rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IFNG(4), IL12A(3), IL2(5)	1033019	14	12	13	1	2	7	2	2	1	0	0.149	0.229	1.000
2	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(4), COQ5(5), COQ6(3), COQ7(1), NDUFA12(2), NDUFA13(4), NDUFB11(1)	1380412	20	14	20	2	5	5	5	1	4	0	0.0820	0.307	1.000
3	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(2), CHRNA1(7), SNAP25(4), STX1A(3)	1118665	16	13	16	3	5	3	5	1	2	0	0.203	0.345	1.000
4	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	11	CCNE1(3), CDK2(4), CDKN1B(3), CUL1(6), E2F1(3), NEDD8(2), SKP2(4), TFDP1(3), UBE2M(1)	2352746	29	22	29	4	5	6	10	6	2	0	0.0820	0.346	1.000
5	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(9), CYP2C9(3)	690893	12	11	12	3	2	3	3	2	2	0	0.540	0.393	1.000
6	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(2), MTMR1(5), MTMR2(2), MTMR6(6), NFS1(4), PHPT1(1), TPK1(5)	2218323	25	20	25	3	1	9	6	7	1	1	0.150	0.539	1.000
7	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CCNE1(3), CDC34(1), CDK2(4), CUL1(6), E2F1(3), FBXW7(4), TFDP1(3)	2268932	24	18	24	2	5	6	8	5	0	0	0.0354	0.586	1.000
8	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	TPI1(6)	566088	6	5	6	0	0	3	2	1	0	0	0.237	0.600	1.000
9	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOA(2), ALDOB(4), ALDOC(1), TPI1(6)	1340337	13	10	13	0	0	5	4	2	2	0	0.0430	0.716	1.000
10	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(3), ALDH1A2(8), BCMO1(4)	1334612	15	13	15	3	2	4	5	1	3	0	0.329	0.752	1.000
11	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(2)	390674	2	2	2	1	0	0	1	1	0	0	0.860	0.761	1.000
12	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	173582	1	1	1	3	0	0	0	0	1	0	0.995	0.766	1.000
13	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP14(3), MMP2(13), MMP9(10), RECK(7), TIMP1(1), TIMP4(1)	2582662	36	27	36	6	3	6	15	6	6	0	0.106	0.783	1.000
14	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), GOT2(4), TAT(4)	902718	10	9	10	3	4	3	2	1	0	0	0.524	0.827	1.000
15	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(22), ATR(17), CDC25C(3), CHEK1(6), CHEK2(2)	5229444	50	39	49	5	2	13	17	10	8	0	0.0550	0.844	1.000
16	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(1), FOSB(3), GRIA2(15), PPP1R1B(1)	1325681	20	19	20	8	1	6	5	1	7	0	0.779	0.867	1.000
17	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), GSTZ1(1), HGD(4)	772188	6	5	6	1	1	3	0	0	2	0	0.479	0.898	1.000
18	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(2), ALDOB(4), ALDOC(1), FBP2(1), GOT1(2), GOT2(4), GPT2(3), MDH1(2), MDH2(2), ME1(1), ME2(7), ME3(2), PGK1(5), PKLR(11), PKM2(4), RPE(2), RPIA(5), TKT(1), TPI1(6)	6166283	65	42	64	7	10	19	17	10	9	0	0.00207	0.899	1.000
19	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(2), TGDS(2), UGDH(4), UXS1(4)	1340337	13	12	13	3	1	3	5	1	3	0	0.590	0.902	1.000
20	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(4), HADH(4), HADHA(3), HADHB(4), HSD17B4(5), MECR(1), PPT1(2), PPT2(7)	2924330	30	23	28	5	4	5	9	3	8	1	0.111	0.919	1.000
21	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	8	CCNA1(2), CCNE1(3), CDC34(1), CDK2(4), CUL1(6), E2F1(3), SKP2(4), TFDP1(3)	2348395	26	20	26	5	6	7	8	5	0	0	0.200	0.925	1.000
22	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(4), IFNG(4), IL10(1), IL12A(3), IL13(1), IL15(2), IL16(9), IL1A(3), IL2(5), IL3(1), IL4(1), LTA(2)	3410955	36	29	35	5	2	15	11	6	2	0	0.0670	0.928	1.000
23	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(5), SPCS1(1), SPCS3(1)	1063476	7	7	7	2	0	1	3	2	1	0	0.615	0.942	1.000
24	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(2), TGDS(2), UGDH(4), UGP2(1), UXS1(4)	1699180	14	12	14	3	2	3	5	1	3	0	0.522	0.946	1.000
25	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CD4(3), CSF1(1), HLA-DRA(3), IFNB1(4), IFNG(4), IL10(1), IL12A(3), IL13(1), IL15(2), IL1A(3), IL2(5), IL3(1), IL4(1), LTA(2), PDGFA(6), TGFB1(2), TGFB2(8), TGFB3(1)	4545421	51	39	50	9	4	17	13	10	7	0	0.0994	0.955	1.000
26	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1), ACAT2(1), OXCT1(4)	1160343	6	5	6	2	1	1	1	1	1	1	0.778	0.984	1.000
27	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(2)	524181	2	1	2	0	1	1	0	0	0	0	0.608	0.986	1.000
28	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(3), CD80(4), HLA-DRA(3), IL10(1), IL2(5), IL4(1)	1359344	18	16	17	5	0	8	4	3	3	0	0.674	0.991	1.000
29	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(3), HLA-DRA(3)	809744	7	7	7	3	0	2	3	1	1	0	0.821	0.993	1.000
30	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	EHHADH(8), HADHA(3), SDS(2)	1650174	13	11	12	4	1	5	3	1	2	1	0.726	0.993	1.000
31	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(3), GLS2(2), GLUD1(3), GLUD2(5)	1555597	13	12	13	4	1	4	6	2	0	0	0.636	0.994	1.000
32	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(4), ACAT1(1), ACAT2(1), EHHADH(8), HADHA(3), HADHB(4), SDS(2)	2851966	23	19	22	5	1	6	8	2	5	1	0.406	0.995	1.000
33	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	SLPI(1)	581889	1	1	1	1	0	0	1	0	0	0	0.956	0.995	1.000
34	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	4	GGT1(1), SHMT1(2), SHMT2(2)	1134008	5	5	5	2	3	0	2	0	0	0	0.567	0.995	1.000
35	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3D(2), IFNG(4), IL2(5), IL2RA(3), IL4(1), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TGFBR2(2), TGFBR3(13), TOB1(1), TOB2(3)	3648199	48	36	46	10	6	20	8	7	7	0	0.262	0.995	1.000
36	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(3), CD34(4), CD3D(2), CD4(3), CD58(1), CD8A(2), IL3(1)	2134738	16	13	16	4	3	2	6	2	3	0	0.329	0.996	1.000
37	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	4	DDC(6), GOT1(2), GOT2(4), TAT(4)	1245073	16	14	16	5	5	4	2	3	2	0	0.548	0.996	1.000
38	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(1), CASP3(4), CASP8(4), CFLAR(1), PDE6D(1)	1316521	11	7	11	5	4	0	4	1	2	0	0.793	0.998	1.000
39	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH6(8), ADH7(4), ADHFE1(2)	1931157	42	27	42	11	2	29	3	4	4	0	0.600	0.998	1.000
40	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(6), EGF(9), EGFR(33), RAB5A(1), TF(4), TFRC(6)	4416036	59	41	45	11	4	14	11	17	13	0	0.355	0.999	1.000
41	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	ARF3(1), CCND1(2), CDK2(4), CDK4(2), CDKN1A(1), CDKN1B(3), E2F1(3), MDM2(2), NXT1(1), PRB1(3)	2444804	22	15	22	5	7	6	3	2	4	0	0.340	0.999	1.000
42	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1), CD28(1), CD3D(2), CD4(3)	1101948	7	7	7	6	0	2	2	1	2	0	0.969	0.999	1.000
43	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADM(3), ACAT1(1), HADHA(3)	1846885	7	7	7	5	0	0	1	2	3	1	0.971	0.999	1.000
44	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(1), ACAT2(1), ACYP2(1), EHHADH(8), GCDH(3), HADHA(3), SDHB(1), SDS(2)	2671972	20	17	18	5	1	5	9	1	3	1	0.530	0.999	1.000
45	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(2), CLOCK(2), CRY1(3), CRY2(2), CSNK1E(6), PER1(3)	2947917	18	13	18	3	7	3	6	0	2	0	0.182	0.999	1.000
46	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(6), DCN(1), FMOD(2), KERA(3), LUM(6)	1242783	18	15	18	5	2	5	3	6	2	0	0.587	0.999	1.000
47	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(2), FDPS(1), IDI1(1), SQLE(1)	1101032	5	5	5	3	0	2	2	0	1	0	0.873	0.999	1.000
48	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(22), CDC25A(4), CDC25B(1), CDC25C(3), CHEK1(6), MYT1(6), WEE1(3)	4733659	45	34	44	8	2	12	11	10	10	0	0.253	0.999	1.000
49	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(4), IFNGR1(3), IFNGR2(3), JAK1(8), JAK2(4), STAT1(4)	2833188	26	23	26	6	4	4	8	5	5	0	0.380	0.999	1.000
50	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	22	ALDOA(2), ALDOB(4), ALDOC(1), FBP2(1), GOT1(2), GOT2(4), GPT2(3), MDH1(2), MDH2(2), ME1(1), ME3(2), PGK1(5), PGK2(14), PKLR(11), PKM2(4), RPE(2), RPIA(5), TKT(1), TKTL1(10), TPI1(6)	6460777	82	55	81	14	12	25	19	14	12	0	0.0170	0.999	1.000
51	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(5), PARK2(7), SNCA(3), SNCAIP(4), UBE2E2(1), UBE2G2(1), UBE2L6(1)	2197713	22	19	22	5	2	11	6	2	1	0	0.431	1.000	1.000
52	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(14), PNPO(1), PSAT1(2)	1669868	17	15	17	7	2	7	2	2	4	0	0.863	1.000	1.000
53	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(5), BCKDK(2), CBS(1), CTH(1), MUT(6)	1685440	15	13	15	9	2	5	3	1	4	0	0.963	1.000	1.000
54	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(2), GAD1(5), HDC(7), TH(2), TPH1(11)	2096495	27	17	27	8	7	6	5	6	3	0	0.577	1.000	1.000
55	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNB1(4), JAK1(8), PTPRU(10), REG1A(9), STAT1(4), STAT2(5), TYK2(2)	4318711	42	33	41	8	4	13	8	10	7	0	0.202	1.000	1.000
56	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	PLCG1(5), PRKCA(7), PTK2B(8)	2300534	20	16	20	5	8	6	5	1	0	0	0.369	1.000	1.000
57	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(5), CSAD(3), GAD1(5), GAD2(10), GGT1(1)	1941004	24	20	24	7	5	4	6	6	3	0	0.520	1.000	1.000
58	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	6	EPHX2(1), HSD3B7(2), RDH11(2)	1449570	5	5	5	2	0	3	2	0	0	0	0.796	1.000	1.000
59	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11	ASAH1(2), BFAR(1), CAMP(2), CREB5(7), RAF1(3), SNX13(3), SRC(2)	3428130	20	12	20	4	6	6	4	2	2	0	0.310	1.000	1.000
60	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(2), HLA-DRA(3), IL3(1)	1035309	6	6	6	3	0	1	3	2	0	0	0.878	1.000	1.000
61	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR2(2), IFNB1(4), JAK1(8), STAT1(4), STAT2(5), TYK2(2)	3732929	25	23	25	5	1	4	6	8	6	0	0.418	1.000	1.000
62	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(11), GNA12(1), PRKACB(3), PRKACG(1), PRKAR2A(1)	3484922	17	13	17	3	2	5	6	2	2	0	0.274	1.000	1.000
63	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(6), ANKRD1(6), CYR61(1), DUSP14(1), EIF4E(3), HBEGF(1), IFNG(4), IFRD1(1), IL1A(3), IL1R1(1), MYOG(1), NR4A3(2), WDR1(2)	3770714	32	24	32	7	6	7	13	4	2	0	0.233	1.000	1.000
64	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), HSD3B7(2), PON1(3), PON3(5), RDH11(2)	2890209	20	18	20	5	1	7	7	4	1	0	0.406	1.000	1.000
65	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	HPRT1(1), IMPDH1(4), MTHFD2(1), POLB(2), POLD1(2), POLG(10), PRPS2(2), RRM1(5), SRM(2)	4356954	29	20	29	5	11	3	9	4	2	0	0.0746	1.000	1.000
66	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA1(2), CCNA2(4), CCND1(2), CCNE1(3), CDK2(4), CDK4(2), CDKN1B(3), E2F1(3), PRB1(3)	2919979	26	19	26	7	6	6	7	3	4	0	0.401	1.000	1.000
67	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(1), B3GALT1(2), B3GALT2(2), B3GALT5(1), B3GNT5(1), FUT1(2), FUT3(2), ST3GAL3(1), ST3GAL4(2)	2472284	14	10	14	4	4	4	4	1	1	0	0.471	1.000	1.000
68	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(2), FDPS(1), GGPS1(1), IDI1(1), SQLE(1)	1470867	6	6	6	4	0	3	2	0	1	0	0.922	1.000	1.000
69	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(5), ALPL(2), ALPP(4), ALPPL2(3), FPGS(1), GCH1(4), GGH(4)	2288626	23	18	23	7	2	2	8	6	5	0	0.518	1.000	1.000
70	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(3), CASP8(4), FADD(1), RIPK1(4), TNFRSF1B(1), TRAF2(1)	2916544	15	12	15	3	1	2	7	2	3	0	0.382	1.000	1.000
71	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(3), MAX(3), SP1(1), SP3(4), WT1(8)	2139776	19	18	19	8	1	7	4	3	4	0	0.891	1.000	1.000
72	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), APEX1(2), CREBBP(4), DFFA(3), DFFB(2), GZMA(4), GZMB(3), HMGB2(4), PRF1(5), SET(1)	3651634	29	21	29	6	5	9	7	4	4	0	0.336	1.000	1.000
73	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(3), ARG1(1), GLS(3), GLUD1(3), OAT(1)	1919478	11	10	11	4	2	1	6	1	1	0	0.672	1.000	1.000
74	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3)	2760595	30	23	30	9	5	10	9	4	2	0	0.452	1.000	1.000
75	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3)	2760595	30	23	30	9	5	10	9	4	2	0	0.452	1.000	1.000
76	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(4), ACTR2(2), ACTR3(1), ARPC1A(1), ARPC1B(1), ARPC2(1), ARPC3(2), CDC42(2), WASF1(8), WASL(5)	2788991	27	22	27	9	1	7	9	3	7	0	0.878	1.000	1.000
77	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(4), CASP7(1), DFFA(3), DFFB(2), GZMB(3), HMGB2(4), TOP2A(6), TOP2B(4)	3305615	27	18	26	6	8	6	4	5	4	0	0.461	1.000	1.000
78	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(4), LPL(5), NR3C1(3), PPARG(3), RXRA(1)	1996193	16	15	16	8	1	6	3	3	3	0	0.943	1.000	1.000
79	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(1), CCNH(1), CDC25A(4), CDC25B(1), CDC25C(3), CDK7(3), MNAT1(2), SHH(4), XPO1(3)	3034937	22	18	22	5	1	7	6	5	3	0	0.484	1.000	1.000
80	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(4), HRAS(1), PTK2B(8), SHC1(2), SOS1(12), SRC(2)	3031273	29	19	29	8	8	8	5	7	1	0	0.438	1.000	1.000
81	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(7), APC(23), AXIN1(3), BTRC(9), CTNNB1(11), DLL1(5), DVL1(1), FZD1(3), GSK3B(2), NOTCH1(8), PSEN1(1), WNT1(3)	7428531	76	52	73	12	10	18	24	10	14	0	0.0297	1.000	1.000
82	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), ACAT2(1), BDH2(1), HMGCS1(5), HMGCS2(6), OXCT1(4)	2479383	18	12	18	5	1	6	4	3	2	2	0.643	1.000	1.000
83	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(4), RAB4A(2), RAB5A(1)	1469493	7	7	7	3	0	2	1	3	1	0	0.895	1.000	1.000
84	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(9), EGFR(33), MAP2K1(6), MAP3K1(4), MAPK14(1), NCOR2(13), RARA(3), RXRA(1), THRA(1), THRB(5)	5922398	76	53	62	17	8	13	15	22	18	0	0.321	1.000	1.000
85	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(9), LARS(7), LARS2(2), PDHA1(3), PDHA2(13)	3442557	35	28	35	9	3	11	8	8	5	0	0.572	1.000	1.000
86	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	8	ACP1(2), ACP2(1), ACP5(3), ACPP(7), ENPP1(6), FLAD1(3)	2355494	22	20	22	9	0	4	10	5	3	0	0.788	1.000	1.000
87	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	FOS(1), FXYD2(1), MAFG(1), MAPK14(1), MAPK8(3), NFE2L2(5), PRKCA(7)	2664186	19	16	19	7	5	4	5	1	4	0	0.734	1.000	1.000
88	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(4), CD36(4), FOS(1), FYN(3), MAPK14(1), THBS1(4)	2528847	17	11	16	5	5	4	2	3	3	0	0.583	1.000	1.000
89	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(4), PLCD1(2), PRKCA(7), TGM2(3)	1714523	16	14	16	5	4	5	4	2	1	0	0.577	1.000	1.000
90	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(1), EGR1(2), HRAS(1), KLK2(4), MAP2K1(6), MAP2K2(1), MAPK3(1), NGFR(2), RAF1(3)	2857691	21	18	21	6	3	6	5	5	2	0	0.397	1.000	1.000
91	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL1(3), ST3GAL2(3), ST3GAL4(2), ST6GALNAC4(1), ST8SIA1(2)	1949706	11	11	11	8	3	0	6	0	2	0	0.935	1.000	1.000
92	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SEC61A2(5), SRP19(1), SRP54(2), SRP68(2), SRP72(2), SRPR(4)	2570754	17	11	16	9	3	5	6	0	3	0	0.967	1.000	1.000
93	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(5), LDLR(4), MBTPS1(6), MBTPS2(2), SCAP(4), SREBF1(2), SREBF2(2)	4127496	25	20	25	6	3	4	11	4	2	1	0.265	1.000	1.000
94	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(2), AASS(7), KARS(4)	1625442	14	10	14	6	3	4	3	3	1	0	0.883	1.000	1.000
95	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD4(3), CD8A(2), CSF1(1), EPO(3), IL2(5), IL3(1), IL4(1)	2063748	16	14	15	5	0	8	4	2	2	0	0.592	1.000	1.000
96	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), CSF1(1), LDLR(4), LPL(5)	1832916	11	11	11	6	1	3	3	3	1	0	0.922	1.000	1.000
97	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(3), F13B(16), HSD17B2(3), HSD17B3(1), HSD17B4(5), HSD17B7(1), HSD3B1(7), HSD3B2(13)	2802273	49	36	48	13	6	17	12	7	6	1	0.460	1.000	1.000
98	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(6), EIF2AK4(6), EIF2B5(3), EIF2S3(2), EIF5(2), GSK3B(2), PPP1CA(2)	3996966	23	16	23	5	4	10	5	1	3	0	0.533	1.000	1.000
99	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(1), MST1(5), MST1R(4)	2269848	10	10	8	8	1	2	5	0	2	0	0.991	1.000	1.000
100	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(1), B3GNT1(3), FUT1(2), FUT9(7), GCNT2(2), ST8SIA1(2)	2110693	17	17	16	9	3	3	5	4	2	0	0.912	1.000	1.000
101	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	5	NFYB(1), NFYC(2), SP1(1), SP3(4)	1674448	8	7	8	5	1	1	2	3	1	0	0.916	1.000	1.000
102	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(2), ALAS1(3), CPOX(4), FECH(2), HMBS(3), PPOX(3)	2627546	17	12	17	5	4	4	4	3	2	0	0.551	1.000	1.000
103	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(2), CD4(3), HLA-DRA(3), IL4(1), IL5RA(5)	1824443	14	14	14	5	0	4	6	3	1	0	0.754	1.000	1.000
104	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(7), DLL1(5), FURIN(7), NOTCH1(8), PSEN1(1)	3239434	28	22	28	8	7	6	5	3	7	0	0.515	1.000	1.000
105	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(18), RANGAP1(2)	2892499	20	14	20	8	5	7	4	1	2	1	0.870	1.000	1.000
106	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(4), CDC25B(1), CDK7(3), CDKN1A(1), CHEK1(6), NEK1(6), WEE1(3)	2473429	24	19	24	8	1	9	6	6	2	0	0.827	1.000	1.000
107	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(8), AASDHPPT(2), AASS(7), KARS(4)	2393279	22	17	22	8	5	7	4	4	2	0	0.833	1.000	1.000
108	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(3), DNAJC3(3), MAP3K14(1), NFKB1(3), NFKBIA(1)	3084859	11	10	11	7	1	1	5	0	4	0	0.967	1.000	1.000
109	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	ATM(22), CDC25A(4), CDC25B(1), CDC25C(3), CDK2(4), CDK4(2), CHEK1(6), MYT1(6), WEE1(3)	5156164	51	35	50	10	7	13	11	10	10	0	0.216	1.000	1.000
110	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNG(4), IFNGR1(3), JAK1(8), JAK2(4), PLA2G2A(3), PTPRU(10), REG1A(9), STAT1(4)	3982997	45	35	44	10	5	14	9	9	8	0	0.313	1.000	1.000
111	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(1), CSNK1D(2), DRD1(3), DRD2(9), GRM1(26), PLCB1(18), PPP1CA(2), PPP1R1B(1), PPP2CA(1), PPP3CA(5), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1)	5549128	80	61	79	18	11	27	28	3	11	0	0.120	1.000	1.000
112	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(4), ACO2(1), FH(7), IDH1(2), IDH2(2), MDH1(2), MDH2(2), SDHB(1)	3049364	21	18	21	6	2	6	5	4	4	0	0.593	1.000	1.000
113	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(3), PAPSS1(3), PAPSS2(4), SULT1A2(1), SULT1E1(1), SULT2A1(3), SUOX(5)	2092144	20	18	20	7	2	6	7	4	1	0	0.740	1.000	1.000
114	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	EIF2B5(3), EIF2S3(2), EIF4E(3), GSK3B(2), IGF1(5), IGF1R(10), INPPL1(6), PDK2(2), PDPK1(1), PIK3CA(11), PIK3R1(3), PPP2CA(1), PTEN(8), RPS6KB1(2)	6777484	59	37	55	11	10	18	18	5	8	0	0.0894	1.000	1.000
115	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA3(2), PSMA4(1), PSMA6(3), PSMA7(1), PSMB4(4), PSMB5(1), PSMB6(1), PSMD14(2), RPN2(4), UBE2A(4), UBE3A(8)	4451531	31	22	31	7	6	8	8	6	3	0	0.255	1.000	1.000
116	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT2(2), AKT3(5), CDKN1A(1), ELK1(2), GRB2(4), HRAS(1), MAP2K1(6), MAP2K2(1), NGFR(2), NTRK1(12), PIK3CA(11), PIK3CD(1), SHC1(2), SOS1(12)	5622866	62	47	58	14	4	17	18	15	8	0	0.200	1.000	1.000
117	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), LDLR(4), NR0B2(1), NR1H3(4), NR1H4(5), RXRA(1)	1876884	16	14	16	6	1	3	7	4	1	0	0.742	1.000	1.000
118	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA2(3), IL4R(5), JAK1(8), JAK2(4), TYK2(2)	3607666	23	22	23	7	1	5	6	7	4	0	0.683	1.000	1.000
119	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA2(3), IL4R(5), JAK1(8), JAK2(4), TYK2(2)	3607666	23	22	23	7	1	5	6	7	4	0	0.683	1.000	1.000
120	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(4), ACO2(1), CS(1), GRHPR(1), HAO1(4), HAO2(8), MDH1(2), MDH2(2), MTHFD1(1), MTHFD1L(5), MTHFD2(1)	4388785	30	24	30	9	6	10	5	3	6	0	0.569	1.000	1.000
121	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(3), KHK(2), LCT(30), PGM1(2), PYGL(3), PYGM(6), TPI1(6), TREH(1)	4612976	53	40	53	12	8	20	19	3	3	0	0.144	1.000	1.000
122	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(2), ALAS1(3), CPO(3), FECH(2), GATA1(2), HBB(4), HMBS(3)	2723039	19	14	19	7	3	10	2	2	2	0	0.757	1.000	1.000
123	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(3), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT5(3), FUT8(4), ST3GAL1(3), ST3GAL2(3), ST3GAL3(1), ST3GAL4(2)	2714337	23	17	22	8	8	1	9	2	3	0	0.487	1.000	1.000
124	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(5), BMPR1A(1), BMPR1B(5), BMPR2(2)	2163363	13	10	13	6	3	2	4	3	1	0	0.883	1.000	1.000
125	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(2), GNAQ(2), GNB1(2), GNGT1(2), HTR2C(6), PLCB1(18), TUB(3)	2457628	35	29	35	10	5	15	9	0	6	0	0.549	1.000	1.000
126	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(2), CAMP(2), DAG1(2), GNAQ(2), ITPKA(1), ITPKB(5)	2119166	14	11	14	6	1	5	4	3	1	0	0.795	1.000	1.000
127	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	35	ANPEP(4), G6PD(2), GCLC(8), GCLM(1), GGT1(1), GPX1(1), GPX3(1), GPX5(4), GPX6(3), GPX7(3), GSR(1), GSS(3), GSTA1(1), GSTA2(3), GSTA3(2), GSTA4(1), GSTA5(3), GSTK1(4), GSTM1(1), GSTM2(2), GSTM3(1), GSTM4(1), GSTM5(2), GSTO2(1), GSTP1(2), GSTZ1(1), IDH1(2), IDH2(2), MGST1(1), MGST3(3), OPLAH(5), TXNDC12(1)	7431279	71	43	71	14	9	21	26	7	7	1	0.0419	1.000	1.000
128	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(1), B3GAT2(3), B3GAT3(1), CHPF(3), CHST11(1), CHST12(5), CHST13(3), CHST3(2), CHSY1(2), DSE(10), UST(1), XYLT1(19)	4717629	51	44	50	12	4	12	20	10	5	0	0.166	1.000	1.000
129	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(2), POLD1(2), POLD2(2), POLE(19), POLG(10), POLL(2), POLQ(17)	5740343	54	37	53	12	16	5	20	7	6	0	0.114	1.000	1.000
130	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA3(2), PSMA4(1), PSMA6(3), PSMA7(1), PSMB4(4), PSMB5(1), PSMB6(1), PSMC2(2), PSMD1(4), PSMD11(5), PSMD12(4), PSMD13(2), PSMD2(3), PSMD6(1)	5480886	34	24	34	8	8	10	9	4	3	0	0.233	1.000	1.000
131	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	APC(23), AXIN1(3), CCND1(2), CD14(1), CTNNB1(11), DVL1(1), FZD1(3), GJA1(6), GNAI1(3), GSK3B(2), IRAK1(3), LBP(5), LEF1(8), LY96(1), MYD88(3), NFKB1(3), PDPK1(1), PIK3CA(11), PIK3R1(3), PPP2CA(1), TLR4(31), TOLLIP(1), WNT1(3)	10579800	129	81	124	24	13	32	42	18	24	0	0.0338	1.000	1.000
132	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), EHHADH(8), HADHA(3), SDS(2)	4179479	43	32	42	12	6	15	12	5	4	1	0.403	1.000	1.000
133	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(2), ACO1(4), ACO2(1), ACSS1(4), ACSS2(4), FH(7), IDH1(2), IDH2(2), MDH1(2), MDH2(2)	4555955	30	23	30	9	5	7	7	6	5	0	0.505	1.000	1.000
134	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	GRB2(4), HRAS(1), KLK2(4), NTRK1(12), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), SHC1(2), SOS1(12)	5335700	61	47	57	15	9	17	18	10	7	0	0.308	1.000	1.000
135	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GUSB(4), HEXA(1), IDS(3), IDUA(2), LCT(30), NAGLU(1)	4924874	42	37	42	11	5	14	13	4	6	0	0.372	1.000	1.000
136	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(23), AXIN1(3), BTRC(9), CCND1(2), CREBBP(4), CSNK1A1(1), CSNK1D(2), CTNNB1(11), DVL1(1), FZD1(3), GSK3B(2), HDAC1(3), MAP3K7(5), PPARD(2), PPP2CA(1), TLE1(3), WNT1(3)	10187065	78	54	75	14	11	19	25	10	13	0	0.0579	1.000	1.000
137	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	PIK3CA(11), PIK3R1(3), PLCB1(18), PLCG1(5), PRKCA(7), VAV1(1)	4363824	45	38	42	11	7	12	17	2	7	0	0.365	1.000	1.000
138	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA3(2), PSMA4(1), PSMA6(3), PSMA7(1), PSMB4(4), PSMB5(1), PSMB6(1), PSMB9(1)	3000587	14	9	14	7	4	4	4	1	1	0	0.811	1.000	1.000
139	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(2), CS(1), MDH1(2), ME1(1), PC(1), PDHA1(3), SLC25A11(2)	3167986	12	11	12	6	3	2	3	3	1	0	0.823	1.000	1.000
140	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), BCAT2(1), IARS(9), IARS2(7), ILVBL(1), LARS(7), LARS2(2), PDHA1(3), PDHA2(13), VARS(6), VARS2(8)	6351773	58	43	58	14	8	16	14	11	9	0	0.305	1.000	1.000
141	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIA(4), CHIT1(4), CMAS(3), CYB5R1(1), GFPT1(4), GFPT2(6), GNE(1), GNPDA1(1), GNPDA2(2), HEXA(1), HK1(3), HK2(9), HK3(12), LHPP(2), MTMR1(5), MTMR2(2), MTMR6(6), NAGK(1), NANS(2), NPL(3), PGM3(4), PHPT1(1), RENBP(3), UAP1(6)	9867381	87	58	87	19	15	23	17	22	10	0	0.135	1.000	1.000
142	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(23), AXIN1(3), CREBBP(4), CTNNB1(11), DVL1(1), EP300(2), FZD1(3), GSK3B(2), HDAC1(3), LDB1(1), LEF1(8), PITX2(4), TRRAP(24), WNT1(3)	11428703	92	56	90	16	17	19	27	13	16	0	0.0195	1.000	1.000
143	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(4), CD2(3), CD33(10), CD5(4), IFNB1(4), IFNG(4), IL10(1), IL12A(3), IL13(1), IL3(1), IL4(1), ITGAX(20), TLR2(2), TLR4(31), TLR7(8), TLR9(6)	6388184	103	69	103	28	9	35	24	19	15	1	0.325	1.000	1.000
144	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	20	CCNA1(2), CCNB1(1), CCND1(2), CCND2(1), CCND3(1), CCNE1(3), CCNH(1), CDC25A(4), CDK2(4), CDK4(2), CDK6(3), CDK7(3), CDKN1A(1), CDKN1B(3), CDKN2D(1), E2F1(3), RBL1(7), TFDP1(3)	4756330	45	31	45	12	8	15	11	7	4	0	0.412	1.000	1.000
145	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(2), CBS(1), CTH(1), GGT1(1), MARS(2), MARS2(8), MAT1A(4), MAT2B(3), PAPSS1(3), PAPSS2(4), SCLY(2), SEPHS1(4)	4248179	35	25	35	10	9	10	10	2	4	0	0.357	1.000	1.000
146	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(23), MAP2(17), PPP1CA(2), PPP2CA(1), PRKACB(3), PRKACG(1), PRKAR2A(1), PRKCE(3)	6259028	51	40	51	11	2	22	13	9	5	0	0.611	1.000	1.000
147	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(1), ESR2(3), ITPKA(1), PDE1A(8), PDE1B(6), PLCB1(18), PLCB2(6), PRL(1), TRH(1), VIP(1)	3826590	46	37	46	13	7	14	13	3	9	0	0.505	1.000	1.000
148	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(20), ABCB11(15), ABCB4(17), ABCC1(6), ABCC3(7), GSTP1(2)	4930599	67	51	66	20	6	18	22	10	11	0	0.477	1.000	1.000
149	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(23), ASAH1(2), CAMP(2), CASP3(4), CERK(3), CREB5(7), DAG1(2), EPHB2(7), FOS(1), GNAQ(2), ITPKA(1), ITPKB(5), MAP2K4(3), MAP2K7(2), MAPK10(5), MAPK8(3), MAPK8IP1(4), MAPK8IP3(4), MAPK9(6)	9859137	86	59	86	19	12	19	25	12	18	0	0.152	1.000	1.000
150	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3)	4584351	66	39	66	20	5	37	9	8	7	0	0.646	1.000	1.000
151	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(2), ATM(22), BRCA1(9), CDKN1A(1), CHEK1(6), CHEK2(2), GADD45A(1), MAPK8(3), MDM2(2), MRE11A(6), NFKB1(3), NFKBIA(1), RAD50(3), RAD51(1), RBBP8(3), TP73(4)	9990125	69	51	68	14	7	19	22	10	11	0	0.260	1.000	1.000
