Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	167.0	8555.0	51.0	-0.04	0.826	1000.0	-1000.0	-0.096	-1000.0
Glypican 2 network	120.0	481.0	4.0	0.084	0.138	1000.0	-1000.0	0.016	-1000.0
Angiopoietin receptor Tie2-mediated signaling	92.0	8182.0	88.0	-0.504	0.104	1000.0	-1000.0	-0.053	-1000.0
Aurora B signaling	90.0	6092.0	67.0	-0.152	0.295	1000.0	-1000.0	-0.028	-1000.0
HIF-1-alpha transcription factor network	85.0	6516.0	76.0	-0.045	0.434	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by the Hedgehog family	77.0	4053.0	52.0	-0.231	0.109	1000.0	-1000.0	-0.025	-1000.0
PLK1 signaling events	58.0	5008.0	85.0	-0.054	0.205	1000.0	-1000.0	-0.025	-1000.0
Endothelins	55.0	5288.0	96.0	-0.3	0.201	1000.0	-1000.0	-0.035	-1000.0
Aurora C signaling	49.0	349.0	7.0	-0.0	0.173	1000.0	-1000.0	-0.005	-1000.0
Signaling mediated by p38-alpha and p38-beta	43.0	1934.0	44.0	-0.096	0.021	1000.0	-1000.0	-0.02	-1000.0
Visual signal transduction: Cones	42.0	1615.0	38.0	-0.084	0.12	1000.0	-1000.0	-0.015	-1000.0
Fc-epsilon receptor I signaling in mast cells	41.0	3995.0	97.0	-0.11	0.021	1000.0	-1000.0	-0.04	-1000.0
FOXA2 and FOXA3 transcription factor networks	40.0	1869.0	46.0	-0.227	0.152	1000.0	-1000.0	-0.091	-1000.0
Signaling events regulated by Ret tyrosine kinase	39.0	3254.0	82.0	-0.084	0.064	1000.0	-1000.0	-0.047	-1000.0
Osteopontin-mediated events	38.0	1462.0	38.0	-0.004	0.252	1000.0	-1000.0	-0.027	-1000.0
IL4-mediated signaling events	38.0	3503.0	91.0	-0.64	0.351	1000.0	-1000.0	-0.112	-1000.0
BMP receptor signaling	37.0	2999.0	81.0	-0.186	0.237	1000.0	-1000.0	-0.021	-1000.0
amb2 Integrin signaling	36.0	2967.0	82.0	-0.307	0.08	1000.0	-1000.0	-0.028	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	33.0	1766.0	52.0	-0.142	0.045	1000.0	-1000.0	-0.031	-1000.0
Ephrin B reverse signaling	32.0	1555.0	48.0	-0.077	0.08	1000.0	-1000.0	-0.027	-1000.0
Visual signal transduction: Rods	32.0	1685.0	52.0	-0.084	0.102	1000.0	-1000.0	-0.032	-1000.0
Syndecan-1-mediated signaling events	29.0	999.0	34.0	-0.0	0.221	1000.0	-1000.0	-0.021	-1000.0
p75(NTR)-mediated signaling	28.0	3529.0	125.0	-0.141	0.141	1000.0	-1000.0	-0.044	-1000.0
IL23-mediated signaling events	28.0	1725.0	60.0	-0.182	0.026	1000.0	-1000.0	-0.084	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	26.0	1822.0	68.0	-0.152	0.068	1000.0	-1000.0	-0.049	-1000.0
LPA4-mediated signaling events	25.0	300.0	12.0	-0.074	0.0	1000.0	-1000.0	-0.015	-1000.0
Integrins in angiogenesis	25.0	2122.0	84.0	-0.09	0.248	1000.0	-1000.0	-0.038	-1000.0
TCGA08_retinoblastoma	24.0	199.0	8.0	-0.021	0.099	1000.0	-1000.0	-0.003	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	24.0	2902.0	120.0	-0.165	0.144	1000.0	-1000.0	-0.043	-1000.0
Arf6 signaling events	23.0	1452.0	62.0	-0.108	0.073	1000.0	-1000.0	-0.025	-1000.0
Canonical Wnt signaling pathway	23.0	1214.0	51.0	-0.211	0.095	1000.0	-1000.0	-0.026	-1000.0
Thromboxane A2 receptor signaling	22.0	2411.0	105.0	-0.105	0.073	1000.0	-1000.0	-0.036	-1000.0
