Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.044 0.128 -9999.0 0.0 -0.278 21.0 21.0 epithelial cell differentiation -0.087 0.137 -9999.0 0.0 -0.329 19.0 19.0 CYFIP2 0.01 0.052 -9999.0 0.0 -0.532 1.0 1.0 ENAH -0.007 0.117 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.087 0.223 -9999.0 0.0 -0.573 19.0 19.0 EPHA2 -0.021 0.138 -9999.0 0.0 -0.548 7.0 7.0 MYO6 -0.05 0.147 -9999.0 0.0 -0.308 19.0 19.0 CTNNB1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.003 0.029 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.154 0.201 -9999.0 0.0 -0.582 14.0 14.0 CTNND1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.049 0.145 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.052 0.147 -9999.0 0.0 -0.304 20.0 20.0 EGF -0.06 0.205 -9999.0 0.0 -0.617 13.0 13.0 NCKAP1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.108 0.151 -9999.0 0.0 -0.466 9.0 9.0 cortical microtubule organization -0.087 0.137 -9999.0 0.0 -0.329 19.0 19.0 GO:0000145 -0.047 0.139 -9999.0 0.0 -0.29 19.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.088 0.138 -9999.0 0.0 -0.333 19.0 19.0 MLLT4 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.077 0.113 -9999.0 0.0 -0.444 2.0 2.0 ARF6 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.021 0.074 -9999.0 0.0 -0.353 1.0 1.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.05 0.15 -9999.0 0.0 -0.384 4.0 4.0 PVRL2 0.009 0.062 -9999.0 0.0 -0.642 1.0 1.0 ZYX -0.055 0.149 -9999.0 0.0 -0.308 19.0 19.0 ARF6/GTP -0.018 0.066 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.163 0.28 -9999.0 0.0 -0.598 32.0 32.0 EGFR/EGFR/EGF/EGF -0.156 0.2 -9999.0 0.0 -0.613 11.0 11.0 RhoA/GDP -0.08 0.127 -9999.0 0.0 -0.305 19.0 19.0 actin cytoskeleton organization -0.042 0.148 -9999.0 0.0 -0.534 1.0 1.0 IGF-1R heterotetramer 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.014 0.133 -9999.0 0.0 -0.62 5.0 5.0 DIAPH1 0.004 0.015 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.087 0.137 0.329 19.0 -9999.0 0.0 19.0 RHOA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.078 0.113 -9999.0 0.0 -0.445 2.0 2.0 CTNNA1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.043 0.151 -9999.0 0.0 -0.55 1.0 1.0 EFNA1 0.01 0.052 -9999.0 0.0 -0.532 1.0 1.0 LPP -0.065 0.167 -9999.0 0.0 -0.505 4.0 4.0 Ephrin A1/EPHA2 -0.094 0.135 -9999.0 0.0 -0.515 2.0 2.0 SEC6/SEC8 -0.07 0.116 -9999.0 0.0 -0.567 1.0 1.0 MGAT3 -0.053 0.149 -9999.0 0.0 -0.308 20.0 20.0 HGF/MET -0.183 0.201 -9999.0 0.0 -0.57 16.0 16.0 HGF -0.073 0.205 -9999.0 0.0 -0.552 17.0 17.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.044 0.129 -9999.0 0.0 -0.28 21.0 21.0 actin cable formation 0.006 0.116 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 -0.078 0.179 -9999.0 0.0 -0.599 4.0 4.0 KIFC3 -0.053 0.148 -9999.0 0.0 -0.308 19.0 19.0 NCK1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.071 0.172 -9999.0 0.0 -0.493 5.0 5.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.087 0.137 -9999.0 0.0 -0.329 19.0 19.0 EXOC4 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.05 0.147 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.05 0.147 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.003 0.088 -9999.0 0.0 -0.642 2.0 2.0 ABI1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.021 0.131 -9999.0 0.0 -0.408 1.0 1.0 adherens junction assembly -0.056 0.171 -9999.0 0.0 -0.537 4.0 4.0 IGF-1R heterotetramer/IGF1 -0.09 0.151 -9999.0 0.0 -0.584 4.0 4.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.004 0.045 -9999.0 0.0 -0.471 1.0 1.0 MET -0.137 0.262 -9999.0 0.0 -0.583 28.0 28.0 PLEKHA7 -0.055 0.149 -9999.0 0.0 -0.308 19.0 19.0 mol:GTP -0.02 0.073 -9999.0 0.0 -0.35 1.0 1.0 establishment of epithelial cell apical/basal polarity -0.016 0.14 -9999.0 0.0 -0.536 1.0 1.0 cortical actin cytoskeleton stabilization -0.044 0.128 -9999.0 0.0 -0.278 21.0 21.0 regulation of cell-cell adhesion -0.042 0.148 -9999.0 0.0 -0.534 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.044 0.129 -9999.0 0.0 -0.28 21.0 21.0