Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.034 0.054 0.246 4.0 -0.235 15.0 19.0 KIRREL 0.017 0.04 -9999.0 0.0 -0.343 4.0 4.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.034 0.054 0.236 15.0 -0.247 4.0 19.0 PLCG1 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.05 0.052 0.22 15.0 -0.186 4.0 19.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.013 0.036 0.163 2.0 -0.199 4.0 6.0 FYN 0.018 0.087 0.217 48.0 -0.179 4.0 52.0 mol:Ca2+ 0.047 0.05 0.212 15.0 -0.185 4.0 19.0 mol:DAG 0.048 0.051 0.216 15.0 -0.186 4.0 19.0 NPHS2 -0.004 0.023 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 0.048 0.051 0.216 15.0 -0.186 4.0 19.0 regulation of endocytosis 0.035 0.045 0.201 14.0 -0.172 4.0 18.0 Nephrin/NEPH1/podocin/Cholesterol 0.039 0.048 0.206 15.0 -0.18 4.0 19.0 establishment of cell polarity 0.034 0.054 0.235 15.0 -0.246 4.0 19.0 Nephrin/NEPH1/podocin/NCK1-2 0.057 0.053 -9999.0 0.0 -0.174 4.0 4.0 Nephrin/NEPH1/beta Arrestin2 0.036 0.046 0.208 14.0 -0.174 4.0 18.0 NPHS1 0.036 0.076 0.34 19.0 -9999.0 0.0 19.0 Nephrin/NEPH1/podocin 0.037 0.045 0.207 15.0 -0.179 4.0 19.0 TJP1 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.021 0.002 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.049 0.052 0.22 15.0 -0.186 4.0 19.0 CD2AP 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.049 0.051 0.22 14.0 -0.186 4.0 18.0 GRB2 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.006 0.095 0.221 43.0 -0.181 21.0 64.0 cytoskeleton organization -0.004 0.051 0.229 8.0 -0.213 4.0 12.0 Nephrin/NEPH1 0.029 0.042 0.193 15.0 -0.165 4.0 19.0 Nephrin/NEPH1/ZO-1 0.04 0.049 0.22 14.0 -0.197 4.0 18.0