Presenilin action in Notch and Wnt signaling	22.0	1357.0	61.0	-0.211	0.095	1000.0	-1000.0	-0.027	-1000.0
Aurora A signaling	22.0	1354.0	60.0	-0.028	0.197	1000.0	-1000.0	-0.019	-1000.0
Glucocorticoid receptor regulatory network	21.0	2406.0	114.0	-0.284	0.175	1000.0	-1000.0	-0.039	-1000.0
Reelin signaling pathway	21.0	1208.0	56.0	-0.038	0.047	1000.0	-1000.0	-0.023	-1000.0
HIF-2-alpha transcription factor network	21.0	942.0	43.0	-0.137	0.15	1000.0	-1000.0	-0.036	-1000.0
IL6-mediated signaling events	21.0	1592.0	75.0	-0.153	0.049	1000.0	-1000.0	-0.036	-1000.0
EGFR-dependent Endothelin signaling events	21.0	445.0	21.0	-0.022	0.073	1000.0	-1000.0	-0.03	-1000.0
Wnt signaling	20.0	146.0	7.0	-0.027	0.039	1000.0	-1000.0	-0.011	-1000.0
Glypican 1 network	18.0	884.0	48.0	-0.051	0.037	1000.0	-1000.0	-0.021	-1000.0
FoxO family signaling	18.0	1171.0	64.0	0.0	0.21	1000.0	-1000.0	-0.054	-1000.0
Effects of Botulinum toxin	18.0	493.0	26.0	-0.0	0.041	1000.0	-1000.0	-0.007	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	18.0	601.0	33.0	-0.08	0.097	1000.0	-1000.0	-0.023	-1000.0
Nongenotropic Androgen signaling	17.0	898.0	52.0	-0.069	0.05	1000.0	-1000.0	-0.021	-1000.0
ErbB2/ErbB3 signaling events	16.0	1058.0	65.0	-0.048	0.03	1000.0	-1000.0	-0.055	-1000.0
Noncanonical Wnt signaling pathway	16.0	425.0	26.0	-0.047	0.039	1000.0	-1000.0	-0.027	-1000.0
TCGA08_p53	16.0	113.0	7.0	-0.02	0.019	1000.0	-1000.0	-0.008	-1000.0
Syndecan-4-mediated signaling events	16.0	1079.0	67.0	-0.043	0.139	1000.0	-1000.0	-0.031	-1000.0
S1P4 pathway	16.0	419.0	25.0	-0.028	0.027	1000.0	-1000.0	-0.014	-1000.0
ErbB4 signaling events	15.0	1080.0	69.0	-0.114	0.138	1000.0	-1000.0	-0.025	-1000.0
Syndecan-2-mediated signaling events	15.0	1049.0	69.0	-0.045	0.059	1000.0	-1000.0	-0.035	-1000.0
PDGFR-alpha signaling pathway	15.0	689.0	44.0	-0.187	0.038	1000.0	-1000.0	-0.03	-1000.0
IL1-mediated signaling events	15.0	965.0	62.0	-0.077	0.041	1000.0	-1000.0	-0.04	-1000.0
Regulation of Androgen receptor activity	15.0	1072.0	70.0	-0.141	0.125	1000.0	-1000.0	-0.038	-1000.0
PLK2 and PLK4 events	14.0	42.0	3.0	-0.005	0.039	1000.0	-1000.0	-0.018	-1000.0
EPHB forward signaling	14.0	1226.0	85.0	-0.031	0.09	1000.0	-1000.0	-0.043	-1000.0
Calcium signaling in the CD4+ TCR pathway	14.0	453.0	31.0	-0.036	0.036	1000.0	-1000.0	-0.034	-1000.0
LPA receptor mediated events	14.0	1496.0	102.0	-0.057	0.071	1000.0	-1000.0	-0.048	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	13.0	442.0	34.0	-0.034	0.057	1000.0	-1000.0	-0.023	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	13.0	711.0	54.0	-0.032	0.109	1000.0	-1000.0	-0.024	-1000.0
Nectin adhesion pathway	13.0	848.0	63.0	-0.039	0.051	1000.0	-1000.0	-0.031	-1000.0
S1P5 pathway	13.0	235.0	17.0	-0.02	0.021	1000.0	-1000.0	-0.002	-1000.0
FAS signaling pathway (CD95)	13.0	632.0	47.0	-0.226	0.034	1000.0	-1000.0	-0.033	-1000.0
Class IB PI3K non-lipid kinase events	13.0	39.0	3.0	-0.008	0.008	1000.0	-1000.0	-0.021	-1000.0
IL12-mediated signaling events	12.0	1081.0	87.0	-0.131	0.06	1000.0	-1000.0	-0.068	-1000.0
