Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	6.0	308.0	51.0	-0.765	0.037	1000.0	-1000.0	-0.059	-1000.0
E-cadherin signaling events	5.0	28.0	5.0	-0.135	0.037	1000.0	-1000.0	0.019	-1000.0
Ephrin A  reverse signaling	4.0	32.0	7.0	-0.105	0.002	1000.0	-1000.0	0.0	-1000.0
Thromboxane A2 receptor signaling	4.0	424.0	105.0	-0.234	0.054	1000.0	-1000.0	-0.037	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	4.0	282.0	68.0	-0.503	0.319	1000.0	-1000.0	-0.07	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	324.0	74.0	-0.135	0.079	1000.0	-1000.0	-0.061	-1000.0
IL23-mediated signaling events	4.0	290.0	60.0	-0.654	0.039	1000.0	-1000.0	-0.071	-1000.0
IL12-mediated signaling events	3.0	285.0	87.0	-0.404	0.073	1000.0	-1000.0	-0.047	-1000.0
PLK2 and PLK4 events	3.0	11.0	3.0	-0.038	-1000.0	1000.0	-1000.0	0.006	-1000.0
Signaling events mediated by the Hedgehog family	3.0	181.0	52.0	-0.135	0.065	1000.0	-1000.0	-0.023	-1000.0
Ephrin B reverse signaling	3.0	152.0	48.0	-0.109	0.043	1000.0	-1000.0	-0.026	-1000.0
Endothelins	3.0	344.0	96.0	-0.324	0.046	1000.0	-1000.0	-0.043	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	253.0	76.0	-0.152	0.057	1000.0	-1000.0	-0.054	-1000.0
TCGA08_retinoblastoma	3.0	28.0	8.0	-0.054	0.086	1000.0	-1000.0	-0.004	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	294.0	136.0	-0.423	0.095	1000.0	-1000.0	-0.034	-1000.0
Syndecan-1-mediated signaling events	2.0	81.0	34.0	-0.184	0.037	1000.0	-1000.0	-0.016	-1000.0
Visual signal transduction: Cones	2.0	84.0	38.0	-0.066	0.042	1000.0	-1000.0	-0.0	-1000.0
Osteopontin-mediated events	2.0	81.0	38.0	-0.106	0.037	1000.0	-1000.0	-0.022	-1000.0
HIF-1-alpha transcription factor network	2.0	191.0	76.0	-0.21	0.066	1000.0	-1000.0	-0.025	-1000.0
Arf6 signaling events	2.0	132.0	62.0	-0.056	0.078	1000.0	-1000.0	-0.008	-1000.0
PLK1 signaling events	2.0	212.0	85.0	-0.15	0.053	1000.0	-1000.0	-0.041	-1000.0
PDGFR-alpha signaling pathway	2.0	99.0	44.0	-0.242	0.046	1000.0	-1000.0	-0.023	-1000.0
Syndecan-3-mediated signaling events	2.0	93.0	35.0	-0.107	0.084	1000.0	-1000.0	-0.016	-1000.0
Calcium signaling in the CD4+ TCR pathway	2.0	62.0	31.0	-0.107	0.043	1000.0	-1000.0	-0.043	-1000.0
Nongenotropic Androgen signaling	2.0	140.0	52.0	-0.202	0.102	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	345.0	125.0	-0.09	0.091	1000.0	-1000.0	-0.033	-1000.0
BCR signaling pathway	2.0	200.0	99.0	-0.103	0.054	1000.0	-1000.0	-0.046	-1000.0
E-cadherin signaling in keratinocytes	2.0	102.0	43.0	-0.135	0.04	1000.0	-1000.0	-0.026	-1000.0
Aurora B signaling	2.0	134.0	67.0	-0.179	0.054	1000.0	-1000.0	-0.031	-1000.0
Caspase cascade in apoptosis	1.0	123.0	74.0	-0.071	0.044	1000.0	-1000.0	-0.038	-1000.0
Coregulation of Androgen receptor activity	1.0	84.0	76.0	-0.084	0.064	1000.0	-1000.0	-0.023	-1000.0
ErbB4 signaling events	1.0	77.0	69.0	-0.117	0.054	1000.0	-1000.0	-0.024	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	28.0	28.0	-0.04	0.048	1000.0	-1000.0	-0.011	-1000.0