152	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	13	ABL1(2), E2F1(3), MDM2(2), PIK3CA(11), PIK3R1(3), POLR1A(8), POLR1B(10), POLR1D(2), TBX2(1), TWIST1(1)	5898582	43	29	39	11	8	8	17	6	4	0	0.270	1.000	1.000
153	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(1), FUCA1(1), FUCA2(1), HEXA(1), LCT(30), MAN2C1(4), MANBA(4), NEU1(1), NEU3(3), NEU4(6)	5739656	52	45	52	14	6	19	20	4	3	0	0.404	1.000	1.000
154	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(8), BIRC2(2), BIRC3(3), CASP10(6), CASP3(4), CASP7(1), CASP8(4), CASP9(3), DFFA(3), DFFB(2), GZMB(3), PRF1(5), SCAP(4), SREBF1(2), SREBF2(2)	6305515	52	37	52	13	7	11	13	10	11	0	0.324	1.000	1.000
155	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(3), ALOX15(4), ALOX15B(2), ALOX5(6), DPEP1(4), GGT1(1), LTA4H(1), PLA2G2A(3), PLA2G6(1), PTGDS(2), PTGIS(5), PTGS1(5), PTGS2(4), TBXAS1(6)	5174942	47	40	47	13	6	6	17	11	7	0	0.364	1.000	1.000
156	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	APAF1(8), ATM(22), BAX(1), BCL2(1), CCND1(2), CCNE1(3), CDK2(4), CDK4(2), CDKN1A(1), E2F1(3), GADD45A(1), MDM2(2), PCNA(1)	5352417	51	38	50	13	8	13	10	10	10	0	0.439	1.000	1.000
157	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	11	BCAT1(1), COASY(5), DPYD(12), DPYS(10), ENPP1(6), PANK1(2), PANK2(4), PANK3(2), PANK4(1), PPCS(1)	4178105	44	32	44	13	4	13	12	7	7	1	0.532	1.000	1.000
158	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	200	ABI2(3), ACTN1(2), ACTN2(23), ACTN3(3), ACTN4(2), APC(23), APC2(2), ARAF(3), ARHGEF1(2), ARHGEF12(11), ARHGEF4(4), ARHGEF6(9), ARHGEF7(6), ARPC1A(1), ARPC1B(1), ARPC2(1), ARPC3(2), ARPC5(1), BAIAP2(2), BCAR1(2), BDKRB1(1), BDKRB2(1), CD14(1), CDC42(2), CFL2(2), CHRM1(2), CHRM2(17), CHRM3(13), CHRM4(2), CHRM5(3), CRKL(2), CYFIP1(7), CYFIP2(8), DIAPH1(4), DIAPH2(6), DIAPH3(6), DOCK1(7), EGF(9), EGFR(33), EZR(1), F2(5), F2R(4), FGD1(2), FGD3(6), FGF1(1), FGF10(2), FGF12(4), FGF13(6), FGF18(1), FGF19(2), FGF20(1), FGF21(2), FGF23(4), FGF3(1), FGF4(2), FGF5(2), FGF9(1), FGFR1(5), FGFR2(8), FGFR3(2), FGFR4(3), FN1(13), GNA12(1), GNA13(5), GNG12(2), GRLF1(9), GSN(3), HRAS(1), IQGAP1(5), IQGAP2(13), IQGAP3(6), ITGA1(9), ITGA10(7), ITGA11(10), ITGA2(11), ITGA2B(4), ITGA3(5), ITGA4(19), ITGA5(6), ITGA6(5), ITGA7(2), ITGA8(24), ITGA9(2), ITGAD(17), ITGAE(9), ITGAL(20), ITGAM(14), ITGAV(9), ITGAX(20), ITGB1(3), ITGB2(2), ITGB3(4), ITGB4(4), ITGB5(6), ITGB6(1), ITGB7(1), ITGB8(5), LIMK2(1), MAP2K1(6), MAP2K2(1), MAPK3(1), MOS(2), MRAS(1), MSN(1), MYH10(6), MYH14(2), MYH9(8), MYL2(2), MYL5(1), MYL7(3), MYLK(16), MYLK2(3), MYLPF(1), NCKAP1(4), NCKAP1L(12), NRAS(4), PAK1(5), PAK2(3), PAK3(7), PAK4(1), PAK7(19), PDGFA(6), PDGFB(1), PDGFRA(17), PDGFRB(8), PFN1(1), PFN2(3), PFN4(1), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PIP4K2A(5), PIP4K2B(2), PIP4K2C(3), PIP5K1A(5), PIP5K1B(7), PIP5K1C(3), PPP1CA(2), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP1R12B(5), PTK2(11), PXN(1), RAC2(1), RAF1(3), RDX(2), RHOA(1), ROCK1(10), ROCK2(4), RRAS(1), RRAS2(1), SCIN(4), SLC9A1(3), SOS1(12), SOS2(6), SSH1(4), SSH2(4), SSH3(2), TIAM1(19), TIAM2(11), TMSL3(1), VAV1(1), VAV2(3), VAV3(14), VCL(2), WAS(3), WASF1(8), WASF2(1), WASL(5)	94893249	935	208	914	303	130	265	243	163	132	2	0.899	1.000	1.000
159	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	190	ACTG1(2), ACTN1(2), ACTN2(23), ACTN3(3), ACTN4(2), AKT2(2), AKT3(5), ARHGAP5(7), BCAR1(2), BCL2(1), BIRC2(2), BIRC3(3), CAPN2(3), CAV3(2), CCND1(2), CCND2(1), CCND3(1), CDC42(2), CHAD(1), COL11A1(66), COL11A2(7), COL1A1(4), COL1A2(19), COL2A1(7), COL3A1(33), COL4A1(16), COL4A2(16), COL4A4(13), COL4A6(17), COL5A1(17), COL5A2(30), COL5A3(12), COL6A1(4), COL6A2(3), COL6A3(35), COL6A6(24), COMP(2), CRKL(2), CTNNB1(11), DIAPH1(4), DOCK1(7), EGF(9), EGFR(33), ELK1(2), ERBB2(10), FARP2(3), FIGF(1), FLNA(11), FLNB(12), FLNC(18), FLT1(21), FN1(13), FYN(3), GRB2(4), GRLF1(9), GSK3B(2), HRAS(1), IBSP(2), IGF1(5), IGF1R(10), ILK(1), ITGA1(9), ITGA10(7), ITGA11(10), ITGA2(11), ITGA2B(4), ITGA3(5), ITGA4(19), ITGA5(6), ITGA6(5), ITGA7(2), ITGA8(24), ITGA9(2), ITGAV(9), ITGB1(3), ITGB3(4), ITGB4(4), ITGB5(6), ITGB6(1), ITGB7(1), ITGB8(5), KDR(30), LAMA1(36), LAMA2(33), LAMA3(25), LAMA4(15), LAMA5(15), LAMB1(21), LAMB2(13), LAMB3(8), LAMB4(23), LAMC1(14), LAMC2(9), LAMC3(13), MAP2K1(6), MAPK10(5), MAPK3(1), MAPK8(3), MAPK9(6), MET(12), MYL2(2), MYL5(1), MYL7(3), MYLK(16), MYLK2(3), MYLPF(1), PAK1(5), PAK2(3), PAK3(7), PAK4(1), PAK7(19), PARVA(2), PARVB(1), PARVG(2), PDGFA(6), PDGFB(1), PDGFD(4), PDGFRA(17), PDGFRB(8), PDPK1(1), PGF(1), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PIP5K1C(3), PPP1CA(2), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PRKCA(7), PRKCG(10), PTEN(8), PTK2(11), PXN(1), RAC2(1), RAF1(3), RAP1A(2), RAP1B(1), RAPGEF1(1), RELN(49), RHOA(1), ROCK1(10), ROCK2(4), SHC1(2), SHC2(1), SHC3(4), SHC4(4), SOS1(12), SOS2(6), SRC(2), THBS1(4), THBS2(16), THBS3(6), THBS4(5), TLN1(13), TLN2(15), TNC(21), TNN(34), TNR(40), TNXB(14), VASP(3), VAV1(1), VAV2(3), VAV3(14), VCL(2), VEGFA(1), VEGFC(11), VTN(2), VWF(13), ZYX(2)	127296291	1526	206	1492	496	200	499	376	221	227	3	0.985	1.000	1.000
160	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(10), ADCY2(18), ADCY3(5), ADCY4(6), ADCY7(7), ADCY8(22), ADCY9(3), ADORA2B(1), ADRA1A(4), ADRA1B(4), ADRA1D(2), ADRB2(2), ADRB3(3), AGTR1(5), ATP2A1(3), ATP2A2(6), ATP2A3(4), ATP2B1(9), ATP2B2(11), ATP2B3(11), ATP2B4(9), AVPR1A(6), AVPR1B(3), BDKRB1(1), BDKRB2(1), CACNA1A(10), CACNA1B(15), CACNA1C(26), CACNA1D(17), CACNA1E(50), CACNA1F(10), CACNA1G(10), CACNA1H(9), CACNA1I(7), CACNA1S(11), CALM1(2), CALML3(3), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(8), CCKAR(7), CCKBR(11), CD38(3), CHRM1(2), CHRM2(17), CHRM3(13), CHRM5(3), CHRNA7(3), CYSLTR1(1), CYSLTR2(4), DRD1(3), EDNRB(6), EGFR(33), ERBB2(10), ERBB3(3), ERBB4(21), F2R(4), GNA11(1), GNAQ(2), GNAS(7), GRIN1(2), GRIN2A(26), GRIN2C(3), GRIN2D(6), GRM1(26), GRM5(13), GRPR(5), HRH1(6), HRH2(6), HTR2A(3), HTR2B(2), HTR2C(6), HTR5A(11), HTR6(5), HTR7(3), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), LHCGR(6), MYLK(16), MYLK2(3), NOS1(9), NOS3(2), NTSR1(5), OXTR(2), P2RX1(1), P2RX2(4), P2RX3(3), P2RX4(1), P2RX5(4), P2RX7(5), PDE1A(8), PDE1B(6), PDE1C(17), PDGFRA(17), PDGFRB(8), PHKA1(4), PHKA2(10), PHKB(7), PHKG1(1), PHKG2(3), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PLCD1(2), PLCD3(2), PLCD4(3), PLCE1(14), PLCG1(5), PLCG2(9), PLCZ1(3), PLN(1), PPID(1), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRKACB(3), PRKACG(1), PRKCA(7), PRKCG(10), PRKX(3), PTAFR(2), PTGER3(4), PTGFR(6), PTK2B(8), RYR1(52), RYR2(166), RYR3(53), SLC25A5(2), SLC25A6(5), SLC8A1(26), SLC8A2(3), SLC8A3(7), SPHK2(2), TACR1(3), TACR3(8), TNNC2(2), TRHR(4), TRPC1(9), VDAC3(1)	93388948	1293	205	1265	463	153	421	358	210	146	5	0.992	1.000	1.000
161	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	243	ACVR1B(5), ACVR1C(3), AKT2(2), AKT3(5), ARRB1(2), ARRB2(1), ATF2(5), ATF4(1), BDNF(1), CACNA1A(10), CACNA1B(15), CACNA1C(26), CACNA1D(17), CACNA1E(50), CACNA1F(10), CACNA1G(10), CACNA1H(9), CACNA1I(7), CACNA1S(11), CACNA2D1(19), CACNA2D2(1), CACNA2D3(14), CACNA2D4(6), CACNB1(1), CACNB2(7), CACNB4(1), CACNG1(1), CACNG2(1), CACNG3(7), CACNG4(2), CACNG5(6), CACNG6(3), CACNG7(1), CACNG8(2), CASP3(4), CD14(1), CDC25B(1), CDC42(2), CHUK(3), CRKL(2), DAXX(6), DDIT3(4), DUSP10(6), DUSP14(1), DUSP16(2), DUSP2(1), DUSP6(3), DUSP7(2), DUSP8(1), DUSP9(2), EGF(9), EGFR(33), ELK1(2), ELK4(4), FAS(3), FASLG(4), FGF1(1), FGF10(2), FGF12(4), FGF13(6), FGF18(1), FGF19(2), FGF20(1), FGF21(2), FGF23(4), FGF3(1), FGF4(2), FGF5(2), FGF9(1), FGFR1(5), FGFR2(8), FGFR3(2), FGFR4(3), FLNA(11), FLNB(12), FLNC(18), FOS(1), GADD45A(1), GNA12(1), GNG12(2), GRB2(4), HRAS(1), IKBKB(3), IL1A(3), IL1R1(1), IL1R2(4), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP2K7(2), MAP3K1(4), MAP3K10(1), MAP3K12(5), MAP3K13(7), MAP3K14(1), MAP3K2(5), MAP3K3(4), MAP3K4(14), MAP3K5(12), MAP3K6(1), MAP3K7(5), MAP3K8(2), MAP4K1(5), MAP4K3(5), MAPK10(5), MAPK11(1), MAPK14(1), MAPK3(1), MAPK7(5), MAPK8(3), MAPK8IP1(4), MAPK8IP3(4), MAPK9(6), MAPKAPK2(3), MAPKAPK3(1), MAPKAPK5(3), MAPT(8), MAX(3), MEF2C(2), MKNK1(2), MKNK2(1), MOS(2), MRAS(1), NF1(29), NFATC2(8), NFATC4(8), NFKB1(3), NFKB2(6), NR4A1(2), NRAS(4), NTF3(7), NTRK1(12), NTRK2(9), PAK1(5), PAK2(3), PDGFA(6), PDGFB(1), PDGFRA(17), PDGFRB(8), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PPM1B(4), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PPP5C(1), PRKACB(3), PRKACG(1), PRKCA(7), PRKCG(10), PRKX(3), PTPN5(4), PTPRR(8), RAC2(1), RAF1(3), RAP1A(2), RAP1B(1), RAPGEF2(10), RASA1(3), RASA2(3), RASGRF1(1), RASGRF2(14), RASGRP1(2), RASGRP2(1), RASGRP3(8), RASGRP4(2), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KA4(1), RPS6KA5(4), RPS6KA6(5), RRAS(1), RRAS2(1), SOS1(12), SOS2(6), STK4(4), STMN1(1), TAOK1(1), TAOK2(6), TAOK3(7), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TGFBR2(2), TRAF2(1), TRAF6(4), ZAK(3)	98008336	955	198	933	306	148	231	262	168	141	5	0.718	1.000	1.000
162	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	233	ADCYAP1R1(6), ADORA1(1), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRA1B(4), ADRA2A(1), ADRA2B(1), ADRA2C(3), ADRB2(2), ADRB3(3), AGTR1(5), AGTR2(2), AVPR1A(6), AVPR1B(3), AVPR2(4), BDKRB1(1), BDKRB2(1), BRS3(8), C3AR1(5), C5AR1(4), CALCR(8), CALCRL(10), CCKAR(7), CCKBR(11), CGA(1), CHRM1(2), CHRM2(17), CHRM3(13), CHRM4(2), CHRM5(3), CNR1(4), CNR2(1), CRHR1(1), CRHR2(2), CTSG(2), CYSLTR1(1), CYSLTR2(4), DRD1(3), DRD2(9), DRD3(9), DRD5(8), EDNRB(6), F2(5), F2R(4), F2RL1(1), F2RL2(5), F2RL3(2), FPR1(4), FSHB(1), FSHR(20), GABBR1(3), GABBR2(6), GABRA1(8), GABRA2(14), GABRA3(8), GABRA4(10), GABRA5(14), GABRA6(12), GABRB1(11), GABRB2(3), GABRD(1), GABRE(5), GABRG1(14), GABRG2(10), GABRG3(10), GABRP(5), GABRQ(11), GABRR1(6), GABRR2(5), GALR1(3), GALR2(1), GH1(2), GH2(5), GHR(5), GHRHR(5), GHSR(4), GIPR(2), GLP1R(1), GLP2R(9), GLRA1(5), GLRA2(10), GLRA3(2), GLRB(4), GNRHR(2), GPR156(6), GPR50(7), GPR63(4), GPR83(4), GRIA1(12), GRIA2(15), GRIA3(11), GRIA4(9), GRID1(14), GRID2(22), GRIK1(11), GRIK2(19), GRIK3(10), GRIK4(8), GRIK5(6), GRIN1(2), GRIN2A(26), GRIN2B(22), GRIN2C(3), GRIN2D(6), GRIN3A(19), GRM1(26), GRM2(5), GRM3(9), GRM4(9), GRM5(13), GRM6(7), GRM7(15), GRM8(19), GRPR(5), GZMA(4), HCRTR1(1), HCRTR2(13), HRH1(6), HRH2(6), HRH3(1), HRH4(4), HTR1A(13), HTR1B(5), HTR1D(1), HTR1E(9), HTR1F(4), HTR2A(3), HTR2B(2), HTR2C(6), HTR5A(11), HTR6(5), HTR7(3), LEP(4), LEPR(13), LHB(1), LHCGR(6), LTB4R(2), MAS1(3), MC2R(2), MC3R(9), MC4R(1), MC5R(10), MCHR2(7), MLNR(1), MTNR1A(5), MTNR1B(6), NMBR(6), NMUR1(4), NMUR2(11), NPBWR1(4), NPBWR2(2), NPY1R(9), NPY2R(6), NPY5R(9), NR3C1(3), NTSR1(5), NTSR2(1), OPRD1(1), OPRK1(5), OPRL1(5), OPRM1(4), OXTR(2), P2RX1(1), P2RX2(4), P2RX3(3), P2RX4(1), P2RX5(4), P2RX7(5), P2RY1(5), P2RY14(1), P2RY4(1), P2RY6(1), P2RY8(3), PARD3(6), PPYR1(2), PRL(1), PRLHR(5), PRLR(9), PRSS1(12), PRSS3(1), PTAFR(2), PTGDR(3), PTGER2(2), PTGER3(4), PTGER4(7), PTGFR(6), PTGIR(2), PTH2R(8), RXFP1(11), RXFP2(4), SCTR(1), SSTR1(3), SSTR3(2), SSTR4(5), SSTR5(2), TAAR1(4), TAAR2(6), TAAR5(8), TAAR6(8), TAAR8(5), TAAR9(4), TACR1(3), TACR3(8), THRA(1), THRB(5), TRHR(4), TRPV1(4), TSHB(1), TSHR(10), UTS2R(1), VIPR2(4)	75308940	1240	198	1234	493	132	448	310	218	130	2	1.000	1.000	1.000
163	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTG1(2), CHAD(1), COL11A1(66), COL11A2(7), COL17A1(9), COL1A1(4), COL1A2(19), COL2A1(7), COL3A1(33), COL4A1(16), COL4A2(16), COL4A4(13), COL4A6(17), COL5A1(17), COL5A2(30), COL5A3(12), COL6A1(4), COL6A2(3), COL6A3(35), COL6A6(24), COMP(2), DSC1(10), DSC2(7), DSC3(13), DSG1(16), DSG2(8), DSG3(16), DSG4(16), FN1(13), GJA1(6), GJA10(4), GJA4(1), GJA5(3), GJA8(7), GJA9(4), GJB1(3), GJB3(1), GJB4(4), GJB5(3), GJB6(1), GJC1(4), GJC2(1), GJD2(2), GJD4(3), IBSP(2), INA(1), ITGA6(5), ITGB4(4), KRT1(4), KRT10(2), KRT12(2), KRT13(5), KRT14(3), KRT15(4), KRT16(3), KRT17(2), KRT18(1), KRT19(1), KRT2(7), KRT20(2), KRT23(2), KRT24(7), KRT25(5), KRT28(8), KRT3(2), KRT31(4), KRT32(4), KRT33A(3), KRT33B(3), KRT34(4), KRT35(4), KRT36(4), KRT37(1), KRT38(8), KRT39(4), KRT4(2), KRT40(3), KRT5(7), KRT6A(7), KRT6B(12), KRT6C(2), KRT7(5), KRT71(8), KRT72(5), KRT73(9), KRT74(5), KRT75(7), KRT76(3), KRT78(1), KRT79(3), KRT8(3), KRT81(2), KRT82(6), KRT83(2), KRT84(3), KRT85(5), KRT86(4), KRT9(2), LAMA1(36), LAMA2(33), LAMA3(25), LAMA4(15), LAMA5(15), LAMB1(21), LAMB2(13), LAMB3(8), LAMB4(23), LAMC1(14), LAMC2(9), LAMC3(13), LMNB1(2), LMNB2(2), NES(10), RELN(49), THBS1(4), THBS2(16), THBS3(6), THBS4(5), TNC(21), TNN(34), TNR(40), TNXB(14), VIM(2), VTN(2), VWF(13)	85825536	1145	192	1137	388	138	400	289	144	171	3	0.995	1.000	1.000
164	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(5), CD36(4), CD44(2), CD47(1), CHAD(1), COL11A1(66), COL11A2(7), COL1A1(4), COL1A2(19), COL2A1(7), COL3A1(33), COL4A1(16), COL4A2(16), COL4A4(13), COL4A6(17), COL5A1(17), COL5A2(30), COL5A3(12), COL6A1(4), COL6A2(3), COL6A3(35), COL6A6(24), DAG1(2), FN1(13), FNDC1(14), FNDC3A(7), FNDC4(1), FNDC5(1), GP5(3), GP6(3), HMMR(4), HSPG2(17), IBSP(2), ITGA1(9), ITGA10(7), ITGA11(10), ITGA2(11), ITGA2B(4), ITGA3(5), ITGA4(19), ITGA5(6), ITGA6(5), ITGA7(2), ITGA8(24), ITGA9(2), ITGAV(9), ITGB1(3), ITGB3(4), ITGB4(4), ITGB5(6), ITGB6(1), ITGB7(1), ITGB8(5), LAMA1(36), LAMA2(33), LAMA3(25), LAMA4(15), LAMA5(15), LAMB1(21), LAMB2(13), LAMB3(8), LAMB4(23), LAMC1(14), LAMC2(9), LAMC3(13), RELN(49), SDC1(5), SDC3(2), SV2A(5), SV2B(8), SV2C(11), THBS1(4), THBS2(16), THBS3(6), THBS4(5), TNC(21), TNN(34), TNR(40), TNXB(14), VTN(2), VWF(13)	77840306	1000	184	992	334	117	357	249	124	150	3	0.992	1.000	1.000
165	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ADCY1(10), ADCY2(18), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), ADRA1A(4), ADRA1B(4), ADRA1D(2), ADRB2(2), ADRB3(3), ANXA6(1), ARRB1(2), ARRB2(1), ATP1A4(15), ATP1B3(1), ATP2A2(6), ATP2A3(4), ATP2B1(9), ATP2B2(11), ATP2B3(11), CACNA1A(10), CACNA1B(15), CACNA1C(26), CACNA1D(17), CACNA1E(50), CACNA1S(11), CACNB1(1), CALM1(2), CALR(1), CAMK1(2), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(8), CASQ1(3), CASQ2(4), CHRM1(2), CHRM2(17), CHRM3(13), CHRM4(2), CHRM5(3), FXYD2(1), GJA1(6), GJA4(1), GJA5(3), GJB1(3), GJB3(1), GJB4(4), GJB5(3), GJB6(1), GNA11(1), GNAI3(1), GNAO1(2), GNAQ(2), GNAZ(4), GNB1(2), GNB3(2), GNB4(1), GNB5(1), GNG12(2), GNG3(2), GNG4(1), GNGT1(2), GRK4(6), GRK5(8), GRK6(1), ITPR1(11), ITPR2(25), ITPR3(6), KCNB1(16), KCNJ3(15), KCNJ5(1), MIB1(6), NME7(4), PEA15(3), PKIA(1), PKIB(1), PLCB3(4), PLN(1), PRKACB(3), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), PRKCD(1), PRKCE(3), PRKCG(10), PRKCH(2), PRKCQ(4), PRKCZ(2), PRKD1(16), RGS1(7), RGS11(1), RGS16(1), RGS18(5), RGS2(1), RGS20(5), RGS3(9), RGS4(4), RGS5(5), RGS6(2), RGS9(5), RYR1(52), RYR2(166), RYR3(53), SLC8A1(26), SLC8A3(7), USP5(3)	64933179	927	181	919	332	115	305	262	133	108	4	0.977	1.000	1.000
166	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	121	ABL1(2), ABLIM1(5), ABLIM2(2), ABLIM3(8), ARHGEF12(11), CDC42(2), CDK5(1), CFL2(2), CXCL12(1), CXCR4(3), DCC(22), DPYSL2(1), DPYSL5(4), EFNA1(1), EFNA2(1), EFNA3(1), EFNB1(1), EFNB2(1), EPHA1(10), EPHA2(2), EPHA3(25), EPHA4(9), EPHA5(26), EPHA8(7), EPHB2(7), EPHB3(6), EPHB4(7), EPHB6(24), FES(1), FYN(3), GNAI1(3), GNAI3(1), GSK3B(2), HRAS(1), ITGB1(3), L1CAM(14), LIMK2(1), LRRC4C(16), MAPK3(1), MET(12), NCK1(3), NCK2(3), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NGEF(4), NRAS(4), NRP1(4), NTN1(1), NTN4(5), PAK1(5), PAK2(3), PAK3(7), PAK4(1), PAK7(19), PLXNA1(9), PLXNA2(14), PLXNA3(8), PLXNB1(4), PLXNB2(8), PLXNB3(3), PLXNC1(11), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PTK2(11), RAC2(1), RASA1(3), RGS3(9), RHOA(1), RHOD(1), ROBO1(14), ROBO2(21), ROBO3(12), ROCK1(10), ROCK2(4), SEMA3B(2), SEMA3C(6), SEMA3D(20), SEMA3E(6), SEMA3F(3), SEMA3G(4), SEMA4A(3), SEMA4C(1), SEMA4D(5), SEMA4F(5), SEMA4G(3), SEMA5A(24), SEMA5B(9), SEMA6A(10), SEMA6B(5), SEMA6C(9), SEMA6D(21), SEMA7A(7), SLIT1(16), SLIT2(28), SLIT3(16), SRGAP1(10), SRGAP2(4), SRGAP3(10), UNC5A(5), UNC5B(8), UNC5C(11), UNC5D(17)	64966613	769	181	762	261	111	230	200	116	111	1	0.917	1.000	1.000
167	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	248	ACVR1(4), ACVR1B(5), ACVR2A(3), ACVR2B(4), AMH(1), AMHR2(2), BMP2(1), BMP7(4), BMPR1A(1), BMPR1B(5), BMPR2(2), CCL13(2), CCL14(2), CCL15(3), CCL17(1), CCL18(1), CCL20(1), CCL22(1), CCL23(1), CCL25(1), CCL28(4), CCL3(1), CCL4(1), CCL7(1), CCR1(2), CCR2(5), CCR3(2), CCR4(2), CCR5(1), CCR6(2), CCR8(6), CD27(1), CD40LG(6), CNTF(1), CNTFR(3), CSF1(1), CSF1R(6), CSF2RA(5), CSF2RB(5), CSF3R(4), CX3CL1(3), CX3CR1(5), CXCL1(2), CXCL12(1), CXCL16(1), CXCL5(1), CXCL6(4), CXCL9(3), CXCR3(1), CXCR4(3), CXCR6(1), EDA(2), EDA2R(2), EDAR(3), EGF(9), EGFR(33), EPO(3), EPOR(1), FAS(3), FASLG(4), FLT1(21), FLT3(10), FLT3LG(2), FLT4(13), GDF5(4), GH1(2), GH2(5), GHR(5), IFNA10(4), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(3), IFNA21(3), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(4), IFNA8(1), IFNAR2(2), IFNB1(4), IFNG(4), IFNGR1(3), IFNGR2(3), IFNW1(1), IL10(1), IL10RA(4), IL10RB(2), IL12A(3), IL12RB1(3), IL12RB2(12), IL13(1), IL15(2), IL15RA(1), IL17A(4), IL17B(3), IL17RA(3), IL18R1(3), IL18RAP(7), IL19(1), IL1A(3), IL1R1(1), IL1R2(4), IL1RAP(2), IL2(5), IL20RA(3), IL21(1), IL21R(9), IL22(2), IL22RA2(2), IL23R(1), IL24(3), IL25(2), IL28B(2), IL28RA(4), IL2RA(3), IL2RB(5), IL2RG(3), IL3(1), IL3RA(5), IL4(1), IL4R(5), IL5RA(5), IL6R(8), IL7R(7), IL9R(5), INHBB(1), INHBC(1), INHBE(3), KDR(30), KIT(6), LEP(4), LEPR(13), LIF(2), LIFR(5), LTA(2), LTB(1), MET(12), MPL(2), NGFR(2), OSM(2), OSMR(5), PDGFB(1), PDGFRA(17), PDGFRB(8), PLEKHO2(2), PRL(1), PRLR(9), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TGFBR2(2), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(1), TNFRSF11A(7), TNFRSF11B(1), TNFRSF12A(1), TNFRSF13B(1), TNFRSF18(1), TNFRSF19(1), TNFRSF1B(1), TNFRSF21(2), TNFRSF25(1), TNFRSF4(2), TNFRSF8(2), TNFRSF9(4), TNFSF10(1), TNFSF11(1), TNFSF13B(1), TNFSF14(1), TNFSF15(1), TNFSF18(1), TNFSF4(3), TNFSF8(1), TNFSF9(1), TPO(16), TSLP(3), VEGFA(1), VEGFC(11), XCL1(3), XCL2(5), XCR1(1)	60369209	663	177	646	217	64	208	172	128	91	0	0.919	1.000	1.000
168	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	128	ACTG1(2), ACTN1(2), ACTN2(23), ACTN3(3), ACTN4(2), AKT2(2), AKT3(5), AMOTL1(7), ASH1L(22), CASK(3), CDC42(2), CDK4(2), CGN(7), CLDN1(3), CLDN10(1), CLDN11(3), CLDN14(4), CLDN15(1), CLDN16(3), CLDN17(7), CLDN18(3), CLDN2(1), CLDN20(1), CLDN4(2), CLDN8(5), CLDN9(2), CSDA(2), CTNNA1(3), CTNNA3(11), CTNNB1(11), CTTN(3), EPB41(1), EPB41L1(9), EPB41L2(9), EPB41L3(17), EXOC3(3), EXOC4(6), F11R(2), GNAI1(3), GNAI3(1), HCLS1(6), HRAS(1), IGSF5(3), INADL(25), JAM2(6), LLGL1(1), LLGL2(2), MAGI1(16), MAGI2(15), MAGI3(4), MLLT4(4), MPDZ(7), MPP5(1), MRAS(1), MYH1(36), MYH10(6), MYH11(15), MYH13(18), MYH14(2), MYH15(15), MYH2(37), MYH3(11), MYH4(24), MYH6(21), MYH7(20), MYH7B(6), MYH8(28), MYH9(8), MYL2(2), MYL5(1), MYL7(3), MYLPF(1), NRAS(4), OCLN(1), PARD3(6), PARD6B(3), PPM1J(1), PPP2CA(1), PPP2CB(3), PPP2R1A(3), PPP2R1B(3), PPP2R2A(4), PPP2R2B(5), PPP2R2C(3), PPP2R3A(1), PPP2R3B(4), PRKCA(7), PRKCD(1), PRKCE(3), PRKCG(10), PRKCH(2), PRKCI(7), PRKCQ(4), PRKCZ(2), PTEN(8), RAB13(2), RAB3B(1), RHOA(1), RRAS(1), RRAS2(1), SPTAN1(12), SRC(2), SYMPK(7), TJAP1(2), TJP1(10), TJP2(4), TJP3(2), VAPA(1), YES1(3), ZAK(3)	66166115	683	174	672	243	112	208	183	102	77	1	0.982	1.000	1.000
169	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	136	ACTA1(4), ACTA2(1), ADCY1(10), ADCY2(18), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), ARRB1(2), ARRB2(1), ATF2(5), ATF4(1), ATP2A2(6), ATP2A3(4), CALCA(2), CALM1(2), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CNN1(2), CORIN(12), CRH(1), CRHR1(1), DGKZ(3), ETS2(3), FOS(1), GABPA(1), GBA2(2), GJA1(6), GNAQ(2), GNB1(2), GNB3(2), GNB4(1), GNB5(1), GNG12(2), GNG3(2), GNG4(1), GNGT1(2), GRK4(6), GRK5(8), GRK6(1), GUCA2B(3), GUCY1A3(6), IGFBP1(3), IGFBP2(1), IGFBP3(2), IGFBP4(1), ITPR1(11), ITPR2(25), ITPR3(6), MIB1(6), MYL2(2), MYL4(1), MYLK2(3), NFKB1(3), NOS1(9), NOS3(2), OXT(1), OXTR(2), PDE4B(7), PDE4D(4), PKIA(1), PKIB(1), PLCB3(4), PLCD1(2), PLCG1(5), PLCG2(9), PRKACB(3), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), PRKCD(1), PRKCE(3), PRKCH(2), PRKCQ(4), PRKCZ(2), PRKD1(16), RAMP2(1), RAMP3(2), RGS1(7), RGS11(1), RGS16(1), RGS18(5), RGS2(1), RGS20(5), RGS3(9), RGS4(4), RGS5(5), RGS6(2), RGS9(5), RYR1(52), RYR2(166), RYR3(53), SLC8A1(26), SP1(1), TNXB(14), USP5(3)	59804037	720	171	716	273	80	232	206	112	87	3	0.999	1.000	1.000
170	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	89	ADCY1(10), ADCY2(18), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), CSNK1D(2), DRD1(3), DRD2(9), EGF(9), EGFR(33), GJA1(6), GJD2(2), GNA11(1), GNAI1(3), GNAI3(1), GNAQ(2), GNAS(7), GRB2(4), GRM1(26), GRM5(13), GUCY1A2(7), GUCY1A3(6), GUCY1B3(5), GUCY2C(7), GUCY2D(1), GUCY2F(12), HRAS(1), HTR2A(3), HTR2B(2), HTR2C(6), ITPR1(11), ITPR2(25), ITPR3(6), MAP2K1(6), MAP2K2(1), MAP3K2(5), MAPK3(1), MAPK7(5), NPR1(6), NPR2(2), NRAS(4), PDGFA(6), PDGFB(1), PDGFD(4), PDGFRA(17), PDGFRB(8), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PRKACB(3), PRKACG(1), PRKCA(7), PRKCG(10), PRKG1(3), PRKG2(7), PRKX(3), RAF1(3), SOS1(12), SOS2(6), SRC(2), TJP1(10), TUBA1A(3), TUBA1B(1), TUBA1C(3), TUBA3D(9), TUBA3E(2), TUBA4A(3), TUBA8(1), TUBB1(3), TUBB2A(2), TUBB2B(1), TUBB2C(3), TUBB4(5), TUBB8(7)	44864306	526	170	508	194	61	151	149	98	67	0	0.989	1.000	1.000
171	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	94	ADCY1(10), ADCY2(18), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), ATF4(1), CACNA1C(26), CACNA1D(17), CACNA1F(10), CACNA1S(11), CALM1(2), CALML3(3), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CDC42(2), CGA(1), EGFR(33), ELK1(2), FSHB(1), GNA11(1), GNAQ(2), GNAS(7), GNRHR(2), GRB2(4), HBEGF(1), HRAS(1), ITPR1(11), ITPR2(25), ITPR3(6), LHB(1), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP2K7(2), MAP3K1(4), MAP3K2(5), MAP3K3(4), MAP3K4(14), MAPK10(5), MAPK11(1), MAPK14(1), MAPK3(1), MAPK7(5), MAPK8(3), MAPK9(6), MMP14(3), MMP2(13), NRAS(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PLD1(9), PLD2(5), PRKACB(3), PRKACG(1), PRKCA(7), PRKCD(1), PRKX(3), PTK2B(8), RAF1(3), SOS1(12), SOS2(6), SRC(2)	43901590	491	170	472	159	75	129	139	81	67	0	0.757	1.000	1.000
172	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	127	ALCAM(3), CADM1(2), CADM3(5), CD2(3), CD22(6), CD226(8), CD274(3), CD276(1), CD28(1), CD34(4), CD4(3), CD40LG(6), CD58(1), CD6(4), CD80(4), CD86(6), CD8A(2), CD8B(3), CD99(3), CDH1(5), CDH15(5), CDH2(20), CDH3(3), CDH4(9), CDH5(7), CLDN1(3), CLDN10(1), CLDN11(3), CLDN14(4), CLDN15(1), CLDN16(3), CLDN17(7), CLDN18(3), CLDN2(1), CLDN20(1), CLDN4(2), CLDN8(5), CLDN9(2), CNTN1(20), CNTN2(9), CNTNAP1(5), CNTNAP2(41), CTLA4(1), ESAM(1), F11R(2), GLG1(9), HLA-A(2), HLA-B(3), HLA-C(1), HLA-DMA(2), HLA-DMB(1), HLA-DOA(2), HLA-DOB(1), HLA-DPA1(2), HLA-DQA2(1), HLA-DRA(3), HLA-G(1), ICAM2(2), ICAM3(2), ICOS(2), ICOSLG(1), ITGA4(19), ITGA6(5), ITGA8(24), ITGA9(2), ITGAL(20), ITGAM(14), ITGAV(9), ITGB1(3), ITGB2(2), ITGB7(1), ITGB8(5), JAM2(6), L1CAM(14), MADCAM1(2), MAG(5), MPZ(1), MPZL1(2), NCAM1(8), NCAM2(13), NEGR1(5), NEO1(13), NFASC(11), NLGN2(4), NLGN3(3), NRCAM(14), NRXN2(11), NRXN3(18), OCLN(1), PDCD1(1), PDCD1LG2(3), PTPRC(21), PTPRF(4), PTPRM(6), PVRL1(4), SDC1(5), SDC3(2), SELE(6), SELL(4), SELP(14), SELPLG(3), SIGLEC1(7), SPN(3), VCAM1(16), VCAN(34)	49314692	635	165	632	226	89	213	170	93	69	1	0.972	1.000	1.000
173	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	143	APC(23), APC2(2), AXIN1(3), AXIN2(2), BTRC(9), CACYBP(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CCND1(2), CCND2(1), CCND3(1), CER1(2), CHD8(13), CREBBP(4), CSNK1A1(1), CSNK1A1L(5), CSNK1E(6), CTNNB1(11), CUL1(6), CXXC4(3), DAAM1(3), DAAM2(4), DKK1(2), DKK2(4), DKK4(2), DVL1(1), DVL2(1), DVL3(5), EP300(2), FOSL1(3), FZD1(3), FZD10(7), FZD2(3), FZD3(4), FZD4(5), FZD5(1), FZD7(3), FZD9(2), GSK3B(2), LEF1(8), LRP5(5), LRP6(10), MAP3K7(5), MAPK10(5), MAPK8(3), MAPK9(6), MMP7(4), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NKD1(6), NKD2(3), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PORCN(3), PPARD(2), PPP2CA(1), PPP2CB(3), PPP2R1A(3), PPP2R1B(3), PPP2R2A(4), PPP2R2B(5), PPP2R2C(3), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRICKLE1(5), PRICKLE2(2), PRKACB(3), PRKACG(1), PRKCA(7), PRKCG(10), PRKX(3), PSEN1(1), RAC2(1), RHOA(1), ROCK1(10), ROCK2(4), RUVBL1(2), SENP2(3), SFRP1(1), SFRP2(2), SFRP4(3), SFRP5(1), SKP1(2), SMAD2(2), SMAD3(3), SMAD4(8), SOX17(1), TBL1XR1(5), TCF7(1), TCF7L1(2), TCF7L2(3), VANGL1(3), VANGL2(8), WNT1(3), WNT10A(4), WNT10B(2), WNT11(2), WNT16(2), WNT2(4), WNT2B(2), WNT3A(4), WNT4(1), WNT5A(1), WNT5B(3), WNT6(1), WNT7A(6), WNT7B(2), WNT8A(3), WNT8B(2), WNT9A(2), WNT9B(5)	55574636	481	164	477	141	82	114	149	62	74	0	0.257	1.000	1.000
174	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	108	ACTN1(2), ACTN2(23), ACTN3(3), ACTN4(2), ARHGAP5(7), BCAR1(2), CD99(3), CDC42(2), CDH5(7), CLDN1(3), CLDN10(1), CLDN11(3), CLDN14(4), CLDN15(1), CLDN16(3), CLDN17(7), CLDN18(3), CLDN2(1), CLDN20(1), CLDN4(2), CLDN8(5), CLDN9(2), CTNNA1(3), CTNNA3(11), CTNNB1(11), CTNND1(9), CXCL12(1), CXCR4(3), CYBB(7), ESAM(1), EZR(1), F11R(2), GNAI1(3), GNAI3(1), GRLF1(9), ITGA4(19), ITGAL(20), ITGAM(14), ITGB1(3), ITGB2(2), ITK(7), JAM2(6), MAPK11(1), MAPK14(1), MLLT4(4), MMP2(13), MMP9(10), MSN(1), MYL2(2), MYL5(1), MYL7(3), MYLPF(1), NCF1(1), NCF2(2), NCF4(2), NOX1(3), NOX3(5), OCLN(1), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PLCG1(5), PLCG2(9), PRKCA(7), PRKCG(10), PTK2(11), PTK2B(8), PTPN11(6), PXN(1), RAC2(1), RAP1A(2), RAP1B(1), RAPGEF3(2), RAPGEF4(6), RHOA(1), RHOH(2), ROCK1(10), ROCK2(4), SIPA1(1), THY1(1), TXK(5), VASP(3), VAV1(1), VAV2(3), VAV3(14), VCAM1(16), VCL(2)	42265156	446	161	439	143	58	140	128	73	47	0	0.722	1.000	1.000
