E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.047 0.103 -9999.0 0.0 -0.324 64.0 64.0 KLHL20 -0.059 0.078 0.476 1.0 -0.267 20.0 21.0 CYFIP2 0.028 0.006 -9999.0 0.0 0.0 24.0 24.0 Rac1/GDP -0.046 0.079 0.236 5.0 -0.258 15.0 20.0 ENAH -0.048 0.104 -9999.0 0.0 -0.322 66.0 66.0 AP1M1 0.026 0.01 -9999.0 0.0 0.0 67.0 67.0 RAP1B 0.029 0.006 -9999.0 0.0 0.0 22.0 22.0 RAP1A 0.029 0.003 -9999.0 0.0 0.0 7.0 7.0 CTNNB1 0.029 0.003 -9999.0 0.0 0.0 7.0 7.0 CDC42/GTP -0.059 0.05 0.124 6.0 -0.233 2.0 8.0 ABI1/Sra1/Nap1 -0.053 0.045 -9999.0 0.0 -0.169 34.0 34.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.056 0.048 -9999.0 0.0 -0.141 9.0 9.0 RAPGEF1 -0.048 0.1 0.25 3.0 -0.307 56.0 59.0 CTNND1 0.029 0.003 -9999.0 0.0 0.0 5.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.024 0.115 -9999.0 0.0 -0.324 68.0 68.0 CRK -0.047 0.102 -9999.0 0.0 -0.318 61.0 61.0 E-cadherin/gamma catenin/alpha catenin 0.043 0.044 -9999.0 0.0 -0.156 20.0 20.0 alphaE/beta7 Integrin 0.041 0.014 -9999.0 0.0 -0.163 1.0 1.0 IQGAP1 0.028 0.006 -9999.0 0.0 0.0 25.0 25.0 NCKAP1 0.029 0.005 -9999.0 0.0 0.0 17.0 17.0 Rap1/GTP/I-afadin 0.04 0.042 -9999.0 0.0 -0.13 21.0 21.0 DLG1 -0.034 0.104 0.194 1.0 -0.325 54.0 55.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.044 0.042 -9999.0 0.0 -0.148 16.0 16.0 MLLT4 0.026 0.01 -9999.0 0.0 0.0 70.0 70.0 ARF6/GTP/NME1/Tiam1 0.048 0.024 -9999.0 0.0 -0.13 1.0 1.0 PI3K -0.054 0.054 -9999.0 0.0 -0.203 8.0 8.0 ARF6 0.029 0.004 -9999.0 0.0 0.0 11.0 11.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.03 0.042 -9999.0 0.0 -0.175 19.0 19.0 TIAM1 0.028 0.006 -9999.0 0.0 -0.001 21.0 21.0 E-cadherin(dimer)/Ca2+ 0.052 0.043 -9999.0 0.0 -0.132 9.0 9.0 AKT1 -0.013 0.069 0.136 52.0 -9999.0 0.0 52.0 PIK3R1 0.021 0.013 -9999.0 0.0 0.0 161.0 161.0 CDH1 0.026 0.01 -9999.0 0.0 -0.0 74.0 74.0 RhoA/GDP -0.046 0.078 0.237 4.0 -0.252 19.0 23.0 actin cytoskeleton organization -0.043 0.058 0.412 1.0 -0.21 10.0 11.0 CDC42/GDP -0.045 0.079 0.237 5.0 -0.251 19.0 24.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.015 0.059 -9999.0 0.0 -0.188 37.0 37.0 ITGB7 0.029 0.004 -9999.0 0.0 0.0 9.0 9.0 RAC1 0.028 0.007 -9999.0 0.0 -0.001 29.0 29.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.057 0.047 -9999.0 0.0 -0.141 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.039 0.033 -9999.0 0.0 -0.121 9.0 9.0 mol:GDP -0.044 0.084 0.264 3.0 -0.277 21.0 24.0 CDC42/GTP/IQGAP1 0.037 0.014 -9999.0 0.0 -0.133 2.0 2.0 JUP 0.027 0.008 -9999.0 0.0 0.0 43.0 43.0 p120 catenin/RhoA/GDP -0.049 0.081 0.242 4.0 -0.258 17.0 21.0 RAC1/GTP/IQGAP1 0.036 0.015 -9999.0 0.0 -0.133 2.0 2.0 PIP5K1C/AP1M1 0.037 0.017 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.029 0.003 -9999.0 0.0 0.0 6.0 6.0 CDC42 0.029 0.004 -9999.0 0.0 0.0 11.0 11.0 CTNNA1 0.029 0.004 -9999.0 0.0 0.0 11.0 11.0 positive regulation of S phase of mitotic cell cycle -0.045 0.057 0.115 1.0 -0.129 145.0 146.0 NME1 0.027 0.008 -9999.0 0.0 0.0 43.0 43.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.049 0.106 -9999.0 0.0 -0.323 68.0 68.0 regulation of cell-cell adhesion -0.054 0.041 0.084 5.0 -0.206 2.0 7.0 WASF2 -0.031 0.035 0.085 5.0 -0.101 42.0 47.0 Rap1/GTP -0.055 0.058 0.252 2.0 -0.251 2.0 4.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.057 0.064 -9999.0 0.0 -0.151 20.0 20.0 CCND1 -0.055 0.069 0.132 1.0 -0.158 145.0 146.0 VAV2 -0.041 0.165 -9999.0 0.0 -0.652 24.0 24.0 RAP1/GDP -0.046 0.066 0.254 3.0 -0.254 3.0 6.0 adherens junction assembly -0.048 0.103 -9999.0 0.0 -0.315 68.0 68.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.005 -9999.0 0.0 0.0 15.0 15.0 PIP5K1C 0.027 0.008 -9999.0 0.0 0.0 44.0 44.0 regulation of heterotypic cell-cell adhesion -0.06 0.03 0.172 4.0 -0.228 2.0 6.0 E-cadherin/beta catenin -0.012 0.05 -9999.0 0.0 -0.18 41.0 41.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.046 0.102 -9999.0 0.0 -0.326 62.0 62.0 PIK3CA 0.021 0.014 -9999.0 0.0 0.0 171.0 171.0 Rac1/GTP -0.089 0.112 0.568 1.0 -0.386 37.0 38.0 E-cadherin/beta catenin/alpha catenin 0.048 0.032 -9999.0 0.0 -0.146 9.0 9.0 ITGAE 0.028 0.007 -9999.0 0.0 0.0 31.0 31.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.025 0.117 -9999.0 0.0 -0.33 68.0 68.0