Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.071 0.149 -9999.0 0.0 -0.257 9.0 9.0 epithelial cell differentiation -0.037 0.149 -9999.0 0.0 -0.238 9.0 9.0 CYFIP2 0.03 0.03 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.062 0.088 -9999.0 0.0 -0.4 1.0 1.0 EGFR -0.007 0.122 -9999.0 0.0 -0.426 2.0 2.0 EPHA2 0.024 0.032 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.076 0.148 0.187 1.0 -0.25 9.0 10.0 CTNNB1 0.001 0.121 -9999.0 0.0 -0.426 2.0 2.0 ABI1/Sra1/Nap1 0.058 0.036 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.048 0.117 -9999.0 0.0 -0.389 1.0 1.0 CTNND1 0.034 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.064 0.126 0.185 1.0 -0.226 9.0 10.0 regulation of calcium-dependent cell-cell adhesion -0.067 0.122 0.185 1.0 -0.222 9.0 10.0 EGF 0.022 0.042 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.059 0.136 -9999.0 0.0 -0.417 2.0 2.0 cortical microtubule organization -0.037 0.149 -9999.0 0.0 -0.238 9.0 9.0 GO:0000145 -0.073 0.112 0.169 1.0 -0.216 9.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.034 0.153 -9999.0 0.0 -0.24 9.0 9.0 MLLT4 0.017 0.087 -9999.0 0.0 -0.426 1.0 1.0 ARF6/GDP -0.075 0.101 -9999.0 0.0 -0.393 1.0 1.0 ARF6 0.037 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.071 0.039 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.072 0.114 -9999.0 0.0 -0.308 3.0 3.0 PVRL2 0.011 0.087 -9999.0 0.0 -0.426 1.0 1.0 ZYX -0.064 0.128 0.187 1.0 -0.229 9.0 10.0 ARF6/GTP 0.079 0.043 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.135 0.198 -9999.0 0.0 -0.426 8.0 8.0 EGFR/EGFR/EGF/EGF -0.068 0.138 -9999.0 0.0 -0.226 11.0 11.0 RhoA/GDP -0.037 0.165 -9999.0 0.0 -0.246 9.0 9.0 actin cytoskeleton organization -0.077 0.141 0.174 1.0 -0.244 9.0 10.0 IGF-1R heterotetramer 0.037 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.037 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.037 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.02 0.087 -9999.0 0.0 -0.426 1.0 1.0 DIAPH1 0.027 0.153 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.037 0.149 0.238 9.0 -9999.0 0.0 9.0 RHOA 0.017 0.087 -9999.0 0.0 -0.426 1.0 1.0 RhoA/GTP -0.08 0.123 -9999.0 0.0 -0.557 1.0 1.0 CTNNA1 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.079 0.144 0.175 1.0 -0.249 9.0 10.0 EFNA1 0.031 0.03 -9999.0 0.0 -0.121 1.0 1.0 LPP -0.065 0.105 0.178 1.0 -0.202 9.0 10.0 Ephrin A1/EPHA2 -0.037 0.14 -9999.0 0.0 -0.222 9.0 9.0 SEC6/SEC8 -0.079 0.132 -9999.0 0.0 -0.388 2.0 2.0 MGAT3 -0.068 0.123 0.187 1.0 -0.225 9.0 10.0 HGF/MET -0.051 0.135 -9999.0 0.0 -0.228 9.0 9.0 HGF 0.02 0.042 -9999.0 0.0 -0.121 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.071 0.15 -9999.0 0.0 -0.259 9.0 9.0 actin cable formation -0.04 0.087 -9999.0 0.0 -0.267 1.0 1.0 KIAA1543 -0.083 0.101 -9999.0 0.0 -0.217 9.0 9.0 KIFC3 -0.069 0.126 0.187 1.0 -0.229 9.0 10.0 NCK1 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.071 0.125 -9999.0 0.0 -0.229 9.0 9.0 NCK1/GIT1 0.052 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.037 0.149 -9999.0 0.0 -0.238 9.0 9.0 EXOC4 0.031 0.013 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.069 0.126 0.187 1.0 -0.229 9.0 10.0 PIP5K1C -0.065 0.127 0.187 1.0 -0.229 9.0 10.0 LIMA1 0.037 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.033 0.012 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.07 0.11 -9999.0 0.0 -0.48 1.0 1.0 adherens junction assembly -0.043 0.126 0.297 1.0 -0.345 1.0 2.0 IGF-1R heterotetramer/IGF1 -0.041 0.16 -9999.0 0.0 -0.243 9.0 9.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.012 0.092 -9999.0 0.0 -0.302 2.0 2.0 MET 0.025 0.032 -9999.0 0.0 -0.121 1.0 1.0 PLEKHA7 -0.075 0.116 -9999.0 0.0 -0.227 9.0 9.0 mol:GTP 0.069 0.038 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.04 0.166 0.293 1.0 -0.521 1.0 2.0 cortical actin cytoskeleton stabilization -0.071 0.149 -9999.0 0.0 -0.257 9.0 9.0 regulation of cell-cell adhesion -0.077 0.141 0.174 1.0 -0.244 9.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.071 0.15 -9999.0 0.0 -0.259 9.0 9.0