175	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(4), ACTA2(1), ACTN2(23), ACTN3(3), ACTN4(2), DMD(41), FAM48A(2), MYBPC1(6), MYBPC2(3), MYBPC3(5), MYH3(11), MYH6(21), MYH7(20), MYH8(28), MYL1(3), MYL2(2), MYL3(2), MYL4(1), MYOM1(4), NEB(36), TMOD1(3), TNNC2(2), TNNI1(2), TNNI2(4), TNNI3(2), TNNT2(4), TNNT3(3), TPM1(1), TPM2(2), TPM3(3), TPM4(1), TTN(375), VIM(2)	47583223	622	161	616	215	63	194	177	121	58	9	1.000	1.000	1.000
176	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	159	ADORA1(1), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRA1B(4), ADRA1D(2), ADRA2A(1), ADRA2C(3), ADRB2(2), ADRB3(3), AGTR1(5), AGTR2(2), AVPR1A(6), AVPR1B(3), AVPR2(4), BDKRB1(1), BDKRB2(1), BRS3(8), C3AR1(5), CCBP2(2), CCKAR(7), CCKBR(11), CCR1(2), CCR2(5), CCR3(2), CCR4(2), CCR5(1), CCR6(2), CCR8(6), CCRL1(2), CCRL2(2), CHML(7), CHRM1(2), CHRM2(17), CHRM3(13), CHRM4(2), CHRM5(3), CNR1(4), CNR2(1), CX3CR1(5), CXCR3(1), CXCR4(3), DRD1(3), DRD2(9), DRD3(9), DRD5(8), EDNRB(6), F2R(4), F2RL1(1), F2RL2(5), F2RL3(2), FPR1(4), FSHR(20), GALR1(3), GALR2(1), GALT(2), GHSR(4), GNB2L1(2), GPR17(3), GPR173(1), GPR27(1), GPR37(5), GPR37L1(2), GPR4(5), GPR50(7), GPR6(2), GPR63(4), GPR77(1), GPR83(4), GPR85(8), GPR87(2), GRPR(5), HCRTR1(1), HCRTR2(13), HRH1(6), HRH2(6), HRH3(1), HTR1A(13), HTR1B(5), HTR1D(1), HTR1E(9), HTR1F(4), HTR2A(3), HTR2B(2), HTR2C(6), HTR5A(11), HTR6(5), HTR7(3), LHCGR(6), LTB4R(2), MAS1(3), MC3R(9), MC4R(1), MC5R(10), MLNR(1), MTNR1A(5), MTNR1B(6), NMBR(6), NMUR1(4), NMUR2(11), NPY1R(9), NPY2R(6), NPY5R(9), NTSR1(5), NTSR2(1), OPN1SW(3), OPN3(2), OPRD1(1), OPRK1(5), OPRL1(5), OPRM1(4), OR10A5(9), OR11A1(3), OR12D3(1), OR1C1(13), OR1F1(3), OR1Q1(5), OR2H1(5), OR5V1(2), OR7A5(2), OR7C1(2), OR8B8(7), OXTR(2), P2RY1(5), P2RY12(4), P2RY14(1), P2RY6(1), PPYR1(2), PTAFR(2), PTGDR(3), PTGER2(2), PTGER4(7), PTGFR(6), PTGIR(2), RHO(1), RRH(2), SSTR1(3), SSTR3(2), SSTR4(5), SUCNR1(1), TRHR(4)	41040693	603	159	601	255	60	218	166	107	51	1	0.994	1.000	1.000
177	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	129	ACACA(10), ACACB(11), AKT2(2), AKT3(5), ARAF(3), CALM1(2), CALML3(3), CBL(9), CBLB(5), CBLC(1), CRKL(2), ELK1(2), EXOC7(2), FASN(4), FBP2(1), FLOT1(2), FLOT2(1), FOXO1(3), G6PC(1), G6PC2(2), GCK(4), GRB2(4), GSK3B(2), GYS1(2), GYS2(3), HRAS(1), IKBKB(3), INPP5D(4), INSR(1), IRS1(15), IRS2(3), IRS4(17), LIPE(2), MAP2K1(6), MAP2K2(1), MAPK10(5), MAPK3(1), MAPK8(3), MAPK9(6), MKNK1(2), MKNK2(1), NRAS(4), PCK1(11), PCK2(3), PDE3A(13), PDE3B(9), PDPK1(1), PFKL(2), PFKM(5), PFKP(3), PHKA1(4), PHKA2(10), PHKB(7), PHKG1(1), PHKG2(3), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PKLR(11), PKM2(4), PPARGC1A(12), PPP1CA(2), PPP1CB(1), PPP1CC(1), PPP1R3A(12), PPP1R3B(1), PPP1R3C(1), PPP1R3D(4), PRKAA1(4), PRKAB1(3), PRKACB(3), PRKACG(1), PRKAG2(4), PRKAG3(4), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCI(7), PRKCZ(2), PRKX(3), PTPN1(1), PTPRF(4), PYGB(1), PYGL(3), PYGM(6), RAF1(3), RAPGEF1(1), RHEB(4), RPS6KB1(2), RPS6KB2(2), SHC1(2), SHC2(1), SHC3(4), SHC4(4), SOCS4(1), SORBS1(7), SOS1(12), SOS2(6), SREBF1(2), TSC1(9), TSC2(4)	54748633	443	159	435	166	77	112	130	69	55	0	0.957	1.000	1.000
178	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	72	ARAF(3), CACNA1A(10), CRH(1), CRHR1(1), GNA11(1), GNA12(1), GNA13(5), GNAI1(3), GNAI3(1), GNAO1(2), GNAQ(2), GNAS(7), GNAZ(4), GRIA1(12), GRIA2(15), GRIA3(11), GRID2(22), GRM1(26), GRM5(13), GUCY1A2(7), GUCY1A3(6), GUCY1B3(5), GUCY2C(7), GUCY2D(1), GUCY2F(12), HRAS(1), IGF1(5), IGF1R(10), ITPR1(11), ITPR2(25), ITPR3(6), LYN(4), MAP2K1(6), MAP2K2(1), MAPK3(1), NOS1(9), NOS3(2), NPR1(6), NPR2(2), NRAS(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PPP2CA(1), PPP2CB(3), PPP2R1A(3), PPP2R1B(3), PPP2R2A(4), PPP2R2B(5), PPP2R2C(3), PRKCA(7), PRKCG(10), PRKG1(3), PRKG2(7), RAF1(3), RYR1(52)	37469667	447	157	443	147	56	130	123	71	66	1	0.814	1.000	1.000
179	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACP1(2), ACTG1(2), ACTN1(2), ACTN2(23), ACTN3(3), ACTN4(2), ACVR1B(5), ACVR1C(3), BAIAP2(2), CDC42(2), CDH1(5), CREBBP(4), CTNNA1(3), CTNNA3(11), CTNNB1(11), CTNND1(9), EGFR(33), EP300(2), ERBB2(10), FARP2(3), FER(6), FGFR1(5), FYN(3), IGF1R(10), INSR(1), IQGAP1(5), LEF1(8), LMO7(10), MAP3K7(5), MAPK3(1), MET(12), MLLT4(4), PARD3(6), PTPN1(1), PTPN6(3), PTPRB(29), PTPRF(4), PTPRJ(5), PTPRM(6), PVRL1(4), PVRL4(3), RAC2(1), RHOA(1), SMAD2(2), SMAD3(3), SMAD4(8), SNAI1(3), SNAI2(4), SORBS1(7), SRC(2), SSX2IP(2), TCF7(1), TCF7L1(2), TCF7L2(3), TGFBR1(2), TGFBR2(2), TJP1(10), VCL(2), WAS(3), WASF1(8), WASF2(1), WASF3(4), WASL(5), YES1(3)	40661469	347	156	325	118	51	89	85	62	60	0	0.909	1.000	1.000
180	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	65	ADCY1(10), ADCY8(22), ARAF(3), ATF4(1), CACNA1C(26), CALM1(2), CALML3(3), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(8), CREBBP(4), EP300(2), GNAQ(2), GRIA1(12), GRIA2(15), GRIN1(2), GRIN2A(26), GRIN2B(22), GRIN2C(3), GRIN2D(6), GRM1(26), GRM5(13), HRAS(1), ITPR1(11), ITPR2(25), ITPR3(6), MAP2K1(6), MAP2K2(1), MAPK3(1), NRAS(4), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PPP1CA(2), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP1R1A(2), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRKACB(3), PRKACG(1), PRKCA(7), PRKCG(10), PRKX(3), RAF1(3), RAP1A(2), RAP1B(1), RAPGEF3(2), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KA6(5)	34022530	382	156	378	126	52	114	102	62	52	0	0.786	1.000	1.000
181	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	140	ADA(2), ADCY1(10), ADCY2(18), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), ADSSL1(1), AK2(3), AK5(10), AK7(7), ALLC(6), AMPD1(6), AMPD2(3), AMPD3(3), ATIC(3), CANT1(3), DCK(2), DGUOK(2), ENPP1(6), ENTPD1(4), ENTPD2(2), ENTPD4(2), ENTPD6(3), FHIT(1), GART(4), GDA(6), GMPR(3), GMPS(8), GUCY1A2(7), GUCY1A3(6), GUCY1B3(5), GUCY2C(7), GUCY2D(1), GUCY2F(12), GUK1(2), HPRT1(1), IMPDH1(4), IMPDH2(1), ITPA(1), NME6(1), NME7(4), NPR1(6), NPR2(2), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5C3(1), NT5E(2), NT5M(1), NUDT2(3), NUDT5(2), NUDT9(2), PAPSS1(3), PAPSS2(4), PDE10A(16), PDE11A(11), PDE1A(8), PDE1C(17), PDE2A(5), PDE3B(9), PDE4A(4), PDE4B(7), PDE4C(2), PDE4D(4), PDE5A(1), PDE6D(1), PDE6G(2), PDE7A(2), PDE7B(3), PDE8A(3), PDE8B(5), PDE9A(2), PFAS(4), PKLR(11), PKM2(4), PNPT1(5), POLA1(6), POLA2(2), POLD1(2), POLD2(2), POLD3(3), POLE(19), POLE2(1), POLR1A(8), POLR1B(10), POLR1D(2), POLR2A(9), POLR2B(5), POLR2C(4), POLR2D(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), POLR3A(12), POLR3B(13), POLR3G(1), POLR3H(1), PPAT(5), PRIM1(3), PRPS1(3), PRPS1L1(3), PRPS2(2), PRUNE(5), RFC5(1), RRM1(5), RRM2(4), XDH(11)	55583796	544	153	540	192	73	151	163	89	68	0	0.954	1.000	1.000
182	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	106	A4GNT(1), ALG10(9), ALG10B(6), ALG12(2), ALG13(9), ALG14(2), ALG2(5), ALG3(5), ALG8(2), ALG9(3), B3GNT1(3), B3GNT2(1), B3GNT6(3), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT4(1), B4GALT5(3), C1GALT1(2), C1GALT1C1(2), CHPF(3), CHST1(10), CHST11(1), CHST12(5), CHST13(3), CHST2(4), CHST3(2), CHST6(3), CHSY1(2), DAD1(1), DDOST(1), DPAGT1(1), EXT1(3), EXT2(7), EXTL1(3), EXTL3(5), FUT11(2), FUT8(4), GALNT1(3), GALNT10(3), GALNT11(2), GALNT12(4), GALNT14(10), GALNT2(4), GALNT3(4), GALNT4(4), GALNT5(6), GALNT6(2), GALNT7(5), GALNT8(6), GALNT9(1), GALNTL1(4), GALNTL2(6), GALNTL4(6), GALNTL5(5), GANAB(3), GCNT1(4), GCNT3(3), GCNT4(3), HS3ST1(2), HS3ST2(2), HS3ST3A1(4), HS3ST3B1(1), HS3ST5(9), HS6ST1(1), HS6ST2(1), HS6ST3(5), MAN1A2(9), MAN1B1(2), MAN1C1(2), MAN2A1(11), MGAT1(2), MGAT3(4), MGAT4A(3), MGAT4B(1), MGAT5(6), MGAT5B(7), NDST1(2), NDST2(7), NDST3(8), NDST4(13), OGT(6), RPN2(4), ST3GAL1(3), ST3GAL2(3), ST3GAL3(1), ST3GAL4(2), ST6GALNAC1(3), STT3B(2), UST(1), WBSCR17(16), XYLT1(19)	37483636	373	150	369	149	61	105	109	59	38	1	0.997	1.000	1.000
183	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT3(5), BCAR1(2), CAPN10(4), CAPN11(9), CAPN2(3), CAPN3(6), CAPN5(10), CAPN6(10), CAPN7(5), CAPN9(6), CAV3(2), CDC42(2), DOCK1(7), FYN(3), GIT2(3), GRB2(4), ILK(1), ITGA10(7), ITGA11(10), ITGA2(11), ITGA2B(4), ITGA3(5), ITGA4(19), ITGA5(6), ITGA6(5), ITGA7(2), ITGA8(24), ITGA9(2), ITGAD(17), ITGAE(9), ITGAL(20), ITGAM(14), ITGAV(9), ITGAX(20), ITGB1(3), ITGB2(2), ITGB3(4), ITGB4(4), ITGB5(6), ITGB6(1), ITGB7(1), ITGB8(5), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K6(1), MAPK10(5), MAPK4(6), MAPK6(1), MAPK7(5), MYLK2(3), PAK1(5), PAK2(3), PAK3(7), PAK4(1), PDPK1(1), PIK3R2(1), PTK2(11), PXN(1), RAC2(1), RAP1B(1), RAPGEF1(1), RHO(1), ROCK1(10), ROCK2(4), SDCCAG8(6), SHC1(2), SHC3(4), SORBS1(7), SOS1(12), SRC(2), TLN1(13), TNS1(14), VASP(3), VAV2(3), VAV3(14), VCL(2), ZYX(2)	46314792	458	150	456	170	67	137	116	71	65	2	0.986	1.000	1.000
184	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	76	ABL1(2), ACTN1(2), ACTR2(2), ACTR3(1), AKT2(2), AKT3(5), ANGPTL2(4), ARHGEF6(9), ARHGEF7(6), BCAR1(2), CDC42(2), CSE1L(3), DOCK1(7), EPHB2(7), FYN(3), GRB2(4), GRB7(3), GRLF1(9), ILK(1), ITGA1(9), ITGA10(7), ITGA11(10), ITGA2(11), ITGA3(5), ITGA4(19), ITGA5(6), ITGA6(5), ITGA7(2), ITGA8(24), ITGA9(2), MAP2K4(3), MAP2K7(2), MAP3K11(7), MAPK10(5), MAPK8(3), MAPK8IP1(4), MAPK8IP3(4), MAPK9(6), MRAS(1), MYLK(16), MYLK2(3), P4HB(4), PAK1(5), PAK2(3), PAK3(7), PAK4(1), PAK7(19), PIK3CA(11), PIK3CB(7), PKLR(11), PLCG1(5), PLCG2(9), PTEN(8), PTK2(11), RAF1(3), RALA(2), RHO(1), ROCK1(10), ROCK2(4), SHC1(2), SOS1(12), SOS2(6), SRC(2), TLN1(13), TLN2(15), VASP(3), WAS(3), ZYX(2)	41364728	407	150	400	120	67	106	118	59	57	0	0.347	1.000	1.000
185	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	150	AKT2(2), AKT3(5), CBL(9), CBLB(5), CBLC(1), CCND1(2), CCND2(1), CCND3(1), CNTF(1), CNTFR(3), CREBBP(4), CSF2RA(5), CSF2RB(5), CSF3R(4), EP300(2), EPO(3), EPOR(1), GH1(2), GH2(5), GHR(5), GRB2(4), IFNA10(4), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(3), IFNA21(3), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(4), IFNA8(1), IFNAR2(2), IFNB1(4), IFNG(4), IFNGR1(3), IFNGR2(3), IFNW1(1), IL10(1), IL10RA(4), IL10RB(2), IL12A(3), IL12RB1(3), IL12RB2(12), IL13(1), IL13RA2(3), IL15(2), IL15RA(1), IL19(1), IL2(5), IL20RA(3), IL21(1), IL21R(9), IL22(2), IL22RA2(2), IL23R(1), IL24(3), IL28B(2), IL28RA(4), IL2RA(3), IL2RB(5), IL2RG(3), IL3(1), IL3RA(5), IL4(1), IL4R(5), IL5RA(5), IL6R(8), IL7R(7), IL9R(5), IRF9(2), JAK1(8), JAK2(4), JAK3(5), LEP(4), LEPR(13), LIF(2), LIFR(5), MPL(2), OSM(2), OSMR(5), PIAS1(2), PIAS2(5), PIAS3(6), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PRL(1), PRLR(9), PTPN11(6), PTPN6(3), SOCS4(1), SOCS5(2), SOS1(12), SOS2(6), SPRED1(1), SPRED2(2), SPRY1(1), SPRY2(2), SPRY3(5), SPRY4(3), STAM(6), STAM2(4), STAT1(4), STAT2(5), STAT3(8), STAT4(6), STAT5A(3), STAT5B(4), STAT6(2), TPO(16), TSLP(3), TYK2(2)	49993906	456	148	450	166	45	136	132	88	55	0	0.994	1.000	1.000
186	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(12), ABCA10(12), ABCA12(21), ABCA13(44), ABCA2(6), ABCA3(6), ABCA4(21), ABCA5(7), ABCA6(10), ABCA7(6), ABCA8(16), ABCA9(11), ABCB1(20), ABCB10(8), ABCB11(15), ABCB4(17), ABCB5(27), ABCB6(3), ABCB7(3), ABCB8(5), ABCB9(3), ABCC1(6), ABCC10(3), ABCC11(17), ABCC12(18), ABCC2(5), ABCC3(7), ABCC4(8), ABCC5(11), ABCC6(3), ABCC8(11), ABCC9(25), ABCD1(1), ABCD2(9), ABCD3(5), ABCD4(2), ABCG1(3), ABCG2(5), ABCG4(6), ABCG5(10), ABCG8(6), CFTR(6), TAP2(7)	40968100	447	145	443	143	62	132	116	76	60	1	0.564	1.000	1.000
187	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	91	AKT2(2), AKT3(5), BCL10(1), CARD11(17), CBL(9), CBLB(5), CBLC(1), CD28(1), CD3D(2), CD4(3), CD40LG(6), CD8A(2), CD8B(3), CDC42(2), CDK4(2), CHUK(3), CTLA4(1), FOS(1), FYN(3), GRAP2(5), GRB2(4), HRAS(1), ICOS(2), IFNG(4), IKBKB(3), IL10(1), IL2(5), IL4(1), ITK(7), LAT(3), LCK(5), LCP2(6), MALT1(6), MAP3K14(1), MAP3K8(2), NCK1(3), NCK2(3), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), NRAS(4), PAK1(5), PAK2(3), PAK3(7), PAK4(1), PAK7(19), PDCD1(1), PDK1(4), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PLCG1(5), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRKCQ(4), PTPN6(3), PTPRC(21), RASGRP1(2), RHOA(1), SOS1(12), SOS2(6), TEC(5), VAV1(1), VAV2(3), VAV3(14), ZAP70(4)	34845327	358	145	350	114	50	100	105	49	54	0	0.712	1.000	1.000
188	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	77	AGL(13), AMY2A(4), AMY2B(16), ASCC3(10), ATP13A2(5), DDX18(3), DDX19A(1), DDX23(8), DDX4(6), DDX41(1), DDX47(1), DDX50(6), DDX52(3), DDX54(2), DDX55(1), DDX56(1), DHX58(1), ENPP1(6), ENTPD7(3), EP400(14), ERCC2(3), ERCC3(5), G6PC(1), G6PC2(2), GAA(2), GANC(1), GBA(3), GBE1(2), GCK(4), GPI(3), GUSB(4), GYS1(2), GYS2(3), HK1(3), HK2(9), HK3(12), IFIH1(6), LYZL1(4), MGAM(30), MOV10L1(9), NUDT5(2), NUDT8(1), PGM1(2), PGM3(4), PYGB(1), PYGL(3), PYGM(6), RAD54B(8), RAD54L(1), RUVBL2(3), SETX(17), SI(63), SKIV2L2(10), SMARCA2(10), SMARCA5(1), TREH(1), UGDH(4), UGP2(1), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2A1(3), UGT2A3(6), UGT2B11(11), UGT2B15(6), UGT2B28(8), UGT2B4(13), UGT2B7(8), UXS1(4)	41295570	440	144	437	138	59	153	117	66	44	1	0.791	1.000	1.000
189	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	109	ADA(2), ADCY1(10), ADCY2(18), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), AK2(3), AK5(10), ALLC(6), AMPD1(6), AMPD2(3), AMPD3(3), ATIC(3), ATP5A1(3), ATP5B(1), ATP5C1(2), ATP5F1(2), ATP5G3(2), CANT1(3), DCK(2), DGUOK(2), ENPP1(6), ENTPD1(4), ENTPD2(2), FHIT(1), GART(4), GDA(6), GMPS(8), GUCY1A2(7), GUCY1A3(6), GUCY1B3(5), GUCY2C(7), GUCY2D(1), GUCY2F(12), GUK1(2), HPRT1(1), IMPDH1(4), IMPDH2(1), ITPA(1), NPR1(6), NPR2(2), NT5E(2), NT5M(1), NUDT2(3), PAPSS1(3), PAPSS2(4), PDE1A(8), PDE4A(4), PDE4B(7), PDE4C(2), PDE4D(4), PDE5A(1), PDE6B(4), PDE6C(5), PDE6G(2), PDE7B(3), PDE8A(3), PDE9A(2), PFAS(4), PKLR(11), PKM2(4), POLB(2), POLD1(2), POLD2(2), POLE(19), POLG(10), POLL(2), POLQ(17), POLR1B(10), POLR2A(9), POLR2B(5), POLR2C(4), POLR2D(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), POLRMT(1), PPAT(5), PRPS1(3), PRPS1L1(3), PRPS2(2), PRUNE(5), RRM1(5), RRM2(4)	43677170	426	144	422	148	62	108	129	71	56	0	0.892	1.000	1.000
190	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	106	ABL1(2), ANAPC1(5), ANAPC10(1), ANAPC11(1), ANAPC2(1), ANAPC4(2), ANAPC5(3), ANAPC7(4), ATM(22), ATR(17), BUB1(4), BUB1B(8), BUB3(1), CCNA1(2), CCNA2(4), CCNB1(1), CCNB2(1), CCNB3(13), CCND1(2), CCND2(1), CCND3(1), CCNE1(3), CCNH(1), CDC14A(7), CDC14B(1), CDC16(3), CDC20(3), CDC23(1), CDC25A(4), CDC25B(1), CDC25C(3), CDC27(2), CDC6(1), CDC7(3), CDK2(4), CDK4(2), CDK6(3), CDK7(3), CDKN1A(1), CDKN1B(3), CDKN2D(1), CHEK1(6), CHEK2(2), CREBBP(4), CUL1(6), DBF4(3), E2F1(3), E2F3(1), EP300(2), ESPL1(4), FZR1(2), GADD45A(1), GSK3B(2), HDAC1(3), HDAC2(8), MAD1L1(5), MAD2L1(3), MCM2(6), MCM3(5), MCM4(6), MCM5(3), MCM6(10), MCM7(4), MDM2(2), ORC1L(4), ORC2L(4), ORC3L(1), ORC4L(1), ORC5L(5), ORC6L(1), PCNA(1), PKMYT1(2), PLK1(3), PRKDC(23), PTTG1(1), PTTG2(2), RBL1(7), RBL2(2), SKP1(2), SKP2(4), SMAD2(2), SMAD3(3), SMAD4(8), SMC1A(4), SMC1B(6), TFDP1(3), TGFB1(2), TGFB2(8), TGFB3(1), WEE1(3), YWHAG(2)	46104799	342	143	340	88	51	86	110	51	44	0	0.162	1.000	1.000
191	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM1(2), CALML3(3), CDIPT(1), CDS1(2), CDS2(3), DGKA(5), DGKB(15), DGKD(3), DGKE(5), DGKG(7), DGKH(5), DGKI(23), DGKZ(3), IMPA1(1), IMPA2(1), INPP1(3), INPP4A(5), INPP4B(14), INPP5A(3), INPP5B(2), INPP5D(4), INPPL1(6), ITGB1BP3(2), ITPK1(1), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), OCRL(6), PI4KA(7), PI4KB(4), PIK3C2A(10), PIK3C2B(7), PIK3C2G(9), PIK3C3(7), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PIP4K2A(5), PIP4K2B(2), PIP4K2C(3), PIP5K1A(5), PIP5K1B(7), PIP5K1C(3), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PLCD1(2), PLCD3(2), PLCD4(3), PLCE1(14), PLCG1(5), PLCG2(9), PLCZ1(3), PRKCA(7), PRKCG(10), PTEN(8), PTPMT1(1), SYNJ1(4), SYNJ2(3)	43347410	400	142	395	121	54	120	109	54	62	1	0.564	1.000	1.000
192	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	123	ARAF(3), BID(1), CASP3(4), CD244(6), CD48(3), FAS(3), FASLG(4), FCER1G(2), FCGR3B(5), FYN(3), GRB2(4), GZMB(3), HCST(3), HLA-A(2), HLA-B(3), HLA-C(1), HLA-G(1), HRAS(1), ICAM2(2), IFNA10(4), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(3), IFNA21(3), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(4), IFNA8(1), IFNAR2(2), IFNB1(4), IFNG(4), IFNGR1(3), IFNGR2(3), ITGAL(20), ITGB2(2), KIR2DL1(4), KIR2DL3(2), KIR2DL4(1), KIR3DL1(10), KLRC1(3), KLRC2(3), KLRC3(3), KLRD1(2), KLRK1(2), LAT(3), LCK(5), LCP2(6), MAP2K1(6), MAP2K2(1), MAPK3(1), NCR1(2), NCR3(1), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NRAS(4), PAK1(5), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PLCG1(5), PLCG2(9), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRF1(5), PRKCA(7), PRKCG(10), PTK2B(8), PTPN11(6), PTPN6(3), RAC2(1), RAF1(3), SH2D1A(1), SH2D1B(1), SH3BP2(3), SHC1(2), SHC2(1), SHC3(4), SHC4(4), SOS1(12), SOS2(6), SYK(3), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(1), TNFSF10(1), ULBP1(1), ULBP2(1), ULBP3(1), VAV1(1), VAV2(3), VAV3(14), ZAP70(4)	38472458	401	142	392	128	58	104	114	77	48	0	0.663	1.000	1.000
193	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(14), BDKRB1(1), BDKRB2(1), C1QA(1), C1QB(2), C1QC(3), C1R(1), C1S(1), C2(3), C3(7), C3AR1(5), C4BPA(6), C5(2), C5AR1(4), C6(14), C8A(6), C8B(9), C9(11), CD46(1), CD55(2), CFB(5), CFH(23), CFI(7), CPB2(4), CR1(14), CR2(8), F10(3), F11(8), F12(1), F13A1(13), F13B(16), F2(5), F2R(4), F3(4), F5(23), F7(2), F8(23), F9(8), FGA(9), FGB(13), FGG(2), KLKB1(3), KNG1(3), MASP1(5), MASP2(2), MBL2(1), PLAT(6), PLAU(1), PLAUR(2), PLG(13), PROC(3), PROS1(13), SERPINA1(2), SERPINA5(7), SERPINC1(8), SERPIND1(1), SERPINE1(5), SERPING1(3), TFPI(1), THBD(1), VWF(13)	30740044	382	141	380	127	36	137	95	59	52	3	0.984	1.000	1.000
194	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	82	ABL1(2), ABL2(7), AKT2(2), AKT3(5), ARAF(3), BTC(2), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CBL(9), CBLB(5), CBLC(1), CDKN1A(1), CDKN1B(3), CRKL(2), EGF(9), EGFR(33), ELK1(2), ERBB2(10), ERBB3(3), ERBB4(21), EREG(4), GAB1(2), GRB2(4), GSK3B(2), HBEGF(1), HRAS(1), MAP2K1(6), MAP2K2(1), MAP2K4(3), MAP2K7(2), MAPK10(5), MAPK3(1), MAPK8(3), MAPK9(6), NCK1(3), NCK2(3), NRAS(4), NRG1(9), NRG2(2), NRG4(1), PAK1(5), PAK2(3), PAK3(7), PAK4(1), PAK7(19), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PLCG1(5), PLCG2(9), PRKCA(7), PRKCG(10), PTK2(11), RAF1(3), RPS6KB1(2), RPS6KB2(2), SHC1(2), SHC2(1), SHC3(4), SHC4(4), SOS1(12), SOS2(6), SRC(2), STAT5A(3), STAT5B(4), TGFA(1)	34326413	357	140	334	105	53	95	90	63	56	0	0.472	1.000	1.000
195	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(4), ACVR1B(5), ACVRL1(4), AURKB(1), BMPR1A(1), BMPR2(2), BUB1(4), CDIPT(1), CDKL1(2), CDKL2(1), CDS1(2), CDS2(3), CLK1(2), CLK2(6), CLK4(6), DGKA(5), DGKB(15), DGKD(3), DGKE(5), DGKG(7), DGKH(5), DGKZ(3), IMPA1(1), INPP1(3), INPP4A(5), INPP4B(14), INPP5A(3), INPPL1(6), ITPKA(1), ITPKB(5), MAP3K10(1), MOS(2), NEK1(6), NEK3(4), OCRL(6), PAK4(1), PIK3C2A(10), PIK3C2B(7), PIK3C2G(9), PIK3CA(11), PIK3CB(7), PIK3CG(11), PIM2(3), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PLCD1(2), PLCG1(5), PLCG2(9), PLK3(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), PRKCD(1), PRKCE(3), PRKCG(10), PRKCH(2), PRKCQ(4), PRKCZ(2), PRKD1(16), PRKG1(3), RAF1(3), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KA4(1), RPS6KB1(2), TGFBR1(2), VRK1(2)	38927710	344	140	340	111	48	93	100	48	55	0	0.807	1.000	1.000
196	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(22), CARM1(3), CTCFL(16), DOT1L(8), EED(4), EHMT1(8), EHMT2(1), EZH1(2), EZH2(8), FBXO11(2), HCFC1(10), HSF4(1), JMJD4(1), KDM6A(2), MEN1(4), MLL(12), MLL2(25), MLL3(55), MLL4(4), MLL5(3), NSD1(11), OGT(6), PAXIP1(3), PPP1CA(2), PPP1CB(1), PPP1CC(1), PRDM2(8), PRDM7(3), PRDM9(32), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), RBBP5(3), SATB1(6), SETD1A(8), SETD2(21), SETD7(1), SETD8(2), SETDB1(5), SETDB2(2), SETMAR(1), SMYD3(4), STK38(2), SUV39H1(2), SUV39H2(3), SUV420H1(5), SUZ12(1), WHSC1(4), WHSC1L1(2)	40876042	350	139	347	95	50	99	103	40	54	4	0.307	1.000	1.000
197	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	91	ADCY1(10), ADCY2(18), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), AKAP1(4), AKAP10(1), AKAP11(8), AKAP12(5), AKAP3(7), AKAP4(7), AKAP5(1), AKAP6(16), AKAP7(1), AKAP9(23), ARHGEF1(2), CALM1(2), GNA11(1), GNA12(1), GNA13(5), GNAI3(1), GNAO1(2), GNAQ(2), GNAZ(4), GNB1(2), GNB3(2), GNB5(1), GNG12(2), GNG3(2), GNG4(1), GNGT1(2), GNGT2(2), HRAS(1), IL18BP(1), ITPR1(11), KCNJ3(15), NRAS(4), PDE1A(8), PDE1B(6), PDE1C(17), PDE4A(4), PDE4B(7), PDE4C(2), PDE4D(4), PDE7A(2), PDE7B(3), PDE8A(3), PDE8B(5), PLCB3(4), PPP3CA(5), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), PRKCD(1), PRKCE(3), PRKCG(10), PRKCH(2), PRKCI(7), PRKCQ(4), PRKCZ(2), PRKD1(16), PRKD3(5), RHOA(1), RRAS(1), SLC9A1(3), USP5(3)	40254078	381	138	376	133	36	128	105	59	53	0	0.972	1.000	1.000
198	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	97	ADCY1(10), ADCY2(18), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), CALM1(2), CALML3(3), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CREB3L1(1), CREB3L2(4), CREB3L3(1), CREB3L4(1), CREBBP(4), CTNNB1(11), DCT(7), DVL1(1), DVL2(1), DVL3(5), EDN1(1), EDNRB(6), EP300(2), FZD1(3), FZD10(7), FZD2(3), FZD3(4), FZD4(5), FZD5(1), FZD7(3), FZD9(2), GNAI1(3), GNAI3(1), GNAO1(2), GNAQ(2), GNAS(7), GSK3B(2), HRAS(1), KIT(6), LEF1(8), MAP2K1(6), MAP2K2(1), MAPK3(1), MITF(1), NRAS(4), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), POMC(1), PRKACB(3), PRKACG(1), PRKCA(7), PRKCG(10), PRKX(3), RAF1(3), TCF7(1), TCF7L1(2), TCF7L2(3), TYRP1(4), WNT1(3), WNT10A(4), WNT10B(2), WNT11(2), WNT16(2), WNT2(4), WNT2B(2), WNT3A(4), WNT4(1), WNT5A(1), WNT5B(3), WNT6(1), WNT7A(6), WNT7B(2), WNT8A(3), WNT8B(2), WNT9A(2), WNT9B(5)	36951440	355	134	350	139	52	89	113	55	46	0	0.972	1.000	1.000
199	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	82	ANPEP(4), CD14(1), CD19(2), CD1A(8), CD1B(11), CD1C(9), CD1D(6), CD1E(12), CD2(3), CD22(6), CD33(10), CD34(4), CD36(4), CD38(3), CD3D(2), CD4(3), CD44(2), CD5(4), CD55(2), CD8A(2), CD8B(3), CR1(14), CR2(8), CSF1(1), CSF1R(6), CSF2RA(5), CSF3R(4), DNTT(3), EPO(3), EPOR(1), FCER2(1), FCGR1A(1), FLT3(10), FLT3LG(2), GP5(3), HLA-DRA(3), IL1A(3), IL1R1(1), IL1R2(4), IL2RA(3), IL3(1), IL3RA(5), IL4(1), IL4R(5), IL5RA(5), IL6R(8), IL7R(7), IL9R(5), ITGA1(9), ITGA2(11), ITGA2B(4), ITGA3(5), ITGA4(19), ITGA5(6), ITGA6(5), ITGAM(14), ITGB3(4), KIT(6), MME(8), MS4A1(4), TFRC(6), THPO(1), TPO(16)	28112498	332	133	330	116	42	126	79	50	35	0	0.943	1.000	1.000
200	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(2), CCKBR(11), CCR2(5), CCR3(2), CCR5(1), CELSR1(8), CELSR2(8), CELSR3(17), CHRM2(17), CHRM3(13), CXCR3(1), EMR2(3), EMR3(5), F2R(4), FSHR(20), GHRHR(5), GNRHR(2), GPR116(5), GPR132(1), GPR133(8), GPR135(1), GPR143(1), GPR17(3), GPR18(2), GPR55(7), GPR56(6), GPR61(4), GPR77(1), GPR84(4), GRM1(26), GRPR(5), HRH4(4), LGR6(11), LPHN2(24), LPHN3(32), NTSR1(5), OR8G2(4), PTGFR(6), SMO(5), TAAR5(8), TSHR(10)	22806797	307	131	307	101	31	93	89	56	38	0	0.539	1.000	1.000
201	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	87	ACVR1(4), ACVR1B(5), ACVR1C(3), ACVR2A(3), ACVR2B(4), ACVRL1(4), AMH(1), AMHR2(2), BMP2(1), BMP4(4), BMP5(4), BMP6(2), BMP7(4), BMP8A(1), BMPR1A(1), BMPR1B(5), BMPR2(2), CHRD(9), COMP(2), CREBBP(4), CUL1(6), DCN(1), EP300(2), FST(2), GDF5(4), GDF6(7), GDF7(1), ID3(1), IFNG(4), INHBB(1), INHBC(1), INHBE(3), LEFTY1(3), LEFTY2(3), LTBP1(28), MAPK3(1), NODAL(1), PITX2(4), PPP2CA(1), PPP2CB(3), PPP2R1A(3), PPP2R1B(3), PPP2R2A(4), PPP2R2B(5), PPP2R2C(3), RBL1(7), RBL2(2), RHOA(1), ROCK1(10), ROCK2(4), RPS6KB1(2), RPS6KB2(2), SKP1(2), SMAD1(3), SMAD2(2), SMAD3(3), SMAD4(8), SMAD5(2), SMAD9(1), SMURF1(3), SMURF2(2), SP1(1), TFDP1(3), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TGFBR2(2), THBS1(4), THBS2(16), THBS3(6), THBS4(5), ZFYVE16(1), ZFYVE9(5)	33862230	270	129	270	108	38	70	78	42	42	0	0.996	1.000	1.000
202	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	BCL2(1), CABIN1(5), CALM1(2), CAMK2B(3), CAMK4(8), CD69(2), CDKN1A(1), CNR1(4), CREBBP(4), CTLA4(1), EGR2(2), EGR3(1), EP300(2), FCER1A(7), FOS(1), FOSL1(3), GATA3(6), GATA4(4), GRLF1(9), GSK3B(2), HRAS(1), ICOS(2), IFNB1(4), IFNG(4), IL10(1), IL13(1), IL2(5), IL2RA(3), IL3(1), IL4(1), ITK(7), KPNA5(2), MAP2K7(2), MAPK14(1), MAPK8(3), MAPK9(6), MEF2A(2), MEF2B(1), MEF2D(1), MYF5(3), NCK2(3), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NFKB2(6), NFKBIE(1), NUP214(18), OPRD1(1), P2RX7(5), PAK1(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PTPRC(21), SLA(1), SP1(1), SP3(4), TGFB1(2), TRAF2(1), TRPV6(8), VAV1(1), VAV2(3), VAV3(14), XPO5(3)	31140336	258	127	254	96	32	86	68	35	37	0	0.951	1.000	1.000
203	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	79	ABL1(2), ATM(22), BUB1(4), BUB1B(8), BUB3(1), CCNA1(2), CCNA2(4), CCNB1(1), CCNB2(1), CCNB3(13), CCND2(1), CCND3(1), CCNE1(3), CCNH(1), CDAN1(2), CDC14A(7), CDC14B(1), CDC20(3), CDC25A(4), CDC25B(1), CDC25C(3), CDC6(1), CDC7(3), CDH1(5), CDK2(4), CDK4(2), CDKN1A(1), CHEK1(6), CHEK2(2), DTX4(1), E2F1(3), E2F3(1), E2F6(3), EP300(2), ESPL1(4), GADD45A(1), GSK3B(2), HDAC1(3), HDAC2(8), HDAC3(1), HDAC4(11), HDAC5(2), HDAC6(5), HDAC8(2), MAD1L1(5), MAD2L1(3), MCM2(6), MCM3(5), MCM4(6), MCM5(3), MCM6(10), MCM7(4), MDM2(2), MPEG1(3), MPL(2), ORC1L(4), ORC2L(4), ORC3L(1), ORC4L(1), ORC5L(5), ORC6L(1), PCNA(1), PLK1(3), PRKDC(23), PTPRA(4), PTTG1(1), PTTG2(2), RBL1(7), SKP2(4), SMAD4(8), TBC1D8(3), TFDP1(3), TGFB1(2), WEE1(3)	37088382	287	127	286	80	46	84	81	41	35	0	0.289	1.000	1.000
204	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT2(2), AKT3(5), CASP8(4), CCL3(1), CCL4(1), CD14(1), CD80(4), CD86(6), CHUK(3), CXCL9(3), FADD(1), FOS(1), IFNA10(4), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(3), IFNA21(3), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(4), IFNA8(1), IFNAR2(2), IFNB1(4), IKBKB(3), IKBKE(5), IL12A(3), IRAK1(3), IRAK4(4), IRF3(1), IRF7(1), LBP(5), LY96(1), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP2K7(2), MAP3K7(5), MAP3K8(2), MAPK10(5), MAPK11(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPK9(6), MYD88(3), NFKB1(3), NFKB2(6), NFKBIA(1), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), RIPK1(4), STAT1(4), TBK1(2), TICAM1(1), TLR1(4), TLR2(2), TLR4(31), TLR5(1), TLR6(6), TLR7(8), TLR8(6), TLR9(6), TOLLIP(1), TRAF3(3), TRAF6(4)	30930343	277	127	272	99	29	67	84	53	44	0	0.935	1.000	1.000