Signaling events mediated by PTP1B	12.0	956.0	76.0	-0.053	0.074	1000.0	-1000.0	-0.035	-1000.0
Ceramide signaling pathway	12.0	986.0	76.0	-0.02	0.073	1000.0	-1000.0	-0.026	-1000.0
BCR signaling pathway	12.0	1207.0	99.0	-0.046	0.08	1000.0	-1000.0	-0.044	-1000.0
Plasma membrane estrogen receptor signaling	12.0	1090.0	86.0	-0.061	0.057	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	12.0	952.0	78.0	-0.047	0.023	1000.0	-1000.0	-0.032	-1000.0
Coregulation of Androgen receptor activity	11.0	891.0	76.0	-0.062	0.096	1000.0	-1000.0	-0.013	-1000.0
BARD1 signaling events	11.0	631.0	57.0	-0.046	0.117	1000.0	-1000.0	-0.032	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	11.0	960.0	85.0	-0.07	0.037	1000.0	-1000.0	-0.033	-1000.0
S1P1 pathway	11.0	398.0	36.0	-0.081	0.021	1000.0	-1000.0	-0.03	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	11.0	868.0	74.0	-0.098	0.073	1000.0	-1000.0	-0.051	-1000.0
Signaling events mediated by HDAC Class III	10.0	403.0	40.0	-0.06	0.068	1000.0	-1000.0	-0.03	-1000.0
TCR signaling in naïve CD8+ T cells	10.0	994.0	93.0	-0.027	0.032	1000.0	-1000.0	-0.04	-1000.0
Caspase cascade in apoptosis	9.0	739.0	74.0	-0.028	0.085	1000.0	-1000.0	-0.039	-1000.0
Syndecan-3-mediated signaling events	9.0	340.0	35.0	-0.116	0.045	1000.0	-1000.0	-0.018	-1000.0
Regulation of p38-alpha and p38-beta	9.0	503.0	54.0	-0.039	0.056	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	9.0	1213.0	125.0	-0.187	0.041	1000.0	-1000.0	-0.037	-1000.0
IL2 signaling events mediated by STAT5	8.0	184.0	22.0	-0.026	0.105	1000.0	-1000.0	-0.025	-1000.0
Ephrin A  reverse signaling	7.0	52.0	7.0	-0.013	0.029	1000.0	-1000.0	-0.013	-1000.0
Hedgehog signaling events mediated by Gli proteins	7.0	482.0	65.0	-0.139	0.048	1000.0	-1000.0	-0.033	-1000.0
IL27-mediated signaling events	7.0	359.0	51.0	-0.045	0.038	1000.0	-1000.0	-0.05	-1000.0
PDGFR-beta signaling pathway	7.0	707.0	97.0	-0.036	0.052	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by PRL	7.0	268.0	34.0	-0.023	0.09	1000.0	-1000.0	-0.029	-1000.0
Regulation of nuclear SMAD2/3 signaling	6.0	845.0	136.0	-0.178	0.071	1000.0	-1000.0	-0.036	-1000.0
JNK signaling in the CD4+ TCR pathway	6.0	103.0	17.0	-0.005	0.046	1000.0	-1000.0	-0.018	-1000.0
Class I PI3K signaling events	6.0	509.0	73.0	-0.039	0.049	1000.0	-1000.0	-0.024	-1000.0
Insulin Pathway	6.0	505.0	74.0	-0.1	0.051	1000.0	-1000.0	-0.033	-1000.0
VEGFR1 specific signals	6.0	369.0	56.0	-0.187	0.049	1000.0	-1000.0	-0.029	-1000.0
Sphingosine 1-phosphate (S1P) pathway	5.0	162.0	28.0	-0.02	0.032	1000.0	-1000.0	-0.018	-1000.0
Cellular roles of Anthrax toxin	5.0	230.0	39.0	-0.033	0.028	1000.0	-1000.0	-0.019	-1000.0
EPO signaling pathway	5.0	319.0	55.0	-0.024	0.046	1000.0	-1000.0	-0.027	-1000.0
mTOR signaling pathway	5.0	310.0	53.0	-0.054	0.024	1000.0	-1000.0	-0.026	-1000.0
IFN-gamma pathway	5.0	395.0	68.0	-0.027	0.062	1000.0	-1000.0	-0.04	-1000.0
