Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling mediated by p38-alpha and p38-beta	38.0	1681.0	44.0	-0.223	0.027	1000.0	-1000.0	-0.029	-1000.0
Wnt signaling	31.0	222.0	7.0	-0.104	0.023	1000.0	-1000.0	-0.024	-1000.0
TCGA08_retinoblastoma	31.0	250.0	8.0	-0.052	0.071	1000.0	-1000.0	-0.005	-1000.0
Signaling events mediated by the Hedgehog family	30.0	1566.0	52.0	-0.235	0.087	1000.0	-1000.0	-0.046	-1000.0
IL23-mediated signaling events	27.0	1665.0	60.0	-0.524	0.027	1000.0	-1000.0	-0.129	-1000.0
IL4-mediated signaling events	24.0	2243.0	91.0	-0.555	0.474	1000.0	-1000.0	-0.146	-1000.0
Syndecan-1-mediated signaling events	22.0	749.0	34.0	-0.074	0.027	1000.0	-1000.0	-0.045	-1000.0
Noncanonical Wnt signaling pathway	22.0	593.0	26.0	-0.104	0.027	1000.0	-1000.0	-0.05	-1000.0
HIF-1-alpha transcription factor network	22.0	1740.0	76.0	-0.265	0.037	1000.0	-1000.0	-0.137	-1000.0
p75(NTR)-mediated signaling	20.0	2538.0	125.0	-0.114	0.065	1000.0	-1000.0	-0.075	-1000.0
Glucocorticoid receptor regulatory network	19.0	2274.0	114.0	-0.443	0.212	1000.0	-1000.0	-0.058	-1000.0
Ephrin A  reverse signaling	17.0	123.0	7.0	-0.042	0.009	1000.0	-1000.0	-0.01	-1000.0
Glypican 1 network	17.0	862.0	48.0	-0.117	0.027	1000.0	-1000.0	-0.032	-1000.0
BCR signaling pathway	17.0	1704.0	99.0	-0.141	0.041	1000.0	-1000.0	-0.06	-1000.0
EGFR-dependent Endothelin signaling events	17.0	365.0	21.0	-0.064	0.039	1000.0	-1000.0	-0.046	-1000.0
Ephrin B reverse signaling	16.0	771.0	48.0	-0.083	0.03	1000.0	-1000.0	-0.032	-1000.0
Endothelins	16.0	1617.0	96.0	-0.154	0.042	1000.0	-1000.0	-0.058	-1000.0
TCR signaling in naïve CD8+ T cells	15.0	1442.0	93.0	-0.085	0.039	1000.0	-1000.0	-0.05	-1000.0
IGF1 pathway	15.0	866.0	57.0	-0.05	0.052	1000.0	-1000.0	-0.046	-1000.0
IL12-mediated signaling events	14.0	1260.0	87.0	-0.26	0.041	1000.0	-1000.0	-0.096	-1000.0
BMP receptor signaling	14.0	1152.0	81.0	-0.098	0.049	1000.0	-1000.0	-0.048	-1000.0
Fc-epsilon receptor I signaling in mast cells	14.0	1448.0	97.0	-0.053	0.069	1000.0	-1000.0	-0.064	-1000.0
S1P5 pathway	14.0	250.0	17.0	-0.047	0.041	1000.0	-1000.0	-0.017	-1000.0
EPHB forward signaling	14.0	1244.0	85.0	-0.087	0.065	1000.0	-1000.0	-0.068	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	14.0	1705.0	120.0	-0.149	0.093	1000.0	-1000.0	-0.049	-1000.0
amb2 Integrin signaling	13.0	1137.0	82.0	-0.12	0.034	1000.0	-1000.0	-0.049	-1000.0
Glypican 2 network	13.0	55.0	4.0	-0.019	-0.0	1000.0	-1000.0	0.003	-1000.0
Calcium signaling in the CD4+ TCR pathway	13.0	403.0	31.0	-0.126	0.026	1000.0	-1000.0	-0.046	-1000.0
LPA receptor mediated events	13.0	1372.0	102.0	-0.113	0.033	1000.0	-1000.0	-0.052	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	13.0	918.0	68.0	-0.174	0.048	1000.0	-1000.0	-0.1	-1000.0
Visual signal transduction: Rods	13.0	679.0	52.0	-0.078	0.028	1000.0	-1000.0	-0.037	-1000.0
FOXA2 and FOXA3 transcription factor networks	12.0	565.0	46.0	-0.235	0.055	1000.0	-1000.0	-0.124	-1000.0
TCGA08_p53	12.0	88.0	7.0	-0.03	0.027	1000.0	-1000.0	-0.005	-1000.0
