E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.027 0.136 -9999.0 0.0 -0.4 14.0 14.0 KLHL20 -0.007 0.11 0.255 1.0 -0.302 10.0 11.0 CYFIP2 0.026 0.047 -9999.0 0.0 -0.513 1.0 1.0 Rac1/GDP -0.001 0.104 0.247 1.0 -0.282 6.0 7.0 ENAH -0.027 0.141 -9999.0 0.0 -0.406 15.0 15.0 AP1M1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.025 0.062 -9999.0 0.0 -0.513 2.0 2.0 CTNNB1 0.029 0.015 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.01 0.077 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.032 0.059 -9999.0 0.0 -0.202 10.0 10.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.054 0.083 -9999.0 0.0 -0.292 7.0 7.0 RAPGEF1 -0.018 0.128 -9999.0 0.0 -0.38 11.0 11.0 CTNND1 0.015 0.097 -9999.0 0.0 -0.513 5.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.022 0.148 -9999.0 0.0 -0.415 15.0 15.0 CRK -0.015 0.132 -9999.0 0.0 -0.393 13.0 13.0 E-cadherin/gamma catenin/alpha catenin 0.017 0.126 -9999.0 0.0 -0.338 16.0 16.0 alphaE/beta7 Integrin 0.046 0.013 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.026 0.047 -9999.0 0.0 -0.513 1.0 1.0 Rap1/GTP/I-afadin 0.053 0.044 -9999.0 0.0 -0.291 2.0 2.0 DLG1 -0.02 0.112 -9999.0 0.0 -0.369 11.0 11.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.01 0.044 -9999.0 0.0 -0.255 2.0 2.0 MLLT4 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.055 0.045 -9999.0 0.0 -0.292 2.0 2.0 PI3K -0.011 0.058 -9999.0 0.0 -0.337 2.0 2.0 ARF6 0.024 0.063 -9999.0 0.0 -0.513 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.002 0.137 -9999.0 0.0 -0.393 16.0 16.0 TIAM1 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.039 0.097 -9999.0 0.0 -0.275 12.0 12.0 AKT1 0.005 0.057 0.147 2.0 -0.215 4.0 6.0 PIK3R1 0.005 0.099 -9999.0 0.0 -0.513 5.0 5.0 CDH1 0.006 0.114 -9999.0 0.0 -0.513 7.0 7.0 RhoA/GDP 0.005 0.103 0.248 1.0 -0.28 6.0 7.0 actin cytoskeleton organization -0.002 0.081 0.177 2.0 -0.214 10.0 12.0 CDC42/GDP 0.002 0.105 0.248 1.0 -0.282 6.0 7.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.016 0.103 -9999.0 0.0 -0.269 20.0 20.0 ITGB7 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.043 0.104 -9999.0 0.0 -0.293 12.0 12.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.035 0.072 -9999.0 0.0 -0.272 7.0 7.0 mol:GDP -0.015 0.111 0.249 1.0 -0.322 7.0 8.0 CDC42/GTP/IQGAP1 0.043 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP -0.004 0.135 -9999.0 0.0 -0.513 10.0 10.0 p120 catenin/RhoA/GDP 0.007 0.112 0.256 1.0 -0.288 6.0 7.0 RAC1/GTP/IQGAP1 0.043 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.043 0.037 -9999.0 0.0 -0.375 1.0 1.0 RHOA 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.007 0.077 0.164 1.0 -0.229 12.0 13.0 NME1 0.033 0.003 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.029 0.142 -9999.0 0.0 -0.406 15.0 15.0 regulation of cell-cell adhesion -0.002 0.062 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.004 0.047 -9999.0 0.0 -0.141 6.0 6.0 Rap1/GTP 0.009 0.086 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.044 0.123 -9999.0 0.0 -0.294 16.0 16.0 CCND1 -0.011 0.095 0.187 1.0 -0.288 12.0 13.0 VAV2 -0.042 0.228 -9999.0 0.0 -0.596 17.0 17.0 RAP1/GDP 0.012 0.095 0.264 1.0 -9999.0 0.0 1.0 adherens junction assembly -0.029 0.138 -9999.0 0.0 -0.394 15.0 15.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.027 0.046 -9999.0 0.0 -0.513 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.023 0.112 -9999.0 0.0 -0.283 16.0 16.0 E-cadherin/beta catenin -0.005 0.083 -9999.0 0.0 -0.352 8.0 8.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.03 0.14 -9999.0 0.0 -0.406 15.0 15.0 PIK3CA 0.009 0.062 -9999.0 0.0 -0.513 2.0 2.0 Rac1/GTP -0.064 0.156 -9999.0 0.0 -0.5 12.0 12.0 E-cadherin/beta catenin/alpha catenin 0.04 0.083 -9999.0 0.0 -0.319 7.0 7.0 ITGAE 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.023 0.151 -9999.0 0.0 -0.424 15.0 15.0