205	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	69	ACACB(11), ACSL1(8), ACSL3(3), ACSL4(2), ACSL5(1), ACSL6(7), ADIPOQ(4), ADIPOR1(3), ADIPOR2(1), AKT2(2), AKT3(5), CAMKK1(2), CAMKK2(1), CD36(4), CHUK(3), CPT1A(7), CPT1B(5), CPT1C(6), CPT2(2), G6PC(1), G6PC2(2), IKBKB(3), IRS1(15), IRS2(3), IRS4(17), JAK1(8), JAK2(4), JAK3(5), LEP(4), LEPR(13), MAPK10(5), MAPK8(3), MAPK9(6), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), NPY(1), PCK1(11), PCK2(3), POMC(1), PPARA(1), PPARGC1A(12), PRKAA1(4), PRKAB1(3), PRKAG2(4), PRKAG3(4), PRKCQ(4), PTPN11(6), RXRA(1), RXRG(11), STAT3(8), TNFRSF1B(1), TRAF2(1), TYK2(2)	28381802	255	127	254	99	41	76	58	44	36	0	0.977	1.000	1.000
206	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(4), BDKRB2(1), CALM1(2), CHRM1(2), CHRNA1(7), FLT1(21), FLT4(13), KDR(30), NOS3(2), PDE2A(5), PDE3A(13), PDE3B(9), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKG1(3), PRKG2(7), RYR2(166), SLC7A1(3), SYT1(3), TNNI1(2)	14213572	305	126	301	85	32	110	71	49	40	3	0.460	1.000	1.000
207	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	58	ALG2(5), BAX(1), BFAR(1), BTK(11), CAD(16), CASP10(6), CASP3(4), CASP8(4), CASP8AP2(10), CDK2AP1(1), CSNK1A1(1), DAXX(6), DEDD(2), DFFA(3), EGFR(33), EPHB2(7), FADD(1), FAF1(4), FAIM2(4), HSPB1(1), IL1A(3), MAP2K4(3), MAP2K7(2), MAP3K1(4), MAP3K5(12), MAPK10(5), MAPK8(3), MAPK8IP1(4), MAPK8IP3(4), MAPK9(6), MET(12), NFAT5(6), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), NR0B2(1), PFN1(1), PFN2(3), PTPN13(11), RALBP1(1), RIPK1(4), ROCK1(10), SMPD1(2), TPX2(3), TRAF2(1), TUFM(2)	25055119	235	124	221	69	29	56	71	37	42	0	0.582	1.000	1.000
208	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	26	CPEB1(5), EGFR(33), ERBB2(10), ERBB4(21), ETS1(7), ETS2(3), ETV6(4), FMN2(31), GRB2(4), MAP2K1(6), MAPK3(1), NOTCH1(8), NOTCH2(26), NOTCH3(6), NOTCH4(23), PIWIL1(11), PIWIL2(6), PIWIL3(6), PIWIL4(4), RAF1(3), SOS1(12), SOS2(6), SPIRE1(5), SPIRE2(1)	17364154	242	121	224	61	29	76	58	46	32	1	0.312	1.000	1.000
209	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	61	AKT2(2), AKT3(5), BCL10(1), BLNK(1), BTK(11), CARD11(17), CD19(2), CD22(6), CD72(1), CD79B(1), CHUK(3), CR2(8), FCGR2B(2), FOS(1), GSK3B(2), HRAS(1), IKBKB(3), INPP5D(4), LILRB3(1), LYN(4), MALT1(6), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), NRAS(4), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PLCG2(9), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PTPN6(3), RAC2(1), RASGRP3(8), SYK(3), VAV1(1), VAV2(3), VAV3(14)	25484265	230	121	224	80	26	58	71	39	36	0	0.834	1.000	1.000
210	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	IMPA1(1), IMPA2(1), INPP1(3), INPP4A(5), INPP4B(14), INPP5A(3), INPP5B(2), INPPL1(6), IPMK(7), ISYNA1(2), ITGB1BP3(2), ITPK1(1), ITPKA(1), ITPKB(5), OCRL(6), PI4KA(7), PI4KB(4), PIK3C3(7), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIP4K2A(5), PIP4K2B(2), PIP4K2C(3), PIP5K1A(5), PIP5K1B(7), PIP5K1C(3), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PLCD1(2), PLCD3(2), PLCD4(3), PLCE1(14), PLCG1(5), PLCG2(9), PLCZ1(3), PTEN(8), PTPMT1(1), SYNJ1(4), SYNJ2(3)	25659221	230	118	226	76	29	69	63	33	36	0	0.786	1.000	1.000
211	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AIFM1(9), AKT2(2), AKT3(5), APAF1(8), ATM(22), BAX(1), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CAPN2(3), CASP10(6), CASP3(4), CASP6(1), CASP7(1), CASP8(4), CASP9(3), CFLAR(1), CHUK(3), CSF2RB(5), DFFA(3), DFFB(2), FADD(1), FAS(3), FASLG(4), IKBKB(3), IL1A(3), IL1R1(1), IL1RAP(2), IL3(1), IL3RA(5), IRAK1(3), IRAK2(3), IRAK3(6), IRAK4(4), MAP3K14(1), MYD88(3), NFKB1(3), NFKB2(6), NFKBIA(1), NTRK1(12), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), RIPK1(4), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(1), TNFSF10(1), TRAF2(1)	28669655	232	118	226	79	27	52	72	42	39	0	0.870	1.000	1.000
212	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CD2BP2(4), CDC40(2), CLK2(6), CLK3(1), CLK4(6), COL2A1(7), CPSF1(6), CPSF2(5), CPSF3(3), CPSF4(2), CSTF1(1), CSTF2T(4), CSTF3(3), DDIT3(4), DDX1(5), DDX20(1), DHX15(4), DHX16(5), DHX38(8), DHX8(8), DHX9(3), DICER1(8), DNAJC8(2), FUS(1), GIPC1(2), METTL3(1), NCBP2(1), NONO(2), NUDT21(1), NXF1(8), PABPN1(1), PAPOLA(6), POLR2A(9), PPM1G(4), PRPF18(2), PRPF3(3), PRPF4(3), PRPF4B(6), PRPF8(6), PSKH1(2), PTBP1(2), PTBP2(8), RBM17(3), RBM5(3), RNGTT(4), RNMT(3), SF3A1(5), SF3A3(1), SF3B1(5), SF3B2(8), SF3B4(6), SF3B5(2), SF4(6), SFRS14(6), SFRS16(1), SFRS4(4), SFRS5(1), SFRS6(4), SFRS8(5), SNRPA(1), SNRPA1(1), SNRPB2(1), SNRPD1(1), SNRPD3(2), SNRPE(1), SNRPG(1), SNRPN(4), SNURF(1), SPOP(1), SRPK1(3), SRPK2(4), SRRM1(1), SUPT5H(5), TXNL4A(3), U2AF1(6), U2AF2(5), XRN2(5)	36262150	279	118	272	77	61	61	77	45	35	0	0.325	1.000	1.000
213	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(5), AGTR2(2), ATP8A1(3), AVPR1A(6), AVPR1B(3), AVPR2(4), BDKRB1(1), BDKRB2(1), BRS3(8), C3AR1(5), CCKAR(7), CCKBR(11), CCR1(2), CCR2(5), CCR3(2), CCR4(2), CCR5(1), CCR6(2), CCR8(6), CX3CR1(5), CXCR3(1), CXCR4(3), CXCR6(1), EDNRB(6), FPR1(4), FSHR(20), GALR1(3), GALR2(1), GALT(2), GHSR(4), GNB2L1(2), GNRHR(2), GPR77(1), GRPR(5), LHCGR(6), MC2R(2), MC3R(9), MC4R(1), MC5R(10), NMBR(6), NPY1R(9), NPY2R(6), NPY5R(9), NTSR1(5), NTSR2(1), OPRD1(1), OPRK1(5), OPRL1(5), OPRM1(4), OXTR(2), PPYR1(2), SSTR1(3), SSTR3(2), SSTR4(5), TAC4(1), TACR1(3), TACR3(8), TRHR(4), TSHR(10)	17948562	255	117	254	98	24	85	73	46	26	1	0.889	1.000	1.000
214	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT2(2), AKT3(5), ASAH1(2), DAG1(2), DRD2(9), EGFR(33), EPHB2(7), GRB2(4), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), KCNJ3(15), KCNJ5(1), PI3(1), PIK3CB(7), PITX2(4), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), RAF1(3), RGS20(5), SHC1(2), SOS1(12), SOS2(6), SRC(2), STAT3(8)	19731327	222	117	206	62	27	61	58	42	34	0	0.457	1.000	1.000
215	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	68	AKT2(2), AKT3(5), CASP9(3), CDC42(2), HRAS(1), KDR(30), MAP2K1(6), MAP2K2(1), MAPK11(1), MAPK14(1), MAPK3(1), MAPKAPK2(3), MAPKAPK3(1), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NOS3(2), NRAS(4), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLCG1(5), PLCG2(9), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRKCA(7), PRKCG(10), PTGS2(4), PTK2(11), PXN(1), RAC2(1), RAF1(3), SH2D2A(7), SHC2(1), SPHK2(2), SRC(2), VEGFA(1)	24724443	246	116	239	80	38	68	66	47	27	0	0.658	1.000	1.000
216	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT2(2), AKT3(5), CDC42(2), CDK2(4), CDKN1B(3), CREB5(7), EBP(2), ERBB4(21), F2RL2(5), GAB1(2), GADD45A(1), GRB2(4), GSK3B(2), IGF1(5), IGFBP1(3), INPPL1(6), IRS1(15), IRS2(3), IRS4(17), MET(12), NOLC1(2), PAK1(5), PAK2(3), PAK3(7), PAK4(1), PAK7(19), PARD3(6), PDK1(4), PIK3CA(11), PIK3CD(1), PPP1R13B(2), PREX1(21), PTEN(8), PTK2(11), PTPN1(1), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KB1(2), SHC1(2), SOS1(12), SOS2(6), TSC1(9), TSC2(4), YWHAG(2)	26448584	269	114	264	80	45	84	68	35	37	0	0.464	1.000	1.000
217	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(2), ACTR3(1), AKT2(2), AKT3(5), ANGPTL2(4), ARHGAP1(3), ARHGAP4(2), ARHGEF11(11), BTK(11), CDC42(2), CFL2(2), GDI1(3), GDI2(1), INPPL1(6), ITPR1(11), ITPR2(25), ITPR3(6), MYLK(16), MYLK2(3), PAK1(5), PAK2(3), PAK3(7), PAK4(1), PAK7(19), PDK1(4), PIK3CA(11), PIK3CD(1), PIK3CG(11), PIK3R1(3), PITX2(4), PPP1R13B(2), PTEN(8), RACGAP1(3), RHO(1), ROCK1(10), ROCK2(4), SAG(3), WASF1(8), WASL(5)	24267588	229	112	223	64	38	68	54	30	39	0	0.371	1.000	1.000
218	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(6), ADAM17(7), ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(4), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(2), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), CASP3(4), CDC42(2), CHUK(3), CXCL1(2), EGFR(33), F11R(2), HBEGF(1), IGSF5(3), IKBKB(3), JAM2(6), LYN(4), MAP2K4(3), MAP3K14(1), MAPK10(5), MAPK11(1), MAPK14(1), MAPK8(3), MAPK9(6), MET(12), NFKB1(3), NFKB2(6), NFKBIA(1), NOD1(3), PAK1(5), PLCG1(5), PLCG2(9), PTPN11(6), PTPRZ1(36), SRC(2), TCIRG1(1), TJP1(10)	24116219	234	110	218	82	37	54	60	40	43	0	0.941	1.000	1.000
219	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(4), AGT(2), CALM1(2), CALR(1), CAMK1(2), CAMK4(8), CREBBP(4), CSNK1A1(1), EDN1(1), ELSPBP1(4), F2(5), GATA4(4), GSK3B(2), HAND1(3), HAND2(3), HRAS(1), IGF1(5), LIF(2), MAP2K1(6), MAPK14(1), MAPK3(1), MAPK8(3), MEF2C(2), MYH2(37), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NKX2-5(3), NPPA(1), PIK3CA(11), PIK3R1(3), PPP3CA(5), PPP3CB(1), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), RAF1(3), RPS6KB1(2), SYT1(3)	17444304	179	110	175	51	25	55	57	21	21	0	0.308	1.000	1.000
220	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	73	AKT2(2), AKT3(5), BTK(11), FCER1A(7), FCER1G(2), FYN(3), GAB2(1), GRB2(4), HRAS(1), IL13(1), IL3(1), IL4(1), INPP5D(4), LAT(3), LCP2(6), LYN(4), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP2K7(2), MAPK10(5), MAPK11(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPK9(6), MS4A2(2), NRAS(4), PDK1(4), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLCG1(5), PLCG2(9), PRKCA(7), PRKCD(1), PRKCE(3), RAC2(1), RAF1(3), SOS1(12), SOS2(6), SYK(3), VAV1(1), VAV2(3), VAV3(14)	24773449	241	109	235	81	30	66	69	44	32	0	0.811	1.000	1.000
221	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(16), COL4A2(16), COL4A3(5), COL4A4(13), COL4A5(23), COL4A6(17), F10(3), F11(8), F12(1), F2(5), F2R(4), F5(23), F8(23), F9(8), FGA(9), FGB(13), FGG(2), KLKB1(3), PROC(3), PROS1(13), SERPINC1(8), SERPING1(3)	15473530	219	108	218	78	18	86	48	35	32	0	0.992	1.000	1.000
222	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(4), ACSS2(4), ACYP2(1), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH3B2(4), ALDH7A1(1), ALDH9A1(3), ALDOA(2), ALDOB(4), ALDOC(1), BPGM(2), DLAT(5), DLD(6), ENO1(3), ENO3(2), FBP2(1), G6PC(1), G6PC2(2), GALM(1), GAPDH(3), GAPDHS(6), GCK(4), GPI(3), HK1(3), HK2(9), HK3(12), LDHA(3), LDHAL6A(3), LDHB(2), LDHC(5), PDHA1(3), PDHA2(13), PFKL(2), PFKM(5), PFKP(3), PGAM1(1), PGAM2(1), PGAM4(2), PGK1(5), PGK2(14), PGM1(2), PGM3(4), PKLR(11), PKM2(4), TPI1(6)	20068415	238	107	235	76	35	93	53	34	23	0	0.619	1.000	1.000
223	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), AGK(2), AGPAT1(1), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPAT6(1), AKR1B1(2), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), CEL(4), DAK(1), DGAT1(2), DGKA(5), DGKB(15), DGKD(3), DGKE(5), DGKG(7), DGKH(5), DGKI(23), DGKZ(3), GK(2), GK2(4), GLA(4), GPAM(3), LCT(30), LIPA(2), LIPC(6), LIPF(3), LIPG(2), LPL(5), MGLL(1), PNLIP(8), PNLIPRP1(7), PNLIPRP2(7), PNPLA3(2), PPAP2B(2), PPAP2C(1)	20368176	243	107	243	65	24	84	72	30	32	1	0.224	1.000	1.000
224	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADM(3), ACOX1(3), ACOX2(2), ACOX3(6), ACSL1(8), ACSL3(3), ACSL4(2), ACSL5(1), ACSL6(7), ADIPOQ(4), ANGPTL4(1), APOA1(1), APOA5(3), APOC3(3), CD36(4), CPT1A(7), CPT1B(5), CPT1C(6), CPT2(2), CYP27A1(5), CYP4A11(4), CYP7A1(7), CYP8B1(2), EHHADH(8), FABP1(1), FABP2(1), FABP3(2), FABP5(1), FABP6(1), FADS2(1), GK(2), GK2(4), HMGCS2(6), ILK(1), LPL(5), ME1(1), MMP1(7), NR1H3(4), OLR1(3), PCK1(11), PCK2(3), PDPK1(1), PLTP(2), PPARA(1), PPARD(2), PPARG(3), RXRA(1), RXRG(11), SCP2(3), SLC27A1(3), SLC27A2(3), SLC27A4(3), SLC27A5(1), SLC27A6(11), SORBS1(7), UBC(10), UCP1(2)	22562683	215	107	213	63	35	71	46	38	25	0	0.411	1.000	1.000
225	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	83	ATF2(5), CHUK(3), DAXX(6), ELK1(2), FOS(1), GRB2(4), HRAS(1), IKBKB(3), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP2K7(2), MAP3K1(4), MAP3K10(1), MAP3K11(7), MAP3K12(5), MAP3K13(7), MAP3K14(1), MAP3K2(5), MAP3K3(4), MAP3K4(14), MAP3K5(12), MAP3K6(1), MAP3K7(5), MAP3K8(2), MAP3K9(11), MAP4K1(5), MAP4K3(5), MAP4K5(1), MAPK10(5), MAPK11(1), MAPK14(1), MAPK3(1), MAPK4(6), MAPK6(1), MAPK7(5), MAPK8(3), MAPK9(6), MAPKAPK2(3), MAPKAPK3(1), MAPKAPK5(3), MAX(3), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), MKNK1(2), MKNK2(1), NFKB1(3), NFKBIA(1), PAK1(5), PAK2(3), RAF1(3), RIPK1(4), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KA4(1), RPS6KA5(4), RPS6KB1(2), RPS6KB2(2), SHC1(2), SP1(1), STAT1(4), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TRAF2(1)	32474032	240	107	240	79	49	50	68	35	38	0	0.639	1.000	1.000
226	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(1), ABP1(10), ACAT1(1), ACAT2(1), ACMSD(2), AFMID(2), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOC2(4), AOC3(5), AOX1(14), ASMT(6), CARM1(3), CAT(3), CYP1A1(6), CYP1A2(2), CYP1B1(2), DDC(6), EHHADH(8), GCDH(3), HADH(4), HADHA(3), HSD17B4(5), INMT(5), KMO(4), KYNU(5), LCMT1(2), LCMT2(4), LNX1(4), MAOA(3), MAOB(1), METTL2B(5), METTL6(1), NFX1(2), OGDH(1), OGDHL(11), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), TDO2(7), TPH1(11), TPH2(8), WARS(3), WARS2(9), WBSCR22(1)	20876098	221	106	215	74	21	59	71	33	36	1	0.781	1.000	1.000
227	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT2(2), AKT3(5), BCL2(1), BCR(3), BLNK(1), BTK(11), CD19(2), CD22(6), CR2(8), DAG1(2), FLOT1(2), FLOT2(1), GRB2(4), GSK3B(2), INPP5D(4), ITPR1(11), ITPR2(25), ITPR3(6), LYN(4), MAP4K1(5), MAPK3(1), NFATC1(3), NFATC2(8), NR0B2(1), PDK1(4), PIK3CA(11), PIK3CD(1), PIK3R1(3), PLCG2(9), PPP1R13B(2), PPP3CA(5), PPP3CB(1), PPP3CC(2), PTPRC(21), RAF1(3), SHC1(2), SOS1(12), SOS2(6), SYK(3), VAV1(1)	25553194	204	106	199	62	24	58	54	34	34	0	0.521	1.000	1.000
228	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	APC(23), AR(4), ASAH1(2), CAMP(2), CCL13(2), CCL15(3), DAG1(2), EGFR(33), GNA11(1), GNAI1(3), GNAQ(2), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), KCNJ3(15), KCNJ5(1), MAPK10(5), MAPK14(1), PHKA2(10), PIK3CA(11), PIK3CD(1), PIK3R1(3), PITX2(4), PTX3(2), RAF1(3), SRC(2)	17984744	183	105	164	47	21	46	45	33	38	0	0.374	1.000	1.000
229	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	CAD(16), CANT1(3), CTPS(5), CTPS2(5), DCK(2), DCTD(5), DHODH(1), DPYD(12), DPYS(10), DTYMK(2), ENTPD1(4), ENTPD4(2), ENTPD6(3), ITPA(1), NME6(1), NME7(4), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5C3(1), NT5E(2), NT5M(1), NUDT2(3), PNPT1(5), POLA1(6), POLA2(2), POLD1(2), POLD2(2), POLD3(3), POLE(19), POLE2(1), POLR1A(8), POLR1B(10), POLR1D(2), POLR2A(9), POLR2B(5), POLR2C(4), POLR2D(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), POLR3A(12), POLR3B(13), POLR3G(1), POLR3H(1), PRIM1(3), RFC5(1), RRM1(5), RRM2(4), TK2(1), TXNRD1(1), TXNRD2(1), UCK2(2), UMPS(2), UPP1(6), UPP2(8), UPRT(4)	27738541	241	104	239	83	45	67	71	33	24	1	0.779	1.000	1.000
230	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	53	AKR1C4(1), AKR1D1(5), ARSD(3), CARM1(3), CYP11B1(10), CYP11B2(7), CYP19A1(3), HSD11B1(4), HSD11B2(1), HSD17B12(1), HSD17B2(3), HSD17B3(1), HSD17B7(1), HSD3B1(7), HSD3B2(13), LCMT1(2), LCMT2(4), METTL2B(5), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), SRD5A1(3), SRD5A2(3), STS(5), SULT1E1(1), SULT2A1(3), SULT2B1(1), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2A1(3), UGT2A3(6), UGT2B11(11), UGT2B15(6), UGT2B28(8), UGT2B4(13), UGT2B7(8), WBSCR22(1)	16681505	200	103	197	63	20	77	60	29	14	0	0.679	1.000	1.000
231	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	55	ABP1(10), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A3(2), ALDH3A1(2), ALDH3B2(4), AOC2(4), AOC3(5), AOX1(14), CARM1(3), DBH(2), DCT(7), DDC(6), ESCO1(7), ESCO2(2), FAH(1), GOT1(2), GOT2(4), GSTZ1(1), HGD(4), HPD(2), LCMT1(2), LCMT2(4), MAOA(3), MAOB(1), METTL2B(5), METTL6(1), MYST3(8), MYST4(8), NAT6(1), PNPLA3(2), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), SH3GLB1(1), TAT(4), TH(2), TPO(16), TYRP1(4), WBSCR22(1)	20147420	214	102	213	65	31	78	51	24	30	0	0.570	1.000	1.000
232	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	67	ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), AKR1C1(2), AKR1C2(2), AKR1C3(2), AKR1C4(1), ALDH1A3(2), ALDH3A1(2), ALDH3B2(4), CYP1A1(6), CYP1A2(2), CYP1B1(2), CYP2B6(8), CYP2C18(4), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2E1(4), CYP2F1(2), CYP2S1(1), CYP3A4(1), CYP3A43(1), CYP3A5(1), CYP3A7(4), DHDH(1), EPHX1(2), GSTA1(1), GSTA2(3), GSTA3(2), GSTA4(1), GSTA5(3), GSTK1(4), GSTM1(1), GSTM2(2), GSTM3(1), GSTM4(1), GSTM5(2), GSTO2(1), GSTP1(2), GSTZ1(1), MGST1(1), MGST3(3), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2A1(3), UGT2A3(6), UGT2B11(11), UGT2B15(6), UGT2B28(8), UGT2B4(13), UGT2B7(8)	19023488	228	102	225	77	23	92	57	31	25	0	0.875	1.000	1.000
233	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ACCN1(5), ADCY4(6), ADCY6(10), ADCY8(22), CACNA1A(10), CACNA1B(15), GNAS(7), GNAT3(1), GNB1(2), GNB3(2), GNG3(2), GRM4(9), ITPR3(6), KCNB1(16), PDE1A(8), PLCB2(6), PRKACB(3), PRKACG(1), PRKX(3), SCNN1A(1), SCNN1B(3), SCNN1G(3), TAS1R1(3), TAS1R2(7), TAS1R3(3), TAS2R10(1), TAS2R13(1), TAS2R14(3), TAS2R16(10), TAS2R3(2), TAS2R38(5), TAS2R39(5), TAS2R40(4), TAS2R41(3), TAS2R42(1), TAS2R46(2), TAS2R5(1), TAS2R50(4), TAS2R60(7), TAS2R9(1), TRPM5(1)	19591637	205	102	204	64	19	79	55	29	23	0	0.449	1.000	1.000
234	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	39	AGL(13), AMY2A(4), AMY2B(16), ENPP1(6), G6PC(1), GAA(2), GANAB(3), GBE1(2), GCK(4), GPI(3), GUSB(4), GYS1(2), GYS2(3), HK1(3), HK2(9), HK3(12), MGAM(30), PGM1(2), PGM3(4), PYGB(1), PYGL(3), PYGM(6), SI(63), UCHL1(1), UGDH(4), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2B15(6), UGT2B4(13), UXS1(4)	18900744	254	102	252	81	38	90	63	38	25	0	0.768	1.000	1.000
235	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(2), ACTG2(5), ACTR2(2), ACTR3(1), ANGPTL2(4), CDC42(2), CFL2(2), FLNA(11), FLNC(18), FSCN1(3), FSCN3(7), GDI1(3), GDI2(1), MYH2(37), MYLK(16), MYLK2(3), PAK1(5), PAK2(3), PAK3(7), PAK4(1), PAK7(19), PFN1(1), PFN2(3), RHO(1), ROCK1(10), ROCK2(4), VASP(3), WASF1(8), WASL(5)	16505633	187	101	186	58	27	67	41	23	29	0	0.671	1.000	1.000
236	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ABP1(10), ACAT1(1), ACAT2(1), ACMSD(2), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), AOC2(4), AOC3(5), AOX1(14), ASMT(6), CAT(3), CYP19A1(3), CYP1A1(6), CYP1A2(2), CYP2A13(4), CYP2A6(4), CYP2A7(4), CYP2B6(8), CYP2C18(4), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2E1(4), CYP2F1(2), CYP2J2(8), CYP3A4(1), CYP3A5(1), CYP3A7(4), CYP4B1(8), CYP4F8(5), CYP51A1(3), DDC(6), EHHADH(8), GCDH(3), HADHA(3), KMO(4), KYNU(5), MAOA(3), MAOB(1), SDS(2), TDO2(7), TPH1(11), WARS(3), WARS2(9)	19017305	226	99	222	74	29	70	56	31	38	2	0.721	1.000	1.000
237	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	APC(23), ASAH1(2), CAMP(2), CAV3(2), DAG1(2), DLG4(3), EPHB2(7), GNAI1(3), GNAQ(2), ITPR1(11), ITPR2(25), ITPR3(6), KCNJ3(15), KCNJ5(1), PITX2(4), PTX3(2), RHO(1), RYR1(52)	15931301	163	98	161	41	18	44	48	25	28	0	0.170	1.000	1.000
238	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(23), AXIN1(3), CCND1(2), CCND2(1), CCND3(1), CSNK1E(6), CTNNB1(11), DVL1(1), DVL2(1), DVL3(5), FBXW2(2), FOSL1(3), FZD1(3), FZD10(7), FZD2(3), FZD3(4), FZD5(1), FZD7(3), FZD9(2), GSK3B(2), LDLR(4), MAPK10(5), MAPK9(6), PLAU(1), PPP2R5C(1), PPP2R5E(4), PRKCA(7), PRKCD(1), PRKCE(3), PRKCG(10), PRKCH(2), PRKCI(7), PRKCQ(4), PRKCZ(2), PRKD1(16), RHOA(1), SFRP4(3), TCF7(1), WNT1(3), WNT10A(4), WNT10B(2), WNT11(2), WNT16(2), WNT2(4), WNT2B(2), WNT4(1), WNT5A(1), WNT5B(3), WNT6(1), WNT7A(6), WNT7B(2)	20636335	195	98	193	52	36	54	57	23	25	0	0.160	1.000	1.000
239	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP2(1), BMP4(4), BMP5(4), BMP6(2), BMP7(4), BMP8A(1), BTRC(9), CSNK1A1(1), CSNK1A1L(5), CSNK1D(2), CSNK1E(6), CSNK1G1(1), CSNK1G2(1), CSNK1G3(3), DHH(1), GAS1(1), GLI1(13), GLI2(10), GLI3(17), GSK3B(2), HHIP(1), IHH(1), LRP2(45), PRKACB(3), PRKACG(1), PRKX(3), PTCH1(8), PTCH2(2), SHH(4), SMO(5), STK36(5), WNT1(3), WNT10A(4), WNT10B(2), WNT11(2), WNT16(2), WNT2(4), WNT2B(2), WNT3A(4), WNT4(1), WNT5A(1), WNT5B(3), WNT6(1), WNT7A(6), WNT7B(2), WNT8A(3), WNT8B(2), WNT9A(2), WNT9B(5), ZIC2(6)	21042352	221	97	217	63	47	63	62	29	19	1	0.313	1.000	1.000
240	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP1(3), INPP4A(5), INPP4B(14), INPP5A(3), INPPL1(6), ITPKA(1), ITPKB(5), OCRL(6), PIK3C2A(10), PIK3C2B(7), PIK3C2G(9), PIK3CA(11), PIK3CB(7), PIK3CG(11), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PLCD1(2), PLCG1(5), PLCG2(9)	15515895	159	97	156	48	21	43	48	20	27	0	0.555	1.000	1.000
241	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(3), F11(8), F12(1), F13B(16), F2(5), F5(23), F7(2), F8(23), F9(8), FGA(9), FGB(13), FGG(2), LPA(26), PLAT(6), PLAU(1), PLG(13), SERPINB2(6), SERPINE1(5), VWF(13)	12094406	183	96	182	44	16	60	43	38	25	1	0.289	1.000	1.000
242	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP2(1), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH3B2(4), ALDH9A1(3), ALDOA(2), ALDOB(4), ALDOC(1), BPGM(2), DLAT(5), DLD(6), ENO1(3), ENO3(2), FBP2(1), G6PC(1), GAPDH(3), GCK(4), GPI(3), HK1(3), HK2(9), HK3(12), LDHA(3), LDHB(2), LDHC(5), PDHA1(3), PDHA2(13), PFKM(5), PFKP(3), PGAM1(1), PGK1(5), PGM1(2), PGM3(4), PKLR(11), PKM2(4), TPI1(6)	16820508	205	96	202	60	32	81	46	26	20	0	0.368	1.000	1.000
243	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP2(1), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH3B2(4), ALDH9A1(3), ALDOA(2), ALDOB(4), ALDOC(1), BPGM(2), DLAT(5), DLD(6), ENO1(3), ENO3(2), FBP2(1), G6PC(1), GAPDH(3), GCK(4), GPI(3), HK1(3), HK2(9), HK3(12), LDHA(3), LDHB(2), LDHC(5), PDHA1(3), PDHA2(13), PFKM(5), PFKP(3), PGAM1(1), PGK1(5), PGM1(2), PGM3(4), PKLR(11), PKM2(4), TPI1(6)	16820508	205	96	202	60	32	81	46	26	20	0	0.368	1.000	1.000
244	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	APAF1(8), ATM(22), ATR(17), BAI1(10), BAX(1), BID(1), CASP3(4), CASP8(4), CASP9(3), CCNB1(1), CCNB2(1), CCNB3(13), CCND1(2), CCND2(1), CCND3(1), CCNE1(3), CCNG1(2), CD82(2), CDK2(4), CDK4(2), CDK6(3), CDKN1A(1), CHEK1(6), CHEK2(2), EI24(1), FAS(3), GADD45A(1), GTSE1(3), IGF1(5), IGFBP3(2), LRDD(1), MDM2(2), PPM1D(6), PTEN(8), RCHY1(1), RFWD2(3), RRM2(4), SERPINB5(6), SERPINE1(5), SESN2(2), THBS1(4), TNFRSF10B(1), TP53I3(2), TP73(4), TSC2(4), ZMAT3(1)	22092088	183	96	181	54	25	48	50	33	27	0	0.560	1.000	1.000
245	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(1), CHUK(3), DAXX(6), EGF(9), EGFR(33), ETS1(7), ETS2(3), FOS(1), HOXA7(3), HRAS(1), IKBKB(3), MAP2K1(6), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP2K7(2), MAP3K1(4), MAP3K14(1), MAP3K5(12), MAPK14(1), MAPK3(1), MAPK8(3), NFKB1(3), NFKBIA(1), PPP2CA(1), PRKCA(7), PRKCD(1), PRKCE(3), PRKCG(10), PRKCH(2), PRKCQ(4), RAF1(3), RIPK1(4), SP1(1), TNFRSF1B(1), TRAF2(1)	16878445	152	96	138	54	19	36	36	32	29	0	0.929	1.000	1.000
246	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	32	AKT2(2), AKT3(5), BCR(3), BTK(11), CD19(2), DAPP1(2), FLOT1(2), FLOT2(1), GAB1(2), ITPR1(11), ITPR2(25), ITPR3(6), LYN(4), NR0B2(1), PDK1(4), PIK3CA(11), PITX2(4), PLCG2(9), PPP1R13B(2), PREX1(21), PTEN(8), PTPRC(21), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KB1(2), SAG(3), SYK(3), TEC(5), VAV1(1)	19018908	180	96	175	46	22	52	50	28	28	0	0.201	1.000	1.000
247	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH6(8), ADH7(4), ADHFE1(2), AGPAT1(1), AGPAT2(3), AGPAT3(3), AGPAT4(3), AKR1B1(2), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), CEL(4), DGAT1(2), DGKA(5), DGKB(15), DGKD(3), DGKE(5), DGKG(7), DGKH(5), DGKZ(3), GK(2), GLA(4), LCT(30), LIPC(6), LIPF(3), LIPG(2), LPL(5), PNLIP(8), PNLIPRP1(7), PNLIPRP2(7), PPAP2B(2), PPAP2C(1)	16758907	210	95	210	55	20	75	60	26	29	0	0.213	1.000	1.000
248	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(5), ALPL(2), ALPP(4), ALPPL2(3), ASCC3(10), ATP13A2(5), DDX18(3), DDX19A(1), DDX23(8), DDX4(6), DDX41(1), DDX47(1), DDX50(6), DDX52(3), DDX54(2), DDX55(1), DDX56(1), DHX58(1), ENTPD7(3), EP400(14), ERCC2(3), ERCC3(5), FPGS(1), GCH1(4), GGH(4), IFIH1(6), MOV10L1(9), NUDT5(2), NUDT8(1), QDPR(4), RAD54B(8), RAD54L(1), RUVBL2(3), SETX(17), SKIV2L2(10), SMARCA2(10), SMARCA5(1)	21726604	169	95	169	53	23	40	52	30	23	1	0.568	1.000	1.000
249	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(7), CREBBP(4), DLL1(5), DLL3(3), DLL4(1), DTX1(4), DTX2(2), DTX3(4), DTX3L(2), DTX4(1), DVL1(1), DVL2(1), DVL3(5), EP300(2), HDAC1(3), HDAC2(8), HES1(1), JAG1(4), JAG2(2), LFNG(1), MAML1(5), MAML2(3), MAML3(7), NCOR2(13), NCSTN(4), NOTCH1(8), NOTCH2(26), NOTCH3(6), NOTCH4(23), NUMB(2), NUMBL(1), PSEN1(1), PSEN2(4), PSENEN(1), PTCRA(2), RBPJ(3), RBPJL(2), SNW1(2)	24025077	174	94	174	60	28	51	50	17	27	1	0.794	1.000	1.000
250	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	49	ABL1(2), ACTG1(2), ARHGEF2(6), ARPC5(1), CD14(1), CDC42(2), CDH1(5), CLDN1(3), CTNNB1(11), CTTN(3), EZR(1), FYN(3), HCLS1(6), ITGB1(3), KRT18(1), LY96(1), NCK1(3), NCK2(3), NCL(4), OCLN(1), PRKCA(7), RHOA(1), ROCK1(10), ROCK2(4), TLR4(31), TLR5(1), TUBA1A(3), TUBA1B(1), TUBA1C(3), TUBA3D(9), TUBA3E(2), TUBA4A(3), TUBA8(1), TUBB1(3), TUBB2A(2), TUBB2B(1), TUBB2C(3), TUBB4(5), TUBB8(7), WAS(3), WASL(5)	17475906	167	94	164	68	29	52	43	24	19	0	0.984	1.000	1.000
251	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	49	ABL1(2), ACTG1(2), ARHGEF2(6), ARPC5(1), CD14(1), CDC42(2), CDH1(5), CLDN1(3), CTNNB1(11), CTTN(3), EZR(1), FYN(3), HCLS1(6), ITGB1(3), KRT18(1), LY96(1), NCK1(3), NCK2(3), NCL(4), OCLN(1), PRKCA(7), RHOA(1), ROCK1(10), ROCK2(4), TLR4(31), TLR5(1), TUBA1A(3), TUBA1B(1), TUBA1C(3), TUBA3D(9), TUBA3E(2), TUBA4A(3), TUBA8(1), TUBB1(3), TUBB2A(2), TUBB2B(1), TUBB2C(3), TUBB4(5), TUBB8(7), WAS(3), WASL(5)	17475906	167	94	164	68	29	52	43	24	19	0	0.984	1.000	1.000
252	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(9), CD28(1), CD3D(2), CTLA4(1), DAG1(2), DTYMK(2), EPHB2(7), FBXW7(4), GRAP2(5), GRB2(4), ITK(7), ITPKA(1), ITPKB(5), LAT(3), LCK(5), LCP2(6), NCK1(3), NFAT5(6), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), PAK1(5), PAK2(3), PAK3(7), PAK4(1), PAK7(19), PLCG1(5), PTPRC(21), RAF1(3), RASGRP1(2), RASGRP2(1), RASGRP3(8), RASGRP4(2), SOS1(12), SOS2(6), VAV1(1), ZAP70(4)	19339966	184	94	184	53	27	60	45	24	28	0	0.454	1.000	1.000
