E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.009 0.096 -9999.0 0.0 -0.338 11.0 11.0 KLHL20 0.003 0.082 0.168 2.0 -0.254 9.0 11.0 CYFIP2 0.02 0.053 -9999.0 0.0 -0.51 2.0 2.0 Rac1/GDP 0.015 0.079 0.249 2.0 -9999.0 0.0 2.0 ENAH -0.007 0.098 -9999.0 0.0 -0.336 12.0 12.0 AP1M1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.02 0.039 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.02 0.046 -9999.0 0.0 -0.172 10.0 10.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.05 0.063 -9999.0 0.0 -0.295 6.0 6.0 RAPGEF1 -0.001 0.09 0.228 1.0 -0.313 4.0 5.0 CTNND1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.0 0.103 -9999.0 0.0 -0.342 12.0 12.0 CRK -0.001 0.092 -9999.0 0.0 -0.323 9.0 9.0 E-cadherin/gamma catenin/alpha catenin 0.049 0.03 -9999.0 0.0 -0.32 1.0 1.0 alphaE/beta7 Integrin 0.027 0.068 -9999.0 0.0 -0.373 6.0 6.0 IQGAP1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.048 0.017 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.001 0.071 -9999.0 0.0 -0.339 7.0 7.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.008 0.015 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.043 0.046 -9999.0 0.0 -0.259 4.0 4.0 PI3K -0.008 0.019 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.036 0.03 -9999.0 0.0 -0.373 1.0 1.0 TIAM1 0.018 0.065 -9999.0 0.0 -0.377 5.0 5.0 E-cadherin(dimer)/Ca2+ 0.057 0.022 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.005 0.033 0.134 1.0 -9999.0 0.0 1.0 PIK3R1 0.022 0.039 -9999.0 0.0 -0.344 2.0 2.0 CDH1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.022 0.073 0.252 2.0 -9999.0 0.0 2.0 actin cytoskeleton organization 0.005 0.063 0.16 3.0 -0.187 8.0 11.0 CDC42/GDP 0.019 0.078 0.237 3.0 -9999.0 0.0 3.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.017 0.019 -9999.0 0.0 -0.247 1.0 1.0 ITGB7 0.013 0.088 -9999.0 0.0 -0.51 6.0 6.0 RAC1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.062 0.024 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.043 0.016 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.003 0.084 0.257 2.0 -0.306 1.0 3.0 CDC42/GTP/IQGAP1 0.036 0.008 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.024 0.036 -9999.0 0.0 -0.51 1.0 1.0 p120 catenin/RhoA/GDP 0.028 0.075 0.256 2.0 -9999.0 0.0 2.0 RAC1/GTP/IQGAP1 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.039 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.0 0.061 0.121 3.0 -0.217 11.0 14.0 NME1 0.026 0.014 -9999.0 0.0 -0.177 1.0 1.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.007 0.098 -9999.0 0.0 -0.336 12.0 12.0 regulation of cell-cell adhesion 0.008 0.027 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.005 0.034 -9999.0 0.0 -0.133 2.0 2.0 Rap1/GTP 0.021 0.045 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.06 0.068 -9999.0 0.0 -0.281 7.0 7.0 CCND1 -0.001 0.075 0.138 3.0 -0.272 11.0 14.0 VAV2 -0.009 0.174 -9999.0 0.0 -0.638 11.0 11.0 RAP1/GDP 0.025 0.06 0.243 1.0 -9999.0 0.0 1.0 adherens junction assembly -0.007 0.096 -9999.0 0.0 -0.327 12.0 12.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.041 0.062 -9999.0 0.0 -0.272 7.0 7.0 E-cadherin/beta catenin 0.012 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.009 0.098 -9999.0 0.0 -0.336 12.0 12.0 PIK3CA 0.014 0.014 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.036 0.11 -9999.0 0.0 -0.414 10.0 10.0 E-cadherin/beta catenin/alpha catenin 0.049 0.018 -9999.0 0.0 -9999.0 0.0 0.0 ITGAE 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.0 0.105 -9999.0 0.0 -0.349 12.0 12.0