Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.048 0.197 -9999.0 0.0 -0.615 10.0 10.0 IHH 0.006 0.057 -9999.0 0.0 -0.186 2.0 2.0 SHH Np/Cholesterol/GAS1 -0.01 0.09 0.137 1.0 -0.236 13.0 14.0 LRPAP1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.01 0.089 0.235 13.0 -0.136 1.0 14.0 SMO/beta Arrestin2 -0.001 0.106 -9999.0 0.0 -0.386 3.0 3.0 SMO -0.017 0.102 -9999.0 0.0 -0.377 4.0 4.0 AKT1 0.001 0.104 -9999.0 0.0 -0.538 3.0 3.0 ARRB2 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.02 0.051 -9999.0 0.0 -0.256 3.0 3.0 ADRBK1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.016 0.101 -9999.0 0.0 -0.356 5.0 5.0 STIL -0.007 0.14 0.193 1.0 -0.308 11.0 12.0 DHH N/PTCH2 0.007 0.084 -9999.0 0.0 -0.307 6.0 6.0 DHH N/PTCH1 -0.024 0.127 -9999.0 0.0 -0.329 11.0 11.0 PIK3CA 0.023 0.044 -9999.0 0.0 -0.437 1.0 1.0 DHH -0.011 0.113 -9999.0 0.0 -0.291 13.0 13.0 PTHLH -0.057 0.246 -9999.0 0.0 -0.773 10.0 10.0 determination of left/right symmetry -0.016 0.101 -9999.0 0.0 -0.356 5.0 5.0 PIK3R1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.056 0.243 -9999.0 0.0 -0.764 10.0 10.0 IHH N/Hhip -0.048 0.137 -9999.0 0.0 -0.341 16.0 16.0 DHH N/Hhip -0.056 0.151 -9999.0 0.0 -0.327 22.0 22.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.016 0.101 -9999.0 0.0 -0.356 5.0 5.0 pancreas development -0.065 0.162 -9999.0 0.0 -0.296 31.0 31.0 HHAT 0.019 0.062 -9999.0 0.0 -0.437 2.0 2.0 PI3K 0.037 0.034 -9999.0 0.0 -0.311 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.009 0.066 -9999.0 0.0 -0.195 9.0 9.0 somite specification -0.016 0.101 -9999.0 0.0 -0.356 5.0 5.0 SHH Np/Cholesterol/PTCH1 -0.035 0.12 -9999.0 0.0 -0.301 14.0 14.0 SHH Np/Cholesterol/PTCH2 -0.016 0.085 -9999.0 0.0 -0.249 12.0 12.0 SHH Np/Cholesterol/Megalin -0.057 0.127 0.137 1.0 -0.265 25.0 26.0 SHH -0.03 0.104 -9999.0 0.0 -0.318 12.0 12.0 catabolic process -0.017 0.118 -9999.0 0.0 -0.357 9.0 9.0 SMO/Vitamin D3 -0.029 0.116 -9999.0 0.0 -0.325 8.0 8.0 SHH Np/Cholesterol/Hhip -0.05 0.12 0.137 1.0 -0.257 23.0 24.0 LRP2 -0.087 0.182 -9999.0 0.0 -0.328 35.0 35.0 receptor-mediated endocytosis -0.065 0.137 -9999.0 0.0 -0.391 10.0 10.0 SHH Np/Cholesterol/BOC -0.017 0.087 -9999.0 0.0 -0.242 13.0 13.0 SHH Np/Cholesterol/CDO -0.021 0.088 -9999.0 0.0 -0.237 14.0 14.0 mesenchymal cell differentiation 0.05 0.119 0.256 23.0 -0.136 1.0 24.0 mol:Vitamin D3 0.003 0.152 0.208 1.0 -0.301 14.0 15.0 IHH N/PTCH2 0.029 0.033 -9999.0 0.0 -0.14 1.0 1.0 CDON 0.01 0.08 -9999.0 0.0 -0.328 5.0 5.0 IHH N/PTCH1 -0.01 0.122 -9999.0 0.0 -0.359 9.0 9.0 Megalin/LRPAP1 -0.047 0.137 -9999.0 0.0 -0.31 21.0 21.0 PTCH2 0.023 0.011 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.019 0.081 -9999.0 0.0 -0.242 12.0 12.0 PTCH1 -0.017 0.118 -9999.0 0.0 -0.358 9.0 9.0 HHIP -0.066 0.163 -9999.0 0.0 -0.297 31.0 31.0