Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Glypican 2 network	130.0	522.0	4.0	-0.203	-0.112	1000.0	-1000.0	-0.031	-1000.0
FOXM1 transcription factor network	100.0	5142.0	51.0	-0.63	0.01	1000.0	-1000.0	-0.186	-1000.0
Aurora B signaling	93.0	6250.0	67.0	-0.44	0.01	1000.0	-1000.0	-0.055	-1000.0
Angiopoietin receptor Tie2-mediated signaling	91.0	8037.0	88.0	-0.53	0.05	1000.0	-1000.0	-0.108	-1000.0
Signaling events mediated by the Hedgehog family	71.0	3727.0	52.0	-0.378	0.183	1000.0	-1000.0	-0.074	-1000.0
Aurora C signaling	55.0	385.0	7.0	-0.277	0.005	1000.0	-1000.0	-0.032	-1000.0
PLK1 signaling events	53.0	4511.0	85.0	-0.313	0.066	1000.0	-1000.0	-0.041	-1000.0
Osteopontin-mediated events	51.0	1975.0	38.0	-0.386	0.011	1000.0	-1000.0	-0.084	-1000.0
HIF-1-alpha transcription factor network	50.0	3855.0	76.0	-0.5	0.016	1000.0	-1000.0	-0.163	-1000.0
Endothelins	48.0	4616.0	96.0	-0.291	0.035	1000.0	-1000.0	-0.077	-1000.0
Signaling events regulated by Ret tyrosine kinase	44.0	3670.0	82.0	-0.17	0.01	1000.0	-1000.0	-0.072	-1000.0
Visual signal transduction: Cones	41.0	1564.0	38.0	-0.164	0.01	1000.0	-1000.0	-0.052	-1000.0
IL4-mediated signaling events	40.0	3704.0	91.0	-0.799	0.522	1000.0	-1000.0	-0.176	-1000.0
amb2 Integrin signaling	36.0	3016.0	82.0	-0.48	0.01	1000.0	-1000.0	-0.066	-1000.0
Signaling mediated by p38-alpha and p38-beta	36.0	1614.0	44.0	-0.107	0.01	1000.0	-1000.0	-0.046	-1000.0
BMP receptor signaling	35.0	2863.0	81.0	-0.378	0.027	1000.0	-1000.0	-0.085	-1000.0
FOXA2 and FOXA3 transcription factor networks	33.0	1522.0	46.0	-0.512	0.016	1000.0	-1000.0	-0.101	-1000.0
Fc-epsilon receptor I signaling in mast cells	33.0	3241.0	97.0	-0.148	0.028	1000.0	-1000.0	-0.075	-1000.0
TCGA08_retinoblastoma	32.0	262.0	8.0	-0.153	0.049	1000.0	-1000.0	-0.025	-1000.0
Visual signal transduction: Rods	31.0	1641.0	52.0	-0.149	0.01	1000.0	-1000.0	-0.064	-1000.0
TCGA08_p53	30.0	212.0	7.0	-0.106	0.053	1000.0	-1000.0	-0.018	-1000.0
Glucocorticoid receptor regulatory network	29.0	3324.0	114.0	-0.39	0.247	1000.0	-1000.0	-0.065	-1000.0
p75(NTR)-mediated signaling	27.0	3380.0	125.0	-0.295	0.016	1000.0	-1000.0	-0.086	-1000.0
LPA4-mediated signaling events	26.0	317.0	12.0	-0.119	0.013	1000.0	-1000.0	-0.023	-1000.0
Canonical Wnt signaling pathway	25.0	1275.0	51.0	-0.344	0.147	1000.0	-1000.0	-0.052	-1000.0
Arf6 signaling events	24.0	1491.0	62.0	-0.188	0.011	1000.0	-1000.0	-0.057	-1000.0
Integrins in angiogenesis	23.0	1977.0	84.0	-0.388	0.025	1000.0	-1000.0	-0.076	-1000.0
Syndecan-1-mediated signaling events	22.0	754.0	34.0	-0.361	0.01	1000.0	-1000.0	-0.057	-1000.0
Presenilin action in Notch and Wnt signaling	22.0	1366.0	61.0	-0.344	0.021	1000.0	-1000.0	-0.065	-1000.0
Aurora A signaling	22.0	1360.0	60.0	-0.311	0.016	1000.0	-1000.0	-0.053	-1000.0
Glypican 1 network	22.0	1076.0	48.0	-0.101	0.019	1000.0	-1000.0	-0.042	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	22.0	1149.0	52.0	-0.246	0.042	1000.0	-1000.0	-0.054	-1000.0
Ephrin B reverse signaling	22.0	1078.0	48.0	-0.096	0.062	1000.0	-1000.0	-0.06	-1000.0
