Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.112 0.321 -9999.0 0.0 -0.768 16.0 16.0 IHH -0.016 0.093 -9999.0 0.0 -0.551 2.0 2.0 SHH Np/Cholesterol/GAS1 -0.109 0.178 -9999.0 0.0 -0.365 33.0 33.0 LRPAP1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.109 0.177 0.363 33.0 -9999.0 0.0 33.0 SMO/beta Arrestin2 -0.042 0.189 -9999.0 0.0 -0.602 5.0 5.0 SMO -0.053 0.199 -9999.0 0.0 -0.644 5.0 5.0 AKT1 -0.003 0.106 -9999.0 0.0 -0.469 2.0 2.0 ARRB2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.001 0.095 -9999.0 0.0 -0.569 3.0 3.0 ADRBK1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.052 0.196 -9999.0 0.0 -0.63 5.0 5.0 STIL -0.102 0.253 -9999.0 0.0 -0.613 16.0 16.0 DHH N/PTCH2 -0.071 0.162 -9999.0 0.0 -0.434 18.0 18.0 DHH N/PTCH1 -0.078 0.209 -9999.0 0.0 -0.611 7.0 7.0 PIK3CA 0.009 0.062 -9999.0 0.0 -0.642 1.0 1.0 DHH -0.056 0.194 -9999.0 0.0 -0.583 13.0 13.0 PTHLH -0.122 0.361 -9999.0 0.0 -0.913 15.0 15.0 determination of left/right symmetry -0.052 0.196 -9999.0 0.0 -0.63 5.0 5.0 PIK3R1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.12 0.355 -9999.0 0.0 -0.898 15.0 15.0 IHH N/Hhip -0.144 0.236 -9999.0 0.0 -0.483 35.0 35.0 DHH N/Hhip -0.177 0.249 -9999.0 0.0 -0.488 40.0 40.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.052 0.196 -9999.0 0.0 -0.63 5.0 5.0 pancreas development -0.172 0.281 -9999.0 0.0 -0.59 34.0 34.0 HHAT 0.003 0.088 -9999.0 0.0 -0.642 2.0 2.0 PI3K -0.004 0.045 -9999.0 0.0 -0.471 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.036 0.161 -9999.0 0.0 -0.543 10.0 10.0 somite specification -0.052 0.196 -9999.0 0.0 -0.63 5.0 5.0 SHH Np/Cholesterol/PTCH1 -0.104 0.253 -9999.0 0.0 -0.625 15.0 15.0 SHH Np/Cholesterol/PTCH2 -0.099 0.178 -9999.0 0.0 -0.364 30.0 30.0 SHH Np/Cholesterol/Megalin -0.191 0.225 -9999.0 0.0 -0.396 53.0 53.0 SHH -0.089 0.206 -9999.0 0.0 -0.445 27.0 27.0 catabolic process -0.05 0.194 -9999.0 0.0 -0.567 7.0 7.0 SMO/Vitamin D3 -0.095 0.251 -9999.0 0.0 -0.659 12.0 12.0 SHH Np/Cholesterol/Hhip -0.183 0.214 -9999.0 0.0 -0.38 53.0 53.0 LRP2 -0.186 0.29 -9999.0 0.0 -0.6 36.0 36.0 receptor-mediated endocytosis -0.19 0.244 -9999.0 0.0 -0.614 21.0 21.0 SHH Np/Cholesterol/BOC -0.091 0.154 -9999.0 0.0 -0.336 30.0 30.0 SHH Np/Cholesterol/CDO -0.098 0.157 -9999.0 0.0 -0.337 32.0 32.0 mesenchymal cell differentiation 0.181 0.212 0.377 53.0 -9999.0 0.0 53.0 mol:Vitamin D3 -0.101 0.254 -9999.0 0.0 -0.624 15.0 15.0 IHH N/PTCH2 -0.016 0.13 -9999.0 0.0 -0.492 7.0 7.0 CDON -0.013 0.128 -9999.0 0.0 -0.598 5.0 5.0 IHH N/PTCH1 -0.05 0.195 -9999.0 0.0 -0.571 7.0 7.0 Megalin/LRPAP1 -0.142 0.205 -9999.0 0.0 -0.434 36.0 36.0 PTCH2 -0.015 0.137 -9999.0 0.0 -0.642 5.0 5.0 SHH Np/Cholesterol -0.085 0.154 -9999.0 0.0 -0.348 27.0 27.0 PTCH1 -0.05 0.195 -9999.0 0.0 -0.57 7.0 7.0 HHIP -0.172 0.281 -9999.0 0.0 -0.591 34.0 34.0