E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.046 0.16 -9999.0 0.0 -0.423 16.0 16.0 KLHL20 0.007 0.078 0.16 1.0 -0.212 1.0 2.0 CYFIP2 0.026 0.019 -9999.0 0.0 -0.165 1.0 1.0 Rac1/GDP -0.016 0.109 0.271 1.0 -0.257 15.0 16.0 ENAH -0.055 0.167 -9999.0 0.0 -0.425 18.0 18.0 AP1M1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.023 0.011 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.013 0.076 -9999.0 0.0 -0.183 10.0 10.0 ABI1/Sra1/Nap1 -0.017 0.038 -9999.0 0.0 -0.147 1.0 1.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.015 0.135 -9999.0 0.0 -0.273 19.0 19.0 RAPGEF1 -0.043 0.154 0.239 1.0 -0.375 18.0 19.0 CTNND1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.049 0.175 -9999.0 0.0 -0.425 19.0 19.0 CRK -0.053 0.159 -9999.0 0.0 -0.402 18.0 18.0 E-cadherin/gamma catenin/alpha catenin -0.017 0.128 -9999.0 0.0 -0.275 19.0 19.0 alphaE/beta7 Integrin 0.021 0.072 -9999.0 0.0 -0.311 4.0 4.0 IQGAP1 0.024 0.026 -9999.0 0.0 -0.165 2.0 2.0 NCKAP1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.041 0.023 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.052 0.165 -9999.0 0.0 -0.415 18.0 18.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.021 0.053 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.051 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.023 0.068 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.039 0.141 -9999.0 0.0 -0.324 19.0 19.0 TIAM1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.002 0.105 -9999.0 0.0 -0.224 16.0 16.0 AKT1 -0.008 0.048 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.072 0.174 -9999.0 0.0 -0.323 31.0 31.0 RhoA/GDP -0.014 0.114 0.27 1.0 -0.257 17.0 18.0 actin cytoskeleton organization 0.012 0.067 0.171 4.0 -0.156 1.0 5.0 CDC42/GDP -0.019 0.108 -9999.0 0.0 -0.25 17.0 17.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.024 0.094 -9999.0 0.0 -0.232 17.0 17.0 ITGB7 0.002 0.095 -9999.0 0.0 -0.286 9.0 9.0 RAC1 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.002 0.112 -9999.0 0.0 -0.239 16.0 16.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.011 0.102 -9999.0 0.0 -0.223 18.0 18.0 mol:GDP -0.03 0.124 0.276 1.0 -0.291 18.0 19.0 CDC42/GTP/IQGAP1 0.029 0.022 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.019 0.062 -9999.0 0.0 -0.437 2.0 2.0 p120 catenin/RhoA/GDP -0.01 0.117 0.27 1.0 -0.263 16.0 17.0 RAC1/GTP/IQGAP1 0.031 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.04 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.011 0.051 0.14 3.0 -0.186 2.0 5.0 NME1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.054 0.168 -9999.0 0.0 -0.424 18.0 18.0 regulation of cell-cell adhesion -0.016 0.065 -9999.0 0.0 -0.163 10.0 10.0 WASF2 0.011 0.029 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.014 0.089 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.006 0.141 -9999.0 0.0 -0.267 20.0 20.0 CCND1 0.012 0.061 0.16 3.0 -0.231 2.0 5.0 VAV2 -0.031 0.161 -9999.0 0.0 -0.396 6.0 6.0 RAP1/GDP -0.011 0.098 -9999.0 0.0 -0.225 7.0 7.0 adherens junction assembly -0.052 0.163 -9999.0 0.0 -0.411 18.0 18.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.016 0.13 -9999.0 0.0 -0.258 20.0 20.0 E-cadherin/beta catenin -0.05 0.124 -9999.0 0.0 -0.325 18.0 18.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.054 0.168 -9999.0 0.0 -0.425 18.0 18.0 PIK3CA 0.023 0.044 -9999.0 0.0 -0.437 1.0 1.0 Rac1/GTP -0.038 0.085 -9999.0 0.0 -0.337 1.0 1.0 E-cadherin/beta catenin/alpha catenin -0.015 0.12 -9999.0 0.0 -0.263 18.0 18.0 ITGAE 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.052 0.178 -9999.0 0.0 -0.434 19.0 19.0