Syndecan-2-mediated signaling events	1.0	82.0	69.0	-0.065	0.052	1000.0	-1000.0	-0.02	-1000.0
Cellular roles of Anthrax toxin	1.0	58.0	39.0	-0.175	0.037	1000.0	-1000.0	-0.028	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	77.0	61.0	-0.176	0.084	1000.0	-1000.0	-0.043	-1000.0
Aurora A signaling	1.0	63.0	60.0	-0.089	0.091	1000.0	-1000.0	-0.01	-1000.0
p75(NTR)-mediated signaling	1.0	142.0	125.0	-0.184	0.084	1000.0	-1000.0	-0.027	-1000.0
IL4-mediated signaling events	1.0	161.0	91.0	-0.515	0.262	1000.0	-1000.0	-0.083	-1000.0
BMP receptor signaling	1.0	121.0	81.0	-0.059	0.068	1000.0	-1000.0	-0.026	-1000.0
EPO signaling pathway	1.0	61.0	55.0	0.0	0.098	1000.0	-1000.0	-0.02	-1000.0
Fc-epsilon receptor I signaling in mast cells	1.0	140.0	97.0	-0.107	0.057	1000.0	-1000.0	-0.068	-1000.0
amb2 Integrin signaling	1.0	101.0	82.0	-0.086	0.046	1000.0	-1000.0	-0.022	-1000.0
Glucocorticoid receptor regulatory network	1.0	130.0	114.0	-0.269	0.081	1000.0	-1000.0	-0.041	-1000.0
Ceramide signaling pathway	1.0	119.0	76.0	-0.08	0.065	1000.0	-1000.0	-0.026	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	42.0	37.0	-0.092	0.067	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by HDAC Class III	1.0	56.0	40.0	-0.136	0.094	1000.0	-1000.0	-0.037	-1000.0
TRAIL signaling pathway	1.0	56.0	48.0	-0.003	0.061	1000.0	-1000.0	-0.022	-1000.0
IL1-mediated signaling events	1.0	118.0	62.0	-0.104	0.061	1000.0	-1000.0	-0.021	-1000.0
Signaling events regulated by Ret tyrosine kinase	1.0	149.0	82.0	-0.057	0.052	1000.0	-1000.0	-0.046	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	64.0	52.0	-0.252	0.106	1000.0	-1000.0	-0.017	-1000.0
S1P1 pathway	1.0	53.0	36.0	-0.096	0.036	1000.0	-1000.0	-0.028	-1000.0
TCGA08_p53	1.0	9.0	7.0	-0.042	0.035	1000.0	-1000.0	-0.004	-1000.0
Signaling mediated by p38-alpha and p38-beta	1.0	81.0	44.0	-0.063	0.035	1000.0	-1000.0	-0.008	-1000.0
Integrins in angiogenesis	1.0	112.0	84.0	-0.08	0.086	1000.0	-1000.0	-0.043	-1000.0
TCR signaling in naïve CD8+ T cells	1.0	95.0	93.0	-0.147	0.171	1000.0	-1000.0	-0.039	-1000.0
Canonical Wnt signaling pathway	1.0	63.0	51.0	-0.175	0.079	1000.0	-1000.0	-0.038	-1000.0
EPHB forward signaling	1.0	111.0	85.0	-0.056	0.08	1000.0	-1000.0	-0.045	-1000.0
Effects of Botulinum toxin	1.0	37.0	26.0	-0.153	0.05	1000.0	-1000.0	-0.0	-1000.0
Wnt signaling	1.0	9.0	7.0	-0.023	0.035	1000.0	-1000.0	-0.01	-1000.0
IL6-mediated signaling events	1.0	145.0	75.0	-0.146	0.059	1000.0	-1000.0	-0.047	-1000.0
Class I PI3K signaling events	1.0	82.0	73.0	-0.066	0.072	1000.0	-1000.0	-0.027	-1000.0
EGFR-dependent Endothelin signaling events	1.0	30.0	21.0	-0.028	0.061	1000.0	-1000.0	-0.03	-1000.0
Syndecan-4-mediated signaling events	1.0	82.0	67.0	-0.102	0.048	1000.0	-1000.0	-0.04	-1000.0
Angiopoietin receptor Tie2-mediated signaling	1.0	129.0	88.0	-0.139	0.048	1000.0	-1000.0	-0.053	-1000.0