Effects of Botulinum toxin	22.0	584.0	26.0	-0.077	0.01	1000.0	-1000.0	-0.051	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	21.0	2533.0	120.0	-0.237	0.195	1000.0	-1000.0	-0.063	-1000.0
Thromboxane A2 receptor signaling	20.0	2132.0	105.0	-0.091	0.023	1000.0	-1000.0	-0.06	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	19.0	1351.0	68.0	-0.145	0.035	1000.0	-1000.0	-0.122	-1000.0
EGFR-dependent Endothelin signaling events	19.0	405.0	21.0	-0.091	0.01	1000.0	-1000.0	-0.051	-1000.0
IL23-mediated signaling events	19.0	1162.0	60.0	-0.267	0.017	1000.0	-1000.0	-0.167	-1000.0
PLK2 and PLK4 events	16.0	48.0	3.0	-0.025	-0.008	1000.0	-1000.0	-0.015	-1000.0
PDGFR-alpha signaling pathway	16.0	718.0	44.0	-0.302	0.018	1000.0	-1000.0	-0.055	-1000.0
Wnt signaling	16.0	116.0	7.0	-0.066	0.008	1000.0	-1000.0	-0.024	-1000.0
IL6-mediated signaling events	16.0	1254.0	75.0	-0.332	0.042	1000.0	-1000.0	-0.094	-1000.0
ErbB4 signaling events	15.0	1057.0	69.0	-0.191	0.201	1000.0	-1000.0	-0.082	-1000.0
Class IB PI3K non-lipid kinase events	15.0	45.0	3.0	-0.012	-1000.0	1000.0	-1000.0	-0.011	-1000.0
HIF-2-alpha transcription factor network	14.0	634.0	43.0	-0.141	0.073	1000.0	-1000.0	-0.093	-1000.0
Nongenotropic Androgen signaling	14.0	756.0	52.0	-0.049	0.01	1000.0	-1000.0	-0.055	-1000.0
Regulation of Androgen receptor activity	14.0	984.0	70.0	-0.249	0.029	1000.0	-1000.0	-0.061	-1000.0
Syndecan-2-mediated signaling events	13.0	915.0	69.0	-0.092	0.03	1000.0	-1000.0	-0.046	-1000.0
Reelin signaling pathway	13.0	774.0	56.0	-0.099	0.01	1000.0	-1000.0	-0.066	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	13.0	448.0	33.0	-0.147	0.021	1000.0	-1000.0	-0.055	-1000.0
Noncanonical Wnt signaling pathway	12.0	320.0	26.0	-0.066	0.01	1000.0	-1000.0	-0.068	-1000.0
Syndecan-4-mediated signaling events	12.0	840.0	67.0	-0.194	0.014	1000.0	-1000.0	-0.079	-1000.0
Coregulation of Androgen receptor activity	11.0	874.0	76.0	-0.147	0.018	1000.0	-1000.0	-0.047	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	11.0	883.0	78.0	-0.044	0.037	1000.0	-1000.0	-0.067	-1000.0
IL12-mediated signaling events	10.0	939.0	87.0	-0.096	0.04	1000.0	-1000.0	-0.12	-1000.0
Nectin adhesion pathway	10.0	639.0	63.0	-0.033	0.02	1000.0	-1000.0	-0.057	-1000.0
Calcium signaling in the CD4+ TCR pathway	10.0	330.0	31.0	-0.106	0.011	1000.0	-1000.0	-0.076	-1000.0
Ephrin A  reverse signaling	9.0	66.0	7.0	-0.012	0.006	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by PTP1B	9.0	712.0	76.0	-0.09	0.016	1000.0	-1000.0	-0.072	-1000.0
Signaling events mediated by HDAC Class III	9.0	393.0	40.0	-0.111	0.018	1000.0	-1000.0	-0.034	-1000.0
FAS signaling pathway (CD95)	9.0	441.0	47.0	-0.228	0.014	1000.0	-1000.0	-0.039	-1000.0
Syndecan-3-mediated signaling events	9.0	334.0	35.0	-0.195	0.01	1000.0	-1000.0	-0.059	-1000.0
EPHB forward signaling	9.0	800.0	85.0	-0.069	0.051	1000.0	-1000.0	-0.075	-1000.0
BCR signaling pathway	9.0	913.0	99.0	-0.132	0.027	1000.0	-1000.0	-0.074	-1000.0
