Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.019 0.046 -9999.0 0.0 -0.279 6.0 6.0 epithelial cell differentiation -0.008 0.051 -9999.0 0.0 -0.343 6.0 6.0 CYFIP2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.046 0.043 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.011 0.114 -9999.0 0.0 -0.573 10.0 10.0 EPHA2 0.009 0.041 -9999.0 0.0 -0.65 1.0 1.0 MYO6 0.021 0.074 -9999.0 0.0 -0.437 6.0 6.0 CTNNB1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.075 0.176 -9999.0 0.0 -0.522 33.0 33.0 CTNND1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.023 0.052 -9999.0 0.0 -0.319 6.0 6.0 regulation of calcium-dependent cell-cell adhesion -0.007 0.112 -9999.0 0.0 -0.335 26.0 26.0 EGF -0.072 0.198 -9999.0 0.0 -0.509 42.0 42.0 NCKAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.027 0.101 -9999.0 0.0 -0.489 10.0 10.0 cortical microtubule organization -0.008 0.051 -9999.0 0.0 -0.343 6.0 6.0 GO:0000145 0.022 0.05 -9999.0 0.0 -0.304 6.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.019 0.056 -9999.0 0.0 -0.346 6.0 6.0 MLLT4 0.006 0.058 -9999.0 0.0 -0.65 2.0 2.0 ARF6/GDP -0.008 0.046 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.027 0.034 -9999.0 0.0 -0.367 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.032 0.052 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.009 0.041 -9999.0 0.0 -0.65 1.0 1.0 ZYX 0.023 0.053 -9999.0 0.0 -0.323 6.0 6.0 ARF6/GTP 0.03 0.032 -9999.0 0.0 -0.336 2.0 2.0 CDH1 -0.001 0.091 -9999.0 0.0 -0.65 5.0 5.0 EGFR/EGFR/EGF/EGF -0.053 0.111 -9999.0 0.0 -0.322 32.0 32.0 RhoA/GDP -0.007 0.048 -9999.0 0.0 -0.32 6.0 6.0 actin cytoskeleton organization 0.024 0.078 -9999.0 0.0 -0.462 6.0 6.0 IGF-1R heterotetramer -0.014 0.127 -9999.0 0.0 -0.649 10.0 10.0 GIT1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.014 0.127 -9999.0 0.0 -0.65 10.0 10.0 IGF1 -0.016 0.125 -9999.0 0.0 -0.551 13.0 13.0 DIAPH1 -0.0 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.008 0.051 0.343 6.0 -9999.0 0.0 6.0 RHOA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.008 0.046 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.009 0.041 -9999.0 0.0 -0.65 1.0 1.0 VCL 0.024 0.08 -9999.0 0.0 -0.477 6.0 6.0 EFNA1 0.009 0.041 -9999.0 0.0 -0.65 1.0 1.0 LPP 0.027 0.055 -9999.0 0.0 -0.305 7.0 7.0 Ephrin A1/EPHA2 -0.009 0.053 -9999.0 0.0 -0.309 8.0 8.0 SEC6/SEC8 -0.01 0.058 -9999.0 0.0 -0.589 1.0 1.0 MGAT3 -0.007 0.114 -9999.0 0.0 -0.34 26.0 26.0 HGF/MET -0.053 0.131 -9999.0 0.0 -0.364 35.0 35.0 HGF -0.031 0.154 -9999.0 0.0 -0.569 19.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.019 0.046 -9999.0 0.0 -0.281 6.0 6.0 actin cable formation 0.06 0.041 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.02 0.101 -9999.0 0.0 -0.576 6.0 6.0 KIFC3 0.023 0.053 -9999.0 0.0 -0.323 6.0 6.0 NCK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.023 0.053 -9999.0 0.0 -0.323 6.0 6.0 NCK1/GIT1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.008 0.051 -9999.0 0.0 -0.343 6.0 6.0 EXOC4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.023 0.053 -9999.0 0.0 -0.323 6.0 6.0 PIP5K1C 0.023 0.053 -9999.0 0.0 -0.323 6.0 6.0 LIMA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.042 0.049 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.034 0.096 -9999.0 0.0 -0.657 4.0 4.0 IGF-1R heterotetramer/IGF1 -0.032 0.102 -9999.0 0.0 -0.358 18.0 18.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.011 0.053 -9999.0 0.0 -0.481 3.0 3.0 MET -0.045 0.181 -9999.0 0.0 -0.607 24.0 24.0 PLEKHA7 0.021 0.068 -9999.0 0.0 -0.373 7.0 7.0 mol:GTP 0.026 0.034 -9999.0 0.0 -0.364 2.0 2.0 establishment of epithelial cell apical/basal polarity 0.04 0.063 -9999.0 0.0 -0.558 1.0 1.0 cortical actin cytoskeleton stabilization 0.019 0.046 -9999.0 0.0 -0.279 6.0 6.0 regulation of cell-cell adhesion 0.024 0.078 -9999.0 0.0 -0.462 6.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.019 0.046 -9999.0 0.0 -0.281 6.0 6.0