253	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	61	ATM(22), CCNA1(2), CCNB1(1), CCND1(2), CCND2(1), CCND3(1), CCNE1(3), CCNH(1), CDC25A(4), CDK2(4), CDK4(2), CDK7(3), CDKN1A(1), CDKN1B(3), CDKN2D(1), CREB3L1(1), CREB3L3(1), CREB3L4(1), E2F1(3), E2F3(1), E2F6(3), GADD45A(1), GBA2(2), MCM2(6), MCM3(5), MCM4(6), MCM5(3), MCM6(10), MCM7(4), MDM2(2), MNAT1(2), MYT1(6), NACA(1), ORC1L(4), ORC2L(4), ORC3L(1), ORC4L(1), ORC5L(5), ORC6L(1), PCNA(1), POLA2(2), POLE(19), POLE2(1), PRIM1(3), RBL1(7), RPA2(1), TFDP1(3), TFDP2(2), TNXB(14), WEE1(3)	25533271	181	93	179	53	36	40	56	24	25	0	0.368	1.000	1.000
254	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(56), CDR1(4), DGKI(23), PIGK(2), RPL10(2), RPL11(1), RPL12(1), RPL14(1), RPL15(1), RPL19(2), RPL21(1), RPL22(1), RPL24(1), RPL27A(1), RPL29(1), RPL3(1), RPL30(3), RPL35(1), RPL37(1), RPL3L(2), RPL4(5), RPL5(1), RPL6(3), RPL7(1), RPL7A(1), RPL8(1), RPLP0(3), RPLP2(1), RPS10(1), RPS11(1), RPS12(1), RPS13(2), RPS15(1), RPS18(1), RPS26(1), RPS29(1), RPS4Y1(1), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KA6(5), RPS6KB1(2), RPS6KB2(2), RPSA(1), SLC36A2(3), UBC(10)	18271223	164	93	163	50	26	55	42	21	19	1	0.629	1.000	1.000
255	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(3), AGPAT1(1), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPAT6(1), CDIPT(1), CDS1(2), CDS2(3), CHAT(8), CHKA(1), CHKB(2), DGKA(5), DGKB(15), DGKD(3), DGKE(5), DGKG(7), DGKH(5), DGKI(23), DGKZ(3), ESCO1(7), ESCO2(2), ETNK1(1), ETNK2(1), GNPAT(3), GPAM(3), GPD1(2), GPD1L(6), GPD2(4), LCAT(1), LYPLA1(1), LYPLA2(1), MYST3(8), MYST4(8), NAT6(1), PCYT1A(2), PCYT1B(3), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLD1(9), PLD2(5), PNPLA3(2), PPAP2B(2), PPAP2C(1), PTDSS1(5), PTDSS2(2), SH3GLB1(1)	22733746	206	92	206	61	28	57	61	31	28	1	0.506	1.000	1.000
256	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	51	ACTG1(2), APAF1(8), BAG4(1), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CASP2(7), CASP3(4), CASP6(1), CASP7(1), CASP8(4), CASP9(3), CFLAR(1), CHUK(3), DAXX(6), DFFA(3), DFFB(2), FADD(1), GSN(3), LMNB1(2), LMNB2(2), MAP2K7(2), MAP3K1(4), MAP3K14(1), MAP3K5(12), MAPK8(3), MDM2(2), NFKB1(3), NFKBIA(1), NUMA1(6), PAK2(3), PRKCD(1), PRKDC(23), PSEN1(1), PSEN2(4), PTK2(11), RASA1(3), RIPK1(4), SPTAN1(12), TNFRSF1B(1), TRAF2(1)	23474561	159	91	159	57	28	39	41	21	30	0	0.947	1.000	1.000
257	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(16), CANT1(3), CTPS(5), CTPS2(5), DCK(2), DCTD(5), DHODH(1), DPYD(12), DPYS(10), DTYMK(2), ENTPD1(4), ITPA(1), NT5E(2), NT5M(1), NUDT2(3), POLB(2), POLD1(2), POLD2(2), POLE(19), POLG(10), POLL(2), POLQ(17), POLR1B(10), POLR2A(9), POLR2B(5), POLR2C(4), POLR2D(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), POLRMT(1), RRM1(5), RRM2(4), TK2(1), TXNRD1(1), UCK2(2), UMPS(2), UNG(5), UPP1(6)	19805523	191	91	189	57	41	42	59	27	21	1	0.338	1.000	1.000
258	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(33), ELK1(2), GNAS(7), GNB1(2), GNGT1(2), GRB2(4), HRAS(1), IGF1R(10), ITGB1(3), KLK2(4), MAP2K1(6), MAP2K2(1), MAPK3(1), MKNK1(2), MKNK2(1), NGFR(2), PDGFRA(17), PPP2CA(1), PTPRR(8), RAF1(3), RPS6KA1(1), RPS6KA5(4), SHC1(2), SOS1(12), SRC(2), STAT3(8)	11376262	139	90	125	46	12	36	35	36	20	0	0.905	1.000	1.000
259	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(2), ALDOB(4), ALDOC(1), DLAT(5), DLD(6), ENO1(3), ENO3(2), FBP2(1), G6PC(1), GAPDH(3), GAPDHS(6), GCK(4), GOT1(2), GOT2(4), GPI(3), HK1(3), HK2(9), HK3(12), LDHA(3), LDHB(2), LDHC(5), MDH1(2), MDH2(2), PC(1), PCK1(11), PDHA1(3), PDHA2(13), PDHX(4), PFKL(2), PFKM(5), PFKP(3), PGAM1(1), PGAM2(1), PGK1(5), PGK2(14), PKLR(11), PKM2(4), TPI1(6)	14625772	169	89	166	55	32	55	40	25	17	0	0.506	1.000	1.000
260	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	AKT2(2), AKT3(5), CAB39(2), DDIT4(2), EIF4B(5), FIGF(1), HIF1A(1), IGF1(5), MAPK3(1), PDPK1(1), PGF(1), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PRKAA1(4), RHEB(4), RICTOR(19), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KA6(5), RPS6KB1(2), RPS6KB2(2), TSC1(9), TSC2(4), ULK1(3), ULK2(2), ULK3(1), VEGFA(1), VEGFC(11)	17774522	145	89	141	47	18	38	48	24	17	0	0.614	1.000	1.000
261	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(10), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH4A1(3), ALDH9A1(3), AMD1(1), AOC2(4), AOC3(5), ARG1(1), ASL(3), CKM(1), CKMT1A(2), CKMT1B(1), CKMT2(2), CPS1(39), DAO(1), GATM(4), GLUD1(3), GOT1(2), GOT2(4), MAOA(3), MAOB(1), NOS1(9), NOS3(2), OAT(1), ODC1(1), OTC(5), P4HA1(3), P4HA2(2), P4HA3(2), P4HB(4), RARS(5), SMS(1)	15277277	155	88	154	56	22	42	46	26	19	0	0.878	1.000	1.000
262	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	EGF(9), EGFR(33), ELK1(2), FOS(1), GRB2(4), HRAS(1), JAK1(8), MAP2K1(6), MAP2K4(3), MAP3K1(4), MAPK3(1), MAPK8(3), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), RAF1(3), RASA1(3), SHC1(2), SOS1(12), STAT1(4), STAT3(8), STAT5A(3)	12854686	136	88	119	37	17	24	35	35	25	0	0.519	1.000	1.000
263	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(4), ACADM(3), ACAT1(1), ACAT2(1), ACOX1(3), ACOX3(6), ACSL1(8), ACSL3(3), ACSL4(2), ACSL5(1), ACSL6(7), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), CPT1A(7), CPT1B(5), CPT1C(6), CPT2(2), CYP4A11(4), DCI(2), EHHADH(8), GCDH(3), HADH(4), HADHA(3), HADHB(4), HSD17B4(5)	16841805	158	87	155	46	18	62	28	26	23	1	0.502	1.000	1.000
264	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	46	AADAT(1), AASDHPPT(2), AASS(7), ACAT1(1), ACAT2(1), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), BBOX1(3), DLST(2), DOT1L(8), EHHADH(8), EHMT1(8), EHMT2(1), GCDH(3), HADH(4), HADHA(3), HSD17B4(5), HSD3B7(2), NSD1(11), OGDH(1), OGDHL(11), PLOD1(2), PLOD2(6), PLOD3(4), RDH11(2), SETD1A(8), SETD7(1), SETDB1(5), SHMT1(2), SHMT2(2), SPCS1(1), SPCS3(1), SUV39H1(2), SUV39H2(3), TMLHE(2)	19810103	143	86	140	53	20	35	46	22	18	2	0.871	1.000	1.000
265	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM1(2), CD3D(2), ELK1(2), FOS(1), FYN(3), GRB2(4), HRAS(1), LAT(3), LCK(5), MAP2K1(6), MAP2K4(3), MAP3K1(4), MAPK3(1), MAPK8(3), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NFKB1(3), NFKBIA(1), PIK3CA(11), PIK3R1(3), PLCG1(5), PPP3CA(5), PPP3CB(1), PPP3CC(2), PRKCA(7), RAF1(3), RASA1(3), SHC1(2), SOS1(12), SYT1(3), VAV1(1), ZAP70(4)	16404415	135	86	130	40	24	31	45	17	18	0	0.406	1.000	1.000
266	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(11), CALM1(2), ELK1(2), FCER1A(7), FCER1G(2), FOS(1), GRB2(4), HRAS(1), LYN(4), MAP2K1(6), MAP2K4(3), MAP2K7(2), MAP3K1(4), MAPK3(1), MAPK8(3), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), PAK2(3), PIK3CA(11), PIK3R1(3), PLA2G4A(10), PLCG1(5), PPP3CA(5), PPP3CB(1), PPP3CC(2), RAF1(3), SHC1(2), SOS1(12), SYK(3), SYT1(3), VAV1(1)	14773706	146	85	142	36	22	37	44	22	21	0	0.148	1.000	1.000
267	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(1), CALR(1), CANX(2), CD4(3), CD8A(2), CD8B(3), CIITA(4), CTSB(1), CTSS(1), HLA-A(2), HLA-B(3), HLA-C(1), HLA-DMA(2), HLA-DMB(1), HLA-DOA(2), HLA-DOB(1), HLA-DPA1(2), HLA-DQA2(1), HLA-DRA(3), HLA-G(1), HSP90AA1(5), HSP90AB1(3), HSPA5(4), IFNA10(4), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(3), IFNA21(3), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(4), IFNA8(1), KIR2DL1(4), KIR2DL3(2), KIR2DL4(1), KIR2DS4(2), KIR3DL1(10), KLRC1(3), KLRC2(3), KLRC3(3), KLRD1(2), LGMN(4), LTA(2), NFYB(1), NFYC(2), PDIA3(2), PSME1(1), PSME2(1), RFX5(6), TAP2(7), TAPBP(2)	16155034	138	85	138	58	20	30	43	27	18	0	0.972	1.000	1.000
268	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(4), ADRA1B(4), ADRA1D(2), ADRA2A(1), ADRA2C(3), ADRB2(2), ADRB3(3), CHRM1(2), CHRM2(17), CHRM3(13), CHRM4(2), CHRM5(3), DRD1(3), DRD2(9), DRD3(9), DRD5(8), HRH1(6), HRH2(6), HTR1A(13), HTR1B(5), HTR1D(1), HTR1E(9), HTR1F(4), HTR2A(3), HTR2B(2), HTR2C(6), HTR5A(11), HTR6(5), HTR7(3)	8817874	159	85	158	69	15	63	48	23	10	0	0.881	1.000	1.000
269	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT2(2), AKT3(5), ARHGEF11(11), BCL2(1), CDC42(2), DLG4(3), GNA13(5), LPA(26), MAP2K4(3), MAP3K1(4), MAP3K5(12), MAPK8(3), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), PDK1(4), PHKA2(10), PI3(1), PIK3CB(7), PLD1(9), PLD2(5), PLD3(1), PTK2(11), RDX(2), ROCK1(10), ROCK2(4), SERPINA4(9)	16867911	161	85	161	40	24	45	39	28	25	0	0.219	1.000	1.000
270	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	ATF2(5), CDC42(2), DLD(6), DUSP10(6), DUSP8(1), GAB1(2), GADD45A(1), GCK(4), IL1R1(1), MAP2K4(3), MAP2K7(2), MAP3K1(4), MAP3K10(1), MAP3K11(7), MAP3K12(5), MAP3K13(7), MAP3K2(5), MAP3K3(4), MAP3K4(14), MAP3K5(12), MAP3K7(5), MAP3K9(11), MAPK10(5), MAPK7(5), MAPK8(3), MAPK9(6), MYEF2(4), NFATC3(10), NR2C2(2), PAPPA(12), SHC1(2), TRAF6(4), ZAK(3)	16997983	164	85	163	46	40	37	47	25	15	0	0.322	1.000	1.000
271	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(4), ADC(2), ALDH4A1(3), ALDH5A1(2), CAD(16), CPS1(39), EARS2(2), EPRS(13), GAD1(5), GAD2(10), GCLC(8), GCLM(1), GFPT1(4), GFPT2(6), GLS(3), GLS2(2), GLUD1(3), GLUD2(5), GLUL(2), GMPS(8), GOT1(2), GOT2(4), GPT2(3), GSR(1), GSS(3), NADSYN1(1), NAGK(1), PPAT(5), QARS(2)	13623439	160	84	159	45	21	47	40	31	20	1	0.488	1.000	1.000
272	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	34	ACTA1(4), CRKL(2), DOCK1(7), ELK1(2), FOS(1), GAB1(2), GRB2(4), HRAS(1), ITGA1(9), ITGB1(3), MAP2K1(6), MAP2K2(1), MAP4K1(5), MAPK3(1), MAPK8(3), MET(12), PAK1(5), PIK3CA(11), PIK3R1(3), PTEN(8), PTK2(11), PTK2B(8), PTPN11(6), PXN(1), RAF1(3), RAP1A(2), RAP1B(1), RASA1(3), SOS1(12), SRC(2), STAT3(8)	14658290	147	84	142	42	22	30	34	36	25	0	0.509	1.000	1.000
273	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(3), APOA1(1), CD36(4), CITED2(2), CPT1B(5), CREBBP(4), EHHADH(8), EP300(2), FABP1(1), HSD17B4(5), LPL(5), MAPK3(1), ME1(1), NCOA1(5), NCOR1(10), NCOR2(13), NFKBIA(1), NR0B2(1), NR1H3(4), NR2F1(1), NRIP1(8), PDGFA(6), PIK3CA(11), PIK3R1(3), PPARA(1), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), PTGS2(4), RXRA(1), SP1(1), STAT5A(3), STAT5B(4)	21115174	138	84	133	50	24	36	40	18	20	0	0.849	1.000	1.000
274	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT2(2), AKT3(5), BCR(3), BLNK(1), BTK(11), CD19(2), DAG1(2), EPHB2(7), GRB2(4), ITPKA(1), ITPKB(5), LYN(4), MAP2K1(6), MAP2K2(1), NFAT5(6), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), PI3(1), PIK3CA(11), PIK3CD(1), PIK3R1(3), PLCG2(9), PPP1R13B(2), RAF1(3), SERPINA4(9), SHC1(2), SOS1(12), SOS2(6), SYK(3), VAV1(1)	18092603	134	84	131	40	14	29	41	30	20	0	0.444	1.000	1.000
275	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(2), AGTR1(5), ATF2(5), CALM1(2), EGFR(33), ELK1(2), GNAQ(2), GRB2(4), HRAS(1), MAP2K1(6), MAP2K2(1), MAP2K4(3), MAP3K1(4), MAPK3(1), MAPK8(3), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), PAK1(5), PRKCA(7), PTK2(11), PTK2B(8), RAF1(3), SHC1(2), SOS1(12), SRC(2), SYT1(3)	11569309	133	83	119	35	24	35	21	30	23	0	0.381	1.000	1.000
276	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(10), ACY3(2), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH3B2(4), ALDH7A1(1), ALDH9A1(3), AMDHD1(3), AOC2(4), AOC3(5), ASPA(2), CARM1(3), CNDP1(5), DDC(6), FTCD(3), HAL(2), HARS(2), HARS2(3), HDC(7), HNMT(2), LCMT1(2), LCMT2(4), MAOA(3), MAOB(1), METTL2B(5), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), PRPS1(3), PRPS2(2), UROC1(9), WBSCR22(1)	13689849	137	83	136	39	24	34	48	18	13	0	0.187	1.000	1.000
277	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(10), ACACB(11), ACAT1(1), ACAT2(1), ACOT12(4), ACSS1(4), ACSS2(4), ACYP2(1), AKR1B1(2), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), DLAT(5), DLD(6), GLO1(1), GRHPR(1), HAGH(1), HAGHL(1), LDHA(3), LDHAL6A(3), LDHB(2), LDHC(5), LDHD(2), MDH1(2), MDH2(2), ME1(1), ME2(7), ME3(2), PC(1), PCK1(11), PCK2(3), PDHA1(3), PDHA2(13), PKLR(11), PKM2(4)	16098013	148	83	147	50	27	43	40	21	17	0	0.720	1.000	1.000
278	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(2), ALOX12(3), ALOX12B(1), ALOX15(4), ALOX15B(2), ALOX5(6), CYP2B6(8), CYP2C18(4), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2E1(4), CYP2J2(8), CYP2U1(2), CYP4A11(4), CYP4F2(5), CYP4F3(12), DHRS4(1), EPHX2(1), GGT1(1), GPX1(1), GPX3(1), GPX5(4), GPX6(3), GPX7(3), LTA4H(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PTGDS(2), PTGIS(5), PTGS1(5), PTGS2(4), TBXAS1(6)	13383676	145	82	144	47	23	42	41	21	17	1	0.578	1.000	1.000
279	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(4), CAPN2(3), CAPNS2(2), CXCR3(1), EGF(9), EGFR(33), HRAS(1), ITGA1(9), ITGB1(3), MAPK3(1), MYL2(2), MYLK(16), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PTK2(11), PXN(1), TLN1(13)	11288326	121	81	106	33	12	31	22	32	24	0	0.555	1.000	1.000
280	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT2(2), AKT3(5), BRD4(6), CBL(9), CDC42(2), F2RL2(5), FLOT1(2), FLOT2(1), GRB2(4), GSK3B(2), IGFBP1(3), INPPL1(6), IRS1(15), IRS2(3), IRS4(17), LNPEP(1), MAPK3(1), PARD3(6), PDK1(4), PIK3CA(11), PIK3CD(1), PIK3R1(3), PPYR1(2), PTEN(8), PTPN1(1), RAF1(3), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KB1(2), SERPINB6(2), SHC1(2), SORBS1(7), SOS1(12), SOS2(6), YWHAG(2)	20221158	165	81	161	59	32	36	56	23	18	0	0.772	1.000	1.000
281	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(2), EIF1(1), EIF2B1(1), EIF2B2(2), EIF2B3(3), EIF2B4(3), EIF2B5(3), EIF2S3(2), ELAVL1(3), FLT1(21), FLT4(13), HIF1A(1), HRAS(1), KDR(30), NOS3(2), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), PTK2(11), PXN(1), SHC1(2), VHL(1)	11744952	129	81	125	31	18	41	39	16	15	0	0.150	1.000	1.000
282	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(10), AGXT(3), AGXT2(8), ALAS1(3), AMT(2), AOC2(4), AOC3(5), BHMT(6), CBS(1), CHKA(1), CHKB(2), CPT1B(5), CTH(1), DAO(1), DLD(6), DMGDH(4), GARS(4), GATM(4), GCAT(4), GLDC(11), MAOA(3), MAOB(1), PLCB2(6), PLCG1(5), PLCG2(9), PSPH(5), SARDH(5), SARS(2), SHMT1(2), SHMT2(2), TARS(5)	14591193	130	80	130	37	23	39	35	23	10	0	0.347	1.000	1.000
283	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	19	ADCYAP1R1(6), CALCR(8), CALCRL(10), CD97(4), CRHR1(1), CRHR2(2), EMR1(10), EMR2(3), GHRHR(5), GIPR(2), GLP1R(1), GLP2R(9), GPR64(7), LPHN1(3), LPHN2(24), LPHN3(32), SCTR(1), VIPR2(4)	8788104	132	80	132	49	9	48	31	29	15	0	0.922	1.000	1.000
284	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(4), APC(23), ATF2(5), AXIN1(3), BMP10(6), BMP2(1), BMP4(4), BMP5(4), BMP7(4), BMPR1A(1), BMPR2(2), CHRD(9), CTNNB1(11), DVL1(1), FZD1(3), GATA4(4), GSK3B(2), MAP3K7(5), MEF2C(2), MYL2(2), NKX2-5(3), NPPA(1), RFC1(6), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TGFBR2(2), TGFBR3(13), WNT1(3)	12563856	137	79	135	41	18	42	34	22	21	0	0.674	1.000	1.000
285	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(2), DLG4(3), GRIN1(2), GRIN2A(26), GRIN2B(22), GRIN2C(3), GRIN2D(6), NOS1(9), PPP3CA(5), PPP3CB(1), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), SYT1(3)	8824973	103	79	102	43	16	29	33	12	13	0	0.948	1.000	1.000
286	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), CHUK(3), ELK1(2), FOS(1), IKBKB(3), IRAK1(3), LY96(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP3K1(4), MAP3K14(1), MAP3K7(5), MAPK14(1), MAPK8(3), MYD88(3), NFKB1(3), NFKBIA(1), PPARA(1), TLR10(6), TLR2(2), TLR4(31), TLR6(6), TLR7(8), TLR9(6), TOLLIP(1), TRAF6(4)	12531338	110	79	109	42	12	32	25	17	24	0	0.951	1.000	1.000
287	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(4), ACAA2(4), ACADM(3), ACAT1(1), ACAT2(1), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOX1(14), AUH(1), BCAT1(1), BCAT2(1), BCKDHB(5), DBT(10), DLD(6), EHHADH(8), HADH(4), HADHA(3), HADHB(4), HIBADH(1), HIBCH(4), HMGCS1(5), HMGCS2(6), HSD17B4(5), IVD(3), MCCC1(2), MCCC2(3), MCEE(1), MUT(6), OXCT1(4), PCCA(5), PCCB(2)	14806911	137	78	135	43	9	44	35	19	27	3	0.733	1.000	1.000
288	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(9), EGF(9), EGFR(33), GRB2(4), HRAS(1), MAP2K1(6), MAPK3(1), PTPRB(29), RAF1(3), RASA1(3), SHC1(2), SOS1(12), SPRY1(1), SPRY2(2), SPRY3(5), SPRY4(3), SRC(2)	8608110	125	78	111	36	17	28	24	35	21	0	0.613	1.000	1.000
289	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT2(2), AKT3(5), ANKRD6(1), APC(23), AXIN1(3), AXIN2(2), CER1(2), CSNK1A1(1), CTNNB1(11), DACT1(12), DKK1(2), DKK2(4), DKK4(2), DVL1(1), FSTL1(3), GSK3B(2), LRP1(21), MVP(3), NKD1(6), NKD2(3), PSEN1(1), PTPRA(4), SENP2(3), SFRP1(1), TSHB(1)	13926635	119	78	117	33	11	36	38	13	21	0	0.495	1.000	1.000
290	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	ELK1(2), FOS(1), GRB2(4), HRAS(1), JAK1(8), MAP2K1(6), MAP2K4(3), MAP3K1(4), MAPK3(1), MAPK8(3), PDGFA(6), PDGFRA(17), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), RAF1(3), RASA1(3), SHC1(2), SOS1(12), STAT1(4), STAT3(8), STAT5A(3)	11969601	117	77	114	34	16	23	37	25	16	0	0.508	1.000	1.000
291	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	31	ABP1(10), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A3(2), ALDH3A1(2), ALDH3B2(4), AOC2(4), AOC3(5), AOX1(14), DBH(2), DCT(7), DDC(6), FAH(1), GOT1(2), GOT2(4), GSTZ1(1), HGD(4), HPD(2), MAOA(3), MAOB(1), TAT(4), TH(2), TPO(16)	10576136	138	77	138	44	17	58	25	17	21	0	0.674	1.000	1.000
292	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(11), CALM1(2), CD79B(1), ELK1(2), FOS(1), GRB2(4), HRAS(1), LYN(4), MAP2K1(6), MAP3K1(4), MAPK14(1), MAPK3(1), MAPK8(3), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), PLCG1(5), PPP3CA(5), PPP3CB(1), PPP3CC(2), PRKCA(7), RAF1(3), SHC1(2), SOS1(12), SYK(3), SYT1(3), VAV1(1)	13125135	115	76	114	33	21	28	35	17	14	0	0.307	1.000	1.000
293	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(3), AGPAT1(1), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPS(3), CDIPT(1), CDS1(2), CDS2(3), CHAT(8), CHKA(1), CHKB(2), CLC(1), CPT1B(5), DGKA(5), DGKB(15), DGKD(3), DGKE(5), DGKG(7), DGKH(5), DGKZ(3), ETNK1(1), GNPAT(3), GPD1(2), GPD2(4), LCAT(1), LGALS13(2), LYPLA1(1), LYPLA2(1), PAFAH2(1), PCYT1A(2), PCYT1B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLCB2(6), PLCG1(5), PLCG2(9), PPAP2B(2), PPAP2C(1)	17365757	147	76	147	44	18	35	46	28	20	0	0.500	1.000	1.000
294	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(14), GABBR1(3), GPRC5A(1), GPRC5B(7), GPRC5C(1), GRM1(26), GRM2(5), GRM3(9), GRM4(9), GRM5(13), GRM7(15), GRM8(19)	7178692	122	76	122	41	11	37	44	21	9	0	0.515	1.000	1.000
295	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	44	ABP1(10), AGXT(3), AGXT2(8), ALAS1(3), AMT(2), AOC2(4), AOC3(5), BHMT(6), CBS(1), CHKA(1), CHKB(2), CTH(1), DAO(1), DLD(6), DMGDH(4), GARS(4), GATM(4), GCAT(4), GLDC(11), HSD3B7(2), MAOA(3), MAOB(1), PHGDH(3), PSAT1(2), PSPH(5), RDH11(2), SARDH(5), SARS(2), SDS(2), SHMT1(2), SHMT2(2), TARS(5), TARS2(9)	14655771	125	76	124	41	20	41	32	19	13	0	0.634	1.000	1.000
296	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	40	ALAD(2), ALAS1(3), BLVRA(1), BLVRB(1), COX15(2), CP(7), CPOX(4), EARS2(2), EPRS(13), FECH(2), FTMT(4), GUSB(4), HMBS(3), HMOX1(3), PPOX(3), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2A1(3), UGT2A3(6), UGT2B11(11), UGT2B15(6), UGT2B28(8), UGT2B4(13), UGT2B7(8)	13908544	139	76	137	43	13	55	35	23	13	0	0.710	1.000	1.000
297	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(8), BAX(1), BCL2(1), BCL2L11(2), BID(1), BIRC2(2), BIRC3(3), BIRC5(1), CASP1(2), CASP10(6), CASP2(7), CASP3(4), CASP4(3), CASP6(1), CASP7(1), CASP8(4), CASP9(3), CHUK(3), DFFA(3), DFFB(2), FADD(1), FAS(3), FASLG(4), GZMB(3), HELLS(1), IKBKB(3), IRF1(1), IRF2(1), IRF3(1), IRF4(3), IRF6(5), IRF7(1), LTA(2), MAP2K4(3), MAP3K1(4), MAPK10(5), MDM2(2), NFKB1(3), NFKBIA(1), NFKBIE(1), PLEKHG5(5), PRF1(5), RIPK1(4), TNFRSF10B(1), TNFRSF1B(1), TNFRSF21(2), TNFRSF25(1), TNFSF10(1), TP73(4), TRAF2(1), TRAF3(3)	19619575	134	75	134	43	15	37	33	21	28	0	0.773	1.000	1.000
298	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(2), CAMK1(2), ELK1(2), FPR1(4), GNB1(2), GNGT1(2), HRAS(1), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K6(1), MAP3K1(4), MAPK14(1), MAPK3(1), NCF1(1), NCF2(2), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NFKB1(3), NFKBIA(1), PAK1(5), PIK3C2G(9), PLCB1(18), PPP3CA(5), PPP3CB(1), PPP3CC(2), RAF1(3), SYT1(3)	13249024	117	75	116	35	22	35	32	8	20	0	0.445	1.000	1.000
299	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(4), ALDH4A1(3), ALDH5A1(2), CAD(16), CPS1(39), EPRS(13), GAD1(5), GAD2(10), GCLC(8), GCLM(1), GFPT1(4), GLS(3), GLS2(2), GLUD1(3), GLUL(2), GMPS(8), GOT1(2), GOT2(4), GPT2(3), GSS(3), NADSYN1(1), PPAT(5), QARS(2)	11439237	143	75	142	41	19	41	39	26	17	1	0.529	1.000	1.000
300	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(10), CALM1(2), ELK1(2), FOS(1), GNAI1(3), GNAQ(2), GNAS(7), GNB1(2), GNGT1(2), HRAS(1), MAP2K1(6), MAPK3(1), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), PLCG1(5), PPP3CA(5), PPP3CB(1), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), RAF1(3), RPS6KA3(1), SYT1(3)	11996852	107	75	106	31	19	28	33	12	15	0	0.363	1.000	1.000
301	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	29	B3GNT6(3), B4GALT5(3), C1GALT1(2), C1GALT1C1(2), GALNT1(3), GALNT10(3), GALNT11(2), GALNT12(4), GALNT14(10), GALNT2(4), GALNT3(4), GALNT4(4), GALNT5(6), GALNT6(2), GALNT7(5), GALNT8(6), GALNT9(1), GALNTL1(4), GALNTL2(6), GALNTL4(6), GALNTL5(5), GCNT1(4), GCNT3(3), GCNT4(3), OGT(6), ST3GAL1(3), ST3GAL2(3), ST6GALNAC1(3), WBSCR17(16)	10699567	126	75	125	51	28	30	30	24	14	0	0.974	1.000	1.000
302	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(8), BAX(1), BCL2(1), CASP1(2), CASP10(6), CASP2(7), CASP3(4), CASP4(3), CASP6(1), CASP7(1), CASP8(4), CASP9(3), CD40LG(6), DAXX(6), DFFA(3), DFFB(2), FADD(1), FAS(3), FASLG(4), IKBKE(5), LTA(2), MCL1(1), NFKB1(3), NFKBIA(1), NGFR(2), NR3C1(3), NTRK1(12), PTPN13(11), RIPK1(4), SFRS2IP(12), TFG(1), TNFRSF1B(1), TRAF2(1), TRAF3(3), TRAF6(4)	15176746	132	74	130	43	15	40	31	24	22	0	0.808	1.000	1.000
303	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(7), ATP4A(7), ATP4B(1), ATP5A1(3), ATP5B(1), ATP5C1(2), ATP5F1(2), ATP5G3(2), ATP5L(2), ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(4), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(2), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), COX15(2), COX4I1(1), COX5B(1), COX6B1(1), COX6B2(1), COX7B2(1), COX8A(1), COX8C(1), CYC1(2), LHPP(2), NDUFA10(2), NDUFA11(1), NDUFA12(2), NDUFA13(4), NDUFA4(1), NDUFA8(3), NDUFA9(5), NDUFB11(1), NDUFB2(4), NDUFB4(1), NDUFB5(4), NDUFB6(1), NDUFB9(1), NDUFC2(1), NDUFS1(7), NDUFS2(6), NDUFS3(1), NDUFS4(1), NDUFS6(1), NDUFS8(1), NDUFV1(3), PPA1(1), SDHA(5), SDHB(1), SDHD(1), TCIRG1(1), UQCRB(4), UQCRC2(4), UQCRFS1(2), UQCRQ(1)	19192261	150	74	149	72	28	31	44	24	23	0	0.999	1.000	1.000
304	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(5), ADRBK2(4), ARRB2(1), CALM1(2), CALML3(3), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CLCA1(5), CLCA2(11), CLCA4(12), CNGA3(9), CNGA4(7), CNGB1(4), GUCA1A(1), GUCA1B(1), GUCA1C(4), PDC(1), PDE1C(17), PRKACB(3), PRKACG(1), PRKG1(3), PRKG2(7), PRKX(3)	10497589	112	74	112	37	19	43	18	14	18	0	0.781	1.000	1.000
305	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(21), AR(4), ESR1(1), ESR2(3), HNF4A(5), NPM1(2), NR0B1(5), NR1D1(3), NR1D2(2), NR1H2(3), NR1H3(4), NR1I2(2), NR1I3(5), NR2C2(2), NR2E1(7), NR2F1(1), NR2F2(2), NR3C1(3), NR4A1(2), NR4A2(7), NR5A1(2), NR5A2(5), PGR(6), PPARA(1), PPARD(2), PPARG(3), RARA(3), RARB(3), RARG(1), ROR1(4), RORA(5), RORC(2), RXRA(1), RXRG(11), THRA(1), THRB(5), VDR(1)	14429519	140	74	140	69	30	45	33	19	13	0	0.998	1.000	1.000
306	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(22), BMPR1B(5), CCND2(1), CDK4(2), CDKN1B(3), DAZL(2), DMC1(1), EGR1(2), ESR2(3), FSHR(20), GJA4(1), LHCGR(6), MLH1(5), MSH5(4), NCOR1(10), NR5A1(2), NRIP1(8), PGR(6), PRLR(9), PTGER2(2), SMPD1(2), VDR(1), ZP2(2)	12067613	119	74	118	38	13	32	40	18	16	0	0.735	1.000	1.000
307	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(10), ACAT1(1), ACAT2(1), ACYP2(1), ADH5(4), AKR1B1(2), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), DLAT(5), DLD(6), GLO1(1), GRHPR(1), HAGH(1), HAGHL(1), LDHA(3), LDHB(2), LDHC(5), LDHD(2), MDH1(2), MDH2(2), ME1(1), ME2(7), ME3(2), PC(1), PCK1(11), PDHA1(3), PDHA2(13), PKLR(11), PKM2(4)	12747514	133	74	132	32	23	39	38	16	17	0	0.126	1.000	1.000
308	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	41	ASAH1(2), CAMP(2), CREB5(7), CREBBP(4), CRKL(2), DAG1(2), EGR1(2), EGR2(2), EGR3(1), EGR4(2), ELK1(2), FRS2(2), GNAQ(2), MAP1B(11), MAP2K4(3), MAP2K7(2), MAPK10(5), MAPK3(1), MAPK8(3), MAPK8IP1(4), MAPK8IP3(4), MAPK9(6), NTRK1(12), OPN1LW(3), PIK3C2G(9), PIK3CA(11), PIK3CD(1), PIK3R1(3), PTPN11(6), RPS6KA3(1), SHC1(2), SRC(2), TH(2)	17342628	123	74	118	44	20	30	41	13	19	0	0.734	1.000	1.000
309	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(22), ATR(17), BRCA1(9), BRCA2(16), CHEK1(6), CHEK2(2), FANCA(5), FANCC(1), FANCD2(9), FANCE(3), FANCF(2), FANCG(4), HUS1(2), MRE11A(6), RAD1(5), RAD17(2), RAD50(3), RAD51(1), RAD9A(2), TREX1(1)	14899885	118	73	112	26	7	33	33	20	25	0	0.484	1.000	1.000
310	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	44	AACS(6), AADAC(3), ABAT(4), ACAT1(1), ACAT2(1), ACSM1(6), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH5A1(2), ALDH7A1(1), ALDH9A1(3), BDH2(1), DDHD1(3), EHHADH(8), GAD1(5), GAD2(10), HADH(4), HADHA(3), HMGCS1(5), HMGCS2(6), HSD17B4(5), HSD3B7(2), ILVBL(1), L2HGDH(2), OXCT1(4), PDHA1(3), PDHA2(13), PLA1A(4), PPME1(3), PRDX6(3), RDH11(2)	13722138	130	73	128	42	16	40	31	20	20	3	0.704	1.000	1.000
311	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), AARS2(4), CARS(1), CARS2(1), DARS2(3), EARS2(2), EPRS(13), FARS2(1), FARSA(2), FARSB(3), GARS(4), HARS(2), HARS2(3), IARS(9), IARS2(7), KARS(4), LARS(7), LARS2(2), MARS(2), MARS2(8), MTFMT(1), NARS(3), NARS2(3), PARS2(1), QARS(2), RARS(5), RARS2(2), SARS(2), TARS(5), TARS2(9), VARS(6), VARS2(8), WARS(3), WARS2(9), YARS(1), YARS2(2)	18699453	141	73	140	39	21	44	39	22	15	0	0.359	1.000	1.000
