Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.022 0.192 -9999.0 0.0 -0.686 19.0 19.0 IHH 0.023 0.059 -9999.0 0.0 -0.521 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.02 0.107 -9999.0 0.0 -0.304 30.0 30.0 LRPAP1 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.02 0.107 0.302 30.0 -9999.0 0.0 30.0 SMO/beta Arrestin2 0.015 0.104 -9999.0 0.0 -0.377 7.0 7.0 SMO -0.006 0.102 -9999.0 0.0 -0.393 8.0 8.0 AKT1 -0.006 0.087 -9999.0 0.0 -0.359 4.0 4.0 ARRB2 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.02 0.057 -9999.0 0.0 -0.491 3.0 3.0 ADRBK1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.005 0.101 -9999.0 0.0 -0.388 8.0 8.0 STIL -0.023 0.114 -9999.0 0.0 -0.382 9.0 9.0 DHH N/PTCH2 0.015 0.097 -9999.0 0.0 -0.357 16.0 16.0 DHH N/PTCH1 0.009 0.11 -9999.0 0.0 -0.314 25.0 25.0 PIK3CA 0.023 0.012 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.013 0.085 -9999.0 0.0 -0.491 7.0 7.0 PTHLH -0.028 0.204 -9999.0 0.0 -0.72 18.0 18.0 determination of left/right symmetry -0.005 0.101 -9999.0 0.0 -0.388 8.0 8.0 PIK3R1 0.025 0.011 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.027 0.201 -9999.0 0.0 -0.711 18.0 18.0 IHH N/Hhip 0.0 0.123 -9999.0 0.0 -0.389 22.0 22.0 DHH N/Hhip -0.004 0.127 -9999.0 0.0 -0.368 27.0 27.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.005 0.101 -9999.0 0.0 -0.388 8.0 8.0 pancreas development -0.021 0.141 -9999.0 0.0 -0.49 21.0 21.0 HHAT 0.009 0.1 -9999.0 0.0 -0.491 10.0 10.0 PI3K 0.03 0.02 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.004 0.109 -9999.0 0.0 -0.491 12.0 12.0 somite specification -0.005 0.101 -9999.0 0.0 -0.388 8.0 8.0 SHH Np/Cholesterol/PTCH1 -0.018 0.113 -9999.0 0.0 -0.284 36.0 36.0 SHH Np/Cholesterol/PTCH2 -0.018 0.098 -9999.0 0.0 -0.286 29.0 29.0 SHH Np/Cholesterol/Megalin -0.079 0.141 -9999.0 0.0 -0.289 77.0 77.0 SHH -0.031 0.101 -9999.0 0.0 -0.372 20.0 20.0 catabolic process 0.001 0.102 -9999.0 0.0 -0.35 19.0 19.0 SMO/Vitamin D3 -0.015 0.122 -9999.0 0.0 -0.404 10.0 10.0 SHH Np/Cholesterol/Hhip -0.032 0.12 -9999.0 0.0 -0.312 37.0 37.0 LRP2 -0.117 0.218 -9999.0 0.0 -0.491 65.0 65.0 receptor-mediated endocytosis -0.072 0.139 -9999.0 0.0 -0.432 12.0 12.0 SHH Np/Cholesterol/BOC -0.009 0.088 -9999.0 0.0 -0.292 21.0 21.0 SHH Np/Cholesterol/CDO -0.008 0.093 -9999.0 0.0 -0.313 20.0 20.0 mesenchymal cell differentiation 0.033 0.119 0.31 37.0 -9999.0 0.0 37.0 mol:Vitamin D3 -0.013 0.119 -9999.0 0.0 -0.284 36.0 36.0 IHH N/PTCH2 0.019 0.093 -9999.0 0.0 -0.393 11.0 11.0 CDON 0.023 0.046 -9999.0 0.0 -0.491 2.0 2.0 IHH N/PTCH1 0.011 0.105 -9999.0 0.0 -0.352 19.0 19.0 Megalin/LRPAP1 -0.06 0.172 -9999.0 0.0 -0.356 65.0 65.0 PTCH2 0.003 0.101 -9999.0 0.0 -0.491 10.0 10.0 SHH Np/Cholesterol -0.013 0.082 -9999.0 0.0 -0.287 20.0 20.0 PTCH1 0.001 0.102 -9999.0 0.0 -0.351 19.0 19.0 HHIP -0.021 0.141 -9999.0 0.0 -0.491 21.0 21.0