1000.0
FOXA2 and FOXA3 transcription factor networks	6.0	313.0	46.0	-0.096	0.022	1000.0	-1000.0	-0.027	-1000.0
FAS signaling pathway (CD95)	6.0	287.0	47.0	-0.07	0.034	1000.0	-1000.0	-0.022	-1000.0
Signaling mediated by p38-gamma and p38-delta	6.0	102.0	15.0	-0.013	0.021	1000.0	-1000.0	-0.007	-1000.0
Class I PI3K signaling events	6.0	499.0	73.0	-0.072	0.023	1000.0	-1000.0	-0.017	-1000.0
Regulation of Telomerase	6.0	613.0	102.0	-0.104	0.044	1000.0	-1000.0	-0.057	-1000.0
Ras signaling in the CD4+ TCR pathway	6.0	112.0	17.0	-0.031	0.03	1000.0	-1000.0	-0.015	-1000.0
Regulation of p38-alpha and p38-beta	5.0	298.0	54.0	-0.072	0.039	1000.0	-1000.0	-0.033	-1000.0
IL27-mediated signaling events	5.0	275.0	51.0	-0.052	0.021	1000.0	-1000.0	-0.034	-1000.0
IL6-mediated signaling events	5.0	375.0	75.0	-0.064	0.055	1000.0	-1000.0	-0.035	-1000.0
IL2 signaling events mediated by STAT5	5.0	122.0	22.0	-0.057	0.042	1000.0	-1000.0	-0.021	-1000.0
Class IB PI3K non-lipid kinase events	5.0	15.0	3.0	-0.003	0.003	1000.0	-1000.0	-0.003	-1000.0
S1P4 pathway	5.0	149.0	25.0	-0.071	0.027	1000.0	-1000.0	-0.018	-1000.0
Arf6 downstream pathway	4.0	190.0	43.0	-0.035	0.026	1000.0	-1000.0	-0.018	-1000.0
PDGFR-alpha signaling pathway	4.0	202.0	44.0	-0.059	0.039	1000.0	-1000.0	-0.01	-1000.0
TRAIL signaling pathway	4.0	216.0	48.0	-0.025	0.039	1000.0	-1000.0	-0.019	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	4.0	153.0	33.0	-0.074	0.045	1000.0	-1000.0	-0.026	-1000.0
ErbB2/ErbB3 signaling events	3.0	246.0	65.0	-0.044	0.039	1000.0	-1000.0	-0.033	-1000.0
Canonical NF-kappaB pathway	3.0	144.0	39.0	-0.05	0.043	1000.0	-1000.0	-0.04	-1000.0
IFN-gamma pathway	3.0	255.0	68.0	-0.032	0.045	1000.0	-1000.0	-0.052	-1000.0
TCGA08_rtk_signaling	3.0	84.0	26.0	-0.032	0.034	1000.0	-1000.0	-0.006	-1000.0
BCR signaling pathway	3.0	386.0	99.0	-0.051	0.045	1000.0	-1000.0	-0.044	-1000.0
Insulin Pathway	3.0	271.0	74.0	-0.053	0.036	1000.0	-1000.0	-0.041	-1000.0
Regulation of Androgen receptor activity	3.0	264.0	70.0	-0.095	0.027	1000.0	-1000.0	-0.026	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	2.0	67.0	23.0	-0.036	0.036	1000.0	-1000.0	-0.013	-1000.0
Circadian rhythm pathway	2.0	50.0	22.0	-0.012	0.038	1000.0	-1000.0	-0.026	-1000.0
JNK signaling in the CD4+ TCR pathway	2.0	45.0	17.0	-0.016	0.033	1000.0	-1000.0	-0.017	-1000.0
EPO signaling pathway	2.0	116.0	55.0	-0.006	0.064	1000.0	-1000.0	-0.043	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	207.0	83.0	-0.032	0.06	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by HDAC Class I	2.0	309.0	104.0	-0.072	0.051	1000.0	-1000.0	-0.02	-1000.0
Atypical NF-kappaB pathway	2.0	89.0	31.0	-0.017	0.033	1000.0	-1000.0	-0.006	-1000.0
IL2 signaling events mediated by PI3K	2.0	146.0	58.0	-0.056	0.064	1000.0	-1000.0	-0.028	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	132.0	45.0	-0.034	0.057	1000.0	-1000.0	-0.047	-1000.0
Arf6 trafficking events	2.0	179.0	71.0	-0.062	0.04	1000.0	-1000.0	-0.028	-1000.0
Rapid glucocorticoid signaling	2.0	59.0	20.0	-0.008	0.015	1000.0	-1000.0	-0.006	-1000.0
p38 MAPK signaling pathway	2.0	99.0	44.0	-0.025	0.033	1000.0	-1000.0	-0.035	-1000.0
Aurora B signaling	2.0	173.0	67.0	-0.073	0.042	1000.0	-1000.0	-0.025	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	6.0	5.0	0.01	0.021	1000.0	-1000.0	-0.004	-1000.0
Aurora A signaling	1.0	87.0	60.0	-0.027	0.043	1000.0	-1000.0	-0.012	-1000.0
Aurora C signaling	1.0	9.0	7.0	-0.0	0.023	1000.0	-1000.0	-0.006	-1000.0
PLK1 signaling events	1.0	137.0	85.0	-0.019	0.036	1000.0	-1000.0	-0.02	-1000.0
Insulin-mediated glucose transport	1.0	53.0	32.0	-0.0	0.031	1000.0	-1000.0	-0.022	-1000.0
mTOR signaling pathway	1.0	94.0	53.0	-0.009	0.031	1000.0	-1000.0	-0.032	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	93.0	68.0	-0.033	0.043	1000.0	-1000.0	-0.018	-1000.0
ceramide signaling pathway	1.0	58.0	49.0	-0.034	0.038	1000.0	-1000.0	-0.022	-1000.0
FoxO family signaling	1.0	114.0	64.0	-0.044	0.105	1000.0	-1000.0	-0.029	-1000.0
Arf1 pathway	1.0	106.0	54.0	-0.018	0.027	1000.0	-1000.0	-0.01	-1000.0
BARD1 signaling events	0.0	53.0	57.0	-0.031	0.059	1000.0	-1000.0	-0.016	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.0	0.039	1000.0	-1000.0	-0.025	-1000.0
Alternative NF-kappaB pathway	0.0	10.0	13.0	-0.0	0.042	1000.0	-1000.0	-0.005	-1000.0
Total	1461	91338	7203	-12.9571304783	5.29327118154	131000	-131000	-3.72535639434	-131000