312	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(5), CDC42(2), DAXX(6), DDIT3(4), ELK1(2), GRB2(4), HRAS(1), HSPB1(1), HSPB2(1), MAP2K4(3), MAP2K6(1), MAP3K1(4), MAP3K5(12), MAP3K7(5), MAP3K9(11), MAPK14(1), MAPKAPK2(3), MAPKAPK5(3), MAX(3), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), MKNK1(2), PLA2G4A(10), RIPK1(4), RPS6KA5(4), SHC1(2), STAT1(4), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TRAF2(1)	12674463	118	73	118	32	17	28	31	25	17	0	0.410	1.000	1.000
313	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(2), AGTR2(2), CALM1(2), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CDK5(1), F2(5), FYN(3), GNA11(1), GNAI1(3), GNB1(2), GNGT1(2), GRB2(4), HRAS(1), JAK2(4), MAP2K1(6), MAP2K2(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPT(8), MYLK(16), PLCG1(5), PRKCA(7), PTK2B(8), RAF1(3), SHC1(2), SOS1(12), STAT1(4), STAT3(8), STAT5A(3), SYT1(3)	14373185	131	72	129	46	23	36	29	23	20	0	0.818	1.000	1.000
314	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT1(1), B4GALT2(2), FBP2(1), G6PC(1), GAA(2), GALE(1), GALK2(2), GALT(2), GANAB(3), GCK(4), GLA(4), HK1(3), HK2(9), HK3(12), LCT(30), MGAM(30), PFKM(5), PFKP(3), PGM1(2), PGM3(4)	11299547	123	72	122	36	25	34	37	19	8	0	0.274	1.000	1.000
315	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	31	AKR1B1(2), B4GALT1(1), B4GALT2(2), G6PC(1), G6PC2(2), GAA(2), GALE(1), GALK2(2), GALT(2), GANC(1), GCK(4), GLA(4), HK1(3), HK2(9), HK3(12), HSD3B7(2), LCT(30), MGAM(30), PFKL(2), PFKM(5), PFKP(3), PGM1(2), PGM3(4), RDH11(2), UGP2(1)	13202537	129	72	128	39	25	36	40	20	8	0	0.331	1.000	1.000
316	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	37	ACAA2(4), ACAD8(3), ACAD9(3), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), AKR1C4(1), AKR1D1(5), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), BAAT(5), CEL(4), CYP27A1(5), CYP7A1(7), HADHB(4), HSD3B7(2), LIPA(2), RDH11(2), SLC27A5(1), SOAT1(7), SRD5A1(3), SRD5A2(3)	10705292	127	72	126	42	9	52	29	20	16	1	0.716	1.000	1.000
317	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(4), ACTN1(2), ACTN2(23), ACTN3(3), BCAR1(2), BCR(3), CAPNS2(2), CRKL(2), FYN(3), GRB2(4), HRAS(1), ITGA1(9), ITGB1(3), MAP2K1(6), MAP2K2(1), MAPK3(1), MAPK8(3), PPP1R12B(5), PTK2(11), PXN(1), RAF1(3), RAP1A(2), ROCK1(10), SHC1(2), SOS1(12), SRC(2), TLN1(13), VCL(2), ZYX(2)	16248466	137	72	135	53	28	38	21	34	16	0	0.922	1.000	1.000
318	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(2), ACTR3(1), ANGPTL2(4), DAG1(2), DGKA(5), GCA(1), ITGA9(2), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), MAP2K1(6), MAPK3(1), NR1I3(5), PAK1(5), PDE3A(13), PDE3B(9), PI3(1), PIK3C2G(9), PIK3CA(11), PIK3CD(1), PIK3R1(3), PSME1(1), RIPK3(4), SGCB(1), VASP(3)	16948061	138	72	134	30	24	35	35	21	23	0	0.0609	1.000	1.000
319	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(9), CSF1R(6), EGF(9), EGFR(33), GRB2(4), MET(12), PDGFRA(17), PRKCA(7), SH3GLB1(1), SH3GLB2(1), SH3KBP1(2), SRC(2)	6663213	103	71	89	31	12	24	20	26	21	0	0.750	1.000	1.000
320	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(3), CDK2(4), CDT1(2), DIAPH2(6), GMNN(1), MCM10(2), MCM2(6), MCM3(5), MCM4(6), MCM5(3), MCM6(10), MCM7(4), NACA(1), ORC1L(4), ORC2L(4), ORC3L(1), ORC4L(1), ORC5L(5), ORC6L(1), PCNA(1), POLA2(2), POLD1(2), POLD2(2), POLD3(3), POLE(19), POLE2(1), PRIM1(3), RFC1(6), RFC2(2), RFC3(1), RFC4(1), RFC5(1), RPA2(1), RPA4(5), UBC(10)	17523538	130	71	129	33	34	28	41	13	14	0	0.126	1.000	1.000
321	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(3), ARG1(1), ASL(3), ASS1(3), CKM(1), CKMT1A(2), CKMT1B(1), CKMT2(2), CPS1(39), DAO(1), EPRS(13), GATM(4), GLUD1(3), GLUD2(5), GOT1(2), GOT2(4), LAP3(1), NOS1(9), NOS3(2), OAT(1), OTC(5), P4HA1(3), P4HA2(2), P4HA3(2), PARS2(1), PYCR2(1), RARS(5), RARS2(2)	12373786	121	71	120	45	15	36	36	20	14	0	0.935	1.000	1.000
322	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT2(2), AKT3(5), GRB2(4), IARS(9), IL2RG(3), IL4(1), IL4R(5), INPP5D(4), JAK1(8), JAK2(4), JAK3(5), NR0B2(1), PI3(1), PIK3CA(11), PPP1R13B(2), RPS6KB1(2), SERPINA4(9), SHC1(2), SOS1(12), SOS2(6), SRC(2), STAT6(2), TYK2(2)	12721179	102	71	99	33	8	27	35	21	11	0	0.698	1.000	1.000
323	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), AKR1D1(5), ARSB(1), ARSD(3), CYP11B1(10), CYP11B2(7), HSD11B1(4), HSD11B2(1), HSD17B2(3), HSD17B3(1), HSD3B1(7), HSD3B2(13), SRD5A1(3), SRD5A2(3), STS(5), SULT1E1(1), SULT2A1(3), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2B15(6), UGT2B4(13)	9448311	120	70	119	40	10	49	30	21	10	0	0.764	1.000	1.000
324	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(22), ATR(17), BRCA1(9), CCNB1(1), CDC25A(4), CDC25B(1), CDC25C(3), CDC34(1), CDKN1A(1), CDKN2D(1), CHEK1(6), CHEK2(2), EP300(2), GADD45A(1), MDM2(2), MYT1(6), PRKDC(23), RPS6KA1(1), WEE1(3)	14339293	106	70	105	21	8	30	30	17	21	0	0.228	1.000	1.000
325	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(10), ADC(2), ALDH18A1(1), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AMD1(1), AOC2(4), AOC3(5), ARG1(1), ASL(3), ASS1(3), CPS1(39), GATM(4), MAOA(3), MAOB(1), ODC1(1), OTC(5), SAT1(1), SMS(1), SRM(2)	10196683	107	70	106	37	12	29	29	21	16	0	0.809	1.000	1.000
326	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(10), ALDH1A3(2), ALDH3A1(2), ALDH3B2(4), AOC2(4), AOC3(5), DDC(6), EPX(7), ESCO1(7), ESCO2(2), GOT1(2), GOT2(4), HPD(2), LPO(4), MAOA(3), MAOB(1), MPO(4), MYST3(8), MYST4(8), NAT6(1), PNPLA3(2), PRDX6(3), SH3GLB1(1), TAT(4), TPO(16)	11768310	112	70	112	39	16	35	28	19	14	0	0.798	1.000	1.000
327	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10(9), ALG10B(6), ALG12(2), ALG13(9), ALG14(2), ALG2(5), ALG3(5), ALG8(2), ALG9(3), B4GALT1(1), B4GALT2(2), B4GALT3(1), DAD1(1), DDOST(1), DHDDS(1), DOLPP1(3), DPAGT1(1), DPM1(1), FUT8(4), GANAB(3), MAN1A2(9), MAN1B1(2), MAN1C1(2), MAN2A1(11), MGAT1(2), MGAT3(4), MGAT4A(3), MGAT4B(1), MGAT5(6), MGAT5B(7), RFT1(4), RPN2(4), STT3B(2)	14680503	119	70	119	40	17	38	35	17	12	0	0.785	1.000	1.000
328	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(1), ARSB(1), FUCA1(1), FUCA2(1), GBA(3), GUSB(4), HEXA(1), HGSNAT(4), HPSE(1), HPSE2(6), HYAL1(1), HYAL2(1), IDS(3), IDUA(2), LCT(30), MAN2B1(2), MAN2B2(3), MAN2C1(4), MANBA(4), NAGLU(1), NEU1(1), NEU3(3), NEU4(6), SPAM1(12)	11948533	96	70	96	35	10	34	31	12	9	0	0.809	1.000	1.000
329	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(8), AASDHPPT(2), AASS(7), ACAT1(1), ACAT2(1), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), BBOX1(3), DLST(2), DOT1L(8), EHHADH(8), EHMT1(8), EHMT2(1), GCDH(3), HADHA(3), PLOD1(2), PLOD2(6), PLOD3(4), SDS(2), SHMT1(2), SHMT2(2), TMLHE(2)	12828351	106	70	104	31	15	29	33	14	13	2	0.456	1.000	1.000
330	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(10), ARHGEF1(2), F2(5), F2R(4), F2RL3(2), GNA12(1), GNA13(5), GNAI1(3), GNAQ(2), GNB1(2), GNGT1(2), MAP3K7(5), PIK3CA(11), PIK3R1(3), PLCB1(18), PPP1R12B(5), PRKCA(7), PTK2B(8), ROCK1(10)	8952755	105	70	102	26	16	32	29	10	18	0	0.254	1.000	1.000
331	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX12(3), ALOX15(4), ALOX5(6), CYP4F2(5), CYP4F3(12), EPX(7), GGT1(1), LPO(4), LTA4H(1), MPO(4), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PRDX1(2), PRDX2(1), PRDX5(1), PRDX6(3), PTGDS(2), PTGIS(5), PTGS1(5), PTGS2(4), TBXAS1(6), TPO(16)	9543117	115	69	115	34	13	28	33	25	16	0	0.479	1.000	1.000
332	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(3), CDK5(1), CHN1(4), MAP3K1(4), MYL2(2), MYLK(16), NCF2(2), PAK1(5), PDGFRA(17), PIK3CA(11), PIK3R1(3), PLD1(9), PPP1R12B(5), RALBP1(1), RPS6KB1(2), TRIO(15), VAV1(1), WASF1(8)	12037385	109	69	104	29	13	29	36	14	17	0	0.329	1.000	1.000
333	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	32	A1BG(2), AKT2(2), AKT3(5), BTK(11), DAPP1(2), GRB2(4), GSK3B(2), IARS(9), IGFBP1(3), INPP5D(4), PDK1(4), PIK3CA(11), PPP1R13B(2), PTEN(8), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KB1(2), SHC1(2), SOS1(12), SOS2(6), TEC(5), YWHAG(2)	12241653	107	69	103	36	9	24	40	20	14	0	0.822	1.000	1.000
334	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(9), CARM1(3), CCND1(2), CREBBP(4), EP300(2), ERCC3(5), ESR1(1), GRIP1(6), GTF2A1(3), GTF2E1(6), GTF2F1(1), HDAC1(3), HDAC2(8), HDAC3(1), HDAC4(11), HDAC5(2), HDAC6(5), MEF2C(2), NCOR2(13), NR0B1(5), NRIP1(8), PELP1(2), POLR2A(9)	15866265	111	68	109	31	24	25	36	14	12	0	0.310	1.000	1.000
335	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(2), ACP2(1), ACP5(3), ACPP(7), ALPI(5), ALPL(2), ALPP(4), ALPPL2(3), CYP19A1(3), CYP1A1(6), CYP1A2(2), CYP2A13(4), CYP2A6(4), CYP2A7(4), CYP2B6(8), CYP2C18(4), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2E1(4), CYP2F1(2), CYP2J2(8), CYP3A4(1), CYP3A5(1), CYP3A7(4), CYP4B1(8), CYP4F8(5), CYP51A1(3), PON1(3)	10113327	115	68	114	42	17	30	30	17	20	1	0.757	1.000	1.000
336	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	39	AKR1B1(2), ALDOA(2), ALDOB(4), ALDOC(1), FBP2(1), FPGT(2), FUK(3), GMDS(6), GMPPA(5), GMPPB(1), HK1(3), HK2(9), HK3(12), HSD3B7(2), KHK(2), LHPP(2), MTMR1(5), MTMR2(2), MTMR6(6), PFKFB1(6), PFKFB2(3), PFKFB3(5), PFKFB4(5), PFKL(2), PFKM(5), PFKP(3), PGM2(5), PHPT1(1), PMM1(1), RDH11(2), SORD(2), TPI1(6), TSTA3(1)	12765147	117	68	115	36	20	34	30	22	11	0	0.365	1.000	1.000
337	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	59	ABO(1), B3GALNT1(1), B3GALT1(2), B3GALT2(2), B3GALT5(1), B3GNT1(3), B3GNT2(1), B3GNT3(1), B3GNT5(1), B4GALNT1(4), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT4(1), B4GALT6(3), FUT1(2), FUT3(2), FUT7(2), FUT9(7), GCNT2(2), PIGB(1), PIGC(2), PIGG(7), PIGK(2), PIGL(2), PIGM(5), PIGN(2), PIGO(7), PIGP(1), PIGQ(1), PIGS(1), PIGT(2), PIGV(3), PIGX(4), PIGZ(1), ST3GAL1(3), ST3GAL2(3), ST3GAL3(1), ST3GAL4(2), ST3GAL6(3), ST6GALNAC4(1), ST6GALNAC5(3), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(4)	16502885	104	68	102	47	25	20	35	17	7	0	0.964	1.000	1.000
338	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ACTR3(1), ARHGAP1(3), ARHGAP4(2), ARHGAP5(7), ARHGAP6(6), ARHGEF1(2), ARHGEF11(11), ARHGEF5(4), ARPC1A(1), ARPC1B(1), ARPC2(1), ARPC3(2), BAIAP2(2), DIAPH1(4), GSN(3), MYL2(2), MYLK(16), OPHN1(6), PFN1(1), PIP5K1A(5), PIP5K1B(7), PPP1R12B(5), ROCK1(10), SRC(2), TLN1(13), VCL(2)	15730697	121	68	120	37	24	32	29	16	20	0	0.587	1.000	1.000
339	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(3), AKT2(2), AKT3(5), DAG1(2), GNAQ(2), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), PDK1(4), PHKA2(10), PIK3CB(7), PITX2(4), PLD1(9), PLD2(5), PLD3(1)	15490934	113	67	112	33	17	32	32	15	17	0	0.346	1.000	1.000
340	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), AARS2(4), ABAT(4), ACY3(2), ADSSL1(1), AGXT(3), AGXT2(8), ASL(3), ASNS(3), ASPA(2), ASRGL1(1), ASS1(3), CAD(16), CRAT(1), DARS2(3), DDO(3), DLAT(5), DLD(6), GAD1(5), GAD2(10), GOT1(2), GOT2(4), GPT2(3), NARS(3), NARS2(3), PC(1), PDHA1(3), PDHA2(13)	13044756	116	66	116	42	22	31	36	17	10	0	0.734	1.000	1.000
341	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSD(3), ASAH1(2), B4GALT6(3), CERK(3), DEGS1(3), DEGS2(1), ENPP7(5), GAL3ST1(3), GALC(5), GBA(3), GLA(4), LCT(30), NEU1(1), NEU3(3), NEU4(6), PPAP2B(2), PPAP2C(1), SGMS1(1), SGMS2(3), SGPP1(1), SMPD1(2), SMPD2(1), SMPD3(1), SMPD4(2), SPHK2(2), SPTLC1(1), SPTLC2(1), UGT8(1)	12407907	95	66	94	30	13	33	31	10	8	0	0.484	1.000	1.000
342	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(2), ASNS(3), ASRGL1(1), CA1(2), CA12(1), CA13(1), CA14(2), CA2(2), CA3(4), CA4(5), CA5A(4), CA5B(1), CA6(1), CA8(2), CA9(3), CPS1(39), CTH(1), GLS(3), GLS2(2), GLUD1(3), GLUD2(5), GLUL(2), HAL(2)	7318840	91	66	90	38	10	29	23	19	10	0	0.982	1.000	1.000
343	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(5), F2R(4), F2RL3(2), GNAI1(3), GNB1(2), GNGT1(2), HRAS(1), ITGA1(9), ITGB1(3), MAP2K1(6), MAPK3(1), PLA2G4A(10), PLCB1(18), PRKCA(7), PTGS1(5), PTK2(11), RAF1(3), SRC(2), SYK(3), TBXAS1(6)	8377736	103	66	103	27	13	32	20	18	20	0	0.478	1.000	1.000
344	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	BAG4(1), CASP2(7), CASP3(4), CASP8(4), DFFA(3), DFFB(2), FADD(1), LMNB1(2), LMNB2(2), MADD(13), MAP2K4(3), MAP3K1(4), MAP3K7(5), MAPK8(3), PAK1(5), PAK2(3), PRKDC(23), RIPK1(4), SPTAN1(12), TRAF2(1)	12976514	102	66	102	28	26	22	24	15	15	0	0.375	1.000	1.000
345	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(4), ABP1(10), ACADM(3), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), AOC2(4), AOC3(5), CNDP1(5), DPYD(12), DPYS(10), EHHADH(8), GAD1(5), GAD2(10), HADHA(3), MLYCD(4), SDS(2), SMS(1)	9987148	116	65	115	39	19	39	26	16	14	2	0.735	1.000	1.000
346	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(7), DIAPH1(4), FYN(3), GSN(3), HRAS(1), ITGA1(9), ITGB1(3), MAP2K1(6), MAPK3(1), MYL2(2), MYLK(16), PFN1(1), PIK3CA(11), PIK3R1(3), PTK2(11), PXN(1), RAF1(3), ROCK1(10), SHC1(2), SRC(2), TLN1(13)	12848503	112	65	107	31	17	28	24	27	16	0	0.439	1.000	1.000
347	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(5), ANAPC10(1), ANAPC11(1), ANAPC2(1), ANAPC4(2), ANAPC5(3), ANAPC7(4), BTRC(9), CDC16(3), CDC20(3), CDC23(1), CDC27(2), CUL1(6), CUL2(6), CUL3(7), FBXW7(4), FZR1(2), ITCH(6), SKP1(2), SKP2(4), SMURF1(3), SMURF2(2), TCEB1(1), UBA1(1), UBE2D2(1), UBE2D3(3), UBE2D4(3), UBE2E2(1), UBE2E3(1), VHL(1), WWP1(3), WWP2(3)	13918391	95	65	93	24	19	16	26	19	15	0	0.292	1.000	1.000
348	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(2), ACTG2(5), ADCY3(5), ADCY9(3), ARF3(1), ARF4(2), ARF5(1), ARL4D(3), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(4), ATP6V1A(4), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(2), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), ERO1L(2), GNAS(7), PDIA4(3), PLCG1(5), PLCG2(9), PRKCA(7), SEC61A1(4), SEC61A2(5), SEC61B(1), SEC61G(1), TRIM23(2)	12707439	100	65	99	39	18	26	27	16	13	0	0.908	1.000	1.000
349	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	15	C3(7), C5(2), C6(14), IL1A(3), ITGA4(19), ITGAL(20), ITGB1(3), ITGB2(2), SELP(14), SELPLG(3), VCAM1(16)	8021183	103	65	102	35	9	35	31	15	13	0	0.872	1.000	1.000
350	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(10), ASAH1(2), GNAI1(3), GNB1(2), GNGT1(2), ITGAV(9), ITGB3(4), MAPK3(1), PDGFA(6), PDGFRA(17), PIK3CA(11), PIK3R1(3), PLCB1(18), PRKCA(7), PTK2(11), SMPD1(2), SMPD2(1), SRC(2)	9425640	111	64	108	34	15	36	29	13	18	0	0.612	1.000	1.000
351	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	22	ABL1(2), ATM(22), ATR(17), CCNA1(2), CCND1(2), CCNE1(3), CDC25A(4), CDK2(4), CDK4(2), CDK6(3), CDKN1A(1), CDKN1B(3), E2F1(3), GSK3B(2), HDAC1(3), SKP2(4), TFDP1(3), TGFB1(2), TGFB2(8), TGFB3(1)	9329002	91	64	90	24	10	30	23	15	13	0	0.511	1.000	1.000
352	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(4), ACADM(3), ACAT1(1), ACAT2(1), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), AOX1(14), BCAT1(1), BCKDHB(5), EHHADH(8), HADHA(3), HADHB(4), HIBADH(1), IVD(3), MCCC1(2), MCCC2(3), MCEE(1), MUT(6), OXCT1(4), PCCA(5), PCCB(2), SDS(2)	12378366	103	64	102	37	9	32	28	12	20	2	0.863	1.000	1.000
353	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(3), AGT(2), AGTR1(5), AGTR2(2), CMA1(6), COL4A1(16), COL4A2(16), COL4A3(5), COL4A4(13), COL4A5(23), COL4A6(17), REN(1)	8864361	109	63	109	51	8	52	24	11	14	0	1.000	1.000	1.000
354	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	CASP10(6), CASP3(4), CASP6(1), CASP7(1), CASP8(4), CFLAR(1), DAXX(6), DFFA(3), DFFB(2), FADD(1), FAF1(4), LMNB1(2), LMNB2(2), MAP2K4(3), MAP3K1(4), MAP3K7(5), MAPK8(3), PAK1(5), PAK2(3), PRKDC(23), PTPN13(11), SPTAN1(12)	13752137	106	63	106	41	24	24	28	12	18	0	0.947	1.000	1.000
355	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(4), ABP1(10), ACADM(3), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOC2(4), AOC3(5), CNDP1(5), DPYD(12), DPYS(10), EHHADH(8), GAD1(5), GAD2(10), HADHA(3), HIBCH(4), MLYCD(4), SMS(1), SRM(2)	9297629	110	63	109	35	17	35	26	16	14	2	0.624	1.000	1.000
356	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(16), COL4A2(16), COL4A3(5), COL4A4(13), COL4A5(23), COL4A6(17), P4HB(4), SLC23A2(5), SLC2A3(6)	8821309	105	63	105	45	11	48	20	11	15	0	0.993	1.000	1.000
357	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(4), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH6(8), ADH7(4), ADHFE1(2), AKR1C4(1), AKR1D1(5), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), BAAT(5), CEL(4), CYP27A1(5), CYP7A1(7), HADHB(4), SRD5A1(3), SRD5A2(3)	7989352	113	62	112	36	11	48	24	16	14	0	0.636	1.000	1.000
358	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	24	AKR1B1(2), DCXR(1), GUSB(4), RPE(2), UGDH(4), UGP2(1), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2A1(3), UGT2A3(6), UGT2B11(11), UGT2B15(6), UGT2B28(8), UGT2B4(13), UGT2B7(8), XYLB(3)	8738182	102	62	100	33	7	43	25	17	10	0	0.790	1.000	1.000
359	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(3), GTF2A2(1), GTF2B(1), GTF2E1(6), GTF2E2(2), GTF2F1(1), GTF2H1(4), GTF2H3(1), GTF2I(4), GTF2IRD1(5), TAF1(9), TAF10(1), TAF1L(25), TAF2(6), TAF4(4), TAF4B(5), TAF5L(4), TAF6(2), TAF7(2), TAF7L(3), TAF9(2), TAF9B(1), TBPL1(1), TBPL2(3)	12389816	96	62	95	28	16	19	31	14	16	0	0.563	1.000	1.000
360	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	23	POLA1(6), POLA2(2), POLB(2), POLD1(2), POLD2(2), POLD3(3), POLE(19), POLE2(1), POLG(10), POLG2(1), POLI(2), POLK(3), POLL(2), POLM(6), POLQ(17), PRIM1(3), REV1(4), REV3L(13), RFC5(1)	13796334	99	62	98	26	22	16	35	16	10	0	0.319	1.000	1.000
361	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(10), ALDH1A3(2), ALDH3A1(2), ALDH3B2(4), AOC2(4), AOC3(5), DDC(6), EPX(7), GOT1(2), GOT2(4), HPD(2), LPO(4), MAOA(3), MAOB(1), MPO(4), PRDX1(2), PRDX2(1), PRDX5(1), PRDX6(3), TAT(4), TPO(16)	7565702	87	62	87	30	12	25	23	17	10	0	0.699	1.000	1.000
362	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(6), ABAT(4), ACAT1(1), ACAT2(1), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH5A1(2), ALDH9A1(3), EHHADH(8), GAD1(5), GAD2(10), HADHA(3), L2HGDH(2), OXCT1(4), PDHA1(3), PDHA2(13), SDHB(1), SDS(2)	8839629	95	61	94	32	14	29	25	12	13	2	0.736	1.000	1.000
363	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(2), ASNS(3), CA1(2), CA12(1), CA14(2), CA2(2), CA3(4), CA4(5), CA5A(4), CA5B(1), CA6(1), CA8(2), CA9(3), CPS1(39), CTH(1), GLS(3), GLS2(2), GLUD1(3), GLUL(2), HAL(2)	6542301	84	61	83	34	10	24	22	18	10	0	0.967	1.000	1.000
364	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(7), ATP4B(1), ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), ATP7A(14), ATP7B(11), COX4I1(1), COX5B(1), COX6B1(1), COX8A(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(3), NDUFB2(4), NDUFB4(1), NDUFB5(4), NDUFB6(1), NDUFS1(7), NDUFS2(6), NDUFV1(3), SDHA(5), SDHB(1), SHMT1(2), UQCRB(4), UQCRFS1(2)	13158111	117	61	116	51	24	34	26	17	16	0	0.983	1.000	1.000
365	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	13	BCL2(1), EGFR(33), IGF1R(10), POLR2A(9), PPP2CA(1), PRKCA(7), TEP1(23), TERF1(1), TERT(4), TNKS(3), XRCC5(6)	8768410	98	61	84	32	18	21	18	20	21	0	0.753	1.000	1.000
366	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	FOS(1), GRB2(4), HRAS(1), JAK2(4), MAP2K1(6), MAPK3(1), MPL(2), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), RAF1(3), RASA1(3), SHC1(2), SOS1(12), STAT1(4), STAT3(8), STAT5A(3), STAT5B(4), THPO(1)	10285764	85	61	82	25	11	17	25	19	13	0	0.567	1.000	1.000
367	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(4), ACACA(10), ACACB(11), ACADM(3), ACAT1(1), ACAT2(1), ACSS1(4), ACSS2(4), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), EHHADH(8), HADHA(3), HIBCH(4), LDHA(3), LDHAL6A(3), LDHB(2), LDHC(5), MCEE(1), MLYCD(4), MUT(6), PCCA(5), PCCB(2), SUCLG1(2), SUCLG2(2)	13612676	108	60	107	48	21	31	25	12	18	1	0.986	1.000	1.000
368	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	BCL2(1), CBL(9), CFLAR(1), CRKL(2), E2F1(3), FOS(1), GRB2(4), HRAS(1), IL2RA(3), IL2RB(5), IL2RG(3), IRS1(15), JAK1(8), JAK3(5), MAPK3(1), NMI(1), PIK3CA(11), PIK3R1(3), PTPN6(3), RAF1(3), RPS6KB1(2), SHC1(2), SOS1(12), STAT5A(3), STAT5B(4), SYK(3)	12429891	109	60	105	36	23	18	33	23	12	0	0.515	1.000	1.000
369	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT2(2), AKT3(5), BCL2(1), GRB2(4), GSK3B(2), IL4R(5), IRS1(15), IRS2(3), JAK1(8), JAK3(5), MAP4K1(5), MAPK3(1), PDK1(4), PIK3CA(11), PIK3CD(1), PIK3R1(3), PPP1R13B(2), RAF1(3), SHC1(2), SOS1(12), SOS2(6), STAT6(2)	12566375	102	60	99	37	16	20	32	21	13	0	0.764	1.000	1.000
370	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(2), GNAQ(2), GNAS(7), GNB1(2), GNGT1(2), HRAS(1), MAP2K1(6), MAPK3(1), MYL2(2), NOX1(3), PIK3C2G(9), PLCB1(18), PPP1R12B(5), PRKCA(7), PTK2(11), RAF1(3), ROCK2(4)	8767494	85	59	85	24	14	25	20	11	15	0	0.596	1.000	1.000
371	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	CABIN1(5), CALM1(2), CAMK1(2), HDAC5(2), IGF1(5), IGF1R(10), INSR(1), MAP2K6(1), MAPK14(1), MAPK7(5), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), MYOD1(5), NFATC1(3), NFATC2(8), PIK3CA(11), PIK3R1(3), PPP3CA(5), PPP3CB(1), PPP3CC(2), SYT1(3)	11979906	81	59	77	23	9	27	22	9	14	0	0.375	1.000	1.000
372	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(2), ANXA2(2), ANXA3(3), ANXA4(3), ANXA5(2), ANXA6(1), CYP11A1(1), EDN1(1), EDNRB(6), HPGD(1), HSD11B1(4), HSD11B2(1), PLA2G4A(10), PRL(1), PTGDR(3), PTGDS(2), PTGER2(2), PTGER4(7), PTGFR(6), PTGIR(2), PTGIS(5), PTGS1(5), PTGS2(4), TBXAS1(6)	7115488	80	59	80	30	12	22	21	11	14	0	0.891	1.000	1.000
373	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	EEF1A2(7), EEF1B2(2), EEF1D(1), EEF1G(2), EEF2(1), EEF2K(2), EIF1AX(1), EIF2AK1(6), EIF2AK2(5), EIF2AK3(6), EIF2B1(1), EIF2B2(2), EIF2B3(3), EIF2B4(3), EIF2B5(3), EIF2S3(2), EIF4A1(2), EIF4A2(4), EIF4E(3), EIF4G1(8), EIF4G3(13), EIF5(2), EIF5B(9), GSPT2(3), PABPC1(3), PAIP1(4)	14706838	98	59	98	26	14	29	36	8	11	0	0.377	1.000	1.000
374	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	EIF4A1(2), EIF4A2(4), EIF4E(3), EIF4G1(8), EIF4G3(13), GHR(5), IRS1(15), MAPK14(1), MAPK3(1), MKNK1(2), PABPC1(3), PDK2(2), PDPK1(1), PIK3CA(11), PIK3R1(3), PRKCA(7), PTEN(8), RPS6KB1(2)	9649373	91	58	87	32	15	21	33	12	10	0	0.801	1.000	1.000
375	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(3), F2(5), F2R(4), F3(4), F5(23), F7(2), FGA(9), FGB(13), FGG(2), PROC(3), PROS1(13), SERPINC1(8), TFPI(1)	5624927	90	58	89	28	11	36	19	10	13	1	0.800	1.000	1.000
376	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(5), GABRA1(8), GABRA2(14), GABRA3(8), GABRA4(10), GABRA5(14), GABRA6(12), GPHN(3), NSF(3), SRC(2), UBQLN1(5)	4109634	84	58	81	26	12	33	14	16	9	0	0.759	1.000	1.000
377	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(2), ACO1(4), ACO2(1), CLYBL(5), CS(1), DLD(6), DLST(2), FH(7), IDH1(2), IDH2(2), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(2), MDH2(2), OGDH(1), OGDHL(11), PC(1), PCK1(11), PCK2(3), SDHA(5), SDHB(1), SDHD(1), SUCLG1(2), SUCLG2(2)	10204698	79	58	79	38	14	13	23	14	15	0	0.972	1.000	1.000
378	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(2), GHR(5), GRB2(4), HRAS(1), INSR(1), IRS1(15), JAK2(4), MAP2K1(6), MAPK3(1), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), PTPN6(3), RAF1(3), RPS6KA1(1), SHC1(2), SOS1(12), STAT5A(3), STAT5B(4)	11358400	93	57	90	30	18	19	26	20	10	0	0.569	1.000	1.000
379	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	ELK1(2), FOS(1), GRB2(4), HRAS(1), IGF1(5), IGF1R(10), IRS1(15), MAP2K1(6), MAPK3(1), MAPK8(3), PIK3CA(11), PIK3R1(3), PTPN11(6), RAF1(3), RASA1(3), SHC1(2), SOS1(12)	8481244	88	57	84	24	16	21	25	16	10	0	0.326	1.000	1.000
380	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(10), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), GNAS(7), GRB2(4), HRAS(1), MAPK14(1), MAPK3(1), PIK3CA(11), PIK3R1(3), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), RPS6KA1(1), RPS6KA5(4), SOS1(12)	9983942	82	56	79	32	11	21	24	15	11	0	0.933	1.000	1.000
381	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(2), ITGA4(19), ITGAL(20), ITGAM(14), ITGB1(3), ITGB2(2), SELE(6), SELL(4), SELP(14)	5528060	84	56	84	31	9	30	25	13	7	0	0.918	1.000	1.000
382	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(7), ARHGEF1(2), GNA12(1), GNA13(5), GNAQ(2), GNB1(2), GNGT1(2), MYL2(2), MYLK(16), PLCB1(18), PPP1R12B(5), PRKCA(7), ROCK1(10)	7129686	79	56	78	20	10	28	19	8	14	0	0.452	1.000	1.000
383	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(2), BLVRA(1), BLVRB(1), CP(7), CPOX(4), EPRS(13), FECH(2), GUSB(4), HMBS(3), HMOX1(3), PPOX(3), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2B15(6), UGT2B4(13)	9435487	92	56	91	28	7	34	23	17	11	0	0.672	1.000	1.000
384	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(11), DLG4(3), EPHB2(7), F2(5), F2RL1(1), F2RL2(5), F2RL3(2), MAPK7(5), MAPK8(3), MYEF2(4), PLD1(9), PLD2(5), PLD3(1), PTK2(11), RAF1(3), RASAL1(7), SRC(2), TEC(5), VAV1(1)	9471669	90	56	90	22	12	23	29	15	11	0	0.170	1.000	1.000
385	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(4), ACTN1(2), ACTN2(23), ACTN3(3), CAPNS2(2), ITGA1(9), ITGB1(3), ITGB3(4), PTK2(11), PXN(1), SPTAN1(12), SRC(2), TLN1(13)	9819062	89	56	88	35	18	26	12	22	11	0	0.927	1.000	1.000
386	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(8), BAX(1), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CASP2(7), CASP3(4), CASP6(1), CASP7(1), CASP8(4), CASP9(3), FADD(1), FAS(3), FASLG(4), GZMB(3), MAP2K4(3), MAP3K1(4), MAP3K14(1), MAPK10(5), MCL1(1), MDM2(2), NFKB1(3), NFKBIA(1), PARP1(2), PRF1(5), RIPK1(4), TNFRSF1B(1), TNFSF10(1), TRAF2(1)	12612862	81	55	81	30	9	23	17	16	16	0	0.911	1.000	1.000
387	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(7), AGT(2), AGTR2(2), EDN1(1), EDNRB(6), EGF(9), EGFR(33), FOS(1), HRAS(1), NFKB1(3), PLCG1(5), PRKCA(7)	7025262	77	55	63	23	11	17	16	20	13	0	0.743	1.000	1.000
388	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(4), F13A1(13), F2(5), F2R(4), FGA(9), FGB(13), FGG(2), PLAT(6), PLAU(1), PLG(13), SERPINB2(6), SERPINE1(5)	4602900	81	55	80	28	7	36	19	12	7	0	0.907	1.000	1.000
389	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(10), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH3B2(4), ALDH9A1(3), AOC2(4), AOC3(5), ASPA(2), CNDP1(5), DDC(6), HAL(2), HARS(2), HDC(7), HNMT(2), MAOA(3), MAOB(1), PRPS1(3), PRPS2(2)	8440940	88	55	88	28	16	25	22	16	9	0	0.486	1.000	1.000
390	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(2), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), CYP2C19(9), CYP2C9(3), DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), EHHADH(8), ESCO1(7), ESCO2(2), HADHA(3), MYST3(8), MYST4(8), NAT6(1), PNPLA3(2), SH3GLB1(1), YOD1(1)	10627890	83	55	82	26	12	26	20	14	10	1	0.615	1.000	1.000