Syndecan-4-mediated signaling events	12.0	818.0	67.0	-0.117	0.036	1000.0	-1000.0	-0.044	-1000.0
Osteopontin-mediated events	11.0	455.0	38.0	-0.06	0.031	1000.0	-1000.0	-0.037	-1000.0
Thromboxane A2 receptor signaling	11.0	1169.0	105.0	-0.06	0.033	1000.0	-1000.0	-0.064	-1000.0
Arf6 signaling events	11.0	722.0	62.0	-0.053	0.039	1000.0	-1000.0	-0.039	-1000.0
Reelin signaling pathway	11.0	631.0	56.0	-0.067	0.059	1000.0	-1000.0	-0.048	-1000.0
Canonical Wnt signaling pathway	11.0	604.0	51.0	-0.121	0.061	1000.0	-1000.0	-0.053	-1000.0
Effects of Botulinum toxin	11.0	288.0	26.0	-0.051	0.027	1000.0	-1000.0	-0.012	-1000.0
LPA4-mediated signaling events	10.0	124.0	12.0	-0.06	0.004	1000.0	-1000.0	-0.024	-1000.0
Visual signal transduction: Cones	10.0	380.0	38.0	-0.036	0.028	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by PTP1B	10.0	830.0	76.0	-0.075	0.043	1000.0	-1000.0	-0.037	-1000.0
Plasma membrane estrogen receptor signaling	10.0	875.0	86.0	-0.088	0.044	1000.0	-1000.0	-0.051	-1000.0
S1P4 pathway	10.0	266.0	25.0	-0.047	0.044	1000.0	-1000.0	-0.029	-1000.0
ErbB2/ErbB3 signaling events	9.0	640.0	65.0	-0.064	0.039	1000.0	-1000.0	-0.054	-1000.0
Caspase cascade in apoptosis	9.0	736.0	74.0	-0.068	0.059	1000.0	-1000.0	-0.048	-1000.0
Syndecan-2-mediated signaling events	9.0	660.0	69.0	-0.117	0.039	1000.0	-1000.0	-0.05	-1000.0
mTOR signaling pathway	9.0	510.0	53.0	-0.046	0.095	1000.0	-1000.0	-0.04	-1000.0
IL1-mediated signaling events	9.0	569.0	62.0	-0.105	0.05	1000.0	-1000.0	-0.058	-1000.0
FAS signaling pathway (CD95)	9.0	431.0	47.0	-0.051	0.068	1000.0	-1000.0	-0.045	-1000.0
Syndecan-3-mediated signaling events	9.0	330.0	35.0	-0.067	0.065	1000.0	-1000.0	-0.024	-1000.0
Nongenotropic Androgen signaling	9.0	501.0	52.0	-0.044	0.027	1000.0	-1000.0	-0.036	-1000.0
Coregulation of Androgen receptor activity	8.0	674.0	76.0	-0.118	0.05	1000.0	-1000.0	-0.032	-1000.0
ErbB4 signaling events	8.0	576.0	69.0	-0.078	0.038	1000.0	-1000.0	-0.049	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	8.0	708.0	85.0	-0.028	0.059	1000.0	-1000.0	-0.048	-1000.0
Presenilin action in Notch and Wnt signaling	8.0	540.0	61.0	-0.121	0.065	1000.0	-1000.0	-0.049	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	8.0	429.0	52.0	-0.057	0.034	1000.0	-1000.0	-0.052	-1000.0
S1P1 pathway	8.0	315.0	36.0	-0.1	0.027	1000.0	-1000.0	-0.048	-1000.0
IL27-mediated signaling events	8.0	428.0	51.0	-0.112	0.044	1000.0	-1000.0	-0.049	-1000.0
Regulation of nuclear SMAD2/3 signaling	7.0	1065.0	136.0	-0.285	0.071	1000.0	-1000.0	-0.054	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	7.0	255.0	34.0	-0.017	0.027	1000.0	-1000.0	-0.037	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	7.0	412.0	54.0	-0.061	0.039	1000.0	-1000.0	-0.048	-1000.0
Nectin adhesion pathway	7.0	456.0	63.0	-0.035	0.048	1000.0	-1000.0	-0.057	-1000.0
Signaling events regulated by Ret tyrosine kinase	7.0	635.0	82.0	-0.029	0.027	1000.0	-1000.0	-0.062	-1000.0