Rapid glucocorticoid signaling	1.0	28.0	20.0	-0.09	0.029	1000.0	-1000.0	-0.0	-1000.0
Visual signal transduction: Rods	1.0	87.0	52.0	-0.066	0.048	1000.0	-1000.0	-0.01	-1000.0
Signaling events mediated by PRL	1.0	66.0	34.0	-0.162	0.048	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	1.0	132.0	78.0	-0.076	0.048	1000.0	-1000.0	-0.048	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	24.0	17.0	-0.044	0.039	1000.0	-1000.0	-0.018	-1000.0
LPA4-mediated signaling events	0.0	8.0	12.0	-0.05	0.011	1000.0	-1000.0	-0.008	-1000.0
ErbB2/ErbB3 signaling events	0.0	49.0	65.0	-0.065	0.052	1000.0	-1000.0	-0.073	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	4.0	23.0	-0.002	0.066	1000.0	-1000.0	-0.021	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	0.0	1.0	34.0	-0.045	0.084	1000.0	-1000.0	-0.024	-1000.0
Canonical NF-kappaB pathway	0.0	10.0	39.0	-0.027	0.075	1000.0	-1000.0	-0.015	-1000.0
Signaling events mediated by HDAC Class II	0.0	19.0	75.0	-0.05	0.092	1000.0	-1000.0	-0.016	-1000.0
BARD1 signaling events	0.0	51.0	57.0	-0.063	0.072	1000.0	-1000.0	-0.039	-1000.0
Circadian rhythm pathway	0.0	13.0	22.0	-0.074	0.062	1000.0	-1000.0	-0.03	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	0.0	35.0	54.0	-0.026	0.092	1000.0	-1000.0	-0.026	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	3.0	17.0	-0.0	0.063	1000.0	-1000.0	-0.02	-1000.0
Noncanonical Wnt signaling pathway	0.0	24.0	26.0	-0.031	0.035	1000.0	-1000.0	-0.042	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	3.0	5.0	0.012	0.035	1000.0	-1000.0	0.016	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	0.0	59.0	85.0	-0.268	0.108	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by PTP1B	0.0	73.0	76.0	-0.034	0.058	1000.0	-1000.0	-0.042	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	46.0	65.0	-0.038	0.077	1000.0	-1000.0	-0.036	-1000.0
Arf6 downstream pathway	0.0	8.0	43.0	-0.053	0.074	1000.0	-1000.0	-0.024	-1000.0
Aurora C signaling	0.0	2.0	7.0	-0.0	0.038	1000.0	-1000.0	-0.016	-1000.0
FOXA2 and FOXA3 transcription factor networks	0.0	16.0	46.0	-0.03	0.067	1000.0	-1000.0	-0.086	-1000.0
Glypican 1 network	0.0	31.0	48.0	-0.038	0.067	1000.0	-1000.0	-0.023	-1000.0
Insulin-mediated glucose transport	0.0	8.0	32.0	-0.0	0.075	1000.0	-1000.0	-0.013	-1000.0
mTOR signaling pathway	0.0	22.0	53.0	-0.028	0.07	1000.0	-1000.0	-0.031	-1000.0
IFN-gamma pathway	0.0	43.0	68.0	-0.067	0.062	1000.0	-1000.0	-0.035	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	16.0	68.0	-0.055	0.072	1000.0	-1000.0	-0.029	-1000.0
Nectin adhesion pathway	0.0	62.0	63.0	-0.135	0.072	1000.0	-1000.0	-0.06	-1000.0
Reelin signaling pathway	0.0	22.0	56.0	-0.048	0.081	1000.0	-1000.0	-0.021	-1000.0
S1P5 pathway	0.0	4.0	17.0	-0.009	0.037	1000.0	-1000.0	-0.003	-1000.0
ceramide signaling pathway	0.0	34.0	49.0	-0.027	0.05	1000.0	-1000.0	-0.026	-1000.0
