E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.004 0.066 -9999.0 0.0 -0.31 14.0 14.0 KLHL20 0.001 0.053 0.164 2.0 -0.211 8.0 10.0 CYFIP2 0.015 0.042 -9999.0 0.0 -0.335 5.0 5.0 Rac1/GDP -0.009 0.061 0.384 2.0 -0.256 6.0 8.0 ENAH -0.004 0.068 -9999.0 0.0 -0.311 15.0 15.0 AP1M1 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.027 0.023 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.014 0.026 -9999.0 0.0 -0.14 10.0 10.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.044 0.03 -9999.0 0.0 -0.188 3.0 3.0 RAPGEF1 -0.009 0.058 0.213 1.0 -0.311 6.0 7.0 CTNND1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.006 0.071 -9999.0 0.0 -0.318 15.0 15.0 CRK -0.01 0.056 -9999.0 0.0 -0.311 10.0 10.0 E-cadherin/gamma catenin/alpha catenin 0.039 0.022 -9999.0 0.0 -0.202 2.0 2.0 alphaE/beta7 Integrin 0.027 0.017 -9999.0 0.0 -0.236 1.0 1.0 IQGAP1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.021 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.034 0.016 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.001 0.062 -9999.0 0.0 -0.316 12.0 12.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.025 0.016 -9999.0 0.0 -0.133 2.0 2.0 MLLT4 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.053 0.06 0.216 36.0 -0.175 3.0 39.0 PI3K -0.031 0.02 -9999.0 0.0 -0.167 2.0 2.0 ARF6 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.029 0.021 -9999.0 0.0 -0.236 2.0 2.0 TIAM1 0.017 0.038 -9999.0 0.0 -0.334 4.0 4.0 E-cadherin(dimer)/Ca2+ 0.045 0.022 -9999.0 0.0 -0.175 2.0 2.0 AKT1 -0.016 0.026 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.019 0.027 -9999.0 0.0 -0.335 2.0 2.0 RhoA/GDP -0.009 0.065 0.384 2.0 -0.253 5.0 7.0 actin cytoskeleton organization 0.004 0.045 0.151 7.0 -0.157 7.0 14.0 CDC42/GDP -0.01 0.065 0.384 2.0 -0.261 5.0 7.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.009 0.015 -9999.0 0.0 -0.19 2.0 2.0 ITGB7 0.02 0.019 -9999.0 0.0 -0.335 1.0 1.0 RAC1 0.019 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.049 0.024 -9999.0 0.0 -0.187 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.034 0.019 -9999.0 0.0 -0.169 2.0 2.0 mol:GDP -0.01 0.07 0.402 2.0 -0.29 6.0 8.0 CDC42/GTP/IQGAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.006 0.059 -9999.0 0.0 -0.255 4.0 4.0 RAC1/GTP/IQGAP1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.004 0.036 0.132 6.0 -0.16 3.0 9.0 NME1 0.056 0.099 0.331 40.0 -9999.0 0.0 40.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.0 0.059 -9999.0 0.0 -0.318 10.0 10.0 regulation of cell-cell adhesion -0.024 0.02 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.002 0.024 -9999.0 0.0 -0.089 1.0 1.0 Rap1/GTP -0.024 0.03 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.05 0.034 -9999.0 0.0 -0.181 3.0 3.0 CCND1 0.004 0.04 0.135 5.0 -0.18 4.0 9.0 VAV2 -0.007 0.122 -9999.0 0.0 -0.594 11.0 11.0 RAP1/GDP -0.019 0.044 0.194 1.0 -0.233 2.0 3.0 adherens junction assembly 0.0 0.057 -9999.0 0.0 -0.31 10.0 10.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.02 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.035 0.029 -9999.0 0.0 -0.178 3.0 3.0 E-cadherin/beta catenin 0.004 0.023 -9999.0 0.0 -0.281 2.0 2.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.005 0.069 -9999.0 0.0 -0.314 15.0 15.0 PIK3CA 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.004 0.065 -9999.0 0.0 -0.319 11.0 11.0 E-cadherin/beta catenin/alpha catenin 0.039 0.022 -9999.0 0.0 -0.202 2.0 2.0 ITGAE 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.002 0.071 -9999.0 0.0 -0.324 15.0 15.0