Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.144 0.255 -9999.0 0.0 -0.572 52.0 52.0 IHH -0.042 0.12 -9999.0 0.0 -0.391 13.0 13.0 SHH Np/Cholesterol/GAS1 -0.049 0.131 -9999.0 0.0 -0.324 36.0 36.0 LRPAP1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.048 0.13 0.322 36.0 -9999.0 0.0 36.0 SMO/beta Arrestin2 -0.117 0.231 -9999.0 0.0 -0.567 31.0 31.0 SMO -0.13 0.238 -9999.0 0.0 -0.555 37.0 37.0 AKT1 -0.063 0.156 -9999.0 0.0 -0.626 10.0 10.0 ARRB2 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.004 0.093 -9999.0 0.0 -0.344 12.0 12.0 ADRBK1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.128 0.233 -9999.0 0.0 -0.544 37.0 37.0 STIL -0.115 0.17 -9999.0 0.0 -0.43 34.0 34.0 DHH N/PTCH2 0.012 0.103 -9999.0 0.0 -0.398 12.0 12.0 DHH N/PTCH1 -0.078 0.17 -9999.0 0.0 -0.333 57.0 57.0 PIK3CA 0.014 0.014 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.013 0.074 -9999.0 0.0 -0.444 5.0 5.0 PTHLH -0.235 0.413 -9999.0 0.0 -0.945 53.0 53.0 determination of left/right symmetry -0.128 0.233 -9999.0 0.0 -0.544 37.0 37.0 PIK3R1 0.022 0.039 -9999.0 0.0 -0.344 2.0 2.0 skeletal system development -0.232 0.407 -9999.0 0.0 -0.932 53.0 53.0 IHH N/Hhip -0.084 0.163 -9999.0 0.0 -0.34 52.0 52.0 DHH N/Hhip -0.047 0.151 -9999.0 0.0 -0.378 33.0 33.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.128 0.233 -9999.0 0.0 -0.544 37.0 37.0 pancreas development -0.074 0.183 -9999.0 0.0 -0.34 59.0 59.0 HHAT 0.003 0.112 -9999.0 0.0 -0.51 10.0 10.0 PI3K 0.017 0.033 -9999.0 0.0 -0.373 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.001 0.114 -9999.0 0.0 -0.415 14.0 14.0 somite specification -0.128 0.233 -9999.0 0.0 -0.544 37.0 37.0 SHH Np/Cholesterol/PTCH1 -0.115 0.177 -9999.0 0.0 -0.387 48.0 48.0 SHH Np/Cholesterol/PTCH2 -0.047 0.122 -9999.0 0.0 -0.295 38.0 38.0 SHH Np/Cholesterol/Megalin -0.089 0.157 -9999.0 0.0 -0.34 53.0 53.0 SHH -0.058 0.132 -9999.0 0.0 -0.385 27.0 27.0 catabolic process -0.09 0.176 -9999.0 0.0 -0.368 53.0 53.0 SMO/Vitamin D3 -0.135 0.215 -9999.0 0.0 -0.524 36.0 36.0 SHH Np/Cholesterol/Hhip -0.087 0.147 -9999.0 0.0 -0.319 54.0 54.0 LRP2 -0.08 0.195 -9999.0 0.0 -0.51 34.0 34.0 receptor-mediated endocytosis -0.172 0.231 -9999.0 0.0 -0.56 40.0 40.0 SHH Np/Cholesterol/BOC -0.044 0.119 -9999.0 0.0 -0.312 31.0 31.0 SHH Np/Cholesterol/CDO -0.045 0.119 -9999.0 0.0 -0.298 35.0 35.0 mesenchymal cell differentiation 0.087 0.146 0.317 54.0 -9999.0 0.0 54.0 mol:Vitamin D3 -0.114 0.178 -9999.0 0.0 -0.432 36.0 36.0 IHH N/PTCH2 -0.028 0.115 -9999.0 0.0 -0.395 15.0 15.0 CDON 0.005 0.094 -9999.0 0.0 -0.32 14.0 14.0 IHH N/PTCH1 -0.086 0.181 -9999.0 0.0 -0.37 53.0 53.0 Megalin/LRPAP1 -0.045 0.149 -9999.0 0.0 -0.371 34.0 34.0 PTCH2 0.003 0.108 -9999.0 0.0 -0.45 11.0 11.0 SHH Np/Cholesterol -0.041 0.105 -9999.0 0.0 -0.296 28.0 28.0 PTCH1 -0.091 0.177 -9999.0 0.0 -0.369 53.0 53.0 HHIP -0.074 0.183 -9999.0 0.0 -0.341 59.0 59.0