Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.209 0.245 -9999.0 0.0 -0.635 62.0 62.0 IHH -0.311 0.271 -9999.0 0.0 -0.544 202.0 202.0 SHH Np/Cholesterol/GAS1 -0.044 0.105 -9999.0 0.0 -0.281 55.0 55.0 LRPAP1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.044 0.104 0.279 55.0 -9999.0 0.0 55.0 SMO/beta Arrestin2 -0.21 0.214 -9999.0 0.0 -0.497 73.0 73.0 SMO -0.226 0.225 -9999.0 0.0 -0.528 73.0 73.0 AKT1 -0.092 0.103 -9999.0 0.0 -0.313 4.0 4.0 ARRB2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.008 0.028 -9999.0 0.0 -0.523 1.0 1.0 ADRBK1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.223 0.221 -9999.0 0.0 -0.519 73.0 73.0 STIL -0.201 0.22 -9999.0 0.0 -0.522 83.0 83.0 DHH N/PTCH2 -0.024 0.09 -9999.0 0.0 -0.356 24.0 24.0 DHH N/PTCH1 -0.188 0.19 -9999.0 0.0 -0.476 67.0 67.0 PIK3CA 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.024 0.127 -9999.0 0.0 -0.504 23.0 23.0 PTHLH -0.275 0.29 -9999.0 0.0 -0.773 62.0 62.0 determination of left/right symmetry -0.223 0.221 -9999.0 0.0 -0.519 73.0 73.0 PIK3R1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.272 0.286 -9999.0 0.0 -0.764 62.0 62.0 IHH N/Hhip -0.378 0.253 -9999.0 0.0 -0.495 272.0 272.0 DHH N/Hhip -0.22 0.198 -9999.0 0.0 -0.38 204.0 204.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.223 0.221 -9999.0 0.0 -0.519 73.0 73.0 pancreas development -0.277 0.254 -9999.0 0.0 -0.503 197.0 197.0 HHAT 0.007 0.039 -9999.0 0.0 -0.504 2.0 2.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.006 0.089 -9999.0 0.0 -0.504 11.0 11.0 somite specification -0.223 0.221 -9999.0 0.0 -0.519 73.0 73.0 SHH Np/Cholesterol/PTCH1 -0.177 0.193 -9999.0 0.0 -0.459 79.0 79.0 SHH Np/Cholesterol/PTCH2 -0.036 0.091 -9999.0 0.0 -0.267 48.0 48.0 SHH Np/Cholesterol/Megalin -0.107 0.153 -9999.0 0.0 -0.301 126.0 126.0 SHH -0.032 0.127 -9999.0 0.0 -0.357 47.0 47.0 catabolic process -0.198 0.197 -9999.0 0.0 -0.507 55.0 55.0 SMO/Vitamin D3 -0.201 0.214 -9999.0 0.0 -0.502 79.0 79.0 SHH Np/Cholesterol/Hhip -0.184 0.165 -9999.0 0.0 -0.304 214.0 214.0 LRP2 -0.129 0.228 -9999.0 0.0 -0.504 95.0 95.0 receptor-mediated endocytosis -0.257 0.225 -9999.0 0.0 -0.543 106.0 106.0 SHH Np/Cholesterol/BOC -0.036 0.091 -9999.0 0.0 -0.267 48.0 48.0 SHH Np/Cholesterol/CDO -0.042 0.101 -9999.0 0.0 -0.277 53.0 53.0 mesenchymal cell differentiation 0.183 0.164 0.302 214.0 -9999.0 0.0 214.0 mol:Vitamin D3 -0.177 0.195 -9999.0 0.0 -0.462 79.0 79.0 IHH N/PTCH2 -0.179 0.167 -9999.0 0.0 -0.32 202.0 202.0 CDON -0.002 0.076 -9999.0 0.0 -0.504 8.0 8.0 IHH N/PTCH1 -0.2 0.199 -9999.0 0.0 -0.513 55.0 55.0 Megalin/LRPAP1 -0.096 0.158 -9999.0 0.0 -0.356 95.0 95.0 PTCH2 0.008 0.027 -9999.0 0.0 -0.504 1.0 1.0 SHH Np/Cholesterol -0.036 0.093 -9999.0 0.0 -0.273 47.0 47.0 PTCH1 -0.199 0.198 -9999.0 0.0 -0.509 55.0 55.0 HHIP -0.277 0.255 -9999.0 0.0 -0.504 197.0 197.0