Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.211 0.336 -9999.0 0.0 -0.65 65.0 65.0 IHH -0.083 0.19 -9999.0 0.0 -0.66 19.0 19.0 SHH Np/Cholesterol/GAS1 -0.112 0.212 -9999.0 0.0 -0.411 68.0 68.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.112 0.21 0.408 68.0 -9999.0 0.0 68.0 SMO/beta Arrestin2 -0.161 0.272 -9999.0 0.0 -0.698 31.0 31.0 SMO -0.176 0.289 -9999.0 0.0 -0.728 33.0 33.0 AKT1 -0.059 0.122 -9999.0 0.0 -0.443 4.0 4.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.032 0.162 -9999.0 0.0 -0.63 15.0 15.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.173 0.282 -9999.0 0.0 -0.711 33.0 33.0 STIL -0.177 0.247 -9999.0 0.0 -0.596 41.0 41.0 DHH N/PTCH2 -0.021 0.141 -9999.0 0.0 -0.514 16.0 16.0 DHH N/PTCH1 -0.124 0.219 -9999.0 0.0 -0.585 25.0 25.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.004 0.1 -9999.0 0.0 -0.658 5.0 5.0 PTHLH -0.323 0.497 -9999.0 0.0 -1.1 55.0 55.0 determination of left/right symmetry -0.173 0.282 -9999.0 0.0 -0.711 33.0 33.0 PIK3R1 0.006 0.062 -9999.0 0.0 -0.637 2.0 2.0 skeletal system development -0.318 0.487 -9999.0 0.0 -1.078 55.0 55.0 IHH N/Hhip -0.178 0.268 -9999.0 0.0 -0.558 70.0 70.0 DHH N/Hhip -0.128 0.23 -9999.0 0.0 -0.482 64.0 64.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.173 0.282 -9999.0 0.0 -0.711 33.0 33.0 pancreas development -0.168 0.29 -9999.0 0.0 -0.635 61.0 61.0 HHAT -0.022 0.149 -9999.0 0.0 -0.671 11.0 11.0 PI3K 0.013 0.046 -9999.0 0.0 -0.469 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.037 0.173 -9999.0 0.0 -0.654 16.0 16.0 somite specification -0.173 0.282 -9999.0 0.0 -0.711 33.0 33.0 SHH Np/Cholesterol/PTCH1 -0.191 0.257 -9999.0 0.0 -0.62 42.0 42.0 SHH Np/Cholesterol/PTCH2 -0.106 0.191 -9999.0 0.0 -0.379 70.0 70.0 SHH Np/Cholesterol/Megalin -0.189 0.253 -9999.0 0.0 -0.441 100.0 100.0 SHH -0.116 0.223 -9999.0 0.0 -0.475 60.0 60.0 catabolic process -0.136 0.231 -9999.0 0.0 -0.6 27.0 27.0 SMO/Vitamin D3 -0.205 0.285 -9999.0 0.0 -0.707 39.0 39.0 SHH Np/Cholesterol/Hhip -0.189 0.234 -9999.0 0.0 -0.411 107.0 107.0 LRP2 -0.169 0.293 -9999.0 0.0 -0.642 61.0 61.0 receptor-mediated endocytosis -0.258 0.303 -9999.0 0.0 -0.682 57.0 57.0 SHH Np/Cholesterol/BOC -0.11 0.195 -9999.0 0.0 -0.38 72.0 72.0 SHH Np/Cholesterol/CDO -0.109 0.194 -9999.0 0.0 -0.381 71.0 71.0 mesenchymal cell differentiation 0.188 0.232 0.408 107.0 -9999.0 0.0 107.0 mol:Vitamin D3 -0.19 0.258 -9999.0 0.0 -0.621 42.0 42.0 IHH N/PTCH2 -0.066 0.168 -9999.0 0.0 -0.466 31.0 31.0 CDON -0.029 0.157 -9999.0 0.0 -0.632 14.0 14.0 IHH N/PTCH1 -0.137 0.233 -9999.0 0.0 -0.605 27.0 27.0 Megalin/LRPAP1 -0.118 0.22 -9999.0 0.0 -0.473 61.0 61.0 PTCH2 -0.025 0.153 -9999.0 0.0 -0.66 12.0 12.0 SHH Np/Cholesterol -0.101 0.17 -9999.0 0.0 -0.374 60.0 60.0 PTCH1 -0.136 0.232 -9999.0 0.0 -0.602 27.0 27.0 HHIP -0.168 0.291 -9999.0 0.0 -0.637 61.0 61.0