Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.137 0.276 -9999.0 0.0 -0.562 43.0 43.0 IHH -0.015 0.09 -9999.0 0.0 -0.54 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.043 0.143 -9999.0 0.0 -0.328 28.0 28.0 LRPAP1 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.043 0.142 0.326 28.0 -9999.0 0.0 28.0 SMO/beta Arrestin2 -0.115 0.236 -9999.0 0.0 -0.574 21.0 21.0 SMO -0.13 0.24 -9999.0 0.0 -0.578 23.0 23.0 AKT1 -0.075 0.22 -9999.0 0.0 -0.728 12.0 12.0 ARRB2 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.022 0.026 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.128 0.236 -9999.0 0.0 -0.568 23.0 23.0 STIL -0.077 0.159 -9999.0 0.0 -0.461 11.0 11.0 DHH N/PTCH2 0.048 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.05 0.163 -9999.0 0.0 -0.303 41.0 41.0 PIK3CA 0.009 0.062 -9999.0 0.0 -0.513 2.0 2.0 DHH 0.033 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.251 0.451 -9999.0 0.0 -0.962 43.0 43.0 determination of left/right symmetry -0.128 0.236 -9999.0 0.0 -0.568 23.0 23.0 PIK3R1 0.005 0.099 -9999.0 0.0 -0.513 5.0 5.0 skeletal system development -0.248 0.445 -9999.0 0.0 -0.948 43.0 43.0 IHH N/Hhip -0.056 0.158 -9999.0 0.0 -0.426 21.0 21.0 DHH N/Hhip -0.024 0.137 -9999.0 0.0 -0.375 19.0 19.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.128 0.236 -9999.0 0.0 -0.568 23.0 23.0 pancreas development -0.058 0.18 -9999.0 0.0 -0.512 20.0 20.0 HHAT -0.006 0.141 -9999.0 0.0 -0.513 11.0 11.0 PI3K 0.003 0.076 -9999.0 0.0 -0.375 5.0 5.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.053 0.186 -9999.0 0.0 -0.513 21.0 21.0 somite specification -0.128 0.236 -9999.0 0.0 -0.568 23.0 23.0 SHH Np/Cholesterol/PTCH1 -0.07 0.164 -9999.0 0.0 -0.382 18.0 18.0 SHH Np/Cholesterol/PTCH2 0.007 0.087 -9999.0 0.0 -0.291 12.0 12.0 SHH Np/Cholesterol/Megalin 0.001 0.092 -9999.0 0.0 -0.297 13.0 13.0 SHH -0.014 0.105 -9999.0 0.0 -0.375 12.0 12.0 catabolic process -0.07 0.173 -9999.0 0.0 -0.339 42.0 42.0 SMO/Vitamin D3 -0.104 0.206 -9999.0 0.0 -0.521 19.0 19.0 SHH Np/Cholesterol/Hhip -0.045 0.129 -9999.0 0.0 -0.301 29.0 29.0 LRP2 0.021 0.052 -9999.0 0.0 -0.513 1.0 1.0 receptor-mediated endocytosis -0.103 0.197 -9999.0 0.0 -0.51 18.0 18.0 SHH Np/Cholesterol/BOC -0.001 0.086 -9999.0 0.0 -0.291 12.0 12.0 SHH Np/Cholesterol/CDO 0.005 0.088 -9999.0 0.0 -0.293 12.0 12.0 mesenchymal cell differentiation 0.044 0.128 0.299 29.0 -9999.0 0.0 29.0 mol:Vitamin D3 -0.07 0.165 -9999.0 0.0 -0.398 16.0 16.0 IHH N/PTCH2 0.015 0.061 -9999.0 0.0 -0.328 1.0 1.0 CDON 0.029 0.02 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.063 0.18 -9999.0 0.0 -0.341 42.0 42.0 Megalin/LRPAP1 0.034 0.044 -9999.0 0.0 -0.375 1.0 1.0 PTCH2 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.005 0.083 -9999.0 0.0 -0.289 12.0 12.0 PTCH1 -0.07 0.174 -9999.0 0.0 -0.34 42.0 42.0 HHIP -0.058 0.18 -9999.0 0.0 -0.513 20.0 20.0