Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.021 0.09 -9999.0 0.0 -0.216 18.0 18.0 epithelial cell differentiation -0.002 0.102 -9999.0 0.0 -0.222 16.0 16.0 CYFIP2 0.026 0.019 -9999.0 0.0 -0.165 1.0 1.0 ENAH -0.031 0.073 0.262 2.0 -9999.0 0.0 2.0 EGFR 0.004 0.089 -9999.0 0.0 -0.382 5.0 5.0 EPHA2 0.009 0.062 -9999.0 0.0 -0.437 1.0 1.0 MYO6 -0.022 0.092 0.179 5.0 -0.214 16.0 21.0 CTNNB1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.048 0.023 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.068 0.167 -9999.0 0.0 -0.472 13.0 13.0 CTNND1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.023 0.091 0.178 5.0 -0.211 16.0 21.0 regulation of calcium-dependent cell-cell adhesion -0.025 0.092 0.178 5.0 -0.21 17.0 22.0 EGF -0.013 0.123 -9999.0 0.0 -0.363 11.0 11.0 NCKAP1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.031 0.11 -9999.0 0.0 -0.418 4.0 4.0 cortical microtubule organization -0.002 0.102 -9999.0 0.0 -0.222 16.0 16.0 GO:0000145 -0.035 0.081 0.166 5.0 -0.202 16.0 21.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.002 0.105 -9999.0 0.0 -0.224 16.0 16.0 MLLT4 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.048 0.066 -9999.0 0.0 -0.2 11.0 11.0 ARF6 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.046 0.052 -9999.0 0.0 -0.239 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.036 0.097 0.176 2.0 -0.256 13.0 15.0 PVRL2 0.019 0.045 -9999.0 0.0 -0.437 1.0 1.0 ZYX -0.017 0.083 0.179 4.0 -0.214 13.0 17.0 ARF6/GTP 0.052 0.053 -9999.0 0.0 -0.223 1.0 1.0 CDH1 -0.072 0.174 -9999.0 0.0 -0.323 31.0 31.0 EGFR/EGFR/EGF/EGF -0.035 0.12 -9999.0 0.0 -0.249 22.0 22.0 RhoA/GDP 0.001 0.099 -9999.0 0.0 -0.212 16.0 16.0 actin cytoskeleton organization -0.027 0.089 0.168 5.0 -0.216 16.0 21.0 IGF-1R heterotetramer 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.008 0.089 -9999.0 0.0 -0.382 5.0 5.0 DIAPH1 0.03 0.101 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.002 0.102 0.222 16.0 -9999.0 0.0 16.0 RHOA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.048 0.067 -9999.0 0.0 -0.201 11.0 11.0 CTNNA1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.027 0.091 0.169 5.0 -0.22 16.0 21.0 EFNA1 0.026 0.019 -9999.0 0.0 -0.165 1.0 1.0 LPP -0.045 0.087 0.172 4.0 -0.214 18.0 22.0 Ephrin A1/EPHA2 -0.016 0.095 -9999.0 0.0 -0.206 17.0 17.0 SEC6/SEC8 -0.023 0.073 -9999.0 0.0 -0.208 13.0 13.0 MGAT3 -0.025 0.093 0.179 5.0 -0.213 17.0 22.0 HGF/MET -0.047 0.117 -9999.0 0.0 -0.251 22.0 22.0 HGF -0.001 0.078 -9999.0 0.0 -0.22 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.021 0.091 -9999.0 0.0 -0.218 18.0 18.0 actin cable formation -0.01 0.092 0.278 3.0 -0.241 1.0 4.0 KIAA1543 -0.037 0.079 0.167 3.0 -0.204 16.0 19.0 KIFC3 -0.023 0.092 0.179 5.0 -0.214 16.0 21.0 NCK1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.031 0.095 0.179 4.0 -0.222 17.0 21.0 NCK1/GIT1 0.041 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.002 0.102 -9999.0 0.0 -0.222 16.0 16.0 EXOC4 0.021 0.012 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.023 0.092 0.179 5.0 -0.214 16.0 21.0 PIP5K1C -0.023 0.092 0.179 5.0 -0.214 16.0 21.0 LIMA1 0.019 0.062 -9999.0 0.0 -0.437 2.0 2.0 ABI1 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.03 0.089 0.287 3.0 -0.227 1.0 4.0 adherens junction assembly -0.012 0.087 0.291 1.0 -0.237 1.0 2.0 IGF-1R heterotetramer/IGF1 -0.011 0.106 -9999.0 0.0 -0.228 18.0 18.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.029 0.037 -9999.0 0.0 -0.311 1.0 1.0 MET -0.043 0.138 -9999.0 0.0 -0.289 22.0 22.0 PLEKHA7 -0.024 0.089 0.177 4.0 -0.213 16.0 20.0 mol:GTP 0.044 0.051 -9999.0 0.0 -0.238 1.0 1.0 establishment of epithelial cell apical/basal polarity 0.012 0.119 0.299 4.0 -0.372 1.0 5.0 cortical actin cytoskeleton stabilization -0.021 0.09 -9999.0 0.0 -0.216 18.0 18.0 regulation of cell-cell adhesion -0.027 0.089 0.168 5.0 -0.216 16.0 21.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.021 0.091 -9999.0 0.0 -0.218 18.0 18.0