E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.067 0.2 -9999.0 0.0 -0.483 19.0 19.0 KLHL20 -0.035 0.062 -9999.0 0.0 -0.283 2.0 2.0 CYFIP2 0.01 0.052 -9999.0 0.0 -0.532 1.0 1.0 Rac1/GDP -0.011 0.134 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.067 0.2 -9999.0 0.0 -0.483 19.0 19.0 AP1M1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.049 0.081 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.023 0.043 -9999.0 0.0 -0.182 3.0 3.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.118 0.176 -9999.0 0.0 -0.406 20.0 20.0 RAPGEF1 -0.041 0.177 -9999.0 0.0 -0.406 19.0 19.0 CTNND1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.106 0.189 -9999.0 0.0 -0.504 19.0 19.0 CRK -0.054 0.19 -9999.0 0.0 -0.447 19.0 19.0 E-cadherin/gamma catenin/alpha catenin -0.115 0.185 -9999.0 0.0 -0.384 33.0 33.0 alphaE/beta7 Integrin -0.034 0.115 -9999.0 0.0 -0.418 9.0 9.0 IQGAP1 0.005 0.073 -9999.0 0.0 -0.532 2.0 2.0 NCKAP1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.067 0.2 -9999.0 0.0 -0.483 19.0 19.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.037 0.059 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.0 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.046 0.074 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.137 0.218 -9999.0 0.0 -0.457 33.0 33.0 TIAM1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ -0.088 0.138 -9999.0 0.0 -0.333 19.0 19.0 AKT1 -0.026 0.042 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.163 0.28 -9999.0 0.0 -0.598 32.0 32.0 RhoA/GDP -0.011 0.134 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.025 0.046 -9999.0 0.0 -0.203 2.0 2.0 CDC42/GDP -0.011 0.134 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.054 0.138 -9999.0 0.0 -0.307 20.0 20.0 ITGB7 -0.034 0.164 -9999.0 0.0 -0.581 9.0 9.0 RAC1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.093 0.147 -9999.0 0.0 -0.353 19.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.09 0.142 -9999.0 0.0 -0.31 32.0 32.0 mol:GDP -0.024 0.152 -9999.0 0.0 -0.346 2.0 2.0 CDC42/GTP/IQGAP1 -0.006 0.043 -9999.0 0.0 -0.319 2.0 2.0 JUP -0.003 0.107 -9999.0 0.0 -0.642 3.0 3.0 p120 catenin/RhoA/GDP -0.061 0.106 -9999.0 0.0 -9999.0 0.0 0.0 RAC1/GTP/IQGAP1 -0.006 0.043 -9999.0 0.0 -0.319 2.0 2.0 PIP5K1C/AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.006 0.067 -9999.0 0.0 -0.221 6.0 6.0 NME1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.067 0.2 -9999.0 0.0 -0.483 19.0 19.0 regulation of cell-cell adhesion -0.044 0.072 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.011 0.022 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.057 0.093 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.118 0.178 -9999.0 0.0 -0.406 21.0 21.0 CCND1 0.005 0.082 -9999.0 0.0 -0.276 6.0 6.0 VAV2 -0.047 0.186 -9999.0 0.0 -0.434 19.0 19.0 RAP1/GDP -0.056 0.099 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.064 0.194 -9999.0 0.0 -0.467 19.0 19.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.079 0.19 -9999.0 0.0 -0.639 5.0 5.0 E-cadherin/beta catenin -0.095 0.161 -9999.0 0.0 -0.332 32.0 32.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.068 0.2 -9999.0 0.0 -0.483 19.0 19.0 PIK3CA 0.009 0.062 -9999.0 0.0 -0.642 1.0 1.0 Rac1/GTP -0.056 0.101 -9999.0 0.0 -0.491 2.0 2.0 E-cadherin/beta catenin/alpha catenin -0.105 0.165 -9999.0 0.0 -0.361 32.0 32.0 ITGAE 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.109 0.194 -9999.0 0.0 -0.516 19.0 19.0