Caspase cascade in apoptosis	8.0	598.0	74.0	-0.046	0.03	1000.0	-1000.0	-0.045	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	8.0	284.0	34.0	-0.031	0.013	1000.0	-1000.0	-0.056	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	8.0	479.0	54.0	-0.144	0.021	1000.0	-1000.0	-0.086	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	8.0	745.0	85.0	-0.046	0.032	1000.0	-1000.0	-0.068	-1000.0
S1P1 pathway	8.0	307.0	36.0	-0.054	0.014	1000.0	-1000.0	-0.048	-1000.0
LPA receptor mediated events	8.0	866.0	102.0	-0.104	0.031	1000.0	-1000.0	-0.077	-1000.0
Signaling events mediated by PRL	8.0	298.0	34.0	-0.182	0.02	1000.0	-1000.0	-0.049	-1000.0
BARD1 signaling events	7.0	406.0	57.0	-0.182	0.03	1000.0	-1000.0	-0.06	-1000.0
IL1-mediated signaling events	7.0	494.0	62.0	-0.139	0.049	1000.0	-1000.0	-0.078	-1000.0
TCR signaling in naïve CD8+ T cells	7.0	671.0	93.0	-0.073	0.043	1000.0	-1000.0	-0.074	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	7.0	973.0	125.0	-0.302	0.041	1000.0	-1000.0	-0.096	-1000.0
IL2 signaling events mediated by STAT5	7.0	167.0	22.0	-0.138	0.053	1000.0	-1000.0	-0.054	-1000.0
S1P4 pathway	7.0	176.0	25.0	-0.031	0.01	1000.0	-1000.0	-0.051	-1000.0
ErbB2/ErbB3 signaling events	6.0	429.0	65.0	-0.085	0.021	1000.0	-1000.0	-0.063	-1000.0
Regulation of p38-alpha and p38-beta	6.0	345.0	54.0	-0.066	0.021	1000.0	-1000.0	-0.055	-1000.0
Arf6 trafficking events	6.0	458.0	71.0	-0.086	0.034	1000.0	-1000.0	-0.062	-1000.0
Plasma membrane estrogen receptor signaling	6.0	568.0	86.0	-0.031	0.029	1000.0	-1000.0	-0.078	-1000.0
Regulation of nuclear SMAD2/3 signaling	5.0	807.0	136.0	-0.104	0.05	1000.0	-1000.0	-0.065	-1000.0
Sphingosine 1-phosphate (S1P) pathway	5.0	146.0	28.0	-0.031	0.019	1000.0	-1000.0	-0.046	-1000.0
S1P5 pathway	5.0	101.0	17.0	-0.031	0.029	1000.0	-1000.0	-0.052	-1000.0
IL27-mediated signaling events	5.0	267.0	51.0	-0.101	0.011	1000.0	-1000.0	-0.071	-1000.0
Regulation of Telomerase	5.0	522.0	102.0	-0.093	0.032	1000.0	-1000.0	-0.097	-1000.0
Cellular roles of Anthrax toxin	4.0	162.0	39.0	-0.04	0.016	1000.0	-1000.0	-0.025	-1000.0
Hedgehog signaling events mediated by Gli proteins	4.0	294.0	65.0	-0.177	0.055	1000.0	-1000.0	-0.06	-1000.0
FoxO family signaling	4.0	269.0	64.0	-0.145	0.054	1000.0	-1000.0	-0.084	-1000.0
Signaling mediated by p38-gamma and p38-delta	4.0	64.0	15.0	-0.0	0.02	1000.0	-1000.0	-0.032	-1000.0
Retinoic acid receptors-mediated signaling	4.0	252.0	58.0	-0.158	0.033	1000.0	-1000.0	-0.061	-1000.0
Insulin Pathway	4.0	321.0	74.0	-0.146	0.03	1000.0	-1000.0	-0.077	-1000.0
VEGFR1 specific signals	4.0	267.0	56.0	-0.302	0.041	1000.0	-1000.0	-0.069	-1000.0
p38 MAPK signaling pathway	4.0	202.0	44.0	-0.077	0.027	1000.0	-1000.0	-0.058	-1000.0
Ras signaling in the CD4+ TCR pathway	4.0	68.0	17.0	-0.011	0.021	1000.0	-1000.0	-0.04	-1000.0
Signaling events mediated by HDAC Class II	3.0	289.0	75.0	-0.044	0.027	1000.0	-1000.0	-0.055	-1000.0
Circadian rhythm pathway	3.0	81.0	22.0	-0.037	0.033	1000.0	-1000.0	-0.056	-1000.0
