Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.021 0.008 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.052 0.02 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.02 0.053 -9999.0 0.0 -0.51 2.0 2.0 ENAH 0.004 0.082 0.259 6.0 -0.341 1.0 7.0 EGFR -0.016 0.143 -9999.0 0.0 -0.51 17.0 17.0 EPHA2 0.004 0.103 -9999.0 0.0 -0.51 8.0 8.0 MYO6 -0.01 0.034 -9999.0 0.0 -0.27 1.0 1.0 CTNNB1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.045 0.041 -9999.0 0.0 -0.32 2.0 2.0 AQP5 -0.079 0.177 -9999.0 0.0 -0.459 38.0 38.0 CTNND1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.009 0.029 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.025 0.058 0.173 3.0 -0.266 9.0 12.0 EGF -0.053 0.176 -9999.0 0.0 -0.383 42.0 42.0 NCKAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.04 0.133 -9999.0 0.0 -0.44 20.0 20.0 cortical microtubule organization 0.052 0.02 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 -0.009 0.026 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.058 0.022 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.028 0.05 -9999.0 0.0 -0.459 1.0 1.0 ARF6 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.039 0.078 -9999.0 0.0 -0.331 7.0 7.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.003 0.019 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.011 0.03 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.042 0.077 -9999.0 0.0 -0.312 7.0 7.0 CDH1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.023 0.135 -9999.0 0.0 -0.305 36.0 36.0 RhoA/GDP 0.053 0.021 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.013 0.027 -9999.0 0.0 -0.246 1.0 1.0 IGF-1R heterotetramer 0.007 0.1 -9999.0 0.0 -0.509 8.0 8.0 GIT1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.007 0.101 -9999.0 0.0 -0.51 8.0 8.0 IGF1 0.001 0.106 -9999.0 0.0 -0.344 16.0 16.0 DIAPH1 0.008 0.156 -9999.0 0.0 -0.53 13.0 13.0 Wnt receptor signaling pathway -0.052 0.02 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.028 0.05 -9999.0 0.0 -0.455 1.0 1.0 CTNNA1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.013 0.027 -9999.0 0.0 -0.251 1.0 1.0 EFNA1 0.021 0.051 -9999.0 0.0 -0.51 2.0 2.0 LPP -0.01 0.025 -9999.0 0.0 -0.264 1.0 1.0 Ephrin A1/EPHA2 0.03 0.07 -9999.0 0.0 -0.293 8.0 8.0 SEC6/SEC8 -0.017 0.012 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.025 0.059 -9999.0 0.0 -0.27 9.0 9.0 HGF/MET 0.018 0.088 -9999.0 0.0 -0.264 17.0 17.0 HGF -0.013 0.134 -9999.0 0.0 -0.41 20.0 20.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.021 0.008 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.049 0.103 0.296 12.0 -0.308 1.0 13.0 KIAA1543 -0.012 0.036 -9999.0 0.0 -0.258 2.0 2.0 KIFC3 -0.015 0.037 0.174 3.0 -0.27 2.0 5.0 NCK1 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.021 0.012 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.01 0.028 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.033 0.016 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.052 0.02 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.009 0.029 0.174 4.0 -9999.0 0.0 4.0 PIP5K1C -0.009 0.029 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.011 0.097 0.277 9.0 -0.4 1.0 10.0 adherens junction assembly -0.012 0.083 0.258 1.0 -0.448 4.0 5.0 IGF-1R heterotetramer/IGF1 0.022 0.081 -9999.0 0.0 -0.261 14.0 14.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.039 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.014 0.081 -9999.0 0.0 -0.455 6.0 6.0 PLEKHA7 -0.012 0.038 -9999.0 0.0 -0.27 2.0 2.0 mol:GTP 0.037 0.077 -9999.0 0.0 -0.329 7.0 7.0 establishment of epithelial cell apical/basal polarity 0.027 0.09 0.349 5.0 -9999.0 0.0 5.0 cortical actin cytoskeleton stabilization 0.021 0.008 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion -0.013 0.027 -9999.0 0.0 -0.246 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.021 0.008 -9999.0 0.0 -9999.0 0.0 0.0