Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.061 0.248 -9999.0 0.0 -0.786 22.0 22.0 IHH -0.059 0.153 -9999.0 0.0 -0.399 41.0 41.0 SHH Np/Cholesterol/GAS1 -0.063 0.163 -9999.0 0.0 -0.441 33.0 33.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.063 0.162 0.437 33.0 -9999.0 0.0 33.0 SMO/beta Arrestin2 -0.02 0.123 -9999.0 0.0 -0.483 7.0 7.0 SMO -0.028 0.129 -9999.0 0.0 -0.499 8.0 8.0 AKT1 0.003 0.064 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.007 0.095 -9999.0 0.0 -0.47 10.0 10.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.028 0.127 -9999.0 0.0 -0.479 9.0 9.0 STIL -0.063 0.16 -9999.0 0.0 -0.472 18.0 18.0 DHH N/PTCH2 -0.042 0.147 -9999.0 0.0 -0.378 39.0 39.0 DHH N/PTCH1 -0.036 0.143 -9999.0 0.0 -0.485 13.0 13.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.014 0.119 -9999.0 0.0 -0.543 12.0 12.0 PTHLH -0.057 0.263 -9999.0 0.0 -0.863 19.0 19.0 determination of left/right symmetry -0.028 0.127 -9999.0 0.0 -0.479 9.0 9.0 PIK3R1 0.008 0.035 -9999.0 0.0 -0.392 2.0 2.0 skeletal system development -0.056 0.258 -9999.0 0.0 -0.848 19.0 19.0 IHH N/Hhip -0.1 0.186 -9999.0 0.0 -0.417 55.0 55.0 DHH N/Hhip -0.074 0.179 -9999.0 0.0 -0.388 58.0 58.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.028 0.127 -9999.0 0.0 -0.479 9.0 9.0 pancreas development -0.087 0.211 -9999.0 0.0 -0.513 49.0 49.0 HHAT -0.016 0.133 -9999.0 0.0 -0.65 11.0 11.0 PI3K 0.015 0.025 -9999.0 0.0 -0.266 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.025 0.151 -9999.0 0.0 -0.633 15.0 15.0 somite specification -0.028 0.127 -9999.0 0.0 -0.479 9.0 9.0 SHH Np/Cholesterol/PTCH1 -0.068 0.163 -9999.0 0.0 -0.504 16.0 16.0 SHH Np/Cholesterol/PTCH2 -0.073 0.156 -9999.0 0.0 -0.392 41.0 41.0 SHH Np/Cholesterol/Megalin -0.194 0.195 -9999.0 0.0 -0.413 98.0 98.0 SHH -0.063 0.162 -9999.0 0.0 -0.356 55.0 55.0 catabolic process -0.031 0.139 -9999.0 0.0 -0.479 11.0 11.0 SMO/Vitamin D3 -0.06 0.161 -9999.0 0.0 -0.494 16.0 16.0 SHH Np/Cholesterol/Hhip -0.098 0.179 -9999.0 0.0 -0.428 47.0 47.0 LRP2 -0.257 0.284 -9999.0 0.0 -0.526 131.0 131.0 receptor-mediated endocytosis -0.153 0.185 -9999.0 0.0 -0.529 27.0 27.0 SHH Np/Cholesterol/BOC -0.052 0.139 -9999.0 0.0 -0.413 23.0 23.0 SHH Np/Cholesterol/CDO -0.046 0.139 -9999.0 0.0 -0.434 21.0 21.0 mesenchymal cell differentiation 0.097 0.177 0.424 47.0 -9999.0 0.0 47.0 mol:Vitamin D3 -0.067 0.164 -9999.0 0.0 -0.505 16.0 16.0 IHH N/PTCH2 -0.065 0.156 -9999.0 0.0 -0.395 38.0 38.0 CDON 0.003 0.067 -9999.0 0.0 -0.521 4.0 4.0 IHH N/PTCH1 -0.031 0.14 -9999.0 0.0 -0.483 11.0 11.0 Megalin/LRPAP1 -0.18 0.211 -9999.0 0.0 -0.481 68.0 68.0 PTCH2 -0.045 0.161 -9999.0 0.0 -0.478 30.0 30.0 SHH Np/Cholesterol -0.049 0.126 -9999.0 0.0 -0.398 21.0 21.0 PTCH1 -0.031 0.139 -9999.0 0.0 -0.48 11.0 11.0 HHIP -0.088 0.212 -9999.0 0.0 -0.513 49.0 49.0