Integrins in angiogenesis	7.0	639.0	84.0	-0.066	0.058	1000.0	-1000.0	-0.05	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	7.0	247.0	33.0	-0.068	0.069	1000.0	-1000.0	-0.028	-1000.0
FOXM1 transcription factor network	7.0	367.0	51.0	-0.032	0.126	1000.0	-1000.0	-0.13	-1000.0
Regulation of Androgen receptor activity	7.0	507.0	70.0	-0.166	0.035	1000.0	-1000.0	-0.051	-1000.0
Sphingosine 1-phosphate (S1P) pathway	6.0	183.0	28.0	-0.034	0.041	1000.0	-1000.0	-0.022	-1000.0
JNK signaling in the CD4+ TCR pathway	6.0	106.0	17.0	-0.017	0.041	1000.0	-1000.0	-0.037	-1000.0
Hedgehog signaling events mediated by Gli proteins	6.0	393.0	65.0	-0.122	0.062	1000.0	-1000.0	-0.054	-1000.0
IFN-gamma pathway	6.0	447.0	68.0	-0.042	0.055	1000.0	-1000.0	-0.063	-1000.0
IL2 signaling events mediated by PI3K	6.0	349.0	58.0	-0.057	0.035	1000.0	-1000.0	-0.051	-1000.0
IL6-mediated signaling events	6.0	495.0	75.0	-0.262	0.053	1000.0	-1000.0	-0.07	-1000.0
Angiopoietin receptor Tie2-mediated signaling	6.0	539.0	88.0	-0.067	0.036	1000.0	-1000.0	-0.083	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	6.0	469.0	78.0	-0.045	0.028	1000.0	-1000.0	-0.056	-1000.0
Ceramide signaling pathway	5.0	419.0	76.0	-0.053	0.07	1000.0	-1000.0	-0.045	-1000.0
HIF-2-alpha transcription factor network	5.0	232.0	43.0	-0.041	0.048	1000.0	-1000.0	-0.062	-1000.0
TCGA08_rtk_signaling	5.0	152.0	26.0	-0.072	0.083	1000.0	-1000.0	-0.021	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	5.0	379.0	74.0	-0.079	0.058	1000.0	-1000.0	-0.072	-1000.0
IL2 signaling events mediated by STAT5	5.0	117.0	22.0	-0.028	0.028	1000.0	-1000.0	-0.049	-1000.0
Regulation of Telomerase	5.0	524.0	102.0	-0.101	0.067	1000.0	-1000.0	-0.045	-1000.0
PDGFR-beta signaling pathway	5.0	528.0	97.0	-0.123	0.064	1000.0	-1000.0	-0.067	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	96.0	17.0	0.0	0.044	1000.0	-1000.0	-0.03	-1000.0
a4b1 and a4b7 Integrin signaling	4.0	21.0	5.0	0.013	0.033	1000.0	-1000.0	0.006	-1000.0
Cellular roles of Anthrax toxin	4.0	172.0	39.0	-0.037	0.031	1000.0	-1000.0	-0.024	-1000.0
PLK1 signaling events	4.0	353.0	85.0	-0.026	0.106	1000.0	-1000.0	-0.032	-1000.0
PDGFR-alpha signaling pathway	4.0	213.0	44.0	-0.024	0.048	1000.0	-1000.0	-0.041	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	4.0	158.0	37.0	-0.027	0.06	1000.0	-1000.0	-0.037	-1000.0
TRAIL signaling pathway	4.0	231.0	48.0	-0.007	0.07	1000.0	-1000.0	-0.043	-1000.0
Signaling mediated by p38-gamma and p38-delta	4.0	64.0	15.0	-0.015	0.027	1000.0	-1000.0	-0.036	-1000.0
Retinoic acid receptors-mediated signaling	4.0	251.0	58.0	-0.022	0.051	1000.0	-1000.0	-0.052	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	4.0	213.0	45.0	-0.031	0.059	1000.0	-1000.0	-0.052	-1000.0
Class I PI3K signaling events	4.0	310.0	73.0	-0.057	0.049	1000.0	-1000.0	-0.043	-1000.0
Insulin Pathway	4.0	355.0	74.0	-0.076	0.067	1000.0	-1000.0	-0.06	-1000.0
S1P3 pathway	4.0	194.0	42.0	-0.028	0.049	1000.0	-1000.0	-0.045	-1000.0
E-cadherin signaling in keratinocytes	4.0	190.0	43.0	-0.057	0.066	1000.0	-1000.0	-0.038	-1000.0
