Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.009 0.027 -9999.0 0.0 -0.176 7.0 7.0 epithelial cell differentiation 0.041 0.021 -9999.0 0.0 -0.173 2.0 2.0 CYFIP2 0.015 0.042 -9999.0 0.0 -0.335 5.0 5.0 ENAH -0.016 0.063 0.354 3.0 -0.235 1.0 4.0 EGFR 0.017 0.037 0.331 1.0 -0.335 3.0 4.0 EPHA2 0.015 0.042 -9999.0 0.0 -0.335 5.0 5.0 MYO6 -0.018 0.044 0.24 7.0 -9999.0 0.0 7.0 CTNNB1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.038 0.025 -9999.0 0.0 -0.202 3.0 3.0 AQP5 -0.063 0.171 0.442 3.0 -0.378 69.0 72.0 CTNND1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.018 0.044 0.229 8.0 -9999.0 0.0 8.0 regulation of calcium-dependent cell-cell adhesion -0.097 0.079 0.162 3.0 -0.171 176.0 179.0 EGF 0.073 0.125 0.331 63.0 -0.335 3.0 66.0 NCKAP1 0.021 0.002 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.026 0.081 0.239 1.0 -0.315 21.0 22.0 cortical microtubule organization 0.041 0.021 -9999.0 0.0 -0.173 2.0 2.0 GO:0000145 -0.017 0.043 0.218 8.0 -0.161 2.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.045 0.022 -9999.0 0.0 -0.175 2.0 2.0 MLLT4 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.033 0.025 -9999.0 0.0 -0.17 4.0 4.0 ARF6 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.04 0.036 -9999.0 0.0 -0.187 5.0 5.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.01 0.043 0.222 8.0 -9999.0 0.0 8.0 PVRL2 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.018 0.045 0.231 8.0 -0.171 2.0 10.0 ARF6/GTP 0.042 0.036 -9999.0 0.0 -0.178 4.0 4.0 CDH1 0.019 0.027 -9999.0 0.0 -0.335 2.0 2.0 EGFR/EGFR/EGF/EGF 0.043 0.054 0.247 1.0 -0.171 6.0 7.0 RhoA/GDP 0.042 0.022 -9999.0 0.0 -0.169 2.0 2.0 actin cytoskeleton organization -0.019 0.042 0.225 7.0 -0.174 2.0 9.0 IGF-1R heterotetramer 0.02 0.019 -9999.0 0.0 -0.334 1.0 1.0 GIT1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.02 0.019 -9999.0 0.0 -0.335 1.0 1.0 IGF1 0.018 0.041 0.331 1.0 -0.335 4.0 5.0 DIAPH1 0.015 0.123 -9999.0 0.0 -0.564 9.0 9.0 Wnt receptor signaling pathway -0.041 0.021 0.173 2.0 -9999.0 0.0 2.0 RHOA 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.034 0.028 -9999.0 0.0 -0.195 5.0 5.0 CTNNA1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.02 0.042 0.226 7.0 -0.178 2.0 9.0 EFNA1 0.017 0.02 -9999.0 0.0 -0.335 1.0 1.0 LPP -0.021 0.043 0.221 8.0 -0.168 1.0 9.0 Ephrin A1/EPHA2 0.026 0.037 -9999.0 0.0 -0.188 7.0 7.0 SEC6/SEC8 -0.025 0.019 -9999.0 0.0 -0.171 1.0 1.0 MGAT3 -0.098 0.08 0.164 3.0 -0.173 176.0 179.0 HGF/MET 0.022 0.057 -9999.0 0.0 -0.175 23.0 23.0 HGF 0.009 0.076 0.331 3.0 -0.335 14.0 17.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.009 0.027 -9999.0 0.0 -0.177 7.0 7.0 actin cable formation 0.01 0.088 0.339 10.0 -0.249 3.0 13.0 KIAA1543 -0.02 0.031 0.182 6.0 -0.163 2.0 8.0 KIFC3 -0.024 0.023 0.164 3.0 -9999.0 0.0 3.0 NCK1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.016 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.018 0.044 0.231 8.0 -0.171 1.0 9.0 NCK1/GIT1 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.041 0.021 -9999.0 0.0 -0.173 2.0 2.0 EXOC4 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.021 0.032 0.193 6.0 -9999.0 0.0 6.0 PIP5K1C -0.018 0.045 0.231 8.0 -9999.0 0.0 8.0 LIMA1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.005 0.083 0.347 7.0 -0.268 1.0 8.0 adherens junction assembly -0.026 0.1 0.36 6.0 -0.458 8.0 14.0 IGF-1R heterotetramer/IGF1 0.032 0.033 -9999.0 0.0 -0.169 7.0 7.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.013 0.073 0.331 5.0 -0.335 11.0 16.0 PLEKHA7 -0.021 0.032 0.193 6.0 -0.171 2.0 8.0 mol:GTP 0.038 0.035 -9999.0 0.0 -0.186 5.0 5.0 establishment of epithelial cell apical/basal polarity 0.02 0.097 0.309 13.0 -9999.0 0.0 13.0 cortical actin cytoskeleton stabilization 0.009 0.027 -9999.0 0.0 -0.176 7.0 7.0 regulation of cell-cell adhesion -0.019 0.042 0.225 7.0 -0.174 2.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.009 0.027 -9999.0 0.0 -0.177 7.0 7.0