ceramide signaling pathway	5.0	270.0	49.0	-0.01	0.026	1000.0	-1000.0	-0.035	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	5.0	418.0	83.0	-0.062	0.04	1000.0	-1000.0	-0.018	-1000.0
Retinoic acid receptors-mediated signaling	5.0	338.0	58.0	-0.095	0.04	1000.0	-1000.0	-0.028	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	5.0	255.0	45.0	-0.024	0.049	1000.0	-1000.0	-0.042	-1000.0
Arf6 trafficking events	5.0	360.0	71.0	-0.039	0.038	1000.0	-1000.0	-0.033	-1000.0
Regulation of Telomerase	5.0	599.0	102.0	-0.02	0.094	1000.0	-1000.0	-0.034	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	87.0	17.0	-0.004	0.03	1000.0	-1000.0	-0.019	-1000.0
Arf6 downstream pathway	4.0	177.0	43.0	-0.051	0.055	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by HDAC Class I	4.0	444.0	104.0	-0.034	0.047	1000.0	-1000.0	-0.03	-1000.0
IL2 signaling events mediated by PI3K	4.0	239.0	58.0	-0.014	0.07	1000.0	-1000.0	-0.037	-1000.0
E-cadherin signaling in the nascent adherens junction	4.0	356.0	76.0	-0.031	0.056	1000.0	-1000.0	-0.044	-1000.0
p38 MAPK signaling pathway	4.0	195.0	44.0	-0.008	0.062	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by HDAC Class II	3.0	261.0	75.0	-0.021	0.057	1000.0	-1000.0	-0.024	-1000.0
Circadian rhythm pathway	3.0	73.0	22.0	-0.004	0.05	1000.0	-1000.0	-0.02	-1000.0
Class I PI3K signaling events mediated by Akt	3.0	217.0	68.0	-0.028	0.046	1000.0	-1000.0	-0.025	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	55.0	15.0	-0.018	0.021	1000.0	-1000.0	-0.021	-1000.0
TCGA08_rtk_signaling	3.0	97.0	26.0	-0.011	0.047	1000.0	-1000.0	-0.006	-1000.0
IGF1 pathway	3.0	227.0	57.0	-0.032	0.048	1000.0	-1000.0	-0.03	-1000.0
S1P3 pathway	3.0	133.0	42.0	-0.025	0.034	1000.0	-1000.0	-0.025	-1000.0
Canonical NF-kappaB pathway	2.0	81.0	39.0	-0.016	0.042	1000.0	-1000.0	-0.018	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	74.0	37.0	-0.025	0.05	1000.0	-1000.0	-0.019	-1000.0
TRAIL signaling pathway	2.0	106.0	48.0	-0.017	0.045	1000.0	-1000.0	-0.023	-1000.0
E-cadherin signaling in keratinocytes	2.0	122.0	43.0	-0.014	0.039	1000.0	-1000.0	-0.024	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	23.0	23.0	0.0	0.036	1000.0	-1000.0	-0.017	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	7.0	5.0	0.019	0.03	1000.0	-1000.0	0.018	-1000.0
Insulin-mediated glucose transport	1.0	59.0	32.0	-0.016	0.038	1000.0	-1000.0	-0.016	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	54.0	36.0	-0.036	0.038	1000.0	-1000.0	-0.025	-1000.0
Atypical NF-kappaB pathway	1.0	38.0	31.0	-0.017	0.029	1000.0	-1000.0	-0.022	-1000.0
Rapid glucocorticoid signaling	1.0	27.0	20.0	-0.008	0.026	1000.0	-1000.0	-0.008	-1000.0
E-cadherin signaling events	1.0	6.0	5.0	0.019	0.039	1000.0	-1000.0	0.017	-1000.0
Arf1 pathway	1.0	90.0	54.0	-0.008	0.034	1000.0	-1000.0	-0.016	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	19.0	27.0	-0.019	0.045	1000.0	-1000.0	-0.028	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.055	1000.0	-1000.0	0.0	-1000.0
Total	2441	144891	7203	-9.66251921749	10.9465715856	131000	-131000	-3.8515691803	-131000