391	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(5), BCR(3), BLNK(1), ELK1(2), FOS(1), GRB2(4), HRAS(1), LYN(4), MAP2K1(6), MAP3K1(4), MAPK3(1), MAPK8IP3(4), PAPPA(12), RPS6KA1(1), RPS6KA3(1), SHC1(2), SOS1(12), SYK(3), VAV1(1), VAV2(3), VAV3(14)	11049708	85	55	85	34	9	24	20	19	13	0	0.934	1.000	1.000
392	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSB(1), ARSD(3), ASAH1(2), GAL3ST1(3), GALC(5), GBA(3), GLA(4), LCT(30), NEU1(1), NEU3(3), NEU4(6), PPAP2B(2), PPAP2C(1), SMPD1(2), SMPD2(1), SPTLC1(1), SPTLC2(1)	8402010	70	54	69	20	9	26	25	5	5	0	0.349	1.000	1.000
393	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	EIF4A1(2), EIF4A2(4), EIF4B(5), EIF4E(3), EIF4G1(8), EIF4G3(13), MKNK1(2), PDK2(2), PDPK1(1), PIK3CA(11), PIK3R1(3), PPP2CA(1), PTEN(8), RPS6KB1(2), TSC1(9), TSC2(4)	9543117	78	54	73	23	7	21	31	11	8	0	0.511	1.000	1.000
394	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(4), ACACA(10), ACADM(3), ACAT1(1), ACAT2(1), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), EHHADH(8), HADHA(3), LDHA(3), LDHB(2), LDHC(5), MCEE(1), MLYCD(4), MUT(6), PCCA(5), PCCB(2), SDS(2), SUCLG1(2), SUCLG2(2)	11345347	94	54	93	34	17	27	24	9	16	1	0.857	1.000	1.000
395	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(2), CALM1(2), CRKL(2), GNAQ(2), GRB2(4), HRAS(1), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K4(3), MAP3K1(4), MAPK14(1), MAPK3(1), MAPK8(3), PAK1(5), PLCG1(5), PRKCA(7), PTK2B(8), RAF1(3), SHC1(2), SOS1(12), SRC(2), SYT1(3)	9781964	85	54	85	26	22	25	16	11	11	0	0.453	1.000	1.000
396	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(1), CDK7(3), ERCC3(5), GTF2A2(1), GTF2B(1), GTF2E1(6), GTF2E2(2), GTF2H1(4), ILK(1), MNAT1(2), POLR1A(8), POLR1B(10), POLR2A(9), POLR2B(5), POLR2C(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR3B(13), POLR3D(2), POLR3E(2), POLR3H(1), TAF6(2), TAF7(2), TAF9(2)	12033034	91	54	89	31	17	22	31	12	9	0	0.741	1.000	1.000
397	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(23), CDH1(5), CREBBP(4), EP300(2), MAP2K1(6), MAP3K7(5), MAPK3(1), SKIL(7), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TGFBR2(2)	8789936	68	54	68	16	3	19	14	16	16	0	0.470	1.000	1.000
398	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(10), CD3D(2), CD4(3), CREBBP(4), GNAS(7), GNB1(2), GNGT1(2), HLA-DRA(3), LCK(5), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PTPRC(21), ZAP70(4)	7926835	75	53	75	26	6	26	23	6	14	0	0.830	1.000	1.000
399	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	APAF1(8), ATM(22), BAX(1), BCL2(1), BID(1), CASP3(4), CASP6(1), CASP7(1), CASP9(3), PRKCA(7), PTK2(11), PXN(1), STAT1(4), TLN1(13)	9164809	78	53	77	27	10	20	16	15	17	0	0.831	1.000	1.000
400	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(10), CD3D(2), CD4(3), CREBBP(4), GNAS(7), GNB1(2), GNGT1(2), HLA-DRA(3), LCK(5), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PTPRC(21), ZAP70(4)	7926835	75	53	75	26	6	26	23	6	14	0	0.830	1.000	1.000
401	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(8), GABRA2(14), GABRA3(8), GABRA4(10), GABRA5(14), GABRA6(12), GPX1(1), PRKCE(3)	2730825	70	53	68	24	7	33	12	13	5	0	0.883	1.000	1.000
402	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(2), ALDOB(4), ALDOC(1), FBP2(1), FPGT(2), GCK(4), GMDS(6), GMPPA(5), GMPPB(1), HK1(3), HK2(9), HK3(12), KHK(2), PFKFB1(6), PFKFB3(5), PFKFB4(5), PFKM(5), PFKP(3), PMM1(1), SORD(2), TPI1(6)	8314532	87	53	85	26	18	25	21	15	8	0	0.322	1.000	1.000
403	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(1), CREBBP(4), EP300(2), FYN(3), IL2RG(3), IL7R(7), JAK1(8), JAK3(5), LCK(5), NMI(1), PIK3CA(11), PIK3R1(3), PTK2B(8), STAT5A(3), STAT5B(4)	9665403	68	53	64	24	9	14	19	16	10	0	0.812	1.000	1.000
404	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(2), CXCL12(1), CXCR4(3), GNAI1(3), GNAQ(2), GNB1(2), GNGT1(2), HRAS(1), MAP2K1(6), MAPK3(1), NFKB1(3), PIK3C2G(9), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), PTK2(11), PTK2B(8), PXN(1), RAF1(3)	9569910	84	52	81	19	15	23	21	11	14	0	0.127	1.000	1.000
405	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	BCL2(1), BCR(3), CRKL(2), FOS(1), GRB2(4), HRAS(1), JAK2(4), MAP2K1(6), MAP2K4(3), MAP3K1(4), MAPK3(1), MAPK8(3), PIK3CA(11), PIK3R1(3), RAF1(3), SOS1(12), STAT1(4), STAT5A(3), STAT5B(4)	9611359	73	52	70	20	10	11	23	16	13	0	0.306	1.000	1.000
406	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GUSB(4), HEXA(1), HGSNAT(4), HPSE(1), HPSE2(6), HYAL1(1), HYAL2(1), IDS(3), IDUA(2), LCT(30), NAGLU(1), SPAM1(12)	7051597	67	52	67	23	7	24	20	8	8	0	0.745	1.000	1.000
407	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(3), EXT2(7), EXTL1(3), EXTL3(5), GLCE(4), HS3ST1(2), HS3ST2(2), HS3ST3A1(4), HS3ST3B1(1), HS3ST5(9), HS6ST1(1), HS6ST2(1), HS6ST3(5), NDST1(2), NDST2(7), NDST3(8), NDST4(13)	7153731	77	52	76	36	8	24	28	9	7	1	0.982	1.000	1.000
408	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(3), ACAD9(3), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), ESCO1(7), ESCO2(2), MYST3(8), MYST4(8), NAT6(1), PNPLA3(2), SH3GLB1(1)	8604904	89	52	89	27	7	45	12	13	12	0	0.752	1.000	1.000
409	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(3), ABP1(10), AOC2(4), AOC3(5), CES1(3), CES7(9), DDHD1(3), ESCO1(7), ESCO2(2), LIPA(2), MYST3(8), MYST4(8), NAT6(1), PLA1A(4), PNPLA3(2), PPME1(3), PRDX6(3), SH3GLB1(1)	8709557	78	52	78	21	11	26	17	13	11	0	0.504	1.000	1.000
410	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(3), IFNB1(4), IKBKB(3), IL1A(3), IL1R1(1), IL1RAP(2), IL1RN(1), IRAK1(3), IRAK2(3), IRAK3(6), MAP2K3(6), MAP2K6(1), MAP3K1(4), MAP3K14(1), MAP3K7(5), MAPK14(1), MAPK8(3), MYD88(3), NFKB1(3), NFKBIA(1), TGFB1(2), TGFB2(8), TGFB3(1), TOLLIP(1), TRAF6(4)	10174928	73	52	72	33	10	19	16	14	14	0	0.986	1.000	1.000
411	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	ELK1(2), FOS(1), GRB2(4), HRAS(1), IL6R(8), JAK1(8), JAK2(4), JAK3(5), MAP2K1(6), MAPK3(1), PTPN11(6), RAF1(3), SHC1(2), SOS1(12), STAT3(8)	8241252	71	52	70	21	9	15	19	22	6	0	0.525	1.000	1.000
412	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(3), FADD(1), IKBKB(3), IL1A(3), IL1R1(1), IRAK1(3), MAP3K1(4), MAP3K14(1), MAP3K7(5), MYD88(3), NFKB1(3), NFKBIA(1), RIPK1(4), TLR4(31), TNFRSF1B(1), TRAF6(4)	8407048	71	52	70	27	8	18	20	11	14	0	0.887	1.000	1.000
413	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	CDC42(2), CREB5(7), DUSP10(6), EEF2K(2), EIF4E(3), ELK1(2), GADD45A(1), HSPB1(1), IL1R1(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP3K10(1), MAP3K4(14), MAP3K5(12), MAP3K7(5), MAPK11(1), MAPK14(1), MAPKAPK2(3), MAPKAPK5(3), MKNK1(2), MKNK2(1), MYEF2(4), NFKB1(3), NR2C2(2), TRAF6(4)	11449542	91	52	90	28	20	24	23	11	13	0	0.589	1.000	1.000
414	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), DAG1(2), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), NFAT5(6), PDE6A(9), PDE6B(4), PDE6C(5), PDE6D(1), PDE6G(2), SLC6A13(4), TF(4)	12435387	93	52	92	28	15	31	17	17	13	0	0.555	1.000	1.000
415	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(8), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CASP10(6), CASP3(4), CASP6(1), CASP7(1), CASP8(4), CASP9(3), CFLAR(1), CHUK(3), DFFA(3), DFFB(2), FADD(1), GAS2(1), MAP3K14(1), NFKB1(3), NFKBIA(1), RIPK1(4), SPTAN1(12), TNFRSF10B(1), TNFRSF25(1), TNFSF10(1), TRAF2(1)	11580988	70	51	70	34	12	14	19	10	15	0	0.994	1.000	1.000
416	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(1), CS(1), DLAT(5), DLD(6), DLST(2), FH(7), IDH2(2), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(2), MDH2(2), OGDH(1), PC(1), PDHA1(3), PDHA2(13), PDHX(4), PDK1(4), PDK2(2), PDK3(2), PDP2(1), SDHA(5), SDHB(1), SDHD(1), SUCLG1(2), SUCLG2(2)	9740515	75	51	75	34	13	21	19	11	11	0	0.961	1.000	1.000
417	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K4(3), MAP2K7(2), MAPK10(5), MAPK11(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPK8IP1(4), MAPK8IP3(4), MAPK9(6), MAPKAPK5(3), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), PIK3CA(11), PIK3CD(1), PIK3R1(3), SYT1(3), TRAF2(1), TRAF3(3), TRAF5(2), TRAF6(4)	11610987	72	51	68	27	12	12	28	8	12	0	0.713	1.000	1.000
418	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(2), CDKN1A(1), GNAQ(2), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), PLCG1(5), PPP3CA(5), PPP3CB(1), PPP3CC(2), PRKCA(7), SP1(1), SP3(4), SYT1(3)	7188768	62	50	61	18	12	18	19	6	7	0	0.376	1.000	1.000
419	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	ELK1(2), FOS(1), GRB2(4), HRAS(1), INSR(1), IRS1(15), MAP2K1(6), MAPK3(1), MAPK8(3), PIK3CA(11), PIK3R1(3), PTPN11(6), RAF1(3), RASA1(3), SHC1(2), SOS1(12)	8739785	74	50	70	22	14	14	23	17	6	0	0.431	1.000	1.000
420	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCL4(1), CCR1(2), CCR2(5), CCR3(2), CCR4(2), CCR5(1), CD28(1), CD4(3), CXCR3(1), CXCR4(3), IFNG(4), IFNGR1(3), IFNGR2(3), IL12A(3), IL12RB1(3), IL12RB2(12), IL18R1(3), IL2(5), IL4(1), IL4R(5), TGFB1(2), TGFB2(8), TGFB3(1)	6867481	75	50	74	24	7	21	20	13	14	0	0.527	1.000	1.000
421	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(1), DAB1(15), FYN(3), LRP8(3), RELN(49), VLDLR(2)	4832816	73	50	72	27	4	26	17	16	10	0	0.963	1.000	1.000
422	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(4), CR1(14), CR2(8), FCGR2B(2), HLA-DRA(3), ITGAL(20), ITGB2(2), PTPRC(21)	5287839	74	49	74	24	8	29	15	8	14	0	0.836	1.000	1.000
423	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(2), AMD1(1), BHMT(6), CBS(1), CTH(1), DNMT1(5), DNMT3A(11), DNMT3B(4), MARS(2), MARS2(8), MAT1A(4), MAT2B(3), MTFMT(1), MTR(11), SRM(2), TAT(4)	7191974	66	49	66	20	13	18	21	8	5	1	0.446	1.000	1.000
424	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(1), FUCA1(1), FUCA2(1), HEXA(1), LCT(30), MAN2B1(2), MAN2B2(3), MAN2C1(4), MANBA(4), NEU1(1), NEU3(3), NEU4(6)	7070604	57	49	57	15	7	21	20	6	3	0	0.323	1.000	1.000
425	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	CREB5(7), DUSP6(3), DUSP9(2), EEF2K(2), EIF4E(3), GRB2(4), MAP2K1(6), MAP2K2(1), MAP3K8(2), MAPK3(1), MKNK1(2), MKNK2(1), MOS(2), NFKB1(3), RAP1A(2), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), SHC1(2), SOS1(12), SOS2(6), TRAF3(3)	9698379	73	49	73	29	8	16	27	12	10	0	0.887	1.000	1.000
426	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(2), CHUK(3), EGR2(2), EGR3(1), GNAQ(2), MAP3K1(4), NFATC1(3), NFATC2(8), NFKB1(3), NFKBIA(1), PLCG1(5), PPP3CA(5), PPP3CB(1), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), SYT1(3), VIP(1), VIPR2(4)	9592581	62	49	61	17	10	18	17	3	14	0	0.369	1.000	1.000
427	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(2), CARM1(3), CBS(1), CTH(1), GGT1(1), LCMT1(2), LCMT2(4), MARS(2), MARS2(8), MAT1A(4), MAT2B(3), METTL2B(5), METTL6(1), PAPSS1(3), PAPSS2(4), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), SCLY(2), SEPHS1(4), WBSCR22(1)	8575363	74	48	73	21	18	16	31	3	6	0	0.215	1.000	1.000
428	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(8), POLR1B(10), POLR1D(2), POLR2A(9), POLR2B(5), POLR2C(4), POLR2D(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), POLR3A(12), POLR3B(13), POLR3G(1), POLR3H(1)	8089883	75	48	74	26	15	16	25	13	6	0	0.733	1.000	1.000
429	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(3), ATG7(1), BECN1(1), GABARAPL1(1), IFNA10(4), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(3), IFNA21(3), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(4), IFNA8(1), IFNG(4), PIK3C3(7), PIK3R4(9), PRKAA1(4), ULK1(3), ULK2(2), ULK3(1)	7295711	67	48	67	23	6	25	18	14	4	0	0.863	1.000	1.000
430	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(10), ACE2(3), AGT(2), AGTR1(5), AGTR2(2), ANPEP(4), CMA1(6), CPA3(6), CTSA(1), CTSG(2), ENPEP(8), LNPEP(1), MAS1(3), MME(8), NLN(5), REN(1), THOP1(2)	7310825	69	48	69	34	6	24	24	6	9	0	0.994	1.000	1.000
431	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(12), APOA1(1), APOA4(3), APOC2(1), APOC3(3), APOE(1), CETP(2), CYP7A1(7), DGAT1(2), HMGCR(4), LCAT(1), LDLR(4), LIPC(6), LPL(5), LRP1(21), SOAT1(7)	9394267	80	48	79	33	17	19	19	18	6	1	0.920	1.000	1.000
432	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), CARS(1), EPRS(13), FARS2(1), GARS(4), HARS(2), IARS(9), KARS(4), LARS(7), LARS2(2), MARS(2), MARS2(8), NARS(3), QARS(2), RARS(5), SARS(2), TARS(5), WARS(3), WARS2(9), YARS(1)	11020854	84	47	84	26	11	29	21	17	6	0	0.709	1.000	1.000
433	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(3), CHAT(8), DBH(2), DDC(6), GAD1(5), GAD2(10), HDC(7), MAOA(3), PAH(3), SLC18A3(8), TH(2), TPH1(11)	4997467	68	47	68	24	14	16	13	16	9	0	0.748	1.000	1.000
434	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(2), AZIN1(1), BTG1(1), CBX3(2), CLOCK(2), CRY1(3), CRY2(2), DAZAP2(1), ETV6(4), GFRA1(8), GSTM3(1), GSTP1(2), HERPUD1(2), HSPA8(3), IDI1(1), MYF6(6), NCKAP1(4), NCOA4(4), NR1D2(2), PER1(3), PER2(4), PPP1R3C(1), PPP2CB(3), PSMA4(1), PURA(1), SF3A3(1), SUMO3(1), TOB1(1), UCP3(1), UGP2(1), VAPA(1), ZFR(5)	12668509	75	47	75	31	14	23	23	5	10	0	0.968	1.000	1.000
435	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPAT6(1), AGPS(3), ENPP2(10), ENPP6(2), PAFAH1B2(2), PAFAH1B3(1), PAFAH2(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLD1(9), PLD2(5), PPAP2B(2), PPAP2C(1)	8004237	75	47	75	26	12	28	19	8	8	0	0.771	1.000	1.000
436	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	30	ALOX15(4), ALOX5(6), CYP1A2(2), CYP2C18(4), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2E1(4), CYP2J2(8), CYP3A4(1), CYP3A43(1), CYP3A5(1), CYP3A7(4), HSD3B7(2), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), RDH11(2)	7996222	81	47	81	35	17	30	17	8	8	1	0.945	1.000	1.000
437	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	ELK1(2), FOS(1), GRB2(4), HRAS(1), IL2(5), IL2RA(3), IL2RB(5), IL2RG(3), JAK1(8), JAK3(5), LCK(5), MAP2K1(6), MAPK3(1), MAPK8(3), RAF1(3), SHC1(2), SOS1(12), STAT5A(3), STAT5B(4), SYK(3)	8085303	79	47	77	25	13	18	18	21	9	0	0.567	1.000	1.000
438	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(20), ATM(22), BAX(1), CDKN1A(1), CPB2(4), CSNK1A1(1), CSNK1D(2), GADD45A(1), HIF1A(1), IGFBP3(2), MAPK8(3), MDM2(2), NQO1(3)	6884198	63	47	61	16	9	18	14	9	13	0	0.521	1.000	1.000
439	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(1), ARG1(1), ASL(3), CKM(1), CKMT1A(2), CKMT1B(1), CKMT2(2), CPS1(39), GATM(4), GLUD1(3), OAT(1), ODC1(1), OTC(5), SMS(1)	5990411	65	47	64	24	8	17	17	13	10	0	0.874	1.000	1.000
440	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(1), CD3D(2), CD80(4), CD86(6), CTLA4(1), GRB2(4), HLA-DRA(3), ICOS(2), IL2(5), ITK(7), LCK(5), PIK3CA(11), PIK3R1(3), PTPN11(6)	4378480	60	46	55	17	4	16	19	11	10	0	0.627	1.000	1.000
441	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	9	ACTA1(4), EPHA4(9), FYN(3), ITGA1(9), ITGB1(3), L1CAM(14), LYN(4), RAP1B(1), SELP(14)	4715339	61	46	59	18	8	15	14	19	5	0	0.709	1.000	1.000
442	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), CSF1R(6), DDX20(1), E2F1(3), ETS1(7), ETS2(3), FOS(1), HDAC2(8), HDAC5(2), HRAS(1), NCOR2(13), RBL1(7), RBL2(2), SIN3A(6)	8949778	61	46	61	25	6	11	22	12	10	0	0.918	1.000	1.000
443	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(4), BAIAP2(2), CASP1(2), CASP3(4), CASP7(1), CASP8(4), GAPDH(3), INSR(1), ITCH(6), MAGI1(16), MAGI2(15), RERE(10), WWP1(3), WWP2(3)	8282472	74	46	73	22	16	24	18	8	8	0	0.518	1.000	1.000
444	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(10), BAX(1), BCL2(1), CSF2RB(5), IGF1(5), IGF1R(10), IL3(1), IL3RA(5), KIT(6), PIK3CA(11), PIK3R1(3), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1)	7509597	70	45	67	25	8	21	24	7	10	0	0.699	1.000	1.000
445	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	12	C1QA(1), C1QB(2), C1R(1), C1S(1), C2(3), C3(7), C5(2), C6(14), C8A(6), C8B(9), C9(11), MASP1(5)	6667106	62	45	61	29	6	23	15	8	10	0	0.994	1.000	1.000
446	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(3), GALNT10(3), GALNT2(4), GALNT3(4), GALNT4(4), GALNT6(2), GALNT7(5), GALNT8(6), GALNT9(1), GCNT1(4), ST3GAL1(3), ST3GAL2(3), ST3GAL4(2), WBSCR17(16)	4952583	60	45	60	30	16	10	18	12	4	0	0.983	1.000	1.000
447	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(2), ACP2(1), ACP5(3), ACP6(3), ACPP(7), ALPI(5), ALPL(2), ALPP(4), ALPPL2(3), CMBL(1), CYP3A4(1), CYP3A43(1), CYP3A5(1), CYP3A7(4), DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), PON1(3), PON3(5)	6216434	54	44	54	28	5	11	19	9	10	0	0.974	1.000	1.000
448	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	GRB2(4), HRAS(1), IGF1R(10), IRS1(15), MAP2K1(6), MAPK3(1), PIK3CA(11), PIK3R1(3), RAF1(3), SHC1(2), SOS1(12)	6468334	68	44	65	19	13	17	17	15	6	0	0.378	1.000	1.000
449	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	ELK1(2), FOS(1), GRB2(4), HRAS(1), KLK2(4), MAP2K1(6), MAPK3(1), MAPK8(3), NGFR(2), PIK3CA(11), PIK3R1(3), PLCG1(5), RAF1(3), SHC1(2), SOS1(12)	6555125	60	44	57	16	9	16	19	12	4	0	0.327	1.000	1.000
450	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(1), HLA-A(2), ITGB1(3), KLRC1(3), KLRC2(3), KLRC3(3), KLRD1(2), LAT(3), MAP2K1(6), MAPK3(1), PAK1(5), PIK3CA(11), PIK3R1(3), PTK2B(8), PTPN6(3), SYK(3), VAV1(1)	6399176	61	44	58	16	12	9	18	13	9	0	0.250	1.000	1.000
451	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), DCXR(1), GUSB(4), RPE(2), UCHL1(1), UGDH(4), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2B15(6), UGT2B4(13)	6090026	63	44	62	23	6	21	15	12	9	0	0.821	1.000	1.000
452	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(3), DYRK1B(2), GLI2(10), GLI3(17), GSK3B(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), SHH(4), SMO(5)	5808356	55	44	55	16	14	17	9	6	9	0	0.435	1.000	1.000
453	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), ABAT(4), AGXT(3), AGXT2(8), ASL(3), ASNS(3), ASPA(2), CAD(16), CRAT(1), DDO(3), GAD1(5), GAD2(10), GOT1(2), GOT2(4), GPT2(3), NARS(3), PC(1)	8995349	72	43	72	31	15	17	21	12	7	0	0.900	1.000	1.000
454	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(4), ACO2(1), CS(1), DLD(6), DLST(2), FH(7), IDH1(2), IDH2(2), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(2), MDH2(2), PC(1), PCK1(11), SDHA(5), SDHB(1), SUCLG1(2), SUCLG2(2)	7035338	56	43	56	23	12	11	13	9	11	0	0.850	1.000	1.000
455	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	15	B4GALNT1(4), HEXA(1), LCT(30), SLC33A1(2), ST3GAL1(3), ST3GAL2(3), ST6GALNAC4(1), ST6GALNAC5(3), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(4)	5435315	54	43	54	18	10	13	22	4	5	0	0.615	1.000	1.000
456	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(2), BHMT(6), CBS(1), CTH(1), DNMT1(5), DNMT3A(11), DNMT3B(4), MARS(2), MARS2(8), MAT1A(4), MAT2B(3), MTR(11)	6019952	58	43	58	16	10	16	19	7	5	1	0.329	1.000	1.000
457	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AP2A1(2), AP2M1(5), BTK(11), EEA1(6), GSK3B(2), LYN(4), PDPK1(1), PFKL(2), PFKM(5), PFKP(3), PLCG1(5), PRKCE(3), PRKCZ(2), RAB5A(1), RPS6KB1(2), VAV2(3)	8585210	57	43	56	19	10	11	19	11	6	0	0.648	1.000	1.000
458	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6R(8), JAK1(8), JAK2(4), JAK3(5), PIAS3(6), PTPRU(10), REG1A(9), SRC(2), STAT3(8)	5302724	60	43	59	18	9	18	12	13	8	0	0.604	1.000	1.000
459	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(8), BIRC2(2), BIRC3(3), CASP1(2), CASP10(6), CASP2(7), CASP3(4), CASP4(3), CASP6(1), CASP7(1), CASP8(4), CASP9(3), DFFA(3), DFFB(2), GZMB(3), LMNB1(2), LMNB2(2), PRF1(5)	6681762	61	42	61	20	8	19	13	11	10	0	0.806	1.000	1.000
460	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(9), EGFR(33), ERBB3(3), NRG1(9)	3545378	54	42	39	17	7	8	10	14	15	0	0.818	1.000	1.000
461	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	25	ALDOA(2), ALDOB(4), ALDOC(1), DERA(1), FBP2(1), G6PD(2), GPI(3), H6PD(3), PFKL(2), PFKM(5), PFKP(3), PGD(2), PGM1(2), PGM3(4), PRPS1(3), PRPS1L1(3), PRPS2(2), RPE(2), RPIA(5), TKT(1), TKTL1(10)	7973780	61	42	60	23	13	12	15	14	7	0	0.760	1.000	1.000
462	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(4), IL22(2), IL22RA2(2), JAK1(8), JAK2(4), JAK3(5), STAT1(4), STAT3(8), STAT5A(3), STAT5B(4), TYK2(2)	6383833	46	42	46	17	3	8	9	16	10	0	0.854	1.000	1.000
463	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(5), CALM1(2), CAPN2(3), CAPNS2(2), EP300(2), HDAC1(3), HDAC2(8), MEF2D(1), NFATC1(3), NFATC2(8), PPP3CA(5), PPP3CB(1), PPP3CC(2), PRKCA(7), SYT1(3)	8365370	55	42	54	18	9	19	15	4	8	0	0.621	1.000	1.000
464	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(10), AP2A1(2), AP2M1(5), BIN1(1), CALM1(2), DNM1(5), EPN1(5), EPS15(3), PICALM(4), PPP3CA(5), PPP3CB(1), PPP3CC(2), SYNJ1(4), SYNJ2(3), SYT1(3)	7450057	55	42	54	18	6	21	12	8	8	0	0.852	1.000	1.000
465	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(2), ITGA4(19), ITGAL(20), ITGB1(3), ITGB2(2), SELE(6), SELL(4)	4197341	56	41	56	22	7	19	15	8	7	0	0.937	1.000	1.000
466	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	BCAR1(2), CDKN1B(3), GRB2(4), ILK(1), ITGB1(3), MAPK3(1), PDK2(2), PDPK1(1), PIK3CA(11), PIK3R1(3), PTEN(8), PTK2(11), SHC1(2), SOS1(12)	6648557	64	41	60	16	6	16	18	14	10	0	0.399	1.000	1.000
467	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT2(2), AKT3(5), BPNT1(3), GRB2(4), ILK(1), MAPK3(1), PDK1(4), PIK3CA(11), PIK3CD(1), PTEN(8), PTK2B(8), RBL2(2), SHC1(2), SOS1(12)	7004194	64	41	60	22	10	16	20	12	6	0	0.754	1.000	1.000
468	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN1(2), ACTN2(23), ACTN3(3), BCAR1(2), CTNNA1(3), CTNNB1(11), PTK2(11), PXN(1), SRC(2), VCL(2)	5975297	60	40	57	19	11	21	8	15	5	0	0.589	1.000	1.000
469	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	ELK1(2), EPO(3), EPOR(1), FOS(1), GRB2(4), HRAS(1), JAK2(4), MAP2K1(6), MAPK3(1), MAPK8(3), PLCG1(5), PTPN6(3), RAF1(3), SHC1(2), SOS1(12), STAT5A(3), STAT5B(4)	7393494	58	40	58	19	10	13	15	14	6	0	0.550	1.000	1.000
470	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	GRB2(4), HRAS(1), MAPK3(1), MAPK7(5), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), NTRK1(12), PIK3CA(11), PIK3R1(3), PLCG1(5), RPS6KA1(1), SHC1(2)	6552835	51	40	47	16	8	9	17	10	7	0	0.526	1.000	1.000
471	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(1), ACAT2(1), ACOT11(2), ACYP2(1), DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), EHHADH(8), ESCO1(7), ESCO2(2), GCDH(3), HADHA(3), ITGB1BP3(2), MYST3(8), MYST4(8), NAT6(1), PNPLA3(2), SH3GLB1(1), YOD1(1)	8925504	59	40	57	16	7	18	16	8	9	1	0.483	1.000	1.000
472	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(4), CAT(3), EPX(7), LPO(4), MPO(4), PRDX1(2), PRDX2(1), PRDX5(1), PRDX6(3), SHMT1(2), SHMT2(2), TPO(16)	4053300	49	40	49	15	6	15	12	10	6	0	0.544	1.000	1.000
473	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(3), CREBBP(4), EP300(2), IKBKB(3), MAP2K3(6), MAP2K6(1), MAP3K14(1), MAP3K7(5), MAPK11(1), MAPK14(1), MYD88(3), NFKB1(3), NFKBIA(1), NR3C1(3), TGFBR1(2), TGFBR2(2), TLR2(2)	10176531	43	40	43	22	3	9	13	5	13	0	0.990	1.000	1.000
474	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(5), CHUK(3), IFNG(4), IKBKB(3), IL2(5), IL4(1), MAP3K1(4), MAP3K5(12), MAP4K5(1), MAPK14(1), MAPK8(3), NFKB1(3), NFKBIA(1), TNFRSF9(4), TNFSF9(1), TRAF2(1)	6665503	52	39	51	14	7	11	14	5	15	0	0.489	1.000	1.000
475	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(4), ACTR2(2), ACTR3(1), ARPC1A(1), ARPC1B(1), ARPC2(1), ARPC3(2), NCK1(3), NCKAP1(4), NTRK1(12), PIR(2), PSMA7(1), WASF1(8), WASF2(1), WASF3(4), WASL(5)	5269061	52	39	51	14	3	13	13	8	15	0	0.663	1.000	1.000
476	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	13	C1QA(1), C1QB(2), C1R(1), C1S(1), C2(3), C3(7), C5(2), C6(14), C8A(6), C9(11), MASP1(5), MASP2(2), MBL2(1)	6859695	56	39	55	31	6	19	14	7	10	0	0.999	1.000	1.000
477	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(5), FOS(1), GRB2(4), HRAS(1), IL3(1), IL3RA(5), JAK2(4), MAP2K1(6), MAPK3(1), PTPN6(3), RAF1(3), SHC1(2), SOS1(12), STAT5A(3), STAT5B(4)	6077431	55	39	55	19	7	12	15	14	7	0	0.657	1.000	1.000
478	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(5), GTF2A1(3), GTF2B(1), GTF2E1(6), GTF2F1(1), HDAC3(1), NCOA1(5), NCOA2(6), NCOA3(8), NCOR2(13), POLR2A(9), RARA(3), RXRA(1)	8569867	62	39	61	21	17	18	12	11	4	0	0.684	1.000	1.000
479	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD28(1), CD3D(2), CD4(3), ITGAL(20), ITGB2(2), PTPRC(21), THY1(1)	3887962	53	39	53	21	8	19	10	6	10	0	0.891	1.000	1.000
480	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	CHRNB1(4), CHRNG(1), MUSK(9), PIK3CA(11), PIK3R1(3), PTK2(11), PTK2B(8), RAPSN(1), SRC(2), TERT(4)	5591493	54	38	51	16	12	13	14	10	5	0	0.383	1.000	1.000
481	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(2), ACTR3(1), ARPC1A(1), ARPC1B(1), ARPC2(1), ARPC3(2), CDC42(2), PAK1(5), PDGFRA(17), PIK3CA(11), PIK3R1(3), WASL(5)	4601984	51	38	48	17	6	12	18	7	8	0	0.853	1.000	1.000
482	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(3), FOS(1), HRAS(1), MAP2K1(6), MAPK3(1), NFKB1(3), NFKBIA(1), PLCB1(18), PRKCA(7), RAF1(3)	5298373	44	38	44	14	9	10	13	5	7	0	0.513	1.000	1.000
483	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(10), CREM(2), FHL5(5), FSHB(1), FSHR(20), GNAS(7), XPO1(3)	3263708	48	38	48	21	4	15	13	9	7	0	0.983	1.000	1.000
484	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(4), PGAP1(4), PIGB(1), PIGC(2), PIGG(7), PIGK(2), PIGL(2), PIGM(5), PIGN(2), PIGO(7), PIGP(1), PIGQ(1), PIGS(1), PIGT(2), PIGV(3), PIGW(1), PIGX(4), PIGZ(1)	8254534	51	38	50	16	9	9	20	10	3	0	0.483	1.000	1.000
485	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(4), CAT(3), EPX(7), LPO(4), MPO(4), MTHFR(1), PRDX6(3), SHMT1(2), SHMT2(2), TPO(16)	3991928	46	38	46	16	6	14	13	7	6	0	0.699	1.000	1.000
486	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	21	AOX1(14), CD38(3), ENPP1(6), NADK(2), NADSYN1(1), NMNAT1(1), NMNAT2(3), NMNAT3(1), NNMT(5), NNT(4), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5C3(1), NT5E(2), NT5M(1), NUDT12(2), QPRT(2)	6816872	53	38	53	26	4	20	12	11	6	0	0.986	1.000	1.000
487	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(1), CD3D(2), CXCR3(1), ETV5(8), IFNG(4), IL12A(3), IL12RB1(3), IL12RB2(12), IL18R1(3), JAK2(4), MAP2K6(1), MAPK14(1), MAPK8(3), STAT4(6), TYK2(2)	6409710	54	38	54	21	3	15	16	8	12	0	0.889	1.000	1.000