EPO signaling pathway	3.0	217.0	55.0	-0.005	0.056	1000.0	-1000.0	-0.051	-1000.0
Signaling events mediated by HDAC Class III	3.0	158.0	40.0	-0.049	0.05	1000.0	-1000.0	-0.026	-1000.0
ceramide signaling pathway	3.0	150.0	49.0	-0.012	0.038	1000.0	-1000.0	-0.049	-1000.0
Regulation of p38-alpha and p38-beta	3.0	209.0	54.0	-0.057	0.063	1000.0	-1000.0	-0.052	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	392.0	125.0	-0.009	0.063	1000.0	-1000.0	-0.056	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	251.0	76.0	-0.036	0.062	1000.0	-1000.0	-0.065	-1000.0
Rapid glucocorticoid signaling	3.0	68.0	20.0	-0.014	0.033	1000.0	-1000.0	-0.005	-1000.0
Class IB PI3K non-lipid kinase events	3.0	9.0	3.0	-0.019	0.019	1000.0	-1000.0	-0.006	-1000.0
Aurora B signaling	3.0	235.0	67.0	-0.073	0.07	1000.0	-1000.0	-0.043	-1000.0
Canonical NF-kappaB pathway	2.0	78.0	39.0	-0.012	0.056	1000.0	-1000.0	-0.042	-1000.0
BARD1 signaling events	2.0	117.0	57.0	-0.033	0.061	1000.0	-1000.0	-0.047	-1000.0
Aurora A signaling	2.0	141.0	60.0	-0.041	0.053	1000.0	-1000.0	-0.03	-1000.0
Arf6 downstream pathway	2.0	114.0	43.0	-0.046	0.047	1000.0	-1000.0	-0.026	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	192.0	83.0	-0.011	0.051	1000.0	-1000.0	-0.046	-1000.0
Signaling events mediated by HDAC Class I	2.0	277.0	104.0	-0.051	0.066	1000.0	-1000.0	-0.035	-1000.0
FoxO family signaling	2.0	136.0	64.0	-0.048	0.065	1000.0	-1000.0	-0.05	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	101.0	36.0	-0.047	0.049	1000.0	-1000.0	-0.042	-1000.0
VEGFR1 specific signals	2.0	141.0	56.0	-0.026	0.059	1000.0	-1000.0	-0.057	-1000.0
Signaling events mediated by PRL	2.0	81.0	34.0	-0.035	0.039	1000.0	-1000.0	-0.047	-1000.0
p38 MAPK signaling pathway	2.0	98.0	44.0	-0.025	0.051	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by HDAC Class II	1.0	127.0	75.0	-0.031	0.069	1000.0	-1000.0	-0.035	-1000.0
Circadian rhythm pathway	1.0	25.0	22.0	-0.007	0.044	1000.0	-1000.0	-0.033	-1000.0
Aurora C signaling	1.0	9.0	7.0	0.0	0.043	1000.0	-1000.0	-0.013	-1000.0
Insulin-mediated glucose transport	1.0	32.0	32.0	-0.0	0.05	1000.0	-1000.0	-0.038	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	109.0	68.0	-0.041	0.056	1000.0	-1000.0	-0.042	-1000.0
Atypical NF-kappaB pathway	1.0	58.0	31.0	0.0	0.028	1000.0	-1000.0	-0.027	-1000.0
Arf6 trafficking events	1.0	119.0	71.0	-0.042	0.049	1000.0	-1000.0	-0.036	-1000.0
Alternative NF-kappaB pathway	1.0	15.0	13.0	0.0	0.066	1000.0	-1000.0	0.0	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	7.0	23.0	0.004	0.05	1000.0	-1000.0	-0.032	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	0.007	0.024	1000.0	-1000.0	-0.023	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	25.0	27.0	-0.01	0.059	1000.0	-1000.0	-0.04	-1000.0
E-cadherin signaling events	0.0	2.0	5.0	0.024	0.047	1000.0	-1000.0	0.004	-1000.0
Arf1 pathway	0.0	48.0	54.0	-0.002	0.037	1000.0	-1000.0	-0.018	-1000.0
Total	1118	67235	7203	-10.0707286956	6.87545921067	131000	-131000	-5.9525311202	-131000