Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.001 0.114 0.365 22.0 -9999.0 0.0 22.0 KIRREL 0.023 0.027 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.001 0.114 -9999.0 0.0 -0.365 22.0 22.0 PLCG1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.028 0.095 -9999.0 0.0 -0.274 21.0 21.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.003 0.079 -9999.0 0.0 -0.259 21.0 21.0 FYN -0.006 0.093 0.273 2.0 -0.256 23.0 25.0 mol:Ca2+ 0.026 0.094 -9999.0 0.0 -0.272 21.0 21.0 mol:DAG 0.027 0.094 -9999.0 0.0 -0.273 21.0 21.0 NPHS2 0.012 0.03 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 0.027 0.094 -9999.0 0.0 -0.273 21.0 21.0 regulation of endocytosis 0.023 0.086 -9999.0 0.0 -0.245 22.0 22.0 Nephrin/NEPH1/podocin/Cholesterol 0.014 0.09 -9999.0 0.0 -0.271 22.0 22.0 establishment of cell polarity 0.001 0.114 -9999.0 0.0 -0.365 22.0 22.0 Nephrin/NEPH1/podocin/NCK1-2 0.04 0.094 -9999.0 0.0 -0.253 21.0 21.0 Nephrin/NEPH1/beta Arrestin2 0.025 0.088 -9999.0 0.0 -0.247 22.0 22.0 NPHS1 -0.031 0.15 -9999.0 0.0 -0.494 24.0 24.0 Nephrin/NEPH1/podocin 0.016 0.088 -9999.0 0.0 -0.257 23.0 23.0 TJP1 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.028 0.095 -9999.0 0.0 -0.274 21.0 21.0 CD2AP 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.029 0.095 -9999.0 0.0 -0.274 21.0 21.0 GRB2 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.015 0.093 0.22 4.0 -0.252 23.0 27.0 cytoskeleton organization -0.02 0.094 0.201 2.0 -0.328 20.0 22.0 Nephrin/NEPH1 0.006 0.081 -9999.0 0.0 -0.254 22.0 22.0 Nephrin/NEPH1/ZO-1 0.016 0.098 -9999.0 0.0 -0.292 22.0 22.0