488	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(4), ADCY1(10), CCNB1(1), CDC25C(3), GNAI1(3), GNAS(7), GNB1(2), GNGT1(2), HRAS(1), MAPK3(1), MYT1(6), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), RPS6KA1(1), SRC(2)	7030758	55	38	55	23	7	13	14	8	13	0	0.939	1.000	1.000
489	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CASP2(7), CHUK(3), IKBKB(3), LTA(2), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP3K1(4), MAP3K14(1), MAPK14(1), MAPK8(3), NFKB1(3), NFKBIA(1), RIPK1(4), TANK(2), TRAF2(1)	8338119	45	38	45	20	5	15	9	4	12	0	0.965	1.000	1.000
490	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(10), GNAS(7), GNB1(2), GNGT1(2), PPP2CA(1), PRKAA1(4), PRKAB1(3), PRKACB(3), PRKACG(1), PRKAG2(4), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1)	5262878	45	37	45	18	5	14	13	5	8	0	0.907	1.000	1.000
491	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	10	C1QA(1), C1QB(2), C1R(1), C1S(1), C2(3), C3(7), C5(2), C6(14), C8A(6), C9(11)	5537449	48	37	47	26	6	14	12	7	9	0	0.998	1.000	1.000
492	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(3), CYP51A1(3), DHCR24(2), DHCR7(2), EBP(2), FDFT1(2), FDPS(1), GGCX(4), GGPS1(1), HMGCR(4), HSD17B7(1), IDI1(1), LSS(3), MVD(2), MVK(1), NQO1(3), NSDHL(3), PMVK(1), SC4MOL(2), SC5DL(3), SQLE(1), TM7SF2(5), VKORC1(1)	6685197	51	37	50	20	5	18	15	9	4	0	0.858	1.000	1.000
493	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	15	BCAT1(1), BCAT2(1), COASY(5), DPYD(12), DPYS(10), ENPP1(6), ILVBL(1), PANK1(2), PANK2(4), PANK3(2), PANK4(1), PPCDC(1), PPCS(1), VNN1(4)	5324250	51	37	51	16	4	14	16	9	7	1	0.585	1.000	1.000
494	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD28(1), CD3D(2), CD8A(2), ITGAL(20), ITGB2(2), PTPRC(21), THY1(1)	3704762	52	37	52	21	8	18	10	6	10	0	0.894	1.000	1.000
495	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(3), CPS1(39), GLS(3), GLUD1(3), GOT1(2)	2677697	51	37	50	17	6	11	15	11	8	0	0.797	1.000	1.000
496	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(3), GCK(4), GFPT1(4), GNE(1), GNPDA1(1), GNPDA2(2), HEXA(1), HK1(3), HK2(9), HK3(12), PGM3(4), RENBP(3), UAP1(6)	5809272	53	36	53	15	13	14	11	9	6	0	0.423	1.000	1.000
497	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(5), CYP11A1(1), CYP11B1(10), CYP11B2(7), CYP17A1(3), CYP21A2(1), HSD11B1(4), HSD11B2(1), HSD3B1(7), HSD3B2(13)	3251113	53	36	53	21	5	22	13	7	6	0	0.860	1.000	1.000
498	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(5), CYP11A1(1), CYP11B1(10), CYP11B2(7), CYP17A1(3), CYP21A2(1), HSD11B1(4), HSD11B2(1), HSD3B1(7), HSD3B2(13)	3251113	53	36	53	21	5	22	13	7	6	0	0.860	1.000	1.000
499	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(3), DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), LCMT1(2), LCMT2(4), METTL2B(5), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), WBSCR22(1)	5179980	47	36	46	14	10	8	22	4	3	0	0.345	1.000	1.000
500	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	16	ABCC1(6), ABCC2(5), ABCG2(5), CES1(3), CES2(1), CYP3A4(1), CYP3A5(1), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5)	7403341	52	36	51	30	11	22	8	8	3	0	0.991	1.000	1.000
501	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(10), ADRB2(2), GNAS(7), PLCE1(14), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), RAP2B(1)	5052427	46	36	46	19	3	17	12	5	9	0	0.927	1.000	1.000
502	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	CASP9(3), CDC42(2), CHUK(3), ELK1(2), H2AFX(1), HRAS(1), MAP2K1(6), MAPK3(1), NFKB1(3), PIK3CA(11), PIK3R1(3), RAF1(3), RALA(2), RALBP1(1), RHOA(1)	6558789	43	36	40	15	7	9	11	9	7	0	0.697	1.000	1.000
503	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(8), JAK2(4), JAK3(5), PIAS1(2), PIAS3(6), PTPRU(10), REG1A(9), SOAT1(7)	4808771	51	36	50	16	6	18	9	10	7	1	0.736	1.000	1.000
504	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), CD86(6), HLA-DRA(3), IFNG(4), IFNGR1(3), IFNGR2(3), IL12A(3), IL12RB1(3), IL12RB2(12), IL18R1(3), IL2(5), IL2RA(3), IL4(1), IL4R(5)	4359702	55	36	53	19	8	12	17	8	10	0	0.662	1.000	1.000
505	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	GRB2(4), IL2RG(3), IL4(1), IL4R(5), IRS1(15), JAK1(8), JAK3(5), RPS6KB1(2), SHC1(2), STAT6(2)	5098914	47	35	47	20	10	10	13	12	2	0	0.867	1.000	1.000
506	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	11	CREBBP(4), DAXX(6), HRAS(1), PAX3(6), PML(7), RARA(3), SIRT1(1), SP100(9), TNFRSF1B(1)	5708054	38	35	38	12	6	6	15	6	5	0	0.558	1.000	1.000
507	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	21	CCND1(2), CCNE1(3), CDK2(4), CDK4(2), CDK6(3), CDKN1A(1), CDKN1B(3), E2F1(3), HRAS(1), MAPK3(1), NFKB1(3), NFKBIA(1), PAK1(5), PIK3CA(11), PIK3R1(3), RAF1(3), TFDP1(3)	6326125	52	35	49	15	15	12	14	6	5	0	0.350	1.000	1.000
508	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), BIRC2(2), BIRC3(3), CASP3(4), CASP8(4), CFLAR(1), FADD(1), MAP2K4(3), MAP3K3(4), MAP3K7(5), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), NR2C2(2), RALBP1(1), RIPK1(4), TNFRSF1B(1), TRAF2(1)	9372512	48	35	48	19	10	9	14	5	10	0	0.823	1.000	1.000
509	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(2), ANXA1(2), CALM1(2), GNAS(7), GNB1(2), GNGT1(2), NFKB1(3), NOS3(2), NPPA(1), NR3C1(3), PIK3CA(11), PIK3R1(3), SYT1(3)	6143154	43	34	40	18	4	12	15	4	8	0	0.920	1.000	1.000
510	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	14	ACP1(2), ACP2(1), ACP5(3), ACP6(3), ACPP(7), ENPP1(6), FLAD1(3), LHPP(2), MTMR1(5), MTMR2(2), MTMR6(6), PHPT1(1)	4208104	41	34	41	13	1	9	16	11	4	0	0.628	1.000	1.000
511	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(2), ITGAL(20), ITGAM(14), ITGB2(2), SELE(6), SELL(4)	3617742	48	34	48	21	8	16	14	5	5	0	0.907	1.000	1.000
512	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(2), ALDOB(4), ALDOC(1), FBP2(1), G6PD(2), GPI(3), H6PD(3), PFKM(5), PFKP(3), PGD(2), PGM1(2), PGM3(4), PRPS1(3), PRPS1L1(3), PRPS2(2), RPE(2), RPIA(5), TAL1(3), TKT(1)	7050223	51	34	50	18	12	11	12	12	4	0	0.693	1.000	1.000
513	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(4), CNR2(1), DNMT1(5), MTNR1A(5), MTNR1B(6), PTAFR(2), PTGDR(3), PTGER2(2), PTGER4(7), PTGFR(6), PTGIR(2)	3896206	43	34	43	18	7	13	12	8	3	0	0.766	1.000	1.000
514	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	29	ANPEP(4), G6PD(2), GCLC(8), GCLM(1), GGT1(1), GPX1(1), GPX3(1), GPX5(4), GSS(3), GSTA1(1), GSTA2(3), GSTA3(2), GSTA4(1), GSTM1(1), GSTM2(2), GSTM3(1), GSTM4(1), GSTM5(2), GSTO2(1), GSTP1(2), GSTZ1(1), IDH1(2), IDH2(2), MGST1(1), MGST3(3), PGD(2)	6155749	53	33	53	13	6	17	19	4	6	1	0.238	1.000	1.000
515	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(5), AMT(2), ATIC(3), FTCD(3), GART(4), MTFMT(1), MTHFD1(1), MTHFD1L(5), MTHFD2(1), MTHFR(1), MTR(11), SHMT1(2), SHMT2(2)	6542530	41	33	41	20	10	14	7	3	6	1	0.966	1.000	1.000
516	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(10), CPT1A(7), LEP(4), LEPR(13), PRKAA1(4), PRKAB1(3), PRKAG2(4)	4972735	45	33	45	13	7	19	7	7	5	0	0.712	1.000	1.000
517	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	CAT(3), GH1(2), GHR(5), HRAS(1), IGF1(5), IGF1R(10), PIK3CA(11), PIK3R1(3), SHC1(2), SOD2(1), SOD3(1)	4524353	44	33	41	16	4	15	11	6	8	0	0.839	1.000	1.000
518	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADM(3), ACSL1(8), ACSL3(3), ACSL4(2), CPT1A(7), CPT2(2), DCI(2), EHHADH(8), HADHA(3), PECR(1), SCP2(3), SLC25A20(2)	5754541	44	33	43	15	6	16	6	9	6	1	0.768	1.000	1.000
519	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(2), CD4(3), FYN(3), HLA-DRA(3), LCK(5), PTPRC(21), ZAP70(4)	3126308	41	33	40	13	3	16	10	4	8	0	0.799	1.000	1.000
520	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(3), LCMT1(2), LCMT2(4), METTL2B(5), METTL6(1), PCYT1A(2), PCYT1B(3), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), WBSCR22(1)	4872662	44	32	43	13	10	7	21	3	3	0	0.372	1.000	1.000
521	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	6	EPX(7), GBA(3), LPO(4), MPO(4), PRDX6(3), TPO(16)	2570067	37	32	37	15	3	12	12	6	4	0	0.813	1.000	1.000
522	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(4), APAF1(8), BCL2(1), CASP3(4), CASP9(3), DAXX(6), FAS(3), FASLG(4), HSPB1(1), HSPB2(1), IL1A(3), MAPKAPK2(3), MAPKAPK3(1)	3892084	42	32	42	16	5	10	8	11	8	0	0.895	1.000	1.000
523	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), BLVRB(1), HMOX1(3), IL10(1), IL10RA(4), IL10RB(2), IL1A(3), JAK1(8), STAT1(4), STAT3(8), STAT5A(3)	4199402	38	32	38	13	1	7	11	11	8	0	0.760	1.000	1.000
524	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), CD2(3), CD3D(2), CD4(3), CXCR3(1), IFNG(4), IL12A(3), IL12RB1(3), IL12RB2(12), JAK2(4), STAT4(6), TYK2(2)	5062961	44	32	44	18	3	11	13	7	10	0	0.890	1.000	1.000
525	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(2), CAMK1(2), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(8), HDAC5(2), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), PPARA(1), PPP3CA(5), PPP3CB(1), PPP3CC(2), SYT1(3)	7036483	40	32	39	17	4	14	9	7	6	0	0.920	1.000	1.000
526	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	8	EPX(7), LPO(4), MPO(4), PRDX1(2), PRDX2(1), PRDX5(1), PRDX6(3), TPO(16)	2630981	38	32	38	12	3	11	11	9	4	0	0.593	1.000	1.000
527	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	IFNG(4), IFNGR1(3), IFNGR2(3), IKBKB(3), JAK2(4), LIN7A(2), NFKB1(3), NFKBIA(1), TNFRSF1B(1), USH1C(4), WT1(8)	5418140	36	32	36	13	7	11	9	2	7	0	0.718	1.000	1.000
528	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(3), CHAT(8), CHKA(1), PCYT1A(2), PDHA1(3), PDHA2(13), SLC18A3(8)	2406790	38	31	38	13	8	8	11	6	5	0	0.556	1.000	1.000
529	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	5	C3(7), C5(2), C6(14), C8A(6), C9(11)	3812163	40	31	39	17	6	14	9	3	8	0	0.968	1.000	1.000
530	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(1), BCL2(1), CASP8(4), FADD(1), MAP2K1(6), MAP2K4(3), MAP3K1(4), MAPK3(1), MAPK8(3), NFKB1(3), NSMAF(2), RAF1(3), RIPK1(4), SMPD1(2), TRAF2(1)	7064879	39	31	39	14	8	6	14	5	6	0	0.639	1.000	1.000
531	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(10), ADRB2(2), CFTR(6), GNAS(7), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), SLC9A3R1(1)	4478782	38	31	38	16	3	12	12	5	6	0	0.904	1.000	1.000
532	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(6), IL13(1), IL4(1), MAF(1), MAP2K3(6), MAPK14(1), NFATC1(3), NFATC2(8), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1)	4203753	39	31	38	13	4	16	8	2	9	0	0.618	1.000	1.000
533	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K6(1), MAP3K1(4), MAPK14(1), MAPK3(1), NFKB1(3), PIK3CA(11), PIK3R1(3), SP1(1)	6044226	38	31	35	13	4	10	10	6	8	0	0.754	1.000	1.000
534	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(5), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT5(3), DDOST(1), DPAGT1(1), DPM1(1), FUT8(4), MAN1B1(2), MGAT1(2), MGAT3(4), MGAT4A(3), MGAT4B(1), MGAT5(6), RPN2(4)	6863359	41	31	41	11	8	11	11	6	5	0	0.344	1.000	1.000
535	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	CASP9(3), CHUK(3), GH1(2), GHR(5), NFKB1(3), NFKBIA(1), PDPK1(1), PIK3CA(11), PIK3R1(3), PPP2CA(1)	4800756	33	30	30	17	2	8	12	4	7	0	0.987	1.000	1.000
536	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(4), ENO1(3), GPI(3), HK1(3), PFKL(2), PGAM1(1), PGK1(5), PKLR(11), TPI1(6)	3205771	38	30	37	15	5	13	11	4	5	0	0.766	1.000	1.000
537	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(10), ACACB(11), FASN(4), MCAT(1), OLAH(7), OXSM(5)	5490275	38	30	38	21	6	15	12	2	3	0	0.983	1.000	1.000
538	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(3), B3GNT2(1), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT4(1), CHST1(10), CHST2(4), CHST6(3), FUT8(4), ST3GAL1(3), ST3GAL2(3), ST3GAL3(1), ST3GAL4(2)	4290773	39	30	38	22	12	6	12	4	5	0	0.968	1.000	1.000
539	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	GOSR2(1), SEC22B(5), SNAP23(1), SNAP25(4), STX11(1), STX12(2), STX16(3), STX17(1), STX18(2), STX19(3), STX2(8), STX3(3), STX7(2), STX8(3), TSNARE1(1), VTI1A(1)	5810875	41	30	40	18	7	9	8	8	9	0	0.957	1.000	1.000
540	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(5), AMT(2), ATIC(3), GART(4), MTHFD1(1), MTHFD1L(5), MTHFD2(1), MTHFR(1), MTR(11), SHMT1(2), SHMT2(2)	6166512	37	30	37	18	9	13	5	3	6	1	0.963	1.000	1.000
541	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(3), IKBKAP(5), IKBKB(3), LTA(2), MAP3K1(4), MAP3K14(1), NFKB1(3), NFKBIA(1), RIPK1(4), TANK(2), TNFRSF1B(1), TRAF2(1), TRAF3(3)	7701270	33	30	33	17	2	7	13	4	7	0	0.977	1.000	1.000
542	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(2), CCL4(1), CCR5(1), CXCL12(1), CXCR4(3), FOS(1), GNAQ(2), MAPK14(1), MAPK8(3), PLCG1(5), PRKCA(7), PTK2B(8), SYT1(3)	4713049	38	29	38	17	10	12	10	1	5	0	0.842	1.000	1.000
543	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(3), DHCR7(2), FDFT1(2), FDPS(1), HMGCR(4), HMGCS1(5), IDI1(1), LSS(3), MVD(2), MVK(1), NSDHL(3), PMVK(1), SC4MOL(2), SC5DL(3), SQLE(1)	4565802	34	29	33	13	2	13	10	7	1	1	0.845	1.000	1.000
544	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(8), ARHGAP5(7), CASP1(2), CASP10(6), CASP3(4), CASP8(4), CASP9(3), GZMB(3), PRF1(5)	4422677	42	29	42	12	5	11	9	11	6	0	0.632	1.000	1.000
545	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	12	AOX1(14), CD38(3), ENPP1(6), NADSYN1(1), NMNAT1(1), NMNAT2(3), NNMT(5), NNT(4), NT5E(2), NT5M(1), QPRT(2)	4394052	42	29	42	19	4	17	7	10	4	0	0.952	1.000	1.000
546	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(2), NFKB1(3), NFKBIA(1), PLCB1(18), PRKCA(7)	2821738	31	29	31	11	6	10	9	0	6	0	0.770	1.000	1.000
547	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(10), POLR2A(9), POLR2B(5), POLR2C(4), POLR2D(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), POLRMT(1)	4631296	39	29	38	16	8	8	13	6	4	0	0.852	1.000	1.000
548	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	14	ACE(10), CD44(2), CSF1(1), IL6R(8), SELL(4), SPN(3), TGFB1(2), TGFB2(8), TNFRSF1B(1), TNFRSF8(2), TNFSF8(1)	4394510	42	29	42	15	6	13	11	7	5	0	0.753	1.000	1.000
549	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), CYP2A13(4), CYP2A6(4), CYP2A7(4), NAT1(3), NAT2(2), XDH(11)	2737695	30	28	30	10	1	11	9	3	6	0	0.507	1.000	1.000
550	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(1), B3GNT1(3), B3GNT2(1), B3GNT3(1), B3GNT5(1), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT4(1), FUT1(2), FUT3(2), FUT7(2), FUT9(7), GCNT2(2), ST3GAL6(3), ST8SIA1(2)	5541571	32	28	31	19	7	6	10	6	3	0	0.980	1.000	1.000
551	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(8), UBE2A(4), UBE2D2(1), UBE2D3(3), UBE2E3(1), UBE2G2(1), UBE2H(1), UBE2I(1), UBE2J1(3), UBE2J2(2), UBE2L6(1), UBE2M(1), UBE2N(1), UBE3A(8)	3617742	37	28	36	14	9	10	4	7	7	0	0.810	1.000	1.000
552	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(3), CREBBP(4), EP300(2), NCOA3(8), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), RARA(3), RXRA(1)	7131289	33	27	32	11	4	11	11	3	4	0	0.692	1.000	1.000
553	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	5	ADAM17(7), ERBB4(21), NRG2(2), PRKCA(7), PSEN1(1)	2639683	38	27	38	12	5	16	11	3	3	0	0.737	1.000	1.000
554	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(4), HK1(3), HK2(9), HK3(12), IMPA1(1), IMPA2(1), ISYNA1(2), PGM1(2), PGM3(4), TGDS(2)	4028339	40	27	40	16	12	10	9	7	2	0	0.735	1.000	1.000
555	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(8), BAX(1), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CASP3(4), CASP6(1), CASP7(1), CASP8(4), CASP9(3), DFFA(3), DFFB(2)	4694500	34	27	34	13	4	8	9	5	8	0	0.889	1.000	1.000
556	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), HDAC9(20), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), MYOD1(5)	2782808	33	27	33	12	3	13	6	5	6	0	0.850	1.000	1.000
557	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), CD3D(2), GZMB(3), HLA-A(2), ITGAL(20), ITGB2(2), PRF1(5)	3004022	35	26	35	14	5	8	10	6	6	0	0.773	1.000	1.000
558	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREM(2), FOS(1), MAPK3(1), OPRK1(5), POLR2A(9), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1)	4408021	30	26	30	10	6	9	9	3	3	0	0.590	1.000	1.000
559	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(5), CYP11A1(1), CYP11B2(7), CYP17A1(3), HSD11B1(4), HSD11B2(1), HSD3B1(7), HSD3B2(13)	2393737	41	26	41	15	7	17	8	6	3	0	0.689	1.000	1.000
560	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	66	MRPL13(1), MRPS7(2), RPL11(1), RPL12(1), RPL14(1), RPL19(2), RPL21(1), RPL23A(2), RPL24(1), RPL27A(1), RPL29(1), RPL3(1), RPL30(3), RPL35(1), RPL36A(1), RPL37(1), RPL3L(2), RPL6(3), RPL7(1), RPL8(1), RPS10(1), RPS11(1), RPS12(1), RPS13(2), RPS18(1), RPS26(1), RPS29(1), RPS4Y1(1), RPSA(1)	7817602	38	26	38	14	9	11	8	5	5	0	0.772	1.000	1.000
561	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), FDXR(2), SHMT1(2)	5516610	37	26	36	13	10	7	9	7	4	0	0.685	1.000	1.000
562	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(8), BAX(1), BCL10(1), BCL2(1), BCL2L11(2), BID(1), CASP8AP2(10), CASP9(3), CES1(3)	3918877	30	26	30	15	4	10	8	5	3	0	0.982	1.000	1.000
563	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(8), JAK2(4), JAK3(5), MAPK3(1), STAT3(8), TYK2(2)	4066582	28	26	28	13	3	5	7	9	4	0	0.938	1.000	1.000
564	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(2), HS3ST2(2), HS3ST3A1(4), HS3ST3B1(1), XYLT1(19)	2303740	29	25	29	12	7	3	13	4	2	0	0.623	1.000	1.000
565	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	14	CCL3(1), EPO(3), FLT3(10), IGF1(5), IL1A(3), IL3(1), TGFB1(2), TGFB2(8), TGFB3(1)	2810059	34	25	34	12	4	12	4	8	6	0	0.755	1.000	1.000
566	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(2), HS3ST2(2), HS3ST3A1(4), HS3ST3B1(1), XYLT1(19)	2303740	29	25	29	12	7	3	13	4	2	0	0.623	1.000	1.000
567	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(3), ACOX3(6), FADS2(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1)	3505761	38	25	38	15	10	13	6	7	2	0	0.864	1.000	1.000
568	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(4), ACO2(1), AFMID(2), CS(1), GRHPR(1), HAO1(4), HAO2(8), MDH1(2), MDH2(2), MTHFD1(1), MTHFD1L(5), MTHFD2(1)	4599007	32	25	32	11	6	12	5	3	6	0	0.715	1.000	1.000
569	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), ESCO1(7), ESCO2(2), MYST3(8), MYST4(8), NAT6(1), PNPLA3(2), SH3GLB1(1)	5698207	37	25	37	12	5	13	6	8	5	0	0.717	1.000	1.000
570	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL1(3), FOSL2(1), IFNAR2(2), IFNB1(4), MAPK8(3), NFKB1(3), TNFRSF11A(7), TNFSF11(1), TRAF6(4)	3820407	29	25	28	11	6	6	6	4	7	0	0.842	1.000	1.000
571	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(4), HK1(3), HK2(9), HK3(12), IMPA1(1), PGM1(2), PGM3(4), TGDS(2)	3534386	37	25	37	15	10	10	9	6	2	0	0.779	1.000	1.000
572	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(2), ARFGAP3(2), ARFGEF2(6), CLTB(1), COPA(10), GBF1(7), GPLD1(4), KDELR1(1), KDELR2(1), KDELR3(5)	5529892	39	24	39	10	6	16	7	5	5	0	0.488	1.000	1.000
573	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), SHMT1(2)	5182499	35	24	34	13	10	7	7	7	4	0	0.757	1.000	1.000
574	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), SHMT1(2)	5182499	35	24	34	13	10	7	7	7	4	0	0.757	1.000	1.000
575	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(1), B3GALT5(1), FUT1(2), FUT9(7), GLA(4), HEXA(1), NAGA(3), ST3GAL1(3), ST3GAL2(3), ST8SIA1(2)	3668122	27	24	27	14	7	2	11	6	1	0	0.935	1.000	1.000
576	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), SHMT1(2)	5182499	35	24	34	13	10	7	7	7	4	0	0.757	1.000	1.000
577	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(3), NDUFB2(4), NDUFB4(1), NDUFB5(4), NDUFB6(1), NDUFS1(7), NDUFS2(6), NDUFV1(3)	2394195	33	24	33	13	4	8	8	5	8	0	0.856	1.000	1.000
578	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(2), GNAS(7), GNB1(2), GNGT1(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7)	3291875	32	23	32	12	7	10	10	1	4	0	0.838	1.000	1.000
579	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(2), CAMK1(2), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(8), CAMKK1(2), CAMKK2(1), SYT1(3)	3999256	26	23	26	10	2	12	3	5	4	0	0.825	1.000	1.000
580	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(2), FUT9(7), GLA(4), HEXA(1), NAGA(3), ST3GAL1(3), ST3GAL2(3), ST3GAL4(2), ST8SIA1(2)	3455839	27	23	27	13	7	2	10	6	2	0	0.886	1.000	1.000
581	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	16	CARS(1), CARS2(1), CTH(1), GOT1(2), GOT2(4), LDHA(3), LDHAL6A(3), LDHB(2), LDHC(5), SDS(2), SULT1C2(2), SULT1C4(1), SULT4A1(3)	4126809	30	23	30	16	6	10	6	6	2	0	0.983	1.000	1.000
582	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(3), CHST11(1), CHST12(5), CHST13(3), PAPSS1(3), PAPSS2(4), SULT1A2(1), SULT1E1(1), SULT2A1(3), SULT2B1(1), SUOX(5)	3174169	30	23	29	10	2	9	10	7	2	0	0.683	1.000	1.000
583	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(2), CLOCK(2), CRY1(3), CRY2(2), CSNK1D(2), CSNK1E(6), NPAS2(1), NR1D1(3), PER1(3), PER2(4), PER3(1)	5916673	29	23	29	12	8	9	9	0	3	0	0.828	1.000	1.000
584	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(4), EP300(2), LPL(5), NCOA1(5), NCOA2(6), PPARG(3), RXRA(1)	6362994	26	23	26	15	3	10	6	4	3	0	0.990	1.000	1.000
585	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(3), CREBBP(4), EP300(2), FADD(1), HDAC3(1), IKBKB(3), NFKB1(3), NFKBIA(1), RIPK1(4), TNFRSF1B(1), TRAF6(4)	7715697	27	23	26	17	5	4	7	3	8	0	0.993	1.000	1.000
586	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(10), AGT(2), AGTR1(5), AGTR2(2), BDKRB2(1), KNG1(3), NOS3(2), REN(1)	3453091	26	22	26	17	2	10	10	2	2	0	0.992	1.000	1.000
587	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDFT1(2), FDPS(1), HMGCR(4), IDI1(1), LSS(3), MVD(2), MVK(1), NQO1(3), NQO2(2), PMVK(1), SC5DL(3), SQLE(1), VKORC1(1)	3835979	27	22	26	13	3	10	7	5	2	0	0.927	1.000	1.000
588	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(3), IKBKAP(5), IKBKB(3), MAP3K1(4), MAP3K14(1), NFKB1(3), NFKBIA(1), TRAF3(3), TRAF6(4)	6216892	27	22	26	16	4	3	11	2	7	0	0.988	1.000	1.000
589	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	EHHADH(8), HADH(4), HADHA(3), HSD17B4(5), SIRT1(1), SIRT2(2), SIRT7(3), VNN2(4)	4077574	30	22	28	10	1	12	6	3	7	1	0.831	1.000	1.000
590	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(2), CTSD(2), ESR1(1), GREB1(14), HSPB1(1), HSPB2(1), MTA1(1), MTA3(3), PDZK1(2), TUBA8(1)	3783767	28	22	28	11	6	7	11	3	1	0	0.631	1.000	1.000
591	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(10), AOC2(4), AOC3(5), CES1(3), ESD(1)	2085274	23	21	23	10	3	9	6	2	3	0	0.862	1.000	1.000
592	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(10), GNAS(7), GNB1(2), GNGT1(2), PRKAR1A(1)	2243513	22	19	22	13	2	6	7	3	4	0	0.981	1.000	1.000
593	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), UGDH(4)	2946314	24	19	24	11	3	7	8	4	2	0	0.848	1.000	1.000
594	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(3), ACOX3(6), ELOVL2(4), ELOVL6(1), FADS2(1), FASN(4), HADHA(3), HSD17B12(1), PECR(1)	4953499	24	19	24	13	4	6	8	4	1	1	0.910	1.000	1.000
595	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(5), CAPNS2(2), CDK5(1), CSNK1A1(1), CSNK1D(2), GSK3B(2), MAPT(8), PPP2CA(1)	3277448	22	18	22	12	4	9	5	3	1	0	0.948	1.000	1.000
596	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(4), CKM(1), EIF4E(3), LDHA(3), LDHB(2), LDHC(5), MAPK14(1), NCL(4)	3040891	23	18	23	10	4	5	7	3	4	0	0.872	1.000	1.000
597	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(1), CDC25A(4), CDC25B(1), CDC25C(3), GRB2(4), PRKCA(7), PTPRA(4), SRC(2)	3158597	26	18	26	10	6	10	5	4	1	0	0.772	1.000	1.000
598	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(3), MAP3K14(1), MAPK14(1), MAPK8(3), NFKB1(3), TNFRSF13B(1), TNFSF13B(1), TRAF2(1), TRAF3(3), TRAF5(2), TRAF6(4)	5003421	23	18	22	15	5	2	8	2	6	0	0.989	1.000	1.000
599	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSR(1), GSS(3), NFKB1(3), NOX1(3), XDH(11)	3426069	22	17	22	10	3	7	8	2	2	0	0.838	1.000	1.000
600	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	12	CYSLTR1(1), CYSLTR2(4), GPR109B(1), GPR171(1), GPR18(2), GPR34(3), GPR39(2), GPR45(3), GPR75(2)	3115316	19	17	19	13	1	4	7	5	2	0	0.985	1.000	1.000
601	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(2), ASPH(2), COPS5(1), EDN1(1), EP300(2), EPO(3), HIF1A(1), LDHA(3), NOS3(2), P4HB(4), VHL(1)	5899498	22	17	22	15	2	8	4	2	5	1	0.999	1.000	1.000
602	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), FARSA(2), FARSB(3), GOT1(2), GOT2(4), PAH(3), TAT(4), YARS(1), YARS2(2)	2995549	22	17	22	10	6	9	5	1	1	0	0.846	1.000	1.000
603	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(9), APOBEC1(1), APOBEC3B(4), APOBEC3F(1), APOBEC3G(3), APOBEC4(1)	2524038	19	17	19	10	5	7	4	1	2	0	0.948	1.000	1.000
604	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(2), CDKN1A(1), EPO(3), EPOR(1), GRIN1(2), HIF1A(1), JAK2(4), NFKB1(3), NFKBIA(1), SOD2(1)	4383747	19	16	19	14	2	7	4	2	4	0	0.997	1.000	1.000
605	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), CYP2E1(4), NR1I3(5), PTGS1(5), PTGS2(4)	1823069	20	15	20	10	5	4	6	3	2	0	0.891	1.000	1.000
606	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(1), CTH(1), GOT1(2), GOT2(4), LDHA(3), LDHB(2), LDHC(5)	2352288	18	15	18	11	5	4	5	2	2	0	0.972	1.000	1.000
607	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(1), CS(1), FH(7), IDH2(2), MDH1(2), OGDH(1), SDHA(5)	3216534	19	14	19	14	5	4	5	3	2	0	0.981	1.000	1.000
608	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(3), ENO3(2), FARS2(1), GOT1(2), GOT2(4), PAH(3), TAT(4), YARS(1)	2843951	20	14	20	10	5	9	4	2	0	0	0.892	1.000	1.000
609	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(3), GPD2(4), SDHA(5), SDHB(1), SDHD(1)	2269619	14	12	14	14	2	1	9	1	1	0	1.000	1.000	1.000
610	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(1), ADORA2B(1), ADORA3(2), LTB4R(2), P2RY1(5), P2RY6(1)	2030772	12	11	12	11	2	1	5	2	2	0	0.979	1.000	1.000
611	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(4), EP300(2), ESR1(1), MAPK3(1), PELP1(2), SRC(2)	5057923	12	10	12	6	4	1	5	0	2	0	0.777	1.000	1.000
612	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	5	ASRGL1(1), GBA(3), GGT1(1), SHMT1(2), SHMT2(2)	1626358	9	8	9	7	3	2	4	0	0	0	0.930	1.000	1.000
613	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(1), FUT1(2), FUT3(2), ST3GAL3(1)	1754827	6	6	6	4	3	0	2	1	0	0	0.872	1.000	1.000
614	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(3)	628834	5	5	5	4	0	1	0	4	0	0	0.964	1.000	1.000
615	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	248236	1	1	1	3	1	0	0	0	0	0	0.998	1.000	1.000
616	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(1)	718144	1	1	1	2	0	0	0	1	0	0	0.990	1.000	1.000