HIF-2-alpha transcription factor network	0.0	26.0	43.0	-0.118	0.12	1000.0	-1000.0	-0.051	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	39.0	83.0	-0.024	0.072	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by HDAC Class I	0.0	28.0	104.0	-0.068	0.077	1000.0	-1000.0	-0.027	-1000.0
FoxO family signaling	0.0	30.0	64.0	-0.098	0.071	1000.0	-1000.0	-0.043	-1000.0
FAS signaling pathway (CD95)	0.0	46.0	47.0	-0.044	0.051	1000.0	-1000.0	-0.041	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	12.0	15.0	-0.056	0.035	1000.0	-1000.0	-0.016	-1000.0
Retinoic acid receptors-mediated signaling	0.0	20.0	58.0	-0.038	0.072	1000.0	-1000.0	-0.031	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	22.0	36.0	-0.092	0.069	1000.0	-1000.0	-0.025	-1000.0
Atypical NF-kappaB pathway	0.0	13.0	31.0	-0.009	0.05	1000.0	-1000.0	-0.009	-1000.0
IL2 signaling events mediated by PI3K	0.0	16.0	58.0	-0.014	0.062	1000.0	-1000.0	-0.036	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	43.0	45.0	-0.027	0.064	1000.0	-1000.0	-0.038	-1000.0
Regulation of p38-alpha and p38-beta	0.0	35.0	54.0	-0.038	0.081	1000.0	-1000.0	-0.046	-1000.0
Glypican 2 network	0.0	0.0	4.0	0.0	0.017	1000.0	-1000.0	0.0	-1000.0
IL27-mediated signaling events	0.0	33.0	51.0	-0.099	0.068	1000.0	-1000.0	-0.053	-1000.0
TCGA08_rtk_signaling	0.0	21.0	26.0	-0.055	0.08	1000.0	-1000.0	-0.006	-1000.0
LPA receptor mediated events	0.0	100.0	102.0	-0.156	0.06	1000.0	-1000.0	-0.077	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.0	0.088	1000.0	-1000.0	-0.024	-1000.0
IL2 signaling events mediated by STAT5	0.0	20.0	22.0	-0.078	0.043	1000.0	-1000.0	-0.027	-1000.0
Arf6 trafficking events	0.0	18.0	71.0	-0.049	0.071	1000.0	-1000.0	-0.025	-1000.0
Regulation of Telomerase	0.0	72.0	102.0	-0.132	0.093	1000.0	-1000.0	-0.037	-1000.0
IGF1 pathway	0.0	19.0	57.0	-0.036	0.096	1000.0	-1000.0	-0.022	-1000.0
Insulin Pathway	0.0	45.0	74.0	-0.039	0.088	1000.0	-1000.0	-0.025	-1000.0
Plasma membrane estrogen receptor signaling	0.0	72.0	86.0	-0.049	0.052	1000.0	-1000.0	-0.042	-1000.0
VEGFR1 specific signals	0.0	13.0	56.0	-0.015	0.082	1000.0	-1000.0	-0.024	-1000.0
S1P3 pathway	0.0	18.0	42.0	-0.04	0.054	1000.0	-1000.0	-0.023	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	9.0	33.0	-0.051	0.089	1000.0	-1000.0	-0.032	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	0.0	112.0	120.0	-0.154	0.106	1000.0	-1000.0	-0.037	-1000.0
PDGFR-beta signaling pathway	0.0	70.0	97.0	-0.043	0.102	1000.0	-1000.0	-0.03	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.034	0.034	1000.0	-1000.0	-0.021	-1000.0
S1P4 pathway	0.0	4.0	25.0	0.0	0.048	1000.0	-1000.0	-0.011	-1000.0
p38 MAPK signaling pathway	0.0	38.0	44.0	-0.046	0.063	1000.0	-1000.0	-0.015	-1000.0
Arf1 pathway	0.0	3.0	54.0	-0.002	0.05	1000.0	-1000.0	-0.007	-1000.0
Alternative NF-kappaB pathway	0.0	6.0	13.0	0.0	0.068	1000.0	-1000.0	0.0	-1000.0
Regulation of Androgen receptor activity	0.0	52.0	70.0	-0.187	0.062	1000.0	-1000.0	-0.043	-1000.0
Total	123	10340	7203	-13.7653520389	-991.272622769	131000	-131000	-3.7804238131	-131000