E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.011 0.103 -9999.0 0.0 -0.378 8.0 8.0 KLHL20 -0.009 0.092 -9999.0 0.0 -0.258 14.0 14.0 CYFIP2 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.011 0.08 0.277 3.0 -0.279 3.0 6.0 ENAH -0.012 0.104 -9999.0 0.0 -0.378 8.0 8.0 AP1M1 0.026 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.02 0.046 -9999.0 0.0 -0.221 2.0 2.0 ABI1/Sra1/Nap1 -0.025 0.051 -9999.0 0.0 -0.172 15.0 15.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.051 0.07 -9999.0 0.0 -0.285 9.0 9.0 RAPGEF1 -0.006 0.096 0.275 3.0 -0.352 6.0 9.0 CTNND1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.004 0.11 -9999.0 0.0 -0.386 8.0 8.0 CRK -0.004 0.091 -9999.0 0.0 -0.366 7.0 7.0 E-cadherin/gamma catenin/alpha catenin 0.045 0.05 -9999.0 0.0 -0.305 4.0 4.0 alphaE/beta7 Integrin 0.033 0.055 -9999.0 0.0 -0.352 5.0 5.0 IQGAP1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.047 0.029 -9999.0 0.0 -0.277 1.0 1.0 DLG1 -0.009 0.095 -9999.0 0.0 -0.358 8.0 8.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.012 0.02 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.025 0.033 -9999.0 0.0 -0.491 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.049 0.039 -9999.0 0.0 -0.277 3.0 3.0 PI3K -0.001 0.03 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.032 0.051 -9999.0 0.0 -0.357 4.0 4.0 TIAM1 0.022 0.056 -9999.0 0.0 -0.491 3.0 3.0 E-cadherin(dimer)/Ca2+ 0.055 0.048 -9999.0 0.0 -0.264 4.0 4.0 AKT1 0.005 0.04 0.162 2.0 -9999.0 0.0 2.0 PIK3R1 0.025 0.011 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.018 0.064 -9999.0 0.0 -0.491 4.0 4.0 RhoA/GDP 0.014 0.081 0.277 3.0 -0.277 3.0 6.0 actin cytoskeleton organization -0.005 0.068 -9999.0 0.0 -0.185 14.0 14.0 CDC42/GDP 0.015 0.08 0.277 3.0 -0.277 3.0 6.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.014 0.035 -9999.0 0.0 -0.238 4.0 4.0 ITGB7 0.019 0.072 -9999.0 0.0 -0.491 5.0 5.0 RAC1 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.059 0.051 -9999.0 0.0 -0.28 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.04 0.043 -9999.0 0.0 -0.26 4.0 4.0 mol:GDP -0.001 0.085 0.282 3.0 -0.316 3.0 6.0 CDC42/GTP/IQGAP1 0.038 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.024 0.084 0.274 3.0 -0.284 3.0 6.0 RAC1/GTP/IQGAP1 0.036 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.035 0.017 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.012 0.075 0.15 1.0 -0.211 27.0 28.0 NME1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.006 0.095 -9999.0 0.0 -0.394 6.0 6.0 regulation of cell-cell adhesion 0.007 0.035 -9999.0 0.0 -0.192 4.0 4.0 WASF2 -0.001 0.036 -9999.0 0.0 -0.123 3.0 3.0 Rap1/GTP 0.02 0.057 0.273 2.0 -0.238 4.0 6.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.06 0.072 -9999.0 0.0 -0.271 9.0 9.0 CCND1 -0.016 0.093 0.171 1.0 -0.264 27.0 28.0 VAV2 -0.017 0.174 -9999.0 0.0 -0.636 13.0 13.0 RAP1/GDP 0.023 0.066 0.29 2.0 -0.244 1.0 3.0 adherens junction assembly -0.005 0.093 -9999.0 0.0 -0.382 6.0 6.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.043 0.064 -9999.0 0.0 -0.263 9.0 9.0 E-cadherin/beta catenin 0.007 0.038 -9999.0 0.0 -0.277 4.0 4.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.01 0.102 -9999.0 0.0 -0.379 8.0 8.0 PIK3CA 0.023 0.012 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.046 0.131 -9999.0 0.0 -0.407 18.0 18.0 E-cadherin/beta catenin/alpha catenin 0.045 0.05 -9999.0 0.0 -0.305 4.0 4.0 ITGAE 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.005 0.112 -9999.0 0.0 -0.394 8.0 8.0