JNK signaling in the CD4+ TCR pathway	3.0	57.0	17.0	-0.013	0.031	1000.0	-1000.0	-0.054	-1000.0
Arf6 downstream pathway	3.0	146.0	43.0	-0.054	0.027	1000.0	-1000.0	-0.035	-1000.0
IFN-gamma pathway	3.0	215.0	68.0	-0.076	0.047	1000.0	-1000.0	-0.087	-1000.0
Ceramide signaling pathway	3.0	289.0	76.0	-0.091	0.034	1000.0	-1000.0	-0.055	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	3.0	271.0	83.0	-0.06	0.04	1000.0	-1000.0	-0.075	-1000.0
Signaling events mediated by HDAC Class I	3.0	315.0	104.0	-0.052	0.043	1000.0	-1000.0	-0.066	-1000.0
IL2 signaling events mediated by PI3K	3.0	183.0	58.0	-0.131	0.064	1000.0	-1000.0	-0.077	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	3.0	278.0	74.0	-0.118	0.061	1000.0	-1000.0	-0.077	-1000.0
Class I PI3K signaling events	3.0	259.0	73.0	-0.054	0.025	1000.0	-1000.0	-0.064	-1000.0
TRAIL signaling pathway	2.0	103.0	48.0	-0.01	0.04	1000.0	-1000.0	-0.057	-1000.0
TCGA08_rtk_signaling	2.0	63.0	26.0	-0.024	0.037	1000.0	-1000.0	-0.018	-1000.0
E-cadherin signaling in the nascent adherens junction	2.0	160.0	76.0	-0.055	0.05	1000.0	-1000.0	-0.071	-1000.0
S1P3 pathway	2.0	118.0	42.0	-0.03	0.022	1000.0	-1000.0	-0.057	-1000.0
Canonical NF-kappaB pathway	1.0	42.0	39.0	-0.017	0.066	1000.0	-1000.0	-0.072	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	8.0	5.0	-0.003	0.008	1000.0	-1000.0	-0.036	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	83.0	45.0	-0.015	0.061	1000.0	-1000.0	-0.088	-1000.0
IGF1 pathway	1.0	94.0	57.0	-0.04	0.043	1000.0	-1000.0	-0.079	-1000.0
Rapid glucocorticoid signaling	1.0	34.0	20.0	-0.005	0.01	1000.0	-1000.0	-0.029	-1000.0
PDGFR-beta signaling pathway	1.0	188.0	97.0	-0.045	0.048	1000.0	-1000.0	-0.066	-1000.0
E-cadherin signaling events	1.0	8.0	5.0	-0.003	0.01	1000.0	-1000.0	-0.038	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	9.0	23.0	-0.003	0.036	1000.0	-1000.0	-0.063	-1000.0
EPO signaling pathway	0.0	37.0	55.0	-0.004	0.06	1000.0	-1000.0	-0.084	-1000.0
Insulin-mediated glucose transport	0.0	19.0	32.0	-0.004	0.034	1000.0	-1000.0	-0.055	-1000.0
mTOR signaling pathway	0.0	10.0	53.0	-0.001	0.026	1000.0	-1000.0	-0.054	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	22.0	68.0	-0.033	0.046	1000.0	-1000.0	-0.057	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	35.0	37.0	-0.005	0.027	1000.0	-1000.0	-0.064	-1000.0
ceramide signaling pathway	0.0	45.0	49.0	-0.015	0.037	1000.0	-1000.0	-0.041	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	18.0	36.0	-0.004	0.018	1000.0	-1000.0	-0.061	-1000.0
Atypical NF-kappaB pathway	0.0	8.0	31.0	-0.002	0.038	1000.0	-1000.0	-0.061	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	14.0	27.0	-0.002	0.023	1000.0	-1000.0	-0.044	-1000.0
E-cadherin signaling in keratinocytes	0.0	25.0	43.0	-0.007	0.038	1000.0	-1000.0	-0.057	-1000.0
Arf1 pathway	0.0	12.0	54.0	-0.005	0.025	1000.0	-1000.0	-0.039	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.01	1000.0	-1000.0	-0.057	-1000.0
Total	2084	120820	7203	-18.6505941735	-995.167923848	131000	-131000